Research Topics
Genomes and GenesSpecies | L B ChibnikSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritisElizabeth Benito-Garcia
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Rheumatol 33:1275-81. 2006..CONCLUSION: Caffeine intake among patients taking high doses of MTX for RA did not affect MTX efficacy and RA disease activity over time...
Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritisLori B Chibnik
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Rheumatol 36:706-11. 2009..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain...- Identification and validation of lupus nephritis cases using administrative dataL B Chibnik
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lupus 19:741-3. 2010..This strategy may offer a sound method of identifying patients with lupus nephritis for health services research in addition to serving as a model for using claims data as a way to better understand rare diseases such as lupus... - The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional studyYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
Arthritis Res Ther 11:R160. 2009..The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA... - A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritisElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Res Ther 11:R97. 2009.... - Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onsetLori B Chibnik
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e24380. 2011..Cumulative genetic profiles can help identify individuals at high-risk for developing RA. We examined the impact of 39 validated genetic risk alleles on the risk of RA phenotypes characterized by serologic and erosive status... - Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritisE W Karlson
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Ann Rheum Dis 69:54-60. 2010..To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted... 
Quantifying anti-cyclic citrullinated peptide titres: clinical utility and association with tobacco exposure in patients with rheumatoid arthritisD M Lee
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 552B, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Ann Rheum Dis 68:201-8. 2009..To determine the significance of quantitative levels of antibodies to cyclic citrullinated peptides (anti-CCP) in a population of patients with rheumatoid arthritis (RA)...- Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis riskElizabeth W Karlson
75 Francis Street, Boston, MA 02115, USA
Ann Rheum Dis 69:1077-85. 2010..This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions... - Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort studyE W Karlson
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ann Rheum Dis 67:358-63. 2008..HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA)... - Complications for racial and ethnic minority groups after total hip and knee replacement: a review of the literatureBenedict U Nwachukwu
Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 92:338-45. 2010..It has been shown that racial and ethnic minority groups underutilize these procedures; however, little information exists on postoperative outcomes for ethnic minorities... - Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban womenAxel Finckh
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 54:3648-54. 2006..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population... - A randomized controlled trial of an intervention to reduce low literacy barriers in inflammatory arthritis managementRima E Rudd
Harvard School of Public Health, Department of Society, Human Development and Health, Boston, MA 02115, United States
Patient Educ Couns 75:334-9. 2009..Test the efficacy of educational interventions to reduce literacy barriers and enhance health outcomes among patients with inflammatory arthritis... - Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scorePhilip L De Jager
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet Neurol 8:1111-9. 2009..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS... - A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosusJ Aizer
Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
Lupus 18:235-42. 2009..FMD did not correlate with PAT except in SLE cases with a history of Raynaud's. Correlation between FMD and PAT may be stronger in populations with greater variation in endothelial function and more cardiovascular risk factors... - Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studiesElizabeth W Karlson
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 60:641-52. 2009..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)... - Discordance between erythrocyte sedimentation rate and C-reactive protein measurements: clinical significanceK H Costenbader
Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
Clin Exp Rheumatol 25:746-9. 2007..C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are common measures of systemic inflammation. Our goal was to identify clinical factors associated with CRP/ESR discordance... - Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritisBrendan T Keenan
Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:3196-210. 2010..This study was undertaken to examine the impact of gene-smoking interactions on susceptibility to rheumatoid arthritis (RA)... - Location specific radiographic joint space width for osteoarthritis progressionG Neumann
Radiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
Osteoarthritis Cartilage 17:761-5. 2009..The study also investigated the most disease-responsive location for measuring medial compartment JSW... - Alcohol consumption and the risk of bladder cancer in the Framingham Heart StudyLuc Djousse
Preventive Medicine and Epidemiology Section, Evans Department of Medicine, Boston University School of Medicine, Rm B 612, 715 Albany St, Boston, MA 02118, USA
J Natl Cancer Inst 96:1397-400. 2004..03), whereas wine (P(trend) =.7) and spirit (P(trend) =.2) consumption were not. Our data suggest that total and beverage-specific alcohol consumption are not associated with an increased risk of bladder cancer... - Development of a preliminary index that predicts adverse events after total knee replacementDaniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
Arthritis Rheum 54:1536-42. 2006.... - Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RASonali P Desai
Brigham and Women s Hospital, PBB B3, Boston, MA 02115, USA
Rheumatology (Oxford) 49:513-9. 2010..RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD... - Pattern of infliximab utilization in rheumatoid arthritis patients at an academic medical centerSandeep K Agarwal
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 53:872-8. 2005..Treatment escalation is commonly used in the management of RA with infliximab and is associated with longer duration of infliximab use... - Intermediate phenotypes identify divergent pathways to Alzheimer's diseaseJoshua M Shulman
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
PLoS ONE 5:e11244. 2010..However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden... - Cutaneous changes of nephrogenic systemic fibrosis: predictor of early mortality and association with gadolinium exposureDerrick J Todd
Massachusetts General Hospital, Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
Arthritis Rheum 56:3433-41. 2007..Little is known about its prevalence or etiology. The aim of this study was to establish the prevalence of NSF and associated risk factors.. - A pravastatin dose-escalation study in systemic lupus erythematosusKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Rheumatol Int 27:1071-7. 2007..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI...