Isaac M Chiu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
  2. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
  3. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
  4. doi A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
    Isaac M Chiu
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 4:385-401. 2013
  5. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012

Detail Information

Publications5

  1. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
    ..These results indicate that T cells play an endogenous neuroprotective role in ALS by modulating a beneficial inflammatory response to neuronal injury...
  2. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
    ..These data reveal a progressive innate and humoral immune response in peripheral nerves that is separate and distinct from spinal cord immune activation in ALS transgenic mice...
  3. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
    ..Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions. ..
  4. doi A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
    Isaac M Chiu
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 4:385-401. 2013
    ..These results provide insights into microglia biology and establish a resource for future studies of neuroinflammation. ..
  5. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012
    ..Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology...