Michael H Cho

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
  2. ncbi request reprint Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
    Michael H Cho
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA, USA Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA, USA Electronic address
    Lancet Respir Med 2:214-25. 2014
  3. pmc Folliculin mutations are not associated with severe COPD
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 9:120. 2008
  4. pmc A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:947-57. 2012
  5. pmc CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland
    Megan Hardin
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:203-8. 2012
  6. pmc Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility
    Mateusz Siedlinski
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 132:431-41. 2013
  7. pmc On the simultaneous association analysis of large genomic regions: a massive multi-locus association test
    Dandi Qiao
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 20115, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Genomic Mathematics, University of Bonn, 53113 Bonn, Germany and Department of Thoracic Medicine, Haukeland University Hospital and Section for Respiratory Medicine Institute of Medicine, University of Bergen, 5006 Bergen, Norway
    Bioinformatics 30:157-64. 2014
  8. pmc Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells
    Xiaobo Zhou
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Genomics 101:263-72. 2013
  9. pmc The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 45:1147-53. 2011
  10. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010

Detail Information

Publications26

  1. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  2. ncbi request reprint Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
    Michael H Cho
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA, USA Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA, USA Electronic address
    Lancet Respir Med 2:214-25. 2014
    ..We sought to identify risk loci for moderate to severe and severe COPD with data from several cohort studies...
  3. pmc Folliculin mutations are not associated with severe COPD
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 9:120. 2008
    ....
  4. pmc A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:947-57. 2012
    ..08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior...
  5. pmc CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland
    Megan Hardin
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:203-8. 2012
    ....
  6. pmc Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility
    Mateusz Siedlinski
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 132:431-41. 2013
    ..While the association of the AGPHD1/CHRNA3 locus with COPD is significantly mediated by smoking-related phenotypes, IREB2 appears to affect COPD independently of smoking...
  7. pmc On the simultaneous association analysis of large genomic regions: a massive multi-locus association test
    Dandi Qiao
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 20115, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Genomic Mathematics, University of Bonn, 53113 Bonn, Germany and Department of Thoracic Medicine, Haukeland University Hospital and Section for Respiratory Medicine Institute of Medicine, University of Bergen, 5006 Bergen, Norway
    Bioinformatics 30:157-64. 2014
    ....
  8. pmc Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells
    Xiaobo Zhou
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Genomics 101:263-72. 2013
    ..Thus, we identified potential HHIP targets in human bronchial epithelial cells that may contribute to COPD pathogenesis...
  9. pmc The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 45:1147-53. 2011
    ....
  10. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  11. pmc Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 40:751-5. 2009
    ..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD...
  12. pmc Genome-wide association study of smoking behaviours in patients with COPD
    Mateusz Siedlinski
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Thorax 66:894-902. 2011
    ..Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD...
  13. pmc Genome-wide association analysis of body mass in chronic obstructive pulmonary disease
    Emily S Wan
    Channing Laboratory, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 45:304-10. 2011
    ..Our analysis suggests a potential role for the FTO locus in the determination of anthropomorphic measures associated with COPD...
  14. pmc Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema
    Peter J Castaldi
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Thorax 69:416-23. 2014
    ..There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene study...
  15. pmc Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
    Deog Kyeom Kim
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:1238-47. 2012
    ..A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility...
  16. pmc The COPD genetic association compendium: a comprehensive online database of COPD genetic associations
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Hum Mol Genet 19:526-34. 2010
    ..Quantitative meta-analysis identified four variants in GSTM1, TGFB1, TNF and SOD3 that show statistically significant evidence of association with COPD susceptibility...
  17. pmc Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP
    Xiaobo Zhou
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 21:1325-35. 2012
    ..Together, our findings reveal one mechanism through which SNPs upstream of the HHIP gene modulate the expression of HHIP and functionally implicate reduced HHIP gene expression in the pathogenesis of COPD...
  18. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  19. pmc Genetics of sputum gene expression in chronic obstructive pulmonary disease
    Weiliang Qiu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24395. 2011
    ..Integrative analysis of GWAS and gene expression data from relevant tissue from diseased subjects has located potential functional variants in two known COPD genes and has identified a novel COPD susceptibility locus...
  20. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  21. pmc High-resolution melting curve analysis of genomic and whole-genome amplified DNA
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chem 54:2055-8. 2008
    ..Few studies have compared the performance of high-resolution DNA melting curve analysis (HRM) in genomic and whole-genome amplified (WGA) DNA...
  22. pmc Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications
    Raul San Jose Estepar
    Department of Radiology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 188:231-9. 2013
    ..Angiographic investigation suggests that pulmonary vascular remodeling in smokers is characterized by distal pruning of the blood vessels...
  23. pmc The impact of self-identified race on epidemiologic studies of gene expression
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genet Epidemiol 35:93-101. 2011
    ....
  24. pmc Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
    Jemma B Wilk
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Respir Crit Care Med 186:622-32. 2012
    ..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...
  25. ncbi request reprint On the follow-up of genome-wide association studies: an overall test for the most promising SNPs
    Peter J Lipman
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genet Epidemiol 35:303-9. 2011
    ..An application to a GWAS for chronic obstructive pulmonary disease suggests that there are true association signals among the top SNPs and that an additional follow-up study is promising...
  26. pmc Combining effects from rare and common genetic variants in an exome-wide association study of sequence data
    Hugues Aschard
    1Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Proc 5:S44. 2011
    ....