William Christen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Does long-term aspirin use increase the risk of neovascular age-related macular degeneration?
    William G Christen
    Brigham and Women s Hospital, Harvard Medical School, Division of Preventive Medicine, Department of Medicine, Boston, MA, USA
    Expert Opin Drug Saf 13:421-9. 2014
  2. pmc Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Ophthalmology 121:525-34. 2014
  3. pmc Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1642-9. 2012
  4. ncbi request reprint Vitamin E and age-related cataract in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 115:822-829.e1. 2008
  5. pmc Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 126:102-9. 2008
  6. pmc Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
    Arch Intern Med 169:335-41. 2009
  7. pmc Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 116:2386-92. 2009
  8. pmc Vitamin E and age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 117:1163-8. 2010
  9. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
  10. pmc Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Ophthalmol 129:921-9. 2011

Research Grants

  1. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William G Christen; Fiscal Year: 2010
  2. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2003
  3. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2004
  4. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2005
  5. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2006
  6. Dietary Factors in Eye Disease
    William Christen; Fiscal Year: 2006
  7. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2007
  8. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William Christen; Fiscal Year: 2009
  9. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
  10. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2001

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Does long-term aspirin use increase the risk of neovascular age-related macular degeneration?
    William G Christen
    Brigham and Women s Hospital, Harvard Medical School, Division of Preventive Medicine, Department of Medicine, Boston, MA, USA
    Expert Opin Drug Saf 13:421-9. 2014
    ..Recent findings from several observational epidemiologic studies indicate that regular aspirin use may also be associated with increased risks of some forms of age-related macular degeneration (AMD)...
  2. pmc Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Ophthalmology 121:525-34. 2014
    ..To test whether long-term multivitamin supplementation affects the incidence of cataract or age-related macular degeneration (AMD) in a large cohort of men...
  3. pmc Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1642-9. 2012
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians...
  4. ncbi request reprint Vitamin E and age-related cataract in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 115:822-829.e1. 2008
    ..To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women...
  5. pmc Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 126:102-9. 2008
    ..To examine in prospective data the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in women...
  6. pmc Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
    Arch Intern Med 169:335-41. 2009
    ..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy...
  7. pmc Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 116:2386-92. 2009
    ..To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women...
  8. pmc Vitamin E and age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 117:1163-8. 2010
    ..To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women...
  9. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men...
  10. pmc Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Ophthalmol 129:921-9. 2011
    ..To examine whether intake of ω-3 fatty acids and fish affects incidence of age-related macular degeneration (AMD) in women...
  11. pmc Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Ophthalmol 125:333-9. 2007
    ..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial...
  12. ncbi request reprint Age-related cataract in a randomized trial of beta-carotene in women
    William Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmic Epidemiol 11:401-12. 2004
    ..To examine the development of age-related cataract in a trial of beta-carotene supplementation in women...
  13. ncbi request reprint Fruit and vegetable intake and the risk of cataract in women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 81:1417-22. 2005
    ..Prospective data on cataract in relation to total fruit and vegetable intake are limited...
  14. ncbi request reprint A randomized trial of beta carotene and age-related cataract in US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Third Floor, Boston, MA 02215 1204, USA
    Arch Ophthalmol 121:372-8. 2003
    ..To examine the development of age-related cataract in a trial of beta carotene supplementation in men...
  15. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  16. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  17. pmc A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration
    Debra A Schaumberg
    Division of Preventive Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, and Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02215, USA
    Invest Ophthalmol Vis Sci 47:2336-40. 2006
