Wendy Y Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint BRCA1/2 genetic testing in the community setting
    Wendy Y Chen
    Department of Adult Oncology, Dana Farber Cancer Institute, and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 20:4485-92. 2002
  2. pmc Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk
    Ying Liu
    Affiliations of authors Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO YL, GAC Alvin J Siteman Cancer Center at Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO GAC Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA BR, CSB, WYC, RMT Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA LCC, SJS, JLC Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA WCW
    J Natl Cancer Inst 105:1571-8. 2013
  3. pmc Lifetime cigarette smoking and breast cancer prognosis in the After Breast Cancer Pooling Project
    John P Pierce
    Affiliations of authors Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA JPP, Rep, CMS, SWF, LN Division of Research, Kaiser Permanente, Oakland, CA BJC Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN SJN, X OS Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA EMP, WYC Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA WYC
    J Natl Cancer Inst 106:djt359. 2014
  4. ncbi request reprint Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies
    Caroline E Boeke
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA
    Breast Cancer Res Treat 146:383-92. 2014
  5. pmc Breast cancer risk prediction with heterogeneous risk profiles according to breast cancer tumor markers
    Bernard Rosner
    Channing Division of Network Medicine, Brigham andWomen s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 178:296-308. 2013
  6. ncbi request reprint Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1483-9. 2006
  7. ncbi request reprint Red meat intake and risk of breast cancer among premenopausal women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2253-9. 2006
  8. ncbi request reprint Smoking and survival after breast cancer diagnosis
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 120:2672-7. 2007
  9. ncbi request reprint Moving forward with breast cancer prevention
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 109:2387-91. 2007
  10. ncbi request reprint Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer
    Wendy Y Chen
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Nat Clin Pract Oncol 4:415-23. 2007

Detail Information

Publications42

  1. ncbi request reprint BRCA1/2 genetic testing in the community setting
    Wendy Y Chen
    Department of Adult Oncology, Dana Farber Cancer Institute, and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 20:4485-92. 2002
    ..This study evaluates the process and early outcomes of BRCA1/2 genetic testing as a clinical service in the community setting...
  2. pmc Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk
    Ying Liu
    Affiliations of authors Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO YL, GAC Alvin J Siteman Cancer Center at Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO GAC Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA BR, CSB, WYC, RMT Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA LCC, SJS, JLC Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA WCW
    J Natl Cancer Inst 105:1571-8. 2013
    ..No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer...
  3. pmc Lifetime cigarette smoking and breast cancer prognosis in the After Breast Cancer Pooling Project
    John P Pierce
    Affiliations of authors Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA JPP, Rep, CMS, SWF, LN Division of Research, Kaiser Permanente, Oakland, CA BJC Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN SJN, X OS Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA EMP, WYC Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA WYC
    J Natl Cancer Inst 106:djt359. 2014
    ..There is controversy on whether former smokers have increased risk for breast cancer recurrence or all-cause mortality, regardless of how much they smoked...
  4. ncbi request reprint Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies
    Caroline E Boeke
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA
    Breast Cancer Res Treat 146:383-92. 2014
    ....
  5. pmc Breast cancer risk prediction with heterogeneous risk profiles according to breast cancer tumor markers
    Bernard Rosner
    Channing Division of Network Medicine, Brigham andWomen s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 178:296-308. 2013
    ..This approach provides a strategy for evaluating heterogeneity of risk factor associations by tumor marker levels while controlling for additional tumor markers. ..
  6. ncbi request reprint Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1483-9. 2006
    ..Given the increasing trend in the use of hormone therapies containing androgens, we evaluated the relation between the use of estrogen and testosterone therapies and breast cancer...
  7. ncbi request reprint Red meat intake and risk of breast cancer among premenopausal women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2253-9. 2006
    ..Although breast tumors differ clinically and biologically by hormone receptor status, few epidemiologic studies of diet have made this distinction...
  8. ncbi request reprint Smoking and survival after breast cancer diagnosis
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 120:2672-7. 2007
    ..We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer...
  9. ncbi request reprint Moving forward with breast cancer prevention
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 109:2387-91. 2007
  10. ncbi request reprint Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer
    Wendy Y Chen
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Nat Clin Pract Oncol 4:415-23. 2007
    ..We also discuss the clinical implications of accounting for hormone-receptor status in breast cancer risk-prediction models...
