Shaoyong Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    Shaoyong Chen
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:8571-83. 2012
  2. ncbi Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    Shaoyong Chen
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:25576-84. 2009
  3. ncbi Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2
    Changmeng Cai
    Cancer Biology Program Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:5202-9. 2009
  4. ncbi Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
  5. ncbi Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
    Shaoyong Chen
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:15969-74. 2006
  6. ncbi Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 20:457-71. 2011
  7. ncbi Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6503-13. 2011
  8. ncbi The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer, Institute, Harvard Medical School, Boston, MA 02115, USA
    Prostate 72:1093-103. 2012
  9. ncbi Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor
    Rupal S Bhatt
    Division of Cancer Biology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BJU Int 102:358-63. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    Shaoyong Chen
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:8571-83. 2012
    ....
  2. ncbi Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    Shaoyong Chen
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:25576-84. 2009
    ..Moreover, AR may function as a PP1 regulatory subunit and mediate PP1 recruitment to chromatin, where it can modulate transcription and splicing...
  3. ncbi Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2
    Changmeng Cai
    Cancer Biology Program Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:5202-9. 2009
    ..These findings show that EGFR and ErbB2 can negatively regulate AR mRNA and may provide an approach to suppress AR expression in CRPC...
  4. ncbi Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
    ..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
  5. ncbi Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
    Shaoyong Chen
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:15969-74. 2006
    ....
  6. ncbi Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 20:457-71. 2011
    ..Androgen levels in CRPC appear adequate to stimulate AR activity on enhancer elements, but not suppressor elements, resulting in increased expression of AR and AR repressed genes that contribute to cellular proliferation...
  7. ncbi Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6503-13. 2011
    ..Together, our results indicate that CRPCs resistant to CYP17A1 inhibition may remain steroid dependent and therefore responsive to therapies that can further suppress de novo intratumoral steroid synthesis...
  8. ncbi The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer, Institute, Harvard Medical School, Boston, MA 02115, USA
    Prostate 72:1093-103. 2012
    ....
  9. ncbi Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor
    Rupal S Bhatt
    Division of Cancer Biology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BJU Int 102:358-63. 2008
    ....