N Chattopadhyay

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Expression of extracellular calcium-sensing receptor by human lens epithelial cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 233:801-5. 1997
  2. ncbi Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87)
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Glia 26:64-72. 1999
  3. ncbi Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Glia 24:449-58. 1998
  4. ncbi Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
  5. ncbi Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy
    J L Sanders
    Endocrine Hypertension Division, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 269:427-32. 2000
  6. ncbi Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, MA 02115, Boston, USA
    Brain Res Mol Brain Res 87:100-8. 2001
  7. ncbi Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells
    J L Sanders
    Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 281:E1267-74. 2001
  8. ncbi Expression of extracellular calcium (Ca2 + o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 243:753-7. 1998
  9. ncbi Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
    T Yamaguchi
    Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 280:C382-93. 2001
  10. ncbi Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Brain Res 851:116-24. 1999

Collaborators

Detail Information

Publications28

  1. ncbi Expression of extracellular calcium-sensing receptor by human lens epithelial cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 233:801-5. 1997
    ..Therefore, our data suggest that human lens-epithelial cells express the CaR, which may be functionally linked to Ca(2+)-activated K+ channels and, perhaps, to other ion channels involved in ionic homeostasis in the lens...
  2. ncbi Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87)
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Glia 26:64-72. 1999
    ..Thus U87 astrocytoma cells express both CaR mRNA and protein, and the receptor activates an outward K+ channel previously suggested to be involved in membrane polarization and cellular excitability...
  3. ncbi Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Glia 24:449-58. 1998
    ....
  4. ncbi Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
    ..These effects are likely direct without the involvement of PTHrP in an autocrine mode...
  5. ncbi Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy
    J L Sanders
    Endocrine Hypertension Division, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 269:427-32. 2000
    ..Thus in HHM caused by H-500 cells, the CaR could participate in a vicious cycle whereby PTHrP-induced increases in Ca(2+)(o) further stimulate PTHrP release and exacerbate hypercalcemia...
  6. ncbi Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, MA 02115, Boston, USA
    Brain Res Mol Brain Res 87:100-8. 2001
    ....
  7. ncbi Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells
    J L Sanders
    Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 281:E1267-74. 2001
    ....
  8. ncbi Expression of extracellular calcium (Ca2 + o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 243:753-7. 1998
    ..Therefore, taken together, our data strongly suggest that the osteoblast-like cell lines, UMR-106 and SAOS-2, possess both CaR protein and mRNA very similar if not identical to those in parathyroid and kidney...
  9. ncbi Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
    T Yamaguchi
    Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 280:C382-93. 2001
    ..5 microM), but not its less active stereoisomer NPS S-467 (0.5 microM), activate an outward K+ channel in MG-63 cells, strongly suggesting that the CaR in MG-63 cells is not only expressed but is functionally active...
  10. ncbi Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Brain Res 851:116-24. 1999
    ..Thus our study strongly suggests that elevated levels of Ca2+o, acting via the CaR, activate an NCC that could contribute to the associated CaR-induced stimulation of proliferation...
  11. ncbi Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines
    J L Sanders
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 141:4357-64. 2000
    ....
  12. ncbi Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 279:C691-9. 2000
    ..5-fold higher in HPA than in the glial tumors studied here. Therefore, our results show that HPA, astrocytomas, and meningiomas express both the CaR and PTHrP and that CaR agonists stimulate PTHrP secretion...
  13. ncbi Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions
    N Chattopadhyay
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Signal 12:361-6. 2000
    ....
  14. ncbi Calcium-sensing receptor in the rat hippocampus: a developmental study
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Brain Res Dev Brain Res 100:13-21. 1997
    ..Further studies are needed to determine the role of the CaR in the development of important aspects of the function of hippocampus and other regions of brain, including LTP...
  15. ncbi Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
    J Tfelt-Hansen
    Endocrine Hypertension Division, Dept of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E329-37. 2003
    ..We conclude that CaR regulation of PTHrP release in H-500 cells involves activation of PKC as well as the ERK1/2, p38 MAPK, and JNK pathways...
  16. ncbi The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis
    R Mentaverri
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 20:2562-4. 2006
    ....
  17. ncbi Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa
    R R Cima
    Department of Surgery, West Roxbury Veterans Affairs Medical Center, Massachusetts, USA
    Am J Physiol 273:G1051-60. 1997
    ..Inhibition of prostaglandin synthesis using indomethacin significantly attenuated these effects. We conclude that the CaR is present and functioning in Necturus gastric antrum...
  18. ncbi Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 139:3561-8. 1998
    ....
  19. ncbi Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells
    M G House
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bone Miner Res 12:1959-70. 1997
    ....
  20. ncbi Biochemistry, physiology and pathophysiology of the extracellular calcium-sensing receptor
    N Chattopadhyay
    Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:789-804. 2000
    ....
  21. ncbi Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Mol Brain Res 92:172-6. 2001
    ....
  22. ncbi Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase
    G Hjälm
    Calcium Section, Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:34880-7. 2001
    ..Therefore, the binding of the CaR's COOH-terminal tail to filamin-A may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CaR-mediated activation of MAPK...
  23. ncbi Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism
    R John Macleod
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 320:455-60. 2004
    ..Proximal and distal signal transduction cascades activated by the CaR may reflect transactivation of the EGFR by the extracellular calcium-sensing receptor...
  24. ncbi Calcium-sensing receptors in bone cells
    E M Brown
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA
    J Musculoskelet Neuronal Interact 4:412-3. 2004
  25. ncbi Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis
    N Chattopadhyay
    Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 61:67-74. 2000
    ..These data show that modulation of the process of apoptosis is one function of PPARgamma in cells derived from the human astrocytic lineage...
  26. ncbi Role of calcium-sensing receptor in bone biology
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Indian J Med Res 127:274-86. 2008
    ..CaR mediates a variety of functions of Ca2+ o in the bone microenvironment under both normal and pathological conditions...
  27. ncbi Role of alphavbeta3 integrin receptors in breast tumor
    S Sengupta
    Dept. of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, Calcutta, India
    J Exp Clin Cancer Res 20:585-90. 2001
    ..Alphavbeta3 integrin receptors can modulate the activity of collagenase enzyme and thereby the invasive property of breast tumor cells...
  28. ncbi Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity
    N Chattopadhyay
    Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, Calcutta, India
    J Cancer Res Clin Oncol 127:653-8. 2001
    ..CONCLUSIONS: SiHa cells express all the molecules which are reported to form a complex to activate pro-MMP-2. Active MMP-2 associated with alphavbeta3 may regulate matrix degradation and thereby modulate directed motility of SiHa cells...