Leo Cheng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy
    Leo L Cheng
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:3030-4. 2005
  2. pmc Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples After Three-Year Storage at -80 degrees C
    Kate W Jordan
    Departments of Pathology and
    Biomark Insights 2:147-54. 2007
  3. ncbi request reprint Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy
    L L Cheng
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, USA
    J Magn Reson 135:194-202. 1998
  4. ncbi request reprint Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T
    L L Cheng
    Department of Pathology, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA
    FEBS Lett 494:112-6. 2001
  5. ncbi request reprint NMR-based metabolomics approach to target biomarkers for human prostate cancer
    Kate W Jordan
    Massachusetts General Hospital, Molecular Pathology, Charlestown, MA 02129, USA
    Expert Rev Proteomics 4:389-400. 2007
  6. ncbi request reprint Assessing prostate cancer growth with mRNA of spermine metabolic enzymes
    David Kaul
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Biol Ther 9:736-42. 2010
  7. pmc Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles
    Andreas Maxeiner
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Prostate 70:710-7. 2010
  8. ncbi request reprint Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS
    Elita M Defeo
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Technol Cancer Res Treat 9:381-91. 2010
  9. ncbi request reprint Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics
    Melissa A Burns
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Pathology Research, CNY 7, 149, 13th Street, Charlestown, MA 02129, USA
    Technol Cancer Res Treat 3:591-8. 2004
  10. ncbi request reprint High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates
    Jennifer L Taylor
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 50:627-32. 2003

Collaborators

  • M Taupitz
  • Bruce Jenkins
  • Nikolaus M Loening
  • Chin Lee Wu
  • Kate W Jordan
  • Elita M Defeo
  • Christen B Adkins
  • W Scott McDougal
  • Melissa A Burns
  • Jennifer L Taylor
  • Elkan F Halpern
  • Wenlei He
  • Anthony Bielecki
  • David Kaul
  • Andreas Maxeiner
  • Andrea G Zepeda
  • David Cory
  • R Gilberto Gonzalez
  • Ute Pohl
  • Jinhua Sheng
  • Leslie Ying
  • Randall T Peterson
  • Piet Habbel
  • Eva M Ratai
  • Yifen Zhang
  • David A Rothenberger
  • Gregory Y Lauwers
  • Karim Alavi
  • Johan Nordenstam
  • Michael Garwood

Detail Information

Publications15

  1. ncbi request reprint Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy
    Leo L Cheng
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:3030-4. 2005
    ....
  2. pmc Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples After Three-Year Storage at -80 degrees C
    Kate W Jordan
    Departments of Pathology and
    Biomark Insights 2:147-54. 2007
    ..Hence, these results indicate that long-term frozen storage of prostate specimens can be quantitatively analyzed by HRMAS MR spectroscopy without concerns regarding significant metabolic degradation or alteration...
  3. ncbi request reprint Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy
    L L Cheng
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, USA
    J Magn Reson 135:194-202. 1998
    ..Our results suggest that biochemical markers thus measured may function as a valuable adjunct to histopathology to improve the accuracy of and reduce the time frame required for the diagnosis of human breast cancer...
  4. ncbi request reprint Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T
    L L Cheng
    Department of Pathology, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA
    FEBS Lett 494:112-6. 2001
    ..Our results show that NMR may serve as a critical tool for the investigation of the inhibitory mechanism of spermine in human subjects...
  5. ncbi request reprint NMR-based metabolomics approach to target biomarkers for human prostate cancer
    Kate W Jordan
    Massachusetts General Hospital, Molecular Pathology, Charlestown, MA 02129, USA
    Expert Rev Proteomics 4:389-400. 2007
    ....
  6. ncbi request reprint Assessing prostate cancer growth with mRNA of spermine metabolic enzymes
    David Kaul
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Biol Ther 9:736-42. 2010
    ..These correlations may function to evaluate the aggressiveness of human prostate cancer, and assist patients and clinicians to select appropriate treatment strategies based on biological activities of individual tumors...
  7. pmc Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles
    Andreas Maxeiner
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Prostate 70:710-7. 2010
    ..We aim to retrospectively evaluate the ability of ex vivo tissue magnetic-resonance-spectroscopy-based metabolomic profiles to estimate the risk of recurrence...
  8. ncbi request reprint Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS
    Elita M Defeo
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Technol Cancer Res Treat 9:381-91. 2010
    ..Not only will this ex vivo technology become a valuable diagnostic tool, it will also provide a way to monitor treatments on an individual basis so they can be adjusted accordingly for the best possible outcome...
  9. ncbi request reprint Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics
    Melissa A Burns
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Pathology Research, CNY 7, 149, 13th Street, Charlestown, MA 02129, USA
    Technol Cancer Res Treat 3:591-8. 2004
    ..CAIA based quantitative pathology is more reliable than human visual assessment in establishing correlations useful for disease diagnosis between prostate pathology and metabolite concentrations...
  10. ncbi request reprint High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates
    Jennifer L Taylor
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 50:627-32. 2003
    ..Among them, DANTE, as the simplest scheme, has shown the most potential in suppression of tissue water signals and spinning sidebands, as well as in quantifying metabolic concentrations...
  11. ncbi request reprint Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning
    Melissa A Burns
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 54:34-42. 2005
    ..These results indicate the empirical utility of this scheme for analyzing intact tissue, which also may be used as an adjunct tool in pathology for diagnosing disease...
  12. pmc Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy
    Kate W Jordan
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Dis Colon Rectum 52:520-5. 2009
    ..This study was designed to test whether metabolic characterization of intact, unaltered human rectal adenocarcinoma specimens is possible using the high-resolution magic angle spinning proton (1H) magnetic resonance spectroscopy technique...
  13. ncbi request reprint Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate
    Chin Lee Wu
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 50:1307-11. 2003
    ..Furthermore, although storage conditions affect absolute metabolite concentrations in NMR analysis, relative metabolite concentrations are less affected...
  14. pmc Metabolomic imaging for human prostate cancer detection
    Chin Lee Wu
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Sci Transl Med 2:16ra8. 2010
    ..This calculated malignancy index is linearly correlated with lesion size and demonstrates a 93 to 97% overall accuracy for detecting the presence of prostate cancer lesions, suggesting the potential clinical utility of this approach...
  15. ncbi request reprint Quantification of phosphocholine and glycerophosphocholine with 31P edited 1H NMR spectroscopy
    Nikolaus M Loening
    Department of Chemistry, Lewis and Clark College, Portland, OR 97219, USA
    NMR Biomed 18:413-20. 2005
    ..Consequently, this scheme has the potential to be used for the analysis of choline compounds in ex vivo tissue samples...

Research Grants11

  1. Characterizing Prostate Cancer By ex vivo MRS Signatures
    Leo L Cheng; Fiscal Year: 2010
    ..Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares. ..
  2. Defining Signatures of Breast Cancer Cells by HRMAS MRS
    Leo Cheng; Fiscal Year: 2006
    ..These signatures should be useful in clinical care of women with breast cancer by identifying less aggressive tumors as candidates for breast-conserving treatment. ..
  3. Characterizing Prostate Cancer By ex vivo MRS Signatures
    Leo Cheng; Fiscal Year: 2009
    ..Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares. ..
  4. Defining Signatures of Breast Cancer Cells by HRMAS MRS
    Leo Cheng; Fiscal Year: 2003
    ..These signatures should be useful in clinical care of women with breast cancer by identifying less aggressive tumors as candidates for breast-conserving treatment. ..
  5. Characterizing Prostate Cancer By ex vivo MRS Signatures
    Leo Cheng; Fiscal Year: 2009
    ..Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares. ..
  6. Characterizing Prostate Cancer By ex vivo MRS Signatures
    Leo Cheng; Fiscal Year: 2006
    ..Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares. ..
  7. Defining Signatures of Breast Cancer Cells by HRMAS MRS
    Leo Cheng; Fiscal Year: 2005
    ..These signatures should be useful in clinical care of women with breast cancer by identifying less aggressive tumors as candidates for breast-conserving treatment. ..
  8. Defining Signatures of Breast Cancer Cells by HRMAS MRS
    Leo Cheng; Fiscal Year: 2004
    ..These signatures should be useful in clinical care of women with breast cancer by identifying less aggressive tumors as candidates for breast-conserving treatment. ..
  9. Characterizing Prostate Cancer By ex vivo MRS Signatures
    Leo Cheng; Fiscal Year: 2007
    ..Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares. ..
  10. EVALUATION OF ASTROCYTOMAS WITH HRMAS 1HMR SPECTROSCOPY
    Leo Cheng; Fiscal Year: 2003
    ..abstract_text> ..