Affiliation: Harvard University
Wang Z, Liu C, Huang S, Chen J. Wnt Signaling in vascular eye diseases. Prog Retin Eye Res. 2018;: pubmed publisher
..This review recapitulates the key roles of the Wnt signaling pathway during ocular vascular development and in vascular eye diseases, and pharmaceutical approaches targeting the Wnt signaling as potential treatment options. ..
Liu C, Sun Y, Li J, Gong Y, Tian K, Evans L, et al
. Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A. 2015;112:12163-8 pubmed publisher
..In conclusion, miR-150 is specifically enriched in quiescent normal vessels and functions as an endothelium-specific endogenous inhibitor of pathologic ocular neovascularization. ..
Wang Z, Liu C, Sun Y, Gong Y, Favazza T, Morss P, et al
. Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016;186:2588-600 pubmed publisher
..These findings suggest that pharmacologic activation of Wnt signaling may help treat ocular pathologies in FEVR and potentially other defective Wnt signaling-related diseases. ..
Chen J, Michan S, Juan A, Hurst C, Hatton C, Pei D, et al
. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013;16:985-92 pubmed publisher
Sun Y, Liu C, SanGiovanni J, Evans L, Tian K, Zhang B, et al
. Nuclear receptor RORÎ± regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015;112:10401-6 pubmed publisher
..Our data demonstrate that RORÎ± is a novel regulator of pathologic retinal neovascularization, and RORÎ± inhibition may represent a new way to treat ocular neovascularization. ..
Sun Y, Liu C, Wang Z, Meng S, Burnim S, SanGiovanni J, et al
. RORÎ± modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. FASEB J. 2017;31:4492-4502 pubmed publisher
..Sun, Y., Liu, C.-H., Wang, Z., Meng, S. S., Burnim, S. B., SanGiovanni, J. P., Kamenecka, T. M., Solt, L. A., Chen, J. RORÎ± modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. ..
Liu C, Wang Z, Sun Y, Chen J. Animal models of ocular angiogenesis: from development to pathologies. FASEB J. 2017;31:4665-4681 pubmed publisher
..Liu, C.-H., Wang, Z., Sun, Y., Chen, J. Animal models of ocular angiogenesis: from development to pathologies. ..