Research Topics
Genomes and GenesSpecies | Wendy Y ChenSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Physical activity and survival after breast cancer diagnosisMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
JAMA 293:2479-86. 2005..Physical activity has been shown to decrease the incidence of breast cancer, but the effect on recurrence or survival after a breast cancer diagnosis is not known...- Unopposed estrogen therapy and the risk of invasive breast cancerWendy Y Chen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Arch Intern Med 166:1027-32. 2006..We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period... 
Exogenous and endogenous hormones and breast cancerWendy Y Chen
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
Best Pract Res Clin Endocrinol Metab 22:573-85. 2008..Current research issues include measurement of levels for routine clinical practice, integration with standard breast cancer risk models and genetic polymorphism data, and applicability to estrogen-receptor-negative cancers...- Moderate alcohol consumption during adult life, drinking patterns, and breast cancer riskWendy Y Chen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
JAMA 306:1884-90. 2011..In addition, the role of drinking patterns (ie, frequency of drinking and "binge" drinking) and consumption at different times of adult life are not well understood... - Postmenopausal hormone therapy and breast cancer risk: current status and unanswered questionsWendy Y Chen
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Endocrinol Metab Clin North Am 40:509-18, viii. 2011..For breast cancer survivors, systemic HT should be discouraged... - Moving forward with breast cancer preventionWendy Y Chen
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 109:2387-91. 2007 - Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancerWendy Y Chen
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Nat Clin Pract Oncol 4:415-23. 2007..We also discuss the clinical implications of accounting for hormone-receptor status in breast cancer risk-prediction models... - +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancerJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 125:1685-91. 2009..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies... - Red meat intake and risk of breast cancer among premenopausal womenEunyoung Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:2253-9. 2006..Although breast tumors differ clinically and biologically by hormone receptor status, few epidemiologic studies of diet have made this distinction... - Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese womenSarah J Nechuta
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Am J Clin Nutr 96:123-32. 2012..Soy isoflavones have antiestrogenic and anticancer properties but also possess estrogen-like properties, which has raised concern about soy food consumption among breast cancer survivors... - Dietary acrylamide intake and risk of premenopausal breast cancerKathryn M Wilson
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Epidemiol 169:954-61. 2009..They found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of premenopausal breast cancer... - COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirinMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 130:657-62. 2011..The survival benefit associated with aspirin use did not differ by COX-2 status. COX-2 breast cancer expression is associated with worse prognosis. If aspirin truly impacts breast cancer survival, then it is not solely via COX-2... - Physical activity's impact on the association of fat and fiber intake with survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 170:1250-6. 2009..40), P = 0.59. Results of simple models adjusted additionally for physical activity were similar to those for full multivariate models. Results show that physical activity strongly confounds the association between diet and survival... - Risk factors for breast cancer according to estrogen and progesterone receptor statusGraham A Colditz
Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, and Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115 5899, USA
J Natl Cancer Inst 96:218-28. 2004..To address this issue, we conducted a prospective evaluation of risk factors for breast cancer classified according to receptor status... - Risk factors for ductal and lobular breast cancer: results from the nurses' health studyJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Breast Cancer Res 12:R106. 2010.... - Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinomaWendy Y Chen
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Cancer 101:1490-500. 2004.... - Smoking and survival after breast cancer diagnosisMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 120:2672-7. 2007..We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer... - Aspirin intake and survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 28:1467-72. 2010..Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer... - Combined estrogen and testosterone use and risk of breast cancer in postmenopausal womenRulla M Tamimi
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:1483-9. 2006..CONCLUSION: Consistent with the elevation in risk for endogenous testosterone levels, women using estrogen and testosterone therapies have a significantly increased risk of invasive breast cancer... - Use of postmenopausal hormones, alcohol, and risk for invasive breast cancerWendy Y Chen
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, and Dana Farber Cancer Institute, 181 Longwood Avenue, Boston, MA 02115, USA
Ann Intern Med 137:798-804. 2002..CONCLUSIONS: Both alcohol consumption and PMH use were associated with an increased incidence of breast cancer. Women who are currently taking PMH may want to consider the added risks of regular alcohol consumption... - Weight, weight gain, and survival after breast cancer diagnosisCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
J Clin Oncol 23:1370-8. 2005..To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival... - Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancerEunyoung Cho
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:713-20. 2003..We found no evidence that higher intakes of vitamins C and E, and folate in early adult life reduce risk of breast cancer. However, intake of vitamin A may be related to a reduced risk of breast cancer among smokers... - Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancerEunyoung Cho
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:1153-8. 2003..Our data do not support a strong association between fiber intake and breast cancer risk... - Premenopausal fat intake and risk of breast cancerEunyoung Cho
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
J Natl Cancer Inst 95:1079-85. 2003..We conducted a prospective analysis of the relation between dietary fat intake and breast cancer risk among premenopausal women enrolled in the Nurses' Health Study II... 