  11. pmc Exogenous and endogenous hormones and breast cancer
    Wendy Y Chen
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
    Best Pract Res Clin Endocrinol Metab 22:573-85. 2008
    ..Current research issues include measurement of levels for routine clinical practice, integration with standard breast cancer risk models and genetic polymorphism data, and applicability to estrogen-receptor-negative cancers...
  12. pmc Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and risk of breast cancer among premenopausal women in the Nurses' Health Study II
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 169:115-21; discussion 121. 2009
    ..In addition, the chemopreventive use of NSAIDs is increasingly common for heart disease and colon cancer. Evidence of a protective association with breast cancer risk has been inconsistent, and few data exist for premenopausal women...
  13. pmc Dietary acrylamide intake and risk of premenopausal breast cancer
    Kathryn M Wilson
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 169:954-61. 2009
    ..They found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of premenopausal breast cancer...
  14. pmc Physical activity's impact on the association of fat and fiber intake with survival after breast cancer
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Epidemiol 170:1250-6. 2009
    ..40), P = 0.59. Results of simple models adjusted additionally for physical activity were similar to those for full multivariate models. Results show that physical activity strongly confounds the association between diet and survival...
  15. pmc Aspirin intake and survival after breast cancer
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 28:1467-72. 2010
    ..Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer...
  16. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
    ....
  17. ncbi request reprint Unopposed estrogen therapy and the risk of invasive breast cancer
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 166:1027-32. 2006
    ..We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period...
  18. ncbi request reprint A prospective study of breast size and premenopausal breast cancer incidence
    Aaron S Kusano
    Department of Epidemiology, Harvard School of Public Health, and Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Cancer 118:2031-4. 2006
    ..Stratifying by BMI at age 18 at a cutoff point of 21 kg/m2 gave similar results. Larger bra cup size at a young age is associated with a higher incidence of premenopausal breast cancer, though this association is limited to leaner women...
  19. ncbi request reprint Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:713-20. 2003
    ..We found no evidence that higher intakes of vitamins C and E, and folate in early adult life reduce risk of breast cancer. However, intake of vitamin A may be related to a reduced risk of breast cancer among smokers...
  20. ncbi request reprint Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer
    Eunyoung Cho
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:1153-8. 2003
    ..Our data do not support a strong association between fiber intake and breast cancer risk...
  21. ncbi request reprint Risk factors for breast cancer according to estrogen and progesterone receptor status
    Graham A Colditz
    Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, and Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115 5899, USA
    J Natl Cancer Inst 96:218-28. 2004
    ..To address this issue, we conducted a prospective evaluation of risk factors for breast cancer classified according to receptor status...
  22. ncbi request reprint A prospective study of smoking and risk of breast cancer in young adult women
    Wael K Al-Delaimy
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:398-404. 2004
    ..To investigate the association between smoking and invasive breast cancers characterized by their estrogen receptor status in a large prospective study of mainly premenopausal women...
  23. ncbi request reprint Functional impact of breast cancer by age at diagnosis
    Candyce H Kroenke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 22:1849-56. 2004
    ..To explore changes in physical and psychosocial function before and after breast cancer by age at diagnosis...
  24. ncbi request reprint Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma
    Wendy Y Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer 101:1490-500. 2004
    ....
  25. ncbi request reprint Premenopausal fat intake and risk of breast cancer
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 95:1079-85. 2003
    ..We conducted a prospective analysis of the relation between dietary fat intake and breast cancer risk among premenopausal women enrolled in the Nurses' Health Study II...
  26. ncbi request reprint Weight, weight gain, and survival after breast cancer diagnosis
    Candyce H Kroenke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    J Clin Oncol 23:1370-8. 2005
    ..To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival...
  27. ncbi request reprint Physical activity and survival after breast cancer diagnosis
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 293:2479-86. 2005
    ..Physical activity has been shown to decrease the incidence of breast cancer, but the effect on recurrence or survival after a breast cancer diagnosis is not known...
  28. pmc Beta blockers and angiotensin-converting enzyme inhibitors' purported benefit on breast cancer survival may be explained by aspirin use
    Michelle D Holmes
    the Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res Treat 139:507-13. 2013
    ..The strong protective association with aspirin use confounds the associations with these other drugs and underscores the importance of considering aspirin use in analyses of breast cancer survival...