    ..Although plasma CRP levels have been related to AMD and plasma CRP levels are partly determined by genetic variation, there is no information on whether genetic variants in CRP are associated with AMD...
  18. pmc High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women
    Debra A Schaumberg
    Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Ophthalmol 125:300-5. 2007
    ..To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD)...
  19. pmc Evaluation of risk factors for cataract types in a competing risks framework
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ophthalmic Epidemiol 16:98-106. 2009
    ..One can compare the impact of risk factors on different types of cataract with methods of competing risk survival analysis that account for tied events...
  20. ncbi request reprint Outcomes of early and late immunomodulatory treatment in patients with HLA-B27-associated chronic uveitis
    Sofia Androudi
    Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114 3069, USA
    Graefes Arch Clin Exp Ophthalmol 241:1000-5. 2003
    ..To evaluate the outcomes of early versus late immunomodulatory treatment (IMT) in patients with HLA-B27-associated chronic uveitis...
  21. ncbi request reprint A nonrandomized comparison of the clinical outcome of ocular involvement in patients with mucous membrane (cicatricial) pemphigoid between conventional immunosuppressive and intravenous immunoglobulin therapies
    Erik Letko
    Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Clin Immunol 111:303-10. 2004
    ..This clinical difference could be because of the reduced production of pathogenic antibody, and/or restoration of the immunoregulation, which may have been disturbed...
  22. ncbi request reprint Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin
    Mohsin Malik
    Department of Medicine, New England Baptist Hospital, Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Pathol Med 36:1-5. 2007
    ..Oral pemphigoid (OP) is limited to the oral cavity. The purpose of this study was to determine the association between malignancy and patients with OP with antibodies to alpha6-integrin subunit...
  23. ncbi request reprint Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies
    Victor L Perez
    Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Ocul Immunol Inflamm 12:193-201. 2004
    ..Review of these studies indicate that Interleukin-6 (IL-6) is present, and animal data suggest the important role of IL-6 in the regulation of ophthalmologic immune responses...
  24. ncbi request reprint Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparison
    Elisabetta Miserocchi
    Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
    Ophthalmology 109:1532-7. 2002
    ..To compare clinical characteristics and outcomes in patients with uveitis caused by herpes simplex virus (HSV) and varicella zoster virus (VZV)...
  25. ncbi request reprint Patterns of exacerbations of chronic non-infectious uveitis in pregnancy and puerperium
    Leila I Kump
    Massachusetts Eye Research and Surgery Institute, Cambridge, MA, USA
    Ocul Immunol Inflamm 14:99-104. 2006
    ..To determine patterns of exacerbations of recurrent non-infectious uveitis during pregnancy and puerperium...
  26. ncbi request reprint Primary pars plana vitrectomy versus scleral buckle surgery for the treatment of pseudophakic retinal detachment: a randomized clinical trial
    Periklis D Brazitikos
    Department of Ophthalmology, Aristotle University, Thessaloniki, Greece
    Retina 25:957-64. 2005
    ..To compare the anatomical and functional outcome of scleral buckle (SB) surgery with that of pars plana vitrectomy (PPV) alone in the treatment of primary rhegmatogenous pseudophakic retinal detachment (RD)...
  27. ncbi request reprint A-scan quantitative echography of senile cataracts and correlation with phacoemulsification parameters
    Periklis D Brazitikos
    Ophthalmology Clinic, Aristotle University of Thessaloniki, Greece
    Curr Eye Res 27:175-81. 2003
    ..To study the echographic appearance of various types of senile cataracts using a-scan quantitative echography and correlate these findings with phacoemulsification parameters indicating surgical lens hardness...

Research Grants20

  1. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William G Christen; Fiscal Year: 2010
    ....
  2. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2003
    ..abstract_text> ..
  3. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2004
    ..abstract_text> ..
  4. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2005
    ..abstract_text> ..
  5. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2006
    ..abstract_text> ..
  6. Dietary Factors in Eye Disease
    William Christen; Fiscal Year: 2006
    ..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
  7. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2007
    ..abstract_text> ..
  8. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William Christen; Fiscal Year: 2009
    ....
  9. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
    ....
  10. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2001
    ....
  11. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 1993
    ....
  12. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 1999
    ....
  13. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2000
    ....