Lichao Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep
    Lichao Chen
    Research Service, VA Boston Healthcare System, Brockton, MA, USA
    Eur J Neurosci 37:957-63. 2013
  2. pmc Animal models of narcolepsy
    Lichao Chen
    Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    CNS Neurol Disord Drug Targets 8:296-308. 2009
  3. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
  4. pmc REM sleep changes in rats induced by siRNA-mediated orexin knockdown
    Lichao Chen
    Department of Psychiatry, Harvard Medical School, Boston VA Healthcare System, 940 Belmont Street, Brockton, MA 02301, USA, and Department of Neurology, Harry Truman Memorial VA Hospital, Columbia, MO 65203, USA
    Eur J Neurosci 24:2039-48. 2006
  5. pmc Decoupling of sleepiness from sleep time and intensity during chronic sleep restriction: evidence for a role of the adenosine system
    Youngsoo Kim
    VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, Brockton, MA 02301 5596, USA
    Sleep 35:861-9. 2012
  6. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
  7. pmc Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system
    Youngsoo Kim
    VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, 940 Belmont St, Brockton, MA 02301 5596, USA
    Brain Res 1531:9-16. 2013

Detail Information

Publications7

  1. pmc Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep
    Lichao Chen
    Research Service, VA Boston Healthcare System, Brockton, MA, USA
    Eur J Neurosci 37:957-63. 2013
    ..Orexin type 1 receptor mRNA level was unaffected. Our results indicate that removal of OxR2 neurotransmission in the lPMT enhances REM sleep by increasing the duration of REM episodes...
  2. pmc Animal models of narcolepsy
    Lichao Chen
    Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    CNS Neurol Disord Drug Targets 8:296-308. 2009
    ..To facilitate further research, it is imperative that researchers reach a consensus concerning the evaluation of narcoleptic behavioral and EEG phenomenology in these models...
  3. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
    ..The results indicate that a modest knockdown of OxR1 is sufficient to induce observable sleep changes. Moreover, orexin neurons, by acting on OxR1 in the LC, play a role in the diurnal gating of REM sleep...
  4. pmc REM sleep changes in rats induced by siRNA-mediated orexin knockdown
    Lichao Chen
    Department of Psychiatry, Harvard Medical School, Boston VA Healthcare System, 940 Belmont Street, Brockton, MA 02301, USA, and Department of Neurology, Harry Truman Memorial VA Hospital, Columbia, MO 65203, USA
    Eur J Neurosci 24:2039-48. 2006
    ..Our results indicate that siRNA can be usefully employed in behavioural studies to complement other loss-of-function approaches. Moreover, these data suggest that the orexin system plays a role in the diurnal gating of REM sleep...
  5. pmc Decoupling of sleepiness from sleep time and intensity during chronic sleep restriction: evidence for a role of the adenosine system
    Youngsoo Kim
    VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, Brockton, MA 02301 5596, USA
    Sleep 35:861-9. 2012
    ..However, it is unknown if these allostatic, or adaptive, sleep responses to CSR are paralleled by behavioral and neurochemical measures of sleepiness...
  6. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
    ..Our results suggest GAD67-GFP knock-in mice are an excellent tool for study of GABAergic neurons involved in sleep-wake regulation...
  7. pmc Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system
    Youngsoo Kim
    VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, 940 Belmont St, Brockton, MA 02301 5596, USA
    Brain Res 1531:9-16. 2013
    ....