ABO blood group and breast cancer incidence and survivalMargaret A Gates
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Int J Cancer 130:2129-37. 2012..35-3.86) for B/B, compared to O/O. No significant association was noted between blood type and overall or breast cancer-specific mortality. Our results suggest no association between ABO blood group and breast cancer risk or survival...- Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and risk of breast cancer among premenopausal women in the Nurses' Health Study IIA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 169:115-21; discussion 121. 2009..In addition, the chemopreventive use of NSAIDs is increasingly common for heart disease and colon cancer. Evidence of a protective association with breast cancer risk has been inconsistent, and few data exist for premenopausal women... - A prospective study of breast size and premenopausal breast cancer incidenceAaron S Kusano
Department of Epidemiology, Harvard School of Public Health, and Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA 02115, USA
Int J Cancer 118:2031-4. 2006..Stratifying by BMI at age 18 at a cutoff point of 21 kg/m2 gave similar results. Larger bra cup size at a young age is associated with a higher incidence of premenopausal breast cancer, though this association is limited to leaner women... - A prospective study of smoking and risk of breast cancer in young adult womenWael K Al-Delaimy
Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 13:398-404. 2004..To investigate the association between smoking and invasive breast cancers characterized by their estrogen receptor status in a large prospective study of mainly premenopausal women... - Associations between polymorphisms in the vitamin D receptor and breast cancer riskWendy Y Chen
Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:2335-9. 2005..Our results suggest that the VDR may be a mediator of breast cancer risk and could represent a target for cancer prevention efforts... - The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristicsSarah J Nechuta
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Cancer Causes Control 22:1319-31. 2011..The project sets the stage for international collaborations for the investigation of modifiable predictors for breast cancer outcomes... - Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivorsJennifer A Ligibel
Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Channing Laboratory, Boston, MA, USA
J Clin Oncol 26:907-12. 2008..We sought to analyze whether exercise lowered insulin concentrations in breast cancer survivors... - Functional impact of breast cancer by age at diagnosisCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 22:1849-56. 2004..To explore changes in physical and psychosocial function before and after breast cancer by age at diagnosis... - BRCA1/2 genetic testing in the community settingWendy Y Chen
Department of Adult Oncology, Dana Farber Cancer Institute, and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 20:4485-92. 2002..This study evaluates the process and early outcomes of BRCA1/2 genetic testing as a clinical service in the community setting... - Novel genetic markers of breast cancer survival identified by a genome-wide association studyXiao Ou Shu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
Cancer Res 72:1182-9. 2012..39 × 10(-7)). Similar associations were observed for these two SNPs with breast cancer-specific mortality. This study provides strong evidence suggesting that the RAD51L1 gene and a chromosome 16 locus influence breast cancer prognosis... - Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomicsErica L Mayer
Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA, 02215, USA
Breast Cancer Res Treat 136:169-78. 2012..Changes in the platelet proteome may serve as pharmacodynamic markers of angiogenesis inhibition. Metronomic chemotherapy is an attractive partner with biologics and deserves further study in metastatic breast cancer... - Phase I trial of liposomal doxorubicin and ZD1839 in patients with refractory gynecological malignancies or metastatic breast cancerSusana M Campos
Department of Gynecology Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, USA
Int J Clin Oncol 15:390-8. 2010.... - The Letrozole Breast Cancer Trial: clinical implications and remaining questionsWendy Y Chen
Womens Health Issues 14:7-10. 2004 - Alcohol consumption and endometrial cancer: some unresolved issuesElisa V Bandera
Department of Nutritional Sciences, Rutgers University, Davison Hall, 26 Nichol Avenue, New Brunswick, NJ 08901, USA
Nutr Cancer 45:24-9. 2003..Moreover, there are some unexplored aspects of the possible effect of alcohol, such as the possible interaction with use of exogenous estrogens, and other factors, that need clarification... - Colon cancer risk counseling by health-care providers: perceived barriers and response to an internet-based cancer risk appraisal instrumentKathleen M Fairfield
Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME 04102, USA
J Cancer Educ 19:95-7. 2004..Risk appraisal instruments may be helpful in reinforcing prevention messages, although little is known about physician acceptance of such instruments... - Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancerElizabeth R Bertone-Johnson
Department of Public Health, University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003 9304, USA
Cancer Epidemiol Biomarkers Prev 14:1991-7. 2005..Our findings suggest that high levels of 25(OH)D, and perhaps 1,25(OH)2D, may be modestly associated with reduced risk of breast cancer... - Premature ovarian failure in cancer survivors: new insights, looming concernsWendy Y Chen
J Natl Cancer Inst 98:880-1. 2006