J Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 58:3307-11. 1998
  2. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
  3. ncbi request reprint Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice
    J Chen
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:2391-4. 2001
  4. pmc Osterix enhances BMSC-associated osseointegration of implants
    B Xu
    Division of Oral Biology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 88:1003-7. 2009
  5. pmc Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
    D Chen
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 99:2334-41. 1997
  6. ncbi request reprint L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice
    D E Handy
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Cell Mol Biol (Noisy-le-grand) 50:903-9. 2004
  7. ncbi request reprint Modeling age x major gene interaction by a variance component approach
    S S Shete
    Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 189, Houston, TX 77030, USA
    Genet Epidemiol 21:S849-53. 2001
  8. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
  9. pmc Phenotypic analysis of Dlx5 overexpression in post-natal bone
    J Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 87:45-50. 2008
  10. pmc Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration
    S Li
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Cell Physiol 215:204-9. 2008

Collaborators

Detail Information

Publications86

  1. ncbi request reprint A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 58:3307-11. 1998
    ..02). These prospective data, which need to be confirmed in other studies, suggest that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk...
  2. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  3. ncbi request reprint Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice
    J Chen
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:2391-4. 2001
    ..To test whether accelerated atherosclerosis and aortic aneurysms were due to hypertension, we administered hydralazine to male apoE/eNOS DKO mice to reduce blood pressure...
  4. pmc Osterix enhances BMSC-associated osseointegration of implants
    B Xu
    Division of Oral Biology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 88:1003-7. 2009
    ..We concluded that exogenous BMSCs participate in the osseointegration after implantation, and that Osx overexpression accelerates osseointegration...
  5. pmc Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
    D Chen
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 99:2334-41. 1997
    ..Thus, the inhibition of cdk2 function and repression of cyclin A gene transcription through the induction of the endogenous p27 protein provides a mechanism for the inhibition of VSMC growth at late time points after angioplasty...
  6. ncbi request reprint L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice
    D E Handy
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Cell Mol Biol (Noisy-le-grand) 50:903-9. 2004
    ..Our data suggest that L-arginine supplementation may contribute to vascular injury and atherogenesis under some circumstances by elevating homocysteine levels...
  7. ncbi request reprint Modeling age x major gene interaction by a variance component approach
    S S Shete
    Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 189, Houston, TX 77030, USA
    Genet Epidemiol 21:S849-53. 2001
    ..Consequently, trait variability is a function of age and also there is interaction of major gene effects with age. By using our model we were able to detect interaction between the major gene effects and age for this trait...
  8. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    ..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies...
  9. pmc Phenotypic analysis of Dlx5 overexpression in post-natal bone
    J Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 87:45-50. 2008
    ..Our results suggest that Dlx5 promotes expression of early markers of osteogenic differentiation and increases mineralization post-natally...
  10. pmc Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration
    S Li
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Cell Physiol 215:204-9. 2008
    ..In conclusion, BMSCs can migrate to bone wound sites and participate in bone regeneration in orocraniofacial region...
  11. ncbi request reprint A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 56:4862-4. 1996
    ..In contrast, when 5-methyltetrahydrofolate is depleted by alcohol consumption, val/val individuals may be less able to compensate, leading to potentially oncogenic alterations in DNA methylation...
  12. pmc Recoverin regulates light-dependent phosphodiesterase activity in retinal rods
    Clint L Makino
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Gen Physiol 123:729-41. 2004
    ..We infer that Ca2+-recoverin potentiates light-triggered phosphodiesterase activity, probably by effectively prolonging the catalytic activity of photoexcited rhodopsin...
  13. ncbi request reprint Independence of R/M/N focus formation and the presence of intact BRCA1
    X Wu
    The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 289:11. 2000
  14. ncbi request reprint Changes in HIV-1 incidence in heroin users in Guangxi Province, China
    S Lai
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 26:365-70. 2001
    ..The high incidence of HCV heightens the importance of enhanced prevention programs to reduce injection and needle sharing among heroin users...
  15. ncbi request reprint Recombinant adenovirus coexpressing covalent peptide/MHC class II complex and B7-1: in vitro and in vivo activation of myelin basic protein-specific T cells
    J Chen
    Division of Rheumatology and Immunology, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA
    J Immunol 167:1297-305. 2001
    ..This approach may be applicable to investigate the roles of other accessory molecules in the engagement of the TCR class II molecule by substituting B7-1 with other accessory molecules in the recombinant adenovirus...
  16. ncbi request reprint Differential activation of adipogenesis by multiple PPAR isoforms
    R P Brun
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:974-84. 1996
    ....
  17. pmc Enhanced osseointegration of titanium implant through the local delivery of transcription factor SATB2
    S G Yan
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA
    Biomaterials 32:8676-83. 2011
    ..These results conclude that in vivo overexpression of SATB2 significantly accelerates osseointegration of titanium implants and SATB2 can serve as a potent molecule in promoting tissue regeneration...
  18. ncbi request reprint Least squares estimation of variance components for linkage
    C I Amos
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genet Epidemiol 19:S1-7. 2000
    ..The LS method was computationally rapid, over 4,000 times faster than ML estimation for bivariate data. Because ML estimation is time consuming, LS methods are suggested for initial interval mapping with multivariate data...
  19. doi request reprint Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial
    C M Rebholz
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Eur J Clin Nutr 67:58-63. 2013
    ..The effect of soybean protein on novel CVD risk factors has not been well studied. The objective of this study was to examine the effect of soybean protein on biomarkers of inflammation, endothelial dysfunction and adipocytokines...
  20. ncbi request reprint Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    J Chen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nature 374:386-8. 1995
    ....
  21. pmc Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants
    Paige L Williams
    Department of Biostatistics, Harvard School of Public Health, 665 Huntington Ave, Building I, 415, Boston, MA 02115 6017, USA
    Pediatrics 125:e250-60. 2010
    ..Although ARV use has significantly reduced mother-to-child transmission to <2% in the United States, it remains crucial to monitor uninfected infants and children for adverse consequences of in utero ARV exposure...
  22. pmc An analysis of transvection at the yellow locus of Drosophila melanogaster
    J R Morris
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:633-51. 1999
    ....
  23. ncbi request reprint Adaptations of linkage and association methods for the study of asthma, a complex trait
    C H Bosken
    Department of Epidemiology, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, USA
    Genet Epidemiol 21:S89-96. 2001
    ..In addition, haplotype analysis may help to identify specific genetic effects...
  24. pmc Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments
    K Nakano
    Biomedical Engineering, Boston University, 36 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 98:4693-8. 2001
    ..By dissociating the Pd/14-3-3 complex, light enables both proteins to function in this role...
  25. pmc The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau
    L A Flanagan
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 73:1440-7. 1997
    ..In contrast, another PIP2 binding protein, profilin, does not modify the aggregates...
  26. ncbi request reprint Tissue- and bone cell-specific expression of bone sialoprotein is directed by a 9.0 kb promoter in transgenic mice
    J Paz
    Division of Oral Biology, Tufts University School of Dental Medicine, Boston, MA 02111, USA
    Matrix Biol 24:341-52. 2005
    ..These results indicate that regulatory elements within the 9.0 kb region of the promoter are required for strong, tissue- and differentiation-specific expression of BSP...
  27. ncbi request reprint Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice
    P J Kuhlencordt
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:3099-104. 2001
    ..To test whether NO produced by iNOS deficiency affects atherosclerosis, we studied apoE/iNOS-double knockout (dKO) and apoE-knockout (KO) control animals fed a "Western-type" diet...
  28. pmc Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Cancer 102:351-60. 2010
    ..However, the events that lead to increased Notch activity during EMT of breast cancer cells are unknown...
  29. ncbi request reprint A photic visual cycle of rhodopsin regeneration is dependent on Rgr
    P Chen
    Department of Ophthalmology, University of Southern California, Los Angeles, California 90033 USA
    Nat Genet 28:256-60. 2001
    ..Here we show that RGR is involved in the formation of 11-cis-retinal in mice and functions in a light-dependent pathway of the rod visual cycle. Mutations in the human gene encoding RGR are associated with retinitis pigmentosa...
  30. ncbi request reprint Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration
    A Roca
    Zilkha Neurogenetic Institute, The Mary D Allen Laboratory for Vision Research, Beckman Macular Research Center, University of Southern California Keck School of Medicine, 1501 San Pablo Street, Los Angeles, CA 90033, USA
    Neuroscience 129:779-90. 2004
    ..These expression changes may constitute the underlying initiating events leading to the two distinct mechanisms of light damage...
  31. ncbi request reprint Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus
    P Sieh
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 167:2121-9. 2001
    ..These findings provide strong evidence for distinct control of the frequency and allelic exclusion of Vbeta gene rearrangement...
  32. pmc Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors
    A Mendez
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089 9112, USA
    Proc Natl Acad Sci U S A 98:9948-53. 2001
    ..We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range...
  33. ncbi request reprint Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
    I M Ward
    Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 276:47755-8. 2001
    ..These results suggest that Chk2 is regulated at the sites of DNA strand breaks in response to ionizing radiation...
  34. pmc Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4
    R B Smeltz
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:143-53. 2001
    ..Thus, positive/negative regulation of the IL-18Ralpha by the major inductive cytokines (IL-12 and IL-4) determines the capacity of IL-18 to polarize an immune response...
  35. ncbi request reprint Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice
    L He
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Am J Physiol Cell Physiol 282:C27-33. 2002
    ..These findings are not in accord with the hypothesis that the phagocytic form of NADPH oxidase acts as a primary O(2) sensor in arterial chemoreception...
  36. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  37. ncbi request reprint MiniCog: a method for administering psychological tests and experiments on a handheld personal digital assistant
    J M Shephard
    Psychology Department, Harvard University, Cambridge, Massachusetts, USA
    Behav Res Methods 38:648-55. 2006
    ..MiniCog performs automatic calculations of mean response time and error rate, available to users with a password and stored with the other data for upload...
  38. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  39. ncbi request reprint Defective clearance of adenovirus in IRF-1 mice associated with defects in NK and T cells but not macrophages
    X Xu
    Department of Medicine, The University of Alabama at Birmingham, 701 S 19th Street, Birmingham, AL 35294 0007, USA
    Scand J Immunol 60:89-99. 2004
    ..These results indicate that delayed clearance of Ad is associated with partial correction of defects of the NK, NK-T and CD8 T cells and increased production of IFN-gamma and IL-18 in IRF-1(-/-) mice...
  40. ncbi request reprint Functional properties and oxidative modulation of A-type K currents in hippocampal granule cells of control and chronically epileptic rats
    C R├╝schenschmidt
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Neurosci 23:675-85. 2006
    ..This finding suggests that the availability of I(A) may be strongly regulated by changes in the GSH/GSSG ratio occurring during prolonged seizure activity or hypoxia...
  41. ncbi request reprint ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis
    J L Andersen
    Department of Pathology, Division of Cellular Biology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell Death Differ 12:326-34. 2005
    ..Our results support a model in which Vpr-induced apoptosis is mediated via ATR phosphorylation of BRCA1, and consequent upregulation of GADD45alpha...
  42. ncbi request reprint FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate
    R Zhao
    Division of Hematology Oncology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, 37232 6305
    Exp Cell Res 265:329-38. 2001
    ..Together with two homologous hypothetical proteins found in Caenorhabditis elegans and Drosophila, FYVE-DSP1 and FYVE-DSP2 form a subfamilyof phosphatases that may have an importantrole in cellular processes...
