Daniel I Chasman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  2. doi request reprint Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Genet 5:257-64. 2012
  3. pmc Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase
    Brian Td Tobe
    Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
    Cell Div 4:12. 2009
  4. pmc Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
  5. pmc Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, United States
    Atherosclerosis 203:371-6. 2009
  6. doi request reprint On the utility of gene set methods in genomewide association studies of quantitative traits
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Genet Epidemiol 32:658-68. 2008
  7. doi request reprint Population-based genomewide genetic analysis of common clinical chemistry analytes
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 55:39-51. 2009
  8. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
  9. ncbi request reprint Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein
    D I Chasman
    Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Genes Immun 7:211-9. 2006
  10. ncbi request reprint Pharmacogenetics: the outlook for genetic testing in statin therapy
    Daniel I Chasman
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Nat Clin Pract Cardiovasc Med 2:2-3. 2005

Detail Information

Publications67

  1. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  2. doi request reprint Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Genet 5:257-64. 2012
    ..However, interindividual variation in low-density lipoprotein cholesterol (LDL-C) response to statins is wide and may partially be determined on a genetic basis...
  3. pmc Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase
    Brian Td Tobe
    Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
    Cell Div 4:12. 2009
    ..When facing nutrient-limited conditions, Ras2-mediated PKA and MAPK signaling cascades induce a switch from round to filamentous morphology resulting in delayed mitotic progression...
  4. pmc Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
    ....
  5. pmc Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, United States
    Atherosclerosis 203:371-6. 2009
    ..We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers...
  6. doi request reprint On the utility of gene set methods in genomewide association studies of quantitative traits
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Genet Epidemiol 32:658-68. 2008
    ..While extremely strong associations remain best identified by conventional methods, the gene set approach may provide a complementary mode of analysis for revealing the full spectrum of genes that influence a quantitative trait...
  7. doi request reprint Population-based genomewide genetic analysis of common clinical chemistry analytes
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 55:39-51. 2009
    ..These early studies have also led to development of a set of principles for conducting a successful genomewide association study (GWAS)...
  8. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  9. ncbi request reprint Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein
    D I Chasman
    Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Genes Immun 7:211-9. 2006
    ..Quantitative analysis suggested that the effect on CRP is more likely a consequence of intrinsic functional differences among the E2, E3, and E4 apoE proteins than different levels of apoE protein or LDL-C in the plasma...
  10. ncbi request reprint Pharmacogenetics: the outlook for genetic testing in statin therapy
    Daniel I Chasman
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Nat Clin Pract Cardiovasc Med 2:2-3. 2005
  11. doi request reprint Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circ Cardiovasc Genet 5:676-85. 2012
    ..Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and no prior data are available addressing genetic determinants of statin-induced changes for this proinflammatory biomarker...
  12. doi request reprint Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy
    Jacqueline S Danik
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am Heart J 165:1008-14. 2013
    ..Whether rosuvastatin has a similar effect is uncertain. This study assesses whether SLCO1B1 polymorphisms relate to clinical myalgia after rosuvastatin therapy...
  13. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ....
  14. pmc Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001374. 2011
    ..These associations provide insights into the genetic regulation of sICAM-1 levels and implicate these loci in the regulation of endothelial function...
  15. pmc Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study
    Jacqueline S Danik
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, and Translational Medicine Division, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:134-41. 2009
    ..Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available...
  16. pmc Novel genetic markers improve measures of atrial fibrillation risk prediction
    Brendan M Everett
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur Heart J 34:2243-51. 2013
    ..Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown...
  17. pmc Novel locus including FGF21 is associated with dietary macronutrient intake
    Audrey Y Chu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 22:1895-902. 2013
    ..9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake...
  18. pmc Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Genet 2:26-33. 2009
    ..One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction...
  19. pmc Association between a literature-based genetic risk score and cardiovascular events in women
    Nina P Paynter
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    JAMA 303:631-7. 2010
    ..While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women...
  20. pmc Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese
    Steven A Lubitz
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 63:1200-10. 2014
    ..This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk...
  21. pmc Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
    ....
  22. doi request reprint Pharmacogenetic determinants of statin-induced reductions in C-reactive protein
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Genet 5:58-65. 2012
    ..However, whether different mechanisms underlie statin-induced CRP and LDL-C reduction is unknown...
  23. pmc Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis
    Markus Schürks
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, 3rd f, Boston, MA 02215 1204, USA
    Cephalalgia 31:1381-404. 2011
    ..Data on the association between TNFα and TNFβ gene polymorphisms and migraine are conflicting...
  24. ncbi request reprint Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    Clin Chem 54:249-55. 2008
    ..Thus, with continued follow-up of the WHS, the WGHS provides a unique scientific resource-a full-cohort, prospective, genome-wide association study among initially healthy American women...
  25. pmc Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 412:785-7. 2011
    ..Islet amyloid polypeptide (IAPP) gene variation has recently been implicated in type 2 diabetes mellitus (T2D). However, to date, no prospective epidemiological data are available...
  26. pmc Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry
    Tariq Ahmad
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 4:74-80. 2011
    ..Whether these associations are modified by physical activity, which increases HDL-C levels and reduces the risk of cardiovascular disease, is uncertain...
  27. pmc Genetic variants of 11 telomere-pathway gene loci and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 218:144-6. 2011
    ..Whether this observation was modulated by genetic variation within the telomere-pathway genes remains elusive. To date, no prospective epidemiological data on the relationship of telomere-pathway gene variation with T2D are available...
  28. pmc Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 214:107-9. 2011
    ..Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available...
  29. ncbi request reprint Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medial School, 900 CommonwealthAvenue East, Boston, MA 02215, USA
    Atherosclerosis 197:694-9. 2008
    ..The present investigation provides evidence for an association of the P2RY12 haplotype H2 with lower risk of DVT/PE; however these findings require replication in other well-designed studies...
  30. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits...
  31. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  32. pmc Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3
    Nina P Paynter
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 150:65-72. 2009
    ..Although genetic variation at chromosome 9p21.3 is associated with incident cardiovascular disease, it is unclear whether screening for this polymorphism improves risk prediction...
  33. pmc Sugar-sweetened beverages and genetic risk of obesity
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 367:1387-96. 2012
    ..Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown...
  34. ncbi request reprint Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarction
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, The LeDucq Center for Cardiovascular Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 181:137-41. 2005
    ..In conclusion, we found no evidence for an association between the common polymorphisms or haplotypes of the tryptophanyl-tRNA synthetase gene tested and risk of myocardial infarction...
  35. pmc Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000118. 2008
    ..2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes...
  36. pmc Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention and the Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:142-50. 2009
    ..Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown...
  37. pmc Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
    ..This observed genetic association between glycated hemoglobin levels and HK1 polymorphisms paves the way for further studies of the role of HK1 in hemoglobin glycation, glucose metabolism, and diabetes...
  38. pmc Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 19:2706-15. 2010
    ..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
  39. ncbi request reprint Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels
    Piotr Kozlowski
    Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Hum Genet 70:574-86. 2006
    ....
  40. pmc Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    BMJ 348:g1610. 2014
    ..To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity...
  41. pmc Prospective evaluation of B-type natriuretic peptide concentrations and the risk of type 2 diabetes in women
    Brendan M Everett
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 59:557-65. 2013
    ....
  42. doi request reprint Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 4:312-7. 2011
    ..Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed...
  43. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2...
  44. pmc Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study
    Markus Schürks
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22106. 2011
    ..Migraine is associated with an increased risk for cardiovascular disease (CVD). Both migraine and CVD are highly heritable. However, the genetic liability for CVD among migraineurs is unclear...
  45. ncbi request reprint Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies
    Debra A Schaumberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts2The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts3Department
    JAMA Ophthalmol 132:84-95. 2014
    ....
  46. pmc Selectivity in genetic association with sub-classified migraine in women
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004366. 2014
    ....
  47. pmc Genetic variation of fifteen folate metabolic pathway associated gene loci and the risk of incident head and neck carcinoma: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02215, USA
    Clin Chim Acta 418:33-6. 2013
    ..Whether the genetic variation within the FMP associated genes modulates HNC remains elusive. To date, prospective, epidemiological data on the relationship of FMP gene variation with the risk of HNC are sparse...
  48. pmc Physical activity, genes for physical fitness, and risk of coronary heart disease
    Andrea K Chomistek
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Med Sci Sports Exerc 45:691-7. 2013
    ..Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD...
  49. pmc Informed conditioning on clinical covariates increases power in case-control association studies
    Noah Zaitlen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003032. 2012
    ..This suggests that applying our method to existing and future association studies of these diseases may identify novel disease loci...
  50. