Yue Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Processing of global, but not local, motion direction is deficient in schizophrenia
    Y Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, USA
    Schizophr Res 61:215-27. 2003
  2. pmc Bipolar and schizophrenic patients differ in patterns of visual motion discrimination
    Yue Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 88:208-16. 2006
  3. ncbi request reprint Visual and cognitive control of attention in smooth pursuit
    Yue Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Prog Brain Res 140:255-65. 2002
  4. pmc Differential roles of low and high spatial frequency content in abnormal facial emotion perception in schizophrenia
    Ryan McBain
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 122:151-5. 2010
  5. ncbi request reprint Compromised late-stage motion processing in schizophrenia
    Yue Chen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 55:834-41. 2004
  6. pmc Visual and cognitive processing of face information in schizophrenia: detection, discrimination and working memory
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, USA
    Schizophr Res 107:92-8. 2009
  7. pmc Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Cogn Affect Behav Neurosci 8:293-303. 2008
  8. pmc Altered center-surround motion inhibition in schizophrenia
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
    Biol Psychiatry 64:74-7. 2008
  9. doi request reprint Females excel at basic face perception
    Ryan McBain
    Mailman Research Center, McLean Hospital, Room G06, Centre Bldg, 115 Mill Street, Belmont, MA 02478, United States
    Acta Psychol (Amst) 130:168-73. 2009
  10. pmc Reduced ability to detect facial configuration in middle-aged and elderly individuals: associations with spatiotemporal visual processing
    Daniel Norton
    Visual Psychophysiology Laboratory, McLean Hospital, Belmont, Massachusetts, USA
    J Gerontol B Psychol Sci Soc Sci 64:328-34. 2009

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Processing of global, but not local, motion direction is deficient in schizophrenia
    Y Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, USA
    Schizophr Res 61:215-27. 2003
    ....
  2. pmc Bipolar and schizophrenic patients differ in patterns of visual motion discrimination
    Yue Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 88:208-16. 2006
    ..Here we examined whether the motion processing impairment found in schizophrenia also occurs in bipolar disorder...
  3. ncbi request reprint Visual and cognitive control of attention in smooth pursuit
    Yue Chen
    Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Prog Brain Res 140:255-65. 2002
    ..The temporal dynamics of these complementary controls of visual and non-visual cognitive attention support the continuous generation of smooth pursuit so that eye tracking of a moving target can be prompt and accurate...
  4. pmc Differential roles of low and high spatial frequency content in abnormal facial emotion perception in schizophrenia
    Ryan McBain
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 122:151-5. 2010
    ..In controls, this effect was found only at low emotional salience. These results indicate that basic visual processing has an amplified modulatory effect on emotion perception in schizophrenia...
  5. ncbi request reprint Compromised late-stage motion processing in schizophrenia
    Yue Chen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 55:834-41. 2004
    ..Based on neurophysiologic and brain lesion studies, a velocity discrimination deficit can implicate early-stage motion processing if it is contrast-dependent or late-stage motion processing if it is contrast-independent...
  6. pmc Visual and cognitive processing of face information in schizophrenia: detection, discrimination and working memory
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, USA
    Schizophr Res 107:92-8. 2009
    ..This pattern of results indicates that greater signal strength is required for visual and cognitive processing of facial information in schizophrenia...
  7. pmc Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Cogn Affect Behav Neurosci 8:293-303. 2008
    ..Furthermore, this result provides evidence that in the context of broadly distributed cortical dysfunction, the usual functional specificity of the cortex becomes modified, even across the domains of sensory and cognitive processing...
  8. pmc Altered center-surround motion inhibition in schizophrenia
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
    Biol Psychiatry 64:74-7. 2008
    ..Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations...
  9. doi request reprint Females excel at basic face perception
    Ryan McBain
    Mailman Research Center, McLean Hospital, Room G06, Centre Bldg, 115 Mill Street, Belmont, MA 02478, United States
    Acta Psychol (Amst) 130:168-73. 2009
    ..5 to 3s. These results reveal a female advantage in processing face-specific information and underscore the role of perceptual factors in socially relevant gender differences...
  10. pmc Reduced ability to detect facial configuration in middle-aged and elderly individuals: associations with spatiotemporal visual processing
    Daniel Norton
    Visual Psychophysiology Laboratory, McLean Hospital, Belmont, Massachusetts, USA
    J Gerontol B Psychol Sci Soc Sci 64:328-34. 2009
    ..Face detection was correlated strongly with contrast sensitivities, but only weakly with verbal IQ. The results suggest that face detection ability begins to reduce in early aging, and is associated with spatiotemporal visual processing...
  11. doi request reprint Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophrenia
    Daniel Norton
    McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 65:1094-8. 2009
    ..We examined whether and how poor facial emotion recognition in schizophrenia is related to basic visual processing and nonaffective face recognition...
