Yuzhi Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
    Yuzhi Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 85:801-9. 2003
  2. pmc APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
    Yuzhi Chen
    MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Cell Biol 163:27-33. 2003
  3. ncbi request reprint DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
  4. ncbi request reprint Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
  5. pmc An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
    Michael Ohh
    Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO Rep 3:177-82. 2002
  6. ncbi request reprint A coarse-to-fine disparity energy model with both phase-shift and position-shift receptive field mechanisms
    Yuzhi Chen
    Center for Neurobiology and Behavior and Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, U S A
    Neural Comput 16:1545-77. 2004
  7. pmc Optimal decoding of correlated neural population responses in the primate visual cortex
    Yuzhi Chen
    Department of Psychology and Center for Perceptual Systems, 1 University Station, A8000, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 9:1412-20. 2006
  8. pmc Amyloid precursor protein modulates beta-catenin degradation
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neuroinflammation 4:29. 2007

Detail Information

Publications8

  1. ncbi request reprint ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
    Yuzhi Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 85:801-9. 2003
    ....
  2. pmc APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
    Yuzhi Chen
    MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Cell Biol 163:27-33. 2003
    ..This translocation of APP-BP1 to lipid rafts is accompanied by a change in the subcellular localization of the ubiquitin-like protein NEDD8, which is activated by APP-BP1...
  3. ncbi request reprint DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
    ..These data suggest that a normal signaling pathway mediated by the interaction of APP, PAK3, and Go is constitutively activated in neurons by FAD mutations in APP and that this activation causes cell cycle entry and consequent apoptosis...
  4. ncbi request reprint Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
    ....
  5. pmc An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
    Michael Ohh
    Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO Rep 3:177-82. 2002
    ..Thus, neddylation regulates the activity of two specific subclasses of mammalian ubiquitin ligases...
  6. ncbi request reprint A coarse-to-fine disparity energy model with both phase-shift and position-shift receptive field mechanisms
    Yuzhi Chen
    Center for Neurobiology and Behavior and Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, U S A
    Neural Comput 16:1545-77. 2004
    ..We have tested the algorithm on both synthetic and natural stereo images and found that it often performs better than a simple scale-averaging procedure...
  7. pmc Optimal decoding of correlated neural population responses in the primate visual cortex
    Yuzhi Chen
    Department of Psychology and Center for Perceptual Systems, 1 University Station, A8000, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 9:1412-20. 2006
    ..Overall, our results suggest an unexpected role for inhibitory mechanisms in efficient decoding of neural population responses...
  8. pmc Amyloid precursor protein modulates beta-catenin degradation
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neuroinflammation 4:29. 2007
    ..Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating neurodegenerative disease...