Zhiqiang Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A method for intracochlear drug delivery in the mouse
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Neurosci Methods 150:67-73. 2006
  2. pmc Development of a microfluidics-based intracochlear drug delivery device
    William F Sewell
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA wfs epl meei harvard edu
    Audiol Neurootol 14:411-22. 2009
  3. pmc Inner ear drug delivery via a reciprocating perfusion system in the guinea pig
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Control Release 110:1-19. 2005
  4. pmc Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 102:1152-9. 2009
  5. pmc Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices
    Ophir Handzel
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02115, USA
    Audiol Neurootol 14:308-14. 2009
  6. ncbi request reprint Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 10:1238-40. 2007
  7. pmc Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
    Karsten Sydow
    The University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    J Clin Invest 113:482-9. 2004
  8. ncbi request reprint Protection of auditory function against noise trauma with local caroverine administration in guinea pigs
    Zhiqiang Chen
    Department of Otolaryngology, National University of Singapore, Lower Kent Ridge Road, Singapore
    Hear Res 197:131-6. 2004
  9. ncbi request reprint Cell death-inducing DFF45-like effector may take part in neuronal apoptosis of the lumbar spinal cord after sciatic nerve injury caused by a firearm
    Jian Min Wang
    Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, People s Republic of China
    Mil Med 171:793-9. 2006

Collaborators

  • Jeffrey T Borenstein
  • Erin E Leary Swan
  • Haobing Wang
  • SHARON KUJAWA
  • William F Sewell
  • Ophir Handzel
  • Jason Fiering
  • Michael J McKenna
  • Marcello Peppi
  • Jian Min Wang
  • Karsten Sydow
  • Brian A Murphy
  • Mark J Mescher
  • Brian Murphy
  • Sarah Tao
  • Maria Holmboe
  • Mark M Mescher
  • Ernest S Kim
  • Gui Bo Wang
  • Bing Cang Li
  • Hongzheng Sun
  • Lei Chen
  • Liang Chao Zhang
  • Andreas Daiber
  • Thomas Munzel
  • Michael August
  • Alexander Mülsch
  • Matthias Oelze
  • Volker Ullrich
  • Eberhard Schulz
  • Jonathan S Stamler
  • John F Keaney
  • Maria Wendt

Detail Information

Publications9

  1. ncbi request reprint A method for intracochlear drug delivery in the mouse
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Neurosci Methods 150:67-73. 2006
    ..The safe delivery of drugs into the cochlea by this approach has immediate application in the study and treatment of various forms of human hearing loss that can be modeled in the mouse...
  2. pmc Development of a microfluidics-based intracochlear drug delivery device
    William F Sewell
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA wfs epl meei harvard edu
    Audiol Neurootol 14:411-22. 2009
    ..Direct delivery of drugs and other agents into the inner ear will be important for many emerging therapies, including the treatment of degenerative disorders and guiding regeneration...
  3. pmc Inner ear drug delivery via a reciprocating perfusion system in the guinea pig
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Control Release 110:1-19. 2005
    ..The magnitude of drug effect decreased with distance from the perfusion pipette for up to 10 mm, and increased with dose and length of application...
  4. pmc Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 102:1152-9. 2009
    ..These results suggest that the reduction of surface AMPAR by endocytosis during excitatory stimulation plays an important role in limiting the excitotoxic damage to the neuron...
  5. pmc Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices
    Ophir Handzel
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02115, USA
    Audiol Neurootol 14:308-14. 2009
    ..Our results are compared to other temporal bone implant virtual fitting studies. Virtual fitting has been suggested for other human applications...
  6. ncbi request reprint Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 10:1238-40. 2007
    ..Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body...
  7. pmc Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
    Karsten Sydow
    The University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    J Clin Invest 113:482-9. 2004
    ..Thus, GTN tolerance may be viewed as a metabolic syndrome characterized by mitochondrial dysfunction...
  8. ncbi request reprint Protection of auditory function against noise trauma with local caroverine administration in guinea pigs
    Zhiqiang Chen
    Department of Otolaryngology, National University of Singapore, Lower Kent Ridge Road, Singapore
    Hear Res 197:131-6. 2004
    ..3 kHz (110 dB SPL) for 1 h. Auditory brainstem responses were measured at regular time intervals afterwards. Caroverine was found to offer significant protection of the cochlear function against noise-induced hearing loss...
  9. ncbi request reprint Cell death-inducing DFF45-like effector may take part in neuronal apoptosis of the lumbar spinal cord after sciatic nerve injury caused by a firearm
    Jian Min Wang
    Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, People s Republic of China
    Mil Med 171:793-9. 2006
    ..To investigate neuronal apoptosis and gene regulation after peripheral nerve injury caused by a firearm...