J Jean Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 30:1094-9. 2010
  2. doi request reprint MRI measurement of the BOLD-specific flow-volume relationship during hypercapnia and hypocapnia in humans
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 53:383-91. 2010
  3. pmc Age-associated reductions in cerebral blood flow are independent from regional atrophy
    J Jean Chen
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 55:468-78. 2011
  4. pmc Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease
    J Jean Chen
    A A Martinos Center for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, USA
    Neuroimage 59:1043-51. 2012
  5. pmc The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span
    J Jean Chen
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Canada
    PLoS ONE 8:e56733. 2013
  6. doi request reprint BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    NMR Biomed 22:1054-62. 2009

Detail Information

Publications6

  1. pmc Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 30:1094-9. 2010
    ....
  2. doi request reprint MRI measurement of the BOLD-specific flow-volume relationship during hypercapnia and hypocapnia in humans
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 53:383-91. 2010
    ..38, but comparable to previous observations during neuronal activation. These results confirm that the BOLD-specific flow-volume relationship during CO(2) challenges is similar to that characterizing neuronal activation...
  3. pmc Age-associated reductions in cerebral blood flow are independent from regional atrophy
    J Jean Chen
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 55:468-78. 2011
    ..These findings demonstrate the dissociation between regional CBF and structural alterations specific to normal aging, and augment our understanding of mechanisms of pathology in older adults...
  4. pmc Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease
    J Jean Chen
    A A Martinos Center for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, USA
    Neuroimage 59:1043-51. 2012
    ..The work described here may have broad-reaching implications for our understanding of HD pathogenesis, progression and emerging therapies...
  5. pmc The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span
    J Jean Chen
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Canada
    PLoS ONE 8:e56733. 2013
    ....
  6. doi request reprint BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans
    J Jean Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    NMR Biomed 22:1054-62. 2009
    ..38 in gradient-echo BOLD modeling results in an underestimation of DeltaCMRo(2)...