  12. ncbi request reprint Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder
    Yue Chen
    Department of Psychiatry, Harvard Medical School, USA
    Schizophr Res 74:271-81. 2005
    ..Our findings suggest that deficiencies in integrating motion signals, while specific for schizophrenia, do not seem to be a co-familial trait...
  13. ncbi request reprint Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia
    Yue Chen
    Psychology Research Laboratory, Mailman Reseach Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 160:1795-801. 2003
    ....
  14. pmc Inefficient face detection in schizophrenia
    Yue Chen
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Schizophr Bull 34:367-74. 2008
    ..Higher levels of facial processing, such as recognition of the individuality and emotional expression of faces, are abnormal in schizophrenia. It is unknown, however, whether the visual detection of a face as face is impaired as well...
  15. ncbi request reprint Two visual motion processing deficits in developmental dyslexia associated with different reading skills deficits
    Jeremy B Wilmer
    Harvard University, Cambridge, MA 02138, USA
    J Cogn Neurosci 16:528-40. 2004
    ..The two distinct patterns of motion processing and reading deficits demonstrated by this study may reflect separable underlying neurocognitive mechanisms of developmental dyslexia...
  16. ncbi request reprint Differences in the pharmacological activation of visual opsins
    T Isayama
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Vis Neurosci 23:899-908. 2006
    ..Thus opsin structure determines the identity of beta-ionone as an agonist or an inverse agonist and in that respect distinguishes the red-sensitive cone opsin from all others...
  17. pmc Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor
    R K Jain
    Edwin L Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 95:10820-5. 1998
    ..Because human tumors often relapse following hormone-ablation therapy, our data suggest that these patients may benefit from combined anti-VEGF therapy...
  18. pmc Can persons with schizophrenia appreciate visual art?
    Y Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, United States
    Schizophr Res 105:245-51. 2008
    ..The reduced sensitivity to visual feature manipulations suggests that the modulation of basic visual signals, often used for vivid and dynamic expressions in art, may be under-appreciated in schizophrenia...
  19. pmc Schizophrenia patients show augmented spatial frame illusion for visual and visuomotor tasks
    Y Chen
    Mailman Research Center, McLean Hospital, Department of Psychiatry, Harvard Medical School 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 172:419-26. 2011
    ..These results provide evidence for a hypothesis of improper inhibitory control as a common mechanism underpinning abnormal visual and visuomotor processes in this mental disorder...
  20. ncbi request reprint Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)
    R L Neve
    Department of Psychiatry, Harvard Medical School, MRC 223 McLean Hospital, 115 Mill St, 02478, Belmont, MA, USA
    Brain Res 886:54-66. 2000
    ....
  21. ncbi request reprint Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6020-4. 2001
    ..These results suggest that VEGF transcription in brain tumors is regulated by both tissue pO(2) and pH via distinct pathways...
  22. ncbi request reprint Less attention is more in the preparation of antisaccades, but not prosaccades
    A Kristjansson
    Vision Sciences Laboratory, Harvard University, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 4:1037-42. 2001
    ..The results suggest that the suppression of sensorimotor reflexes can facilitate volitional motor acts...
  23. ncbi request reprint In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice
    P A Gonnella
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 160:4708-18. 1998
    ..The induction of cytokines known to inhibit autoimmune disease at the site of Ag absorption indicates an important role for the mucosal immune system in the establishment of oral tolerance...
  24. pmc Effects of domain-specific noise on visual motion processing in schizophrenia
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 9:e99031. 2014
    ..Filtering out noise is a critical aspect of information processing, and needs to be critically examined in schizophrenia...
  25. ncbi request reprint The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons
    Y Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Biol Chem 275:8929-35. 2000
    ..A specific caspase-6 inhibitor blocks this apoptosis. These findings are discussed in the context of abnormalities in the cell cycle that have been observed in Alzheimer's disease...
  26. pmc Aging and visual motion discrimination in normal adults and schizophrenia patients
    L Cinnamon Bidwell
    Department of Psychology, University of Colorado, Boulder, CO, USA
    Psychiatry Res 145:1-8. 2006
    ..A similar motion-discrimination deficit in schizophrenia patients and aging normal adults suggests that the mechanisms underlying motion processing in schizophrenia and normal aging may be associated...
  27. pmc Altered 'three-flash' illusion in response to two light pulses in schizophrenia
    Dan Norton
    McLean Hospital, United States
    Schizophr Res 103:275-82. 2008
    ..We examined the perceived interaction of two elementary visual events in schizophrenia patients, using a psychophysical approach...
  28. ncbi request reprint MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis
    Dong Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, China
    J Clin Periodontol 34:384-9. 2007
    ..The study was carried out to analyse the association of functional polymorphisms in MMP-2, MMP-9 and TIMP-2 with generalized AgP (G-AgP) in a Chinese population...
  29. pmc The influence of ambient coarse particulate matter on asthma hospitalization in children: case-crossover and time-series analyses
    Mei Lin
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Canada
    Environ Health Perspect 110:575-81. 2002
    ..For the most part, relative risk estimates from the unidirectional case-crossover analysis were more pronounced compared with both bidirectional case-crossover and time-series analyses...
