Isaac M Chiu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
  2. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
  3. ncbi A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
    Isaac M Chiu
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 4:385-401. 2013
  4. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
  5. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012

Detail Information

Publications5

  1. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
    ..These results indicate that T cells play an endogenous neuroprotective role in ALS by modulating a beneficial inflammatory response to neuronal injury...
  2. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
    ..These data reveal a progressive innate and humoral immune response in peripheral nerves that is separate and distinct from spinal cord immune activation in ALS transgenic mice...
  3. ncbi A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
    Isaac M Chiu
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 4:385-401. 2013
    ..These results provide insights into microglia biology and establish a resource for future studies of neuroinflammation. ..
  4. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
    ..Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions. ..
  5. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012
    ..Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology...