John W Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
    John W Chen
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 5404 Building 149, 13th St, Charlestown, MA 02129, USA
    Radiology 240:473-81. 2006
  2. ncbi request reprint Vulnerable plaque imaging
    John W Chen
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Neuroimaging Clin N Am 15:609-21, xi. 2005
  3. doi request reprint Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis
    John W Chen
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 5404 Building 149, 13th Street, Charlestown, MA 02129, USA
    Brain 131:1123-33. 2008
  4. pmc Angiotensin II drives the production of tumor-promoting macrophages
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 38:296-308. 2013
  5. pmc Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase
    Henry S Su
    Center for Molecular Imaging Research, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Radiology 262:181-90. 2012
  6. pmc Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma
    Wei Zhang
    Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Ther 20:37-45. 2012
  7. pmc Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target
    Reza Forghani
    Center for Systems Biology, Harvard Medical School, Richard B Simches Research Center, Boston, MA 02114, USA
    Radiology 263:451-60. 2012
  8. pmc Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase
    Michael O Breckwoldt
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, CNY 149, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:18584-9. 2008
  9. ncbi request reprint Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis
    John W Chen
    Center for Molecular Imagina Research, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 52:1021-8. 2004
  10. pmc Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging
    Anne Kleijn
    Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 17:4484-93. 2011

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
    John W Chen
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 5404 Building 149, 13th St, Charlestown, MA 02129, USA
    Radiology 240:473-81. 2006
    ....
  2. ncbi request reprint Vulnerable plaque imaging
    John W Chen
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Neuroimaging Clin N Am 15:609-21, xi. 2005
    ..Although MR imaging, CT, and ultrasound provide data regarding single lesions, future investigations relying heavily on nuclear medicine techniques may offer functional assessment of the entire cardiovascular system...
  3. doi request reprint Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis
    John W Chen
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 5404 Building 149, 13th Street, Charlestown, MA 02129, USA
    Brain 131:1123-33. 2008
    ..This approach could be used in longitudinal studies to identify active demyelinating plaques as well as to more accurately track disease course following treatment in clinical trials...
  4. pmc Angiotensin II drives the production of tumor-promoting macrophages
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 38:296-308. 2013
    ..These findings indicate that AngII acts upstream of a potent macrophage amplification program and that tumors can remotely exploit the hormone's pathway to stimulate cancer-promoting immunity...
  5. pmc Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase
    Henry S Su
    Center for Molecular Imaging Research, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Radiology 262:181-90. 2012
    ..To determine if a molecular imaging approach targeting the highly oxidative enzyme myeloperoxidase (MPO) can help noninvasively identify and confirm sites of vascular wall inflammation in a murine model of vasculitis...
  6. pmc Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma
    Wei Zhang
    Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Ther 20:37-45. 2012
    ....
  7. pmc Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target
    Reza Forghani
    Center for Systems Biology, Harvard Medical School, Richard B Simches Research Center, Boston, MA 02114, USA
    Radiology 263:451-60. 2012
    ....
  8. pmc Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase
    Michael O Breckwoldt
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, CNY 149, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:18584-9. 2008
    ..Our findings could allow efficient noninvasive serial screening of therapies targeting inflammation and the use of MPO imaging as an imaging biomarker to risk-stratify patients...
  9. ncbi request reprint Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis
    John W Chen
    Center for Molecular Imagina Research, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 52:1021-8. 2004
    ..As a result, we were able to demonstrate MPO activity in enzyme solutions and in a model tissue-like system. These studies suggest that activatable paramagnetic MR imaging agents can be used to directly image MPO activity...
  10. pmc Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging
    Anne Kleijn
    Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 17:4484-93. 2011
    ..The imaging results were compared with histopathologic and molecular analyses of the tumors for macrophage/microglia infiltration, virus persistence, and MPO levels...
  11. pmc Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway
    John W Chen
    Center for Systems Biology, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 5:1127-38. 2012
    ..The purpose of this study was use molecular imaging targeting coagulation pathway and inflammation to better understand the pathophysiology of silent brain ischemia (SBI) and monitor the effects of factor XIIa inhibition...