  29. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    ..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies...
  30. ncbi request reprint Associations between polymorphisms in the vitamin D receptor and breast cancer risk
    Wendy Y Chen
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2335-9. 2005
    ..Our results suggest that the VDR may be a mediator of breast cancer risk and could represent a target for cancer prevention efforts...
  31. ncbi request reprint Use of postmenopausal hormones, alcohol, and risk for invasive breast cancer
    Wendy Y Chen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, and Dana Farber Cancer Institute, 181 Longwood Avenue, Boston, MA 02115, USA
    Ann Intern Med 137:798-804. 2002
    ..Physiologic evidence suggests that use of alcohol increases the risk for breast cancer through a hormonal mechanism, but the relationship among breast cancer, alcohol, and postmenopausal hormones (PMH) remains unclear...
  32. doi request reprint Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors
    Jennifer A Ligibel
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Channing Laboratory, Boston, MA, USA
    J Clin Oncol 26:907-12. 2008
    ..We sought to analyze whether exercise lowered insulin concentrations in breast cancer survivors...
  33. pmc Postdiagnosis supplement use and breast cancer prognosis in the After Breast Cancer Pooling Project
    Elizabeth M Poole
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Breast Cancer Res Treat 139:529-37. 2013
    ..Stratification by ER status and considering antioxidants as a group may be more clinically relevant when evaluating associations with cancer risk and mortality...
  34. doi request reprint Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics
    Erica L Mayer
    Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    Breast Cancer Res Treat 136:169-78. 2012
    ..Changes in the platelet proteome may serve as pharmacodynamic markers of angiogenesis inhibition. Metronomic chemotherapy is an attractive partner with biologics and deserves further study in metastatic breast cancer...
  35. ncbi request reprint Premenopausal dietary fat in relation to pre- and post-menopausal breast cancer
    Maryam S Farvid
    Department of Nutrition, Harvard School of Public Health, Boston, 02115, MA, USA
    Breast Cancer Res Treat 145:255-65. 2014
    ..Our finding suggests a positive association between early adult intake of animal fat and breast cancer risk...
  36. pmc ABO blood group and breast cancer incidence and survival
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cancer 130:2129-37. 2012
    ..35-3.86) for B/B, compared to O/O. No significant association was noted between blood type and overall or breast cancer-specific mortality. Our results suggest no association between ABO blood group and breast cancer risk or survival...
  37. doi request reprint Phase I trial of liposomal doxorubicin and ZD1839 in patients with refractory gynecological malignancies or metastatic breast cancer
    Susana M Campos
    Department of Gynecology Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, USA
    Int J Clin Oncol 15:390-8. 2010
    ....
  38. ncbi request reprint Colon cancer risk counseling by health-care providers: perceived barriers and response to an internet-based cancer risk appraisal instrument
    Kathleen M Fairfield
    Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME 04102, USA
    J Cancer Educ 19:95-7. 2004
    ..Risk appraisal instruments may be helpful in reinforcing prevention messages, although little is known about physician acceptance of such instruments...
  39. ncbi request reprint Alcohol consumption and endometrial cancer: some unresolved issues
    Elisa V Bandera
    Department of Nutritional Sciences, Rutgers University, Davison Hall, 26 Nichol Avenue, New Brunswick, NJ 08901, USA
    Nutr Cancer 45:24-9. 2003
    ..Moreover, there are some unexplored aspects of the possible effect of alcohol, such as the possible interaction with use of exogenous estrogens, and other factors, that need clarification...
  40. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer
    Elizabeth R Bertone-Johnson
    Department of Public Health, University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003 9304, USA
    Cancer Epidemiol Biomarkers Prev 14:1991-7. 2005
    ..Our findings suggest that high levels of 25(OH)D, and perhaps 1,25(OH)2D, may be modestly associated with reduced risk of breast cancer...
  41. ncbi request reprint Premature ovarian failure in cancer survivors: new insights, looming concerns
    Wendy Y Chen
    J Natl Cancer Inst 98:880-1. 2006
  42. ncbi request reprint The Letrozole Breast Cancer Trial: clinical implications and remaining questions
    Wendy Y Chen
    Womens Health Issues 14:7-10. 2004