Zheng W Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Immunology of AIDS virus and mycobacterial co-infection
    Zheng W Chen
    Department of Microbiology and Immunology and Center for Primate Biomedical Research, University of Illinois, Chicago, Illinois 60612, USA
    Curr HIV Res 2:351-5. 2004
  2. pmc Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys
    Dejiang Zhou
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2998-3006. 2003
  3. ncbi request reprint Comparative biology of gamma delta T cells
    Zheng W Chen
    Sci Prog 85:347-58. 2002
  4. pmc Vgamma2Vdelta2+ T cells and anti-microbial immune responses
    Zheng W Chen
    Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE 113 213C, Boston MA 02115, USA
    Microbes Infect 5:491-8. 2003
  5. pmc In vivo T-lymphocyte activation and transient reduction of viral replication in macaques infected with simian immunodeficiency virus
    Z W Chen
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 75:4713-20. 2001
  6. ncbi request reprint The TCR repertoire of an immunodominant CD8+ T lymphocyte population
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4525-33. 2001
  7. ncbi request reprint Down-regulation of macaque gammadelta + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Med Primatol 29:143-7. 2000
  8. pmc Prolonged dominance of clonally restricted CD4(+) T cells in macaques infected with simian immunodeficiency viruses
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 74:7442-50. 2000
  9. ncbi request reprint Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 164:6474-9. 2000
  10. pmc Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm
    Zheng W Chen
    Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113 RE216, Boston, MA 02115, USA
    Trends Immunol 24:213-9. 2003

Collaborators

  • CRAIG MORITA
  • Norman Letvin
  • Daohong Zhou
  • M J Kuroda
  • Y Li
  • A J Nahmias
  • P Morrison
  • J E Schmitz
  • Michael D Miller
  • C Ibegbu
  • P N Fultz
  • B F Haynes
  • JACK BUKOWSKI
  • Yun Shen
  • Dan Huang
  • Ling Shen
  • Liyou Qiu
  • George Du
  • Y Shen
  • Xioamin Lai
  • Prabhat Sehgal
  • Lin Yan
  • Yong Chen
  • Lingyun Shao
  • M Simon
  • L Shen
  • Jim Estep
  • Robert Hunt
  • Hong Wang
  • X Lai
  • Xuejun Zeng
  • P Sehgal
  • Meredith Simon
  • Lijun Rong
  • Nancy E Freitag
  • Andrew A Lackner
  • Jody A Melton-Witt
  • Pyone Aye
  • Crystal Y Chen
  • Jianbo Chen
  • Bridgett Ryan-Payseur
  • Michelle H Larsen
  • Zahida Ali
  • Jin Qiu
  • Daphne Vasconcelos
  • Yunqi Wang
  • William R Jacobs
  • Jiye Cai
  • Richard Wang
  • Lisa Halliday
  • Jeff Fortman
  • Probhat Seghal
  • Z C Kou
  • Probhat Sehgal
  • George Z Du
  • L Qiu
  • Roy A Mariuzza
  • Hoi K Lee
  • Hongmin Li
  • Ki Hoan Nam
  • Laura Chalifoux
  • Prabhat K Sehgal
  • Liming Jiang
  • Zhongchen Kou
  • Michael B Brenner
  • Michelle Clagett
  • Qifan Wang
  • B Henckler
  • L Chalifoux
  • N Sehgal
  • M Gastron
  • E A Enimi
  • D Lee-Parritz
  • P K Sehgal
  • M Halloran

