Research Topics
Species | William ChristenSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physiciansWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Ophthalmology 119:1642-9. 2012..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians...- Beta carotene supplementation and age-related maculopathy in a randomized trial of US physiciansWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
Arch Ophthalmol 125:333-9. 2007..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial... - Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective studyWilliam G Christen
Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
Arch Ophthalmol 126:102-9. 2008..To examine in prospective data the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in women... - Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular StudyWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
Arch Intern Med 169:335-41. 2009..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy... - Fruit and vegetable intake and the risk of cataract in womenWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 81:1417-22. 2005..Prospective data on cataract in relation to total fruit and vegetable intake are limited... - Age-related cataract in a randomized trial of beta-carotene in womenWilliam Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ophthalmic Epidemiol 11:401-12. 2004..To examine the development of age-related cataract in a trial of beta-carotene supplementation in women... - Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of womenWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ophthalmology 116:2386-92. 2009..To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women... - Vitamin E and age-related macular degeneration in a randomized trial of womenWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ophthalmology 117:1163-8. 2010..To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women... - Age-related cataract in a randomized trial of vitamins E and C in menWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
Arch Ophthalmol 128:1397-405. 2010..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men... - Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in womenWilliam G Christen
Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arch Ophthalmol 129:921-9. 2011..To examine whether intake of ω-3 fatty acids and fish affects incidence of age-related macular degeneration (AMD) in women... - A randomized trial of beta carotene and age-related cataract in US physiciansWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Third Floor, Boston, MA 02215 1204, USA
Arch Ophthalmol 121:372-8. 2003..To examine the development of age-related cataract in a trial of beta carotene supplementation in men... - Vitamin E and age-related cataract in a randomized trial of womenWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ophthalmology 115:822-829.e1. 2008..To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women... - Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trialJ Michael Gaziano
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
JAMA 301:52-62. 2009..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer... - Evaluation of risk factors for cataract types in a competing risks frameworkRobert J Glynn
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Ophthalmic Epidemiol 16:98-106. 2009..One can compare the impact of risk factors on different types of cataract with methods of competing risk survival analysis that account for tied events... - Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trialHoward D Sesso
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
JAMA 300:2123-33. 2008..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease... - High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in womenDebra A Schaumberg
Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA
Arch Ophthalmol 125:300-5. 2007..To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD)... - A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degenerationDebra A Schaumberg
Division of Preventive Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, and Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02215, USA
Invest Ophthalmol Vis Sci 47:2336-40. 2006..Although plasma CRP levels have been related to AMD and plasma CRP levels are partly determined by genetic variation, there is no information on whether genetic variants in CRP are associated with AMD... - Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrinMohsin Malik
Department of Medicine, New England Baptist Hospital, Harvard School of Dental Medicine, Boston, MA, USA
J Oral Pathol Med 36:1-5. 2007..Oral pemphigoid (OP) is limited to the oral cavity. The purpose of this study was to determine the association between malignancy and patients with OP with antibodies to alpha6-integrin subunit... - Outcomes of early and late immunomodulatory treatment in patients with HLA-B27-associated chronic uveitisSofia Androudi
Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114-3069, USA
Graefes Arch Clin Exp Ophthalmol 241:1000-5. 2003..However, introduction of IMT within 3 years of the disease onset prevents the adverse effects of steroids (cataract, glaucoma) and reduces the likelihood of repeated recurrences of the uveitis... - A nonrandomized comparison of the clinical outcome of ocular involvement in patients with mucous membrane (cicatricial) pemphigoid between conventional immunosuppressive and intravenous immunoglobulin therapiesErik Letko
Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Clin Immunol 111:303-10. 2004..This clinical difference could be because of the reduced production of pathogenic antibody, and/or restoration of the immunoregulation, which may have been disturbed... - Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studiesVictor L Perez
Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Ocul Immunol Inflamm 12:193-201. 2004..Review of these studies indicate that Interleukin-6 (IL-6) is present, and animal data suggest the important role of IL-6 in the regulation of ophthalmologic immune responses... - Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparisonElisabetta Miserocchi
Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
Ophthalmology 109:1532-7. 2002..Other parameters evaluated in this study were not statistically different in the two patient groups... - Patterns of exacerbations of chronic non-infectious uveitis in pregnancy and puerperiumLeila I Kump
Massachusetts Eye Research and Surgery Institute, Cambridge, MA, USA
Ocul Immunol Inflamm 14:99-104. 2006..To determine patterns of exacerbations of recurrent non-infectious uveitis during pregnancy and puerperium... - Primary pars plana vitrectomy versus scleral buckle surgery for the treatment of pseudophakic retinal detachment: a randomized clinical trialPeriklis D Brazitikos
Department of Ophthalmology, Aristotle University, Thessaloniki, Greece
Retina 25:957-64. 2005..Retinal reattachment rate with multiple surgeries and final visual acuity at 1 year were similar for SB surgery and PPV... - A-scan quantitative echography of senile cataracts and correlation with phacoemulsification parametersPeriklis D Brazitikos
Ophthalmology Clinic, Aristotle University of Thessaloniki, Greece
Curr Eye Res 27:175-81. 2003..To study the echographic appearance of various types of senile cataracts using a-scan quantitative echography and correlate these findings with phacoemulsification parameters indicating surgical lens hardness...
Research Grants
- Folic Acid, B-Vitamins and AMD: Blood and Diet-based StudiesWilliam G Christen; Fiscal Year: 2010....
- Dietary Factors in Eye DiseaseWilliam Christen; Fiscal Year: 2006..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
- Eye Disease in a Trial of Selenium and Vitamin EWilliam Christen; Fiscal Year: 2007..abstract_text> ..
- Folic Acid, B-Vitamins and AMD: Blood and Diet-based StudiesWilliam Christen; Fiscal Year: 2009....
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 2002....
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 1993....