  30. ncbi request reprint Hospital readmissions for asthma in children and young adults in Canada
    Yue Chen
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Pediatr Pulmonol 36:22-6. 2003
    ..Airway size, female hormonal changes, increased use of cosmetic products, and cigarette smoking among adolescent girls may contribute to the age- and sex-differences in adolescence...
  31. ncbi request reprint [Hfgl2/fibroleukin expression in liver and peripheral blood mononuclear cells (PBMC) and its correlation with disease severity]
    Fan Zhu
    Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Gan Zang Bing Za Zhi 12:385-8. 2004
    ..The undergoing study in this report is designed to identify the role of hfgl 2 (human fibrinogen like protein 2) /fibroleukin in patients with viral hepatitis...
  32. ncbi request reprint HBV infection and familial aggregation of liver cancer: an analysis of case-control family study
    Yanhui Gao
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
    Cancer Causes Control 15:845-50. 2004
    ..Hepatitis B virus (HBV) infection is one of the most important risk factors for hepatocellular carcinoma (HCC). The specific aim of this study is to assess the influence of HBV infection on familial aggregation of HCC...
  33. ncbi request reprint Association between particulate air pollution and first hospital admission for childhood respiratory illness in Vancouver, Canada
    Qiuying Yang
    McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
    Arch Environ Health 59:14-21. 2004
    ..22 (1.02, 1.48) and 1.14 (0.99, 1.32). The data indicated the possibility of harmful effects from coarse PM on first hospitalization for respiratory disease in early childhood...
  34. ncbi request reprint An overview of the association between allergy and cancer
    Michelle C Turner
    R Samuel McLaughlin Center for Population Health Risk Assessment, University of Ottawa, Canada
    Int J Cancer 118:3124-32. 2006
    ..There is also a need for further basic research to clarify a potential mechanism, should an association exist...
  35. doi request reprint Alcohol drinking and renal cell carcinoma in Canadian men and women
    Jinfu Hu
    Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 120 Colonnade Road, AL 6701A, Ottawa, Ontario, Canada
    Cancer Detect Prev 32:7-14. 2008
    ..The present study examines the association between alcohol intake and the risk of RCC among men and women...
  36. ncbi request reprint Noninvasive scintigraphic detection of tumor with 99mTc-DTPA-deoxyglucose: an experimental study
    Yue Chen
    Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China
    Cancer Biother Radiopharm 22:403-5. 2007
    ..We investigated (99m)Tc-DTPA-DG for tumor detection...
  37. ncbi request reprint Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain
    Hao Zhang
    Key Laboratory for Cell Proliferation and Regulation Biology Ministry of Education, Beijing Normal University, 19th Xinjiekouwai St, 100875 Beijing, China
    Lung Cancer 57:37-45. 2007
    ..These findings suggest that S100A7 expression is closely associated with SCC metastasis to brain and may be a potential biomarker for monitoring the development of SCC...
  38. ncbi request reprint Elevation of serum l-lactate dehydrogenase B correlated with the clinical stage of lung cancer
    Yue Chen
    Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, 19th Xinjiekouwai St, Beijing 100875, PR China
    Lung Cancer 54:95-102. 2006
    ..These findings demonstrated that secretome could open up a possibility to find, identify, and characterize novel biomarkers related with invasion and metastasis...

Research Grants8

  1. MOTION PROCESSING SYSTEM IN SCHIZOPHRENIA
    Yue Chen; Fiscal Year: 2001
    ..The results of these studies will generate a systematic characterization of the functional properties of the motion processing system as well as the parietal system in schizophrenia. ..
  2. MOTION PROCESSING SYSTEM IN SCHIZOPHRENIA
    Yue Chen; Fiscal Year: 2002
    ..The results of these studies will generate a systematic characterization of the functional properties of the motion processing system as well as the parietal system in schizophrenia. ..
  3. Motion Processing System in Schizophrenia
    Yue Chen; Fiscal Year: 2005
    ..sum of the parts" hypothesis can be evaluated empirically. ..
  4. MOTION PROCESSING SYSTEM IN SCHIZOPHRENIA
    Yue Chen; Fiscal Year: 2004
    ..The results of these studies will generate a systematic characterization of the functional properties of the motion processing system as well as the parietal system in schizophrenia. ..
  5. Motion Processing System in Schizophrenia
    Yue Chen; Fiscal Year: 2006
    ..sum of the parts" hypothesis can be evaluated empirically. ..
  6. Motion Processing System in Schizophrenia
    Yue Chen; Fiscal Year: 2007
    ..sum of the parts" hypothesis can be evaluated empirically. ..
  7. Motion Processing System in Schizophrenia
    Yue Chen; Fiscal Year: 2009
    ..sum of the parts" hypothesis can be evaluated empirically. ..