Research Topics
| Zheng W ChenSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Immunology of AIDS virus and mycobacterial co-infectionZheng W Chen
Department of Microbiology and Immunology and Center for Primate Biomedical Research, University of Illinois, Chicago, Illinois 60612, USA
Curr HIV Res 2:351-5. 2004..This article discusses recent progress in immune aspects of HIV and mycobacterial coinfection...
Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeysDejiang Zhou
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 77:2998-3006. 2003..Thus, an SIVmac-induced compromise of the adaptive Vgamma2Vdelta2(+) T-cell responses may contribute to the immunopathogenesis of the SIV-related tuberculosis-like disease in macaques...- Comparative biology of gamma delta T cellsZheng W Chen
Sci Prog 85:347-58. 2002..This article compares biological features between resident and circulating gamma delta T cells... - Vgamma2Vdelta2+ T cells and anti-microbial immune responsesZheng W Chen
Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE 113 213C, Boston MA 02115, USA
Microbes Infect 5:491-8. 2003..Recent studies have demonstrated that this unique gammadelta T cell subpopulation can be a component of adaptive immune responses and contribute to anti-microbial immunity to infections... - In vivo T-lymphocyte activation and transient reduction of viral replication in macaques infected with simian immunodeficiency virusZ W Chen
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Virol 75:4713-20. 2001..These studies provide in vivo evidence that potent T-cell stimulation driven by antigens other than the virus itself can, under some circumstances, mediate short-term reduction of viremia in AIDS virus-infected individuals... - The TCR repertoire of an immunodominant CD8+ T lymphocyte populationZ W Chen
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 166:4525-33. 2001.... - Down-regulation of macaque gammadelta + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14Z W Chen
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Med Primatol 29:143-7. 2000.... - Prolonged dominance of clonally restricted CD4(+) T cells in macaques infected with simian immunodeficiency virusesZ W Chen
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 74:7442-50. 2000..These results support the notions that a chronic AIDS virus infection can induce clonal expansion, in addition to depletion of CD4(+) T cells, and that some of these clones may be SIV specific... - Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class IZ W Chen
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 164:6474-9. 2000..Therefore, these findings suggest that AIDS viruses can evade virus-specific CTL responses through the accelerated dissociation of mutant peptide from MHC class I... - Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigmZheng W Chen
Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113 RE216, Boston, MA 02115, USA
Trends Immunol 24:213-9. 2003.... - Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cellsLing Shen
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Infect Dis 190:1438-47. 2004.... - Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infectionsYun Shen
Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Science 295:2255-8. 2002..This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections... - Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfectionYun Shen
Tuberculosis Research Unit, Beth Israel Deaconess Center. Harvard Medical School, Boston, Massachusetts 02215, USA
Infect Immun 70:869-77. 2002..These results provide in vivo evidence that coinfection of AIDS virus-infected individuals with an avirulent mycobacterium can lead to development of a tuberculosis-like disease... - Antiretroviral agents restore Mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in Macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCGY Shen
Beth Israel Deaconess Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 75:8690-6. 2001..These results provide in vivo evidence that the restoration of anti-mycobacterial immunity by antiretroviral agents can improve the clinical outcome of an AIDS virus-related tuberculosis-like disease... - The T cell receptor gene usage by simian immunodeficiency virus gag-specific cytotoxic T lymphocytes in rhesus monkeysZ W Chen
Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
J Immunol 156:1469-75. 1996..Such a broad CTL-TCR repertoire may be advantageous for the host in containing an AIDS virus infection... - In vivo effects of a bacterial superantigen on macaque TCR repertoiresZ C Kou
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 160:5170-80. 1998.... - Immune biology of macaque lymphocyte populations during mycobacterial infectionX Lai
Tuberculosis Research Unit, Beth Israel Deaconess, Medical Center, Harvard Medical School, Boston, MA, USA
Clin Exp Immunol 133:182-92. 2003..The patterns and kinetics of CD4+, CD8+ and gammadelta T cell immune responses during BCG infection might contribute to characterizing immune protection against tuberculosis and testing new tuberculosis vaccines in primates... - Immune regulation of gammadelta T cell responses in mycobacterial infectionsZheng W Chen
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine Chicago, 835 South Wolcott Avenue, MC790, Chicago, IL 60612, USA
Clin Immunol 116:202-7. 2005..Multiple host and microbial factors can regulate diverse immune responses of phosphoantigen-specific gammadelta T cells during mycobacterial infections... - Clinical latency and reactivation of AIDS-related mycobacterial infectionsYun Shen
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois, Chicago, IL, USA
J Virol 78:14023-32. 2004..Thus, reactivation of latent mycobacterial infections in HIV-1-infected individuals may result from a loss of T-cell immunity or from a superimposed further compromise of the immune system... - Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cellsHong Wang
Division of Rheumatology, Department of Internal Medicine and Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City, IA 52442, USA
J Immunol 170:3696-706. 2003..Thus, recognition of nonpeptide prenyl pyrophosphate, bisphosphonate, and alkylamine Ags is conserved in primates suggesting that primates can provide an animal model for human gammadelta T cell Ag responses... - Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infectionGeorge Du
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, 835 S. Wocoltt, MC790, Chicago, IL 60612, USA
J Immunol Methods 308:19-35. 2006..This assay system may be useful for studies of antigen-specific T cell clones in tumors, autoimmune and infectious diseases... - Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunityDan Huang
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, IL, 60612, USA
J Infect Dis 195:55-69. 2007..These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria... - Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infectionDan Huang
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, 909 S Wolcott Ave, Chicago, IL 60612, USA
Infect Immun 76:426-36. 2008..Thus, clonally expanded Vgamma2Vdelta2 T cells appeared to undergo trans-endothelial migration, interstitial localization, and granuloma infiltration as immune responses to M. tuberculosis infection... - NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal Vγ2Vδ2 T-cell expansionYong Chen
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612, USA
Blood 111:4220-32. 2008..These studies provided nanoscale insight into the in vivo T-cell immune response... - Selected prfA* mutations in recombinant attenuated Listeria monocytogenes strains augment expression of foreign immunogens and enhance vaccine-elicited humoral and cellular immune responsesLin Yan
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Infect Immun 76:3439-50. 2008..monocytogenes DeltaactA vaccine vector. Thus, recombinant attenuated L. monocytogenes DeltaactA prfA* vaccine vectors potentially are better antimicrobial and anticancer vaccines...