Detail Information

Publications25

  1. ncbi request reprint Immunology of AIDS virus and mycobacterial co-infection
    Zheng W Chen
    Department of Microbiology and Immunology and Center for Primate Biomedical Research, University of Illinois, Chicago, Illinois 60612, USA
    Curr HIV Res 2:351-5. 2004
    ..This article discusses recent progress in immune aspects of HIV and mycobacterial coinfection...
  2. pmc Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys
    Dejiang Zhou
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2998-3006. 2003
    ..Thus, an SIVmac-induced compromise of the adaptive Vgamma2Vdelta2(+) T-cell responses may contribute to the immunopathogenesis of the SIV-related tuberculosis-like disease in macaques...
  3. ncbi request reprint Comparative biology of gamma delta T cells
    Zheng W Chen
    Sci Prog 85:347-58. 2002
    ..This article compares biological features between resident and circulating gamma delta T cells...
  4. pmc Vgamma2Vdelta2+ T cells and anti-microbial immune responses
    Zheng W Chen
    Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE 113 213C, Boston MA 02115, USA
    Microbes Infect 5:491-8. 2003
    ..Recent studies have demonstrated that this unique gammadelta T cell subpopulation can be a component of adaptive immune responses and contribute to anti-microbial immunity to infections...
  5. pmc In vivo T-lymphocyte activation and transient reduction of viral replication in macaques infected with simian immunodeficiency virus
    Z W Chen
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 75:4713-20. 2001
    ..These studies provide in vivo evidence that potent T-cell stimulation driven by antigens other than the virus itself can, under some circumstances, mediate short-term reduction of viremia in AIDS virus-infected individuals...
  6. ncbi request reprint The TCR repertoire of an immunodominant CD8+ T lymphocyte population
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4525-33. 2001
    ....
  7. ncbi request reprint Down-regulation of macaque gammadelta + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Med Primatol 29:143-7. 2000
    ....
  8. pmc Prolonged dominance of clonally restricted CD4(+) T cells in macaques infected with simian immunodeficiency viruses
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 74:7442-50. 2000
    ..These results support the notions that a chronic AIDS virus infection can induce clonal expansion, in addition to depletion of CD4(+) T cells, and that some of these clones may be SIV specific...
  9. ncbi request reprint Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I
    Z W Chen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 164:6474-9. 2000
    ..Therefore, these findings suggest that AIDS viruses can evade virus-specific CTL responses through the accelerated dissociation of mutant peptide from MHC class I...
  10. pmc Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm
    Zheng W Chen
    Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113 RE216, Boston, MA 02115, USA
    Trends Immunol 24:213-9. 2003
    ....
  11. pmc Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells
    Ling Shen
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Infect Dis 190:1438-47. 2004
    ....
  12. pmc Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections
    Yun Shen
    Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Science 295:2255-8. 2002
    ..This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections...
  13. pmc Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection
    Yun Shen
    Tuberculosis Research Unit, Beth Israel Deaconess Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 70:869-77. 2002
    ..These results provide in vivo evidence that coinfection of AIDS virus-infected individuals with an avirulent mycobacterium can lead to development of a tuberculosis-like disease...
  14. pmc Antiretroviral agents restore Mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in Macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCG
    Y Shen
    Beth Israel Deaconess Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:8690-6. 2001
    ..These results provide in vivo evidence that the restoration of anti-mycobacterial immunity by antiretroviral agents can improve the clinical outcome of an AIDS virus-related tuberculosis-like disease...
  15. ncbi request reprint The T cell receptor gene usage by simian immunodeficiency virus gag-specific cytotoxic T lymphocytes in rhesus monkeys
    Z W Chen
    Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    J Immunol 156:1469-75. 1996
    ..Such a broad CTL-TCR repertoire may be advantageous for the host in containing an AIDS virus infection...
  16. ncbi request reprint In vivo effects of a bacterial superantigen on macaque TCR repertoires
    Z C Kou
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 160:5170-80. 1998
    ....
  17. pmc Immune biology of macaque lymphocyte populations during mycobacterial infection
    X Lai
    Tuberculosis Research Unit, Beth Israel Deaconess, Medical Center, Harvard Medical School, Boston, MA, USA
    Clin Exp Immunol 133:182-92. 2003
    ..The patterns and kinetics of CD4+, CD8+ and gammadelta T cell immune responses during BCG infection might contribute to characterizing immune protection against tuberculosis and testing new tuberculosis vaccines in primates...
  18. pmc Immune regulation of gammadelta T cell responses in mycobacterial infections
    Zheng W Chen
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine Chicago, 835 South Wolcott Avenue, MC790, Chicago, IL 60612, USA
    Clin Immunol 116:202-7. 2005
    ..Multiple host and microbial factors can regulate diverse immune responses of phosphoantigen-specific gammadelta T cells during mycobacterial infections...
  19. pmc Clinical latency and reactivation of AIDS-related mycobacterial infections
    Yun Shen
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois, Chicago, IL, USA
    J Virol 78:14023-32. 2004
    ..Thus, reactivation of latent mycobacterial infections in HIV-1-infected individuals may result from a loss of T-cell immunity or from a superimposed further compromise of the immune system...
  20. ncbi request reprint Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells
    Hong Wang
    Division of Rheumatology, Department of Internal Medicine and Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City, IA 52442, USA
    J Immunol 170:3696-706. 2003
    ..Thus, recognition of nonpeptide prenyl pyrophosphate, bisphosphonate, and alkylamine Ags is conserved in primates suggesting that primates can provide an animal model for human gammadelta T cell Ag responses...
  21. pmc Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infection
    George Du
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, 835 S Wocoltt, MC790, Chicago, IL 60612, USA
    J Immunol Methods 308:19-35. 2006
    ..This assay system may be useful for studies of antigen-specific T cell clones in tumors, autoimmune and infectious diseases...
  22. pmc Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunity
    Dan Huang
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, IL, 60612, USA
    J Infect Dis 195:55-69. 2007
    ..These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria...
  23. pmc Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection
    Dan Huang
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, 909 S Wolcott Ave, Chicago, IL 60612, USA
    Infect Immun 76:426-36. 2008
    ..Thus, clonally expanded Vgamma2Vdelta2 T cells appeared to undergo trans-endothelial migration, interstitial localization, and granuloma infiltration as immune responses to M. tuberculosis infection...
  24. pmc NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal Vγ2Vδ2 T-cell expansion
    Yong Chen
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 111:4220-32. 2008
    ..These studies provided nanoscale insight into the in vivo T-cell immune response...
  25. pmc Selected prfA* mutations in recombinant attenuated Listeria monocytogenes strains augment expression of foreign immunogens and enhance vaccine-elicited humoral and cellular immune responses
    Lin Yan
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Infect Immun 76:3439-50. 2008
    ..monocytogenes DeltaactA vaccine vector. Thus, recombinant attenuated L. monocytogenes DeltaactA prfA* vaccine vectors potentially are better antimicrobial and anticancer vaccines...