Ji Kyung Choi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models
    Ji Kyung Choi
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA 02114, USA
    Neuropharmacology 59:353-7. 2010
  2. ncbi request reprint Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
    Yin Ching I Chen
    Athinoula A Martinos Center for Biomedical Imaging and MGH NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacology (Berl) 180:705-15. 2005
  3. pmc Combination therapy in a transgenic model of Alzheimer's disease
    Nurgul Aytan
    Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA Electronic address
    Exp Neurol 250:228-38. 2013
  4. ncbi request reprint Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI
    Y Iris Chen
    MGH NMR Center and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Synapse 55:80-8. 2005
  5. pmc fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia
    Joseph B Mandeville
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA, USA
    Neuropsychopharmacology 36:1187-98. 2011
  6. pmc Anti-inflammatory treatment in AD mice protects against neuronal pathology
    Ji Kyung Choi
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Exp Neurol 223:377-84. 2010
  7. ncbi request reprint High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging
    Ji Kyung Choi
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Synapse 60:152-7. 2006
  8. pmc Moderate exercise delays the motor performance decline in a transgenic model of ALS
    Isabel Carreras
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Brain Res 1313:192-201. 2010
  9. pmc Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation
    Ji Kyung Choi
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Eur J Neurosci 30:2143-50. 2009
  10. ncbi request reprint 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
    Orhan Tansel Korkmaz
    VA Boston Healthcare System, Boston, MA 02130, USA Neurology and Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA Physiology and Neurophysiology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
    Neurosci Lett 566:286-91. 2014

Collaborators

Detail Information

Publications21

  1. pmc Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models
    Ji Kyung Choi
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA 02114, USA
    Neuropharmacology 59:353-7. 2010
    ..Given the ease with which scyllo-inositol can be measured in human MRS data with high signal to noise ratios, these data suggest that MRS will prove useful for evaluation of inositol treatment trials in AD subjects...
  2. ncbi request reprint Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
    Yin Ching I Chen
    Athinoula A Martinos Center for Biomedical Imaging and MGH NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacology (Berl) 180:705-15. 2005
    ..We wished to show that pharmacological magnetic resonance imaging (phMRI) may prove useful for this purpose...
  3. pmc Combination therapy in a transgenic model of Alzheimer's disease
    Nurgul Aytan
    Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA Electronic address
    Exp Neurol 250:228-38. 2013
    ..Scyllo-inositol treated mice performed significantly better at the radial arm water maze (RAWM) task than untreated and scyllo-inositol+R-flurbiprofen treated mice. ..
  4. ncbi request reprint Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI
    Y Iris Chen
    MGH NMR Center and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Synapse 55:80-8. 2005
    ..These experiments demonstrate the utility of phMRI for probing, in a noninvasive manner, the temporal and spatial dynamics of neurotransmitter interactions...
  5. pmc fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia
    Joseph B Mandeville
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA, USA
    Neuropsychopharmacology 36:1187-98. 2011
    ....
  6. pmc Anti-inflammatory treatment in AD mice protects against neuronal pathology
    Ji Kyung Choi
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Exp Neurol 223:377-84. 2010
    ..NAA levels significantly correlated with plaque burden. These results suggest that selective NSAIDs (ibuprofen and possibly celecoxib) treatment can protect against the neuronal pathology...
  7. ncbi request reprint High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging
    Ji Kyung Choi
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Synapse 60:152-7. 2006
    ..The high spatial and temporal resolution of the phMRI technique lends itself well to further, more detailed, studies of nicotine dynamics...
  8. pmc Moderate exercise delays the motor performance decline in a transgenic model of ALS
    Isabel Carreras
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Brain Res 1313:192-201. 2010
    ..These results show the beneficial effects of moderate exercise on the preservation of motor performance that correlates with higher motor neuron density in the ventral horn of the lumbar spinal cord in G93A mice...
  9. pmc Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation
    Ji Kyung Choi
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Eur J Neurosci 30:2143-50. 2009
    ..Creatine supplementation had a positive effect on weight retention, leading to a 13% increase in weight between 120 and 130 days. MRS shows promise in monitoring multiple facets of neuroprotective strategies in ALS and ALS models...
  10. ncbi request reprint 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
    Orhan Tansel Korkmaz
    VA Boston Healthcare System, Boston, MA 02130, USA Neurology and Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA Physiology and Neurophysiology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
    Neurosci Lett 566:286-91. 2014
    ..These data suggest that 7,8-DHF should be considered as a potential therapy for ALS and the other motor neuron diseases. ..
  11. pmc R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease
    Isabel Carreras
    Research GRECC, VA Boston Healthcare System, Boston, MA, USA Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Brain Res 1541:115-27. 2013
    ..Glutamine and glutamate, neurochemicals that shuttles between neurons and astrocytes to maintain glutamate homeostasis in the synapses, deserve further attention as MR markers of cognitive function. ..
  12. pmc Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses
    Jiaqian Ren
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Synapse 63:764-72. 2009
    ..In conclusion, degree of postsynaptic signal transduction is linearly correlated to the extracellular DA concentration. However, the presynaptic binding may dominate the overall DA innervation at the lower range of DA concentration...
  13. pmc Pharmacologic neuroimaging of the ontogeny of dopamine receptor function
    Y Iris Chen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Dev Neurosci 32:125-38. 2010
    ..These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age...
  14. ncbi request reprint Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T
    Joseph B Mandeville
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston 02129, USA
    Magn Reson Med 52:1272-81. 2004
    ..The derived field dependencies for relative sensitivity and MRI estimates of the percentage change in CBV suggest that the benefits provided by exogenous agents will persist even at much higher magnetic fields than 9.4 T...
  15. pmc In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Neurobiol Dis 27:220-7. 2007
    ....
  16. ncbi request reprint Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling
    Ji Kyung Choi
    MGH NMR Center and Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street Charlestown, MA 02129, USA
    Neuroimage 30:700-12. 2006
    ..These data provide additional support for the role of local post-synaptic events in neurovascular coupling and emphasize that the interpretation of fMRI signals exclusively in terms of neuronal activity may be incomplete...
  17. pmc Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI
    Ji Kyung Choi
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 21:157-62. 2010
    ..It may be plausible to use a passive amphetamine challenge as a biomarker to assess progression of the disease and efficacy of potential treatments...
  18. ncbi request reprint Application of MRS to mouse models of neurodegenerative illness
    Ji Kyung Choi
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 20:216-37. 2007
    ..The argument is made that use of MRS, combined with correlative histology and other MRI techniques, will enable objective markers with which potential therapies can be followed in a quantitative fashion...
  19. ncbi request reprint Basal ganglia activity remains elevated after movement in focal hand dystonia
    Anne J Blood
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Ann Neurol 55:744-8. 2004
    ..We posit that inhibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we observe in "resting" activity may mask basal ganglia abnormalities in standard imaging contrast analyses...
  20. ncbi request reprint Interactions of very long-chain saturated fatty acids with serum albumin
    Ji Kyung Choi
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Lipid Res 43:1000-10. 2002
    ..Our studies suggest that albumin has adequate binding capacity for the low plasma levels of VLCFA with 20 to 26 carbons, but the protein may not be able to bind longer chain VLCFA...
  21. pmc Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists
    Ji Kyung Choi
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    Psychopharmacology (Berl) 212:59-72. 2010
    ..Dopamine D3 receptors (D3R) may be important therapeutic targets for both drug abuse and dyskinesias in Parkinson's disease; however, little is known about their functional circuitry...