  43. ncbi request reprint Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2
    K Howes
    Moran Eye Center, University of Utah Health Science Center, Salt Lake City 84132, USA
    Invest Ophthalmol Vis Sci 39:867-75. 1998
    ..To identify gene arrangement, chromosomal localization, and expression pattern of mouse guanylate cyclase activating proteins GCAP1 and GCAP2, retina-specific Ca2+-binding proteins, and photoreceptor guanylate cyclase activators...
  44. ncbi request reprint Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate
    K F Tolias
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Biol Chem 273:18040-6. 1998
    ..The ability of PIP5Ks to produce multiple signaling molecules indicates that they may participate in a variety of cellular processes...
  45. ncbi request reprint T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta
    B Wang
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 162:88-94. 1999
    ..Moreover, CD3 proteins are dispensable for NK cell development...
  46. pmc Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase
    C K Chen
    Division of Biology, 147 75, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 96:3718-22. 1999
    ..Mice lacking RK provide a valuable model for the study of Oguchi disease, a human RK deficiency that causes congenital stationary night blindness...
  47. ncbi request reprint Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle 98195, USA
    Biochemistry 38:12012-9. 1999
    ..Thus, the absence of arrestin appeared to have a minor effect on the kinetics of the visual cycle...
  48. ncbi request reprint Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)
    J Chen
    Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, USA
    Invest Ophthalmol Vis Sci 40:2978-82. 1999
    ..To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice...
  49. ncbi request reprint Expression cloning of protein targets for 3-phosphorylated phosphoinositides
    V R Rao
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:37893-900. 1999
    ..This report demonstrates the utility of this technique for isolating and characterizing 3'-PPI-binding proteins and has broad applicability for the isolation of binding domains for other lipid products...
  50. ncbi request reprint Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis
    P Poussier
    Arthritis and Immune Disorder Research Centre, Toronto, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 118:880-91. 2000
    ..This led us to reassess intraintestinal T lymphopoiesis in these 3 mutant strains...
  51. ncbi request reprint Characterization of the rat DNA fragmentation factor 35/Inhibitor of caspase-activated DNase (Short form). The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis
    D Chen
    Departments of Neurology, Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Biol Chem 275:38508-17. 2000
    ..These results establish that DFF35/ICAD(S) is the endogenous inhibitor of DFF40/CAD and caspase-dependent apoptotic DNA fragmentation in neurons...
  52. pmc Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail
    X Liu
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, New South Wales 2010, Australia
    Proc Natl Acad Sci U S A 95:13024-9. 1998
    ....
  53. pmc T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
    A Ma
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 182:1567-72. 1995
    ..IL-2-/-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells...
  54. pmc N-cadherin mediates nitric oxide-induced neurogenesis in young and retired breeder neurospheres
    J Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 140:377-88. 2006
    ....
  55. ncbi request reprint Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl
    M R Mark
    Department of Molecular Biology, Genentech, San Francisco, California 94080, USA
    J Biol Chem 271:9785-9. 1996
    ..Furthermore, they provide a structural link between the activation of cell adhesion related receptors and the control of cell growth and differentiation by the G domain-containing superfamily of proteins...
  56. pmc Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis
    J Chen
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 95:2648-52. 1998
    ..Interactions between the Gs/adenylyl cyclase and MAPK-1,2 signaling pathways could be one mechanism by which expression of the transformed phenotype in mammary epithelial cells are regulated...
  57. ncbi request reprint Cloning a cDNA from human NK/T cells which codes for a protein with high proline content
    J Chen
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochim Biophys Acta 1264:19-22. 1995
    ..A polyclonal antiserum raised against recombinant B4-2 recognizes a 32-34 kDa protein in lymphocytes...
  58. pmc The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice
    J Chen
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Genes Brain Behav 6:776-83. 2007
    ..These findings show that amygdala ENT1 modulates anxiety-like behavior. The ENT1 may be a drug target for the treatment of anxiety disorders...
  59. ncbi request reprint Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke
    L H Shen
    Department of Neurology, Henry Ford Health Sciences Center, E and R 3056, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Neuroscience 137:393-9. 2006
    ....
