Research Topics
| Ji Kyung ChoiSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse modelsJi Kyung Choi
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA 02114, USA
Neuropharmacology 59:353-7. 2010..Given the ease with which scyllo-inositol can be measured in human MRS data with high signal to noise ratios, these data suggest that MRS will prove useful for evaluation of inositol treatment trials in AD subjects...- fMRI of cocaine self-administration in macaques reveals functional inhibition of basal gangliaJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA, USA
Neuropsychopharmacology 36:1187-98. 2011.... - Anti-inflammatory treatment in AD mice protects against neuronal pathologyJi Kyung Choi
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Exp Neurol 223:377-84. 2010..NAA levels significantly correlated with plaque burden. These results suggest that selective NSAIDs (ibuprofen and possibly celecoxib) treatment can protect against the neuronal pathology... - Moderate exercise delays the motor performance decline in a transgenic model of ALSIsabel Carreras
Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
Brain Res 1313:192-201. 2010..These results show the beneficial effects of moderate exercise on the preservation of motor performance that correlates with higher motor neuron density in the ventral horn of the lumbar spinal cord in G93A mice... - Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementationJi Kyung Choi
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Eur J Neurosci 30:2143-50. 2009..Creatine supplementation had a positive effect on weight retention, leading to a 13% increase in weight between 120 and 130 days. MRS shows promise in monitoring multiple facets of neuroprotective strategies in ALS and ALS models... - Dopaminergic response to graded dopamine concentration elicited by four amphetamine dosesJiaqian Ren
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Synapse 63:764-72. 2009..In conclusion, degree of postsynaptic signal transduction is linearly correlated to the extracellular DA concentration. However, the presynaptic binding may dominate the overall DA innervation at the lower range of DA concentration... - Pharmacologic neuroimaging of the ontogeny of dopamine receptor functionY Iris Chen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Dev Neurosci 32:125-38. 2010..These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age... - In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesiasRosario Sanchez-Pernaute
McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Neurobiol Dis 27:220-7. 2007.... 
Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 TJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston 02129, USA
Magn Reson Med 52:1272-81. 2004..The derived field dependencies for relative sensitivity and MRI estimates of the percentage change in CBV suggest that the benefits provided by exogenous agents will persist even at much higher magnetic fields than 9.4 T...- Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRIJi Kyung Choi
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 21:157-62. 2010..It may be plausible to use a passive amphetamine challenge as a biomarker to assess progression of the disease and efficacy of potential treatments... - Application of MRS to mouse models of neurodegenerative illnessJi Kyung Choi
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
NMR Biomed 20:216-37. 2007..The argument is made that use of MRS, combined with correlative histology and other MRI techniques, will enable objective markers with which potential therapies can be followed in a quantitative fashion... - Basal ganglia activity remains elevated after movement in focal hand dystoniaAnne J Blood
Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Ann Neurol 55:744-8. 2004..We posit that inhibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we observe in "resting" activity may mask basal ganglia abnormalities in standard imaging contrast analyses... 
Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonistsJi Kyung Choi
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
Psychopharmacology (Berl) 212:59-72. 2010..Dopamine D3 receptors (D3R) may be important therapeutic targets for both drug abuse and dyskinesias in Parkinson's disease; however, little is known about their functional circuitry...