Honglei Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Diet and Parkinson's disease: a potential role of dairy products in men
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Neurol 52:793-801. 2002
  2. ncbi request reprint Physical activity and the risk of Parkinson disease
    H Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Neurology 64:664-9. 2005
  3. ncbi request reprint Folate intake and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 160:368-75. 2004
  4. ncbi request reprint Obesity and the risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 159:547-55. 2004
  5. ncbi request reprint Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Arch Neurol 60:1059-64. 2003
  6. ncbi request reprint Height and the survival of prostate cancer patients
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:215-8. 2003
  7. ncbi request reprint Weight loss in Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 53:676-9. 2003
  8. ncbi request reprint Dietary intakes of fat and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 157:1007-14. 2003
  9. pmc Plasma urate and Parkinson's disease in women
    Eilis J O'Reilly
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 172:666-70. 2010
  10. ncbi request reprint Diet and risk of adult glioma in eastern Nebraska, United States
    Honglei Chen
    Tufts University, Human Nutrition Research Center on Aging, Boston, MA, USA
    Cancer Causes Control 13:647-55. 2002

Research Grants

Detail Information

Publications46

  1. ncbi request reprint Diet and Parkinson's disease: a potential role of dairy products in men
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Neurol 52:793-801. 2002
    ..Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified...
  2. ncbi request reprint Physical activity and the risk of Parkinson disease
    H Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Neurology 64:664-9. 2005
    ..To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD)...
  3. ncbi request reprint Folate intake and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 160:368-75. 2004
    ..Intake of vitamin B(6) or vitamin B(12) also was not related to the risk of Parkinson's disease. The current study does not support the hypothesis that higher intake of folate or related B vitamins lowers the risk of Parkinson's disease...
  4. ncbi request reprint Obesity and the risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 159:547-55. 2004
    ..03) for waist-to-hip ratio. The results do not support a role of overall obesity in PD pathogenesis; however, central obesity may be associated with higher PD risk among never smokers, and this finding merits further investigation...
  5. ncbi request reprint Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Arch Neurol 60:1059-64. 2003
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce dopaminergic neuron degeneration in animal models of Parkinson disease (PD). However, no epidemiological data have been available on NSAID use and the risk of PD...
  6. ncbi request reprint Height and the survival of prostate cancer patients
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:215-8. 2003
    ..Our results suggest that greater height may be associated with better survival of prostate cancer patients...
  7. ncbi request reprint Weight loss in Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 53:676-9. 2003
    ..002). In conclusion, weight loss in PD patients appears to be a continuous process that starts several years before the diagnosis and is not caused by reduced energy intake...
  8. ncbi request reprint Dietary intakes of fat and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 157:1007-14. 2003
    ..65, 95% CI: 0.46, 0.91; p for trend = 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinson's disease, but a possible adverse effect of saturated fat for men could not be excluded...
  9. pmc Plasma urate and Parkinson's disease in women
    Eilis J O'Reilly
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 172:666-70. 2010
    ..Unlike in men, these findings do not support the hypothesis that urate is strongly associated with lower rates of Parkinson's disease among women...
  10. ncbi request reprint Diet and risk of adult glioma in eastern Nebraska, United States
    Honglei Chen
    Tufts University, Human Nutrition Research Center on Aging, Boston, MA, USA
    Cancer Causes Control 13:647-55. 2002
    ..To investigate potential associations between diet and adult glioma...
  11. ncbi request reprint Nutrient intakes and adenocarcinoma of the esophagus and distal stomach
    Honglei Chen
    Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Cancer 42:33-40. 2002
    ....
  12. pmc Recreational physical activity and risk of Parkinson's disease
    Evan L Thacker
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 23:69-74. 2008
    ..Our results may be explained either by a reduction in PD risk through moderate to vigorous activity, or by decreased baseline recreational activity due to preclinical PD...
  13. pmc Reproductive factors, exogenous estrogen use, and risk of Parkinson's disease
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 24:1359-65. 2009
    ..The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations...