  60. pmc Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice
    K E Govoni
    Musculoskeletal Disease Center, 151, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 79:112-7. 2006
    ..In conclusion, FHL2 is an important regulator of peak bone mass, lack of FHL2 produces gender- and site-specific effects on bone accretion and IGFBP-5 expression, and FHL2 is important for optimal osteoblast differentiation in vitro...
  61. ncbi request reprint Chimaeric protein improved immunogenicity compared with fusion protein of Ag85B and ESAT-6 antigens of Mycobacterium tuberculosis
    Y Xu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    Scand J Immunol 64:476-81. 2006
    ..These results suggest that the chimaeric protein Ag85B(N)-ESAT-6-Ag85B(C) is a strong candidate for further study and the T-cell epitopes of the antigens should be considered when we design the subunit vaccine...
  62. pmc Leaf permease1 gene of maize is required for chloroplast development
    N P Schultes
    Department of Biology, Yale University, New Haven, Connecticut 06511, USA
    Plant Cell 8:463-75. 1996
    ....
  63. ncbi request reprint IL-2 receptor alpha chain expression during early B lymphocyte differentiation
    J Chen
    Howard Hughes Medical Institute, Boston, MA
    Int Immunol 6:1265-8. 1994
    ..Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation...
  64. ncbi request reprint Prolonged photoresponses in transgenic mouse rods lacking arrestin
    J Xu
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nature 389:505-9. 1997
    ..The intensity dependence of the photoresponse in rods lacking arrestin further suggests that, although arrestin is required for normal signal termination, it does not participate directly in light adaptation...
  65. pmc Stat5 is a physiological substrate of the insulin receptor
    J Chen
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 94:2295-300. 1997
    ..Taken together, our data strongly suggest that IR interacts with and phosphorylates Stat5 in vitro and in tissues physiologically sensitive to insulin...
  66. ncbi request reprint An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  67. ncbi request reprint Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2
    J Chen
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
    J Biol Chem 269:2365-8. 1994
    ....
  68. pmc bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations
    J Chen
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 93:7042-7. 1996
    ..Apoptosis was induced in normal photoreceptors by very high levels of bcl-2. We conclude that bcl-2 is an important regulator of photoreceptor cell death in retinal degenerations...
  69. pmc Spatiotemporal integration of light by the cat X-cell center under photopic and scotopic conditions
    J B Troy
    Department of Biomedical Engineering and the Neuroscience Institute, Northwestern University, Evanston, IL 60208 3107, USA
    Vis Neurosci 22:493-500. 2005
    ..These results are discussed within the context of the known retinal circuitry that underlies the X-cell center for photopic and scotopic conditions...
  70. pmc Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT
    J Chen
    Laboratoire de Biochimie, URA 1970 CNRS, Ecole Polytechnique, Palaiseau, France
    J Bacteriol 180:2345-9. 1998
    ..Accordingly, disruption of the APH1 gene produced viable S. cerevisiae cells containing reduced Ap3A-hydrolyzing activity and a 30-fold-elevated Ap3N concentration...
  71. pmc Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
    J E Kim
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, B107, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 97:14340-5. 2000
    ..These findings uncover a function for the nucleus in the direct regulation of the protein synthesis machinery via extracellular signals...
  72. ncbi request reprint Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
    L V Ravichandran
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:3543-9. 2001
    ....
  73. ncbi request reprint Folding of malate dehydrogenase inside the GroEL-GroES cavity
    J Chen
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
    Nat Struct Biol 8:721-8. 2001
    ..Moreover, deprotection is broadly distributed throughout MDH, suggesting that it results from breaking hydrogen bonds between MDH and the cavity wall or global destabilization, as opposed to forced mechanical unfolding...
  74. ncbi request reprint Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel
    J Chen
    Department of Medicine, Division of Cardiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    J Biol Chem 275:36465-71. 2000
    ....
  75. ncbi request reprint Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
    H M Krumholz
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8025, USA
    J Am Coll Cardiol 38:453-9. 2001
    ..CONCLUSIONS: We demonstrate that a simple risk model can stratify older patients well by their risk of death one year after discharge for AMI...
  76. ncbi request reprint Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis
    S Brodsky
    Department of Medicine, State University of New York, Stony Brook, New York 11794 8152, USA
    Am J Physiol Heart Circ Physiol 281:H1784-92. 2001
    ....
  77. ncbi request reprint Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase
    D Jo
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21 Avenue South, AA4210, Nashville, TN 37232-2363, USA
    Nat Biotechnol 19:929-33. 2001
    ..This represents the first use of protein transduction to induce the enzymatic conversion of a substrate in living cells and animals and provides a rapid and efficient means to manipulate mammalian gene structure and function...
  78. pmc Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
    J Chen
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 98:13716-21. 2001
    ..Of six beta 4galactosyltransferases (beta 4GalT) in Chinese hamster ovary cells, only beta 4GalT-1 is required to add Gal to GlcNAc beta 3Fuc, identifying beta 4GalT-1 as a new modulator of Notch signaling...
  79. pmc Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes
    K Souza
    Department of Biology, Providence College, and Roger Williams Medical Center, Providence, RI, USA
    Mol Med 7:767-72. 2001
    ..CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes...
  80. ncbi request reprint [Treatment of spontaneous metastatic lung cancer with tumor antigen-pulsed, interleukin-18 gene-modified dendritic cells]
    J Chen
    Department of Respiratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Yi Xue Za Zhi 81:779-82. 2001
    ..CONCLUSION: Tumor antigen-pulsed, IL-18 gene-modified dendritic cells have a significant therapeutic effect on spontaneous netastatic lung cancer through induction of anti-tumor immunological responses...
  81. ncbi request reprint Bleeding complications associated with the use of rt-PA versus r-PA for peripheral arterial and venous thromboembolic occlusions
    T O McNamara
    UCLA Medical Center, 10833 Le Conte Avenue, CHS B-2115, Los Angeles, CA 90095-1721, USA
    Tech Vasc Interv Radiol 4:92-8. 2001
    ..It also appears that r-PA is less likely than rt-PA to be associated with significant bleeding during such infusions, especially if the patient is concomitantly anticoagulated...
  82. ncbi request reprint Hematopoietic stem cell functional failure in interleukin-2-deficient mice
    J Chen
    Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892 1652, USA
    J Hematother Stem Cell Res 11:905-12. 2002
    ..Thus, HSCs from Il2(-/-) mice can proliferate normally but are functionally defective for reconstituting lethally irradiated recipients...
  83. pmc Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction
    Y Okamoto
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210, USA
    Am J Pathol 159:639-50. 2001
    ..Taken together, our results indicate that expression of ATF3, a stress-inducible gene, in the heart leads to altered gene expression and impaired cardiac function...
  84. ncbi request reprint Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts
    J Chen
    Section of Biochemistry, Brown University, Providence, Rhode Island 02912
    J Biol Chem 269:7957-62. 1994
    ..The results show that PP2A is phosphorylated in intact cells, and the extent of this modification is increased by growth factors or cell transformation, providing evidence for a physiological mechanism of PP2A regulation...
  85. ncbi request reprint The role of D1 dopamine receptors and phospho-ERK in mediating cytotoxicity. Commentary
    J Chen
    Department of Pediatrics, Georgetown University, Washington D C 20007, USA
    Neurotox Res 7:179-81. 2005
    ..Here we comment on the role of extracellular signal-regulated kinase (ERK) activation in the cytotoxicity mediated upon activation of the D1 DA receptor, and describe a possible mechanism for phospho-ERK (p-ERK) in inducing cytotoxicity...
  86. ncbi request reprint Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism
    N Cheng
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 276:13771-7. 2001
    ..Taken together, the results of our study demonstrated that induction of ephrin A1 in endothelial cells by TNF-alpha is mediated through both p38 MAPK and SAPK/JNK, but not p42/44 MAPK or NF-kappaB, pathways...