  12. pmc Single reporter for targeted multimodal in vivo imaging
    Johanna M Niers
    Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, United States
    J Am Chem Soc 134:5149-56. 2012
    ....
  13. pmc Ligation of the jugular veins does not result in brain inflammation or demyelination in mice
    Wendy Atkinson
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33671. 2012
    ..Therefore, our murine model does not support CCSVI as a cause of demyelinating diseases such as multiple sclerosis...
  14. pmc Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2627-34. 2010
    ..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored...
  15. pmc Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity
    Elisenda Rodriguez
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Chem Soc 132:168-77. 2010
    ..Gd kinetic lability and cytotoxicity studies further confirm stability of the Gd ion and low toxicity for the 5HT-based agents, suggesting that these agents are suitable for translational in vivo studies...
  16. pmc Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy
    Corey M McCann
    Center for Molecular Imaging Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Neuroimage 45:360-9. 2009
    ..Our results reveal that combined FMT-MR imaging of fluorescent molecular probes could be valuable for brain tumor drug development and other neurological and somatic imaging applications...
  17. ncbi request reprint Myeloperoxidase activity imaging using (67)Ga labeled substrate
    Manel Querol Sans
    Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Imaging Biol 7:403-10. 2005
    ....
  18. pmc Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice
    Maulik D Majmudar
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circulation 127:2038-46. 2013
    ..We used dual-target positron emission tomography/magnetic resonance imaging of transglutaminase factor XIII (FXIII) and myeloperoxidase (MPO) activity to monitor how monocyte subset-targeted RNAi altered infarct inflammation and healing...
  19. pmc Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1153-60. 2008
    ..We hypothesized that MPO imaging could be used to measure inflammatory responses after myocardial ischemia locally and noninvasively in a murine model...
  20. pmc Measuring myeloperoxidase activity in biological samples
    Benjamin Pulli
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e67976. 2013
    ..Thus, validation and standardization are needed to establish a robust method that is highly specific, sensitive, and reproducible for assaying MPO activity in biological samples...
  21. ncbi request reprint DTPA-bisamide-based MR sensor agents for peroxidase imaging
    Manuel Querol
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Org Lett 7:1719-22. 2005
    ..Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity...
  22. pmc Enhanced in vivo imaging of metabolically biotinylated cell surface reporters
    Johanna M Niers
    Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Anal Chem 83:994-9. 2011
    ..These findings have practical applications in designing more efficient targeting and imaging strategies...
  23. pmc Origins of tumor-associated macrophages and neutrophils
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:2491-6. 2012
    ..The present study sheds light on the origins of TAMs and TANs, and positions the spleen as an important extramedullary site, which can continuously supply growing tumors with these cells...
  24. pmc Stochastic model of Tsc1 lesions in mouse brain
    Shilpa Prabhakar
    Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Massachusetts General Hospital, and Program in Neuroscience, Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64224. 2013
    ..This model provides a valuable and unique addition for therapeutic assessment...
  25. ncbi request reprint Metabolic biotinylation of cell surface receptors for in vivo imaging
    Bakhos A Tannous
    Center for Molecular Imaging Research, Massachusetts General Hospital East, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Methods 3:391-6. 2006
    ..This BAP-TM allows noninvasive real-time imaging of any cell type transduced to express this reporter protein in culture or in vivo...
  26. pmc Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
    Haihao Zhu
    Molecular Oncology Research Institute, Department of Neurosurgery, Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 106:2712-6. 2009
    ..Our findings provide critical insights into the role of mutant EGFR signaling function in GBM tumor biology and set the stage for testing of targeted therapeutic agents in the preclinical models described herein...
  27. ncbi request reprint A paramagnetic contrast agent with myeloperoxidase-sensing properties
    Manel Querol
    University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01655, USA
    Org Biomol Chem 4:1887-95. 2006
    ..We expected that upon activation by MPO/H2O2 L1-Gd3+ would not only oligomerise but also bind to other macromolecules present in the media and that the overall process will give rise to a net T1-weighted MRI signal increase...