  14. pmc Calcium channel blocker use and risk of Parkinson's disease
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 25:1818-22. 2010
    ..18, 95% CI: 0.73-1.92), frequency of use or duration of use of CCBs and PD risk was observed (P > 0.2 for all). These findings do not support a role for CCBs in providing neuroprotection against development of PD...
  15. pmc Prenatal and early life factors and risk of Parkinson's disease
    Hannah Gardener
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 25:1560-7. 2010
    ..Left-handedness was associated with a 62% increased risk of PD in women but not in men. Further investigation of the relation between prenatal, perinatal, or neonatal factors and PD in other study populations is suggested...
  16. ncbi request reprint Alcohol consumption and the incidence of Parkinson's disease
    Miguel A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Ann Neurol 54:170-5. 2003
    ..7 (0.5-0.9) for one to three drinks of beer per month, and 0.7 (0.5, 0.9) for one or more drinks of beer per week. The risk of PD was similar in individuals who usually consume moderate amounts of alcohol and in abstainers...
  17. pmc Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality
    Eilis J O'Reilly
    Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 169:678-82. 2009
    ..If the inverse association between smoking and Parkinson's disease were due to confounding by an environmental factor or were the result of reverse causation, it is unlikely that parental smoking would predict Parkinson's disease...
  18. pmc Prospective study of dietary pattern and risk of Parkinson disease
    Xiang Gao
    Department of Nutrition, Harvard School of Public Health, Cambridge, MA 02115, USA
    Am J Clin Nutr 86:1486-94. 2007
    ..Several studies have shown associations between Parkinson Disease (PD) risk and individual foods and nutrients with inconsistent results...
  19. pmc Erectile function and risk of Parkinson's disease
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 166:1446-50. 2007
    ..In conclusion, in this retrospective analysis in a large cohort of men, the authors observed that erectile dysfunction was associated with a higher risk of developing Parkinson's disease...
  20. ncbi request reprint Caffeinated clues from epidemiology of Parkinson's disease
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 61:S51-4. 2003
  21. pmc Use of ibuprofen and risk of Parkinson disease
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Neurology 76:863-9. 2011
    ..Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies...
  22. pmc Diet, urate, and Parkinson's disease risk in men
    Xiang Gao
    Department of Nutrition, School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Epidemiol 167:831-8. 2008
    ..These potential benefits, however, should be weighed against expected adverse effects on risk of gout and other chronic diseases...
  23. ncbi request reprint Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:245-52. 2002
    ..Several nutrients are known to affect bone mineral density (BMD). However, these nutrients occur together in foods and dietary patterns, and the overall effects of dietary choices are not well understood...
  24. ncbi request reprint Pesticide exposure and risk for Parkinson's disease
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Ann Neurol 60:197-203. 2006
    ..Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive...
  25. pmc Perceived imbalance and risk of Parkinson's disease
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 23:613-6. 2008
    ..This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized...
  26. pmc Telomere length and risk of Parkinson's disease
    Hao Wang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 23:302-5. 2008
    ..the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD...
  27. pmc A prospective study of bowel movement frequency and risk of Parkinson's disease
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 174:546-51. 2011
    ..In conclusion, infrequent bowel movements may antedate the onset of cardinal motor symptoms of Parkinson's disease and may contribute to the identification of populations with higher than average Parkinson's disease risk...
  28. ncbi request reprint Prospective study of phobic anxiety and risk of Parkinson's disease
    Marc G Weisskopf
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 18:646-51. 2003
    ..Our results suggest that anxiety is a risk factor for PD. Whether this association is causal or the result of shared underlying biology remains a question...
  29. ncbi request reprint Blood donations, iron stores, and risk of Parkinson's disease
    Giancarlo Logroscino
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 21:835-8. 2006
    ..6). Unexpectedly, the risk of PD was higher among men who reported recent multiple blood donations (P for trend = 0.05). The results of this study do not support the hypothesis that reduced systemic iron stores lower the risk of PD...
  30. pmc Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 34:108-14. 2011
    ..Understanding the relationship between multivitamin use and diabetes risk is important given the wide use of multivitamin supplements among U.S. adults...
  31. pmc Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease
    Kelly Claire Simon
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 69:1688-95. 2007
    ..To determine whether history of hypertension, hypercholesterolemia, or diabetes is associated with risk of Parkinson disease (PD)...
  32. pmc No association between Parkinson disease alleles and the risk of melanoma
    Shasha Meng
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 21:243-5. 2012
    ..It has been hypothesized that these two diseases may share common genetic and environmental risk factors...
  33. ncbi request reprint Waist circumference and weight change are associated with disability among elderly Hispanics
    Honglei Chen
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 57:M19-25. 2002
    ..Therefore, we examined these relationships in a mostly Puerto Rican group of Hispanic elders...
  34. ncbi request reprint Dietary patterns and adenocarcinoma of the esophagus and distal stomach
    Honglei Chen
    Human Nutrition Research Center on Aging, Tufts University, Boston, USA
    Am J Clin Nutr 75:137-44. 2002
    ..Dietary pattern analysis is a unique approach to studying relations between diet and disease...
  35. ncbi request reprint Circulating melatonin levels: possible link between Parkinson's disease and cancer risk?
    Eva Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 17:577-82. 2006
    ..We therefore hypothesize that elevated circulating melatonin levels in PD patients may contribute to their lower cancer rates...
  36. ncbi request reprint The tau gene haplotype h1 confers a susceptibility to Parkinson's disease
    Jun Zhang
    Department of Neurology, The Third Hospital of Beijing University, Beijing, China
    Eur Neurol 53:15-21. 2005
    ....
  37. ncbi request reprint Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Ann Neurol 58:963-7. 2005
    ..03). No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk. The results suggest that ibuprofen use may delay or prevent the onset of PD...
  38. ncbi request reprint A prospective study of night shift work, sleep duration, and risk of Parkinson's disease
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 163:726-30. 2006
    ..Conversely, habitual longer sleep duration may be an earlier marker of Parkinson's disease. Because of the novelty and the exploratory nature of these findings, confirmation is needed...
  39. pmc Obesity and functional disability in elderly Americans
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Am Geriatr Soc 56:689-94. 2008
    ..To investigate whether indicators of obesity are associated with functional disabilities in elderly American women and men...
  40. ncbi request reprint Survival of Parkinson's disease patients in a large prospective cohort of male health professionals
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mov Disord 21:1002-7. 2006
    ..However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals...
  41. pmc Consumption of dairy products and risk of Parkinson's disease
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Epidemiol 165:998-1006. 2007
    ..8, 2.1). These data suggest that dairy consumption may increase the risk of Parkinson's disease, particularly in men. More studies are needed to further examine these findings and to explore underlying mechanisms...
  42. pmc Head injury and amyotrophic lateral sclerosis
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 166:810-6. 2007
    ..7, 95 percent CI: 1.3, 2.2). In this study population, physical injuries to other body parts, including the trunk, arms, or legs, were not related to ALS risk. These data support the notion that head injury may increase the risk of ALS...
  43. ncbi request reprint Incidence and trends of stroke and its subtypes in China: results from three large cities
    Bin Jiang
    Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing 100050, P R China
    Stroke 37:63-8. 2006
    ..To examine the incidence and trends of stroke and its major subtypes during the 1990s in 3 cities in China...
  44. pmc Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease
    Xuemei Huang
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Mov Disord 22:377-81. 2007
    ..Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation...
  45. ncbi request reprint Diurnal temperature range and daily mortality in Shanghai, China
    Haidong Kan
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    Environ Res 103:424-31. 2007
    ..This study suggests within-day variation in temperature may be a novel risk factor for death...
  46. ncbi request reprint Peripheral inflammatory biomarkers and risk of Parkinson's disease
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Epidemiol 167:90-5. 2008
    ..However, this finding should be interpreted with caution because of the small sample size and the lack of associations with other biomarkers of inflammation...

Research Grants1

  1. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    The candidate, Honglei Chen, M.D., Ph.D., has more than two years research experience in Parkinson's disease (PD) and is currently a Research Associate at Harvard School of Public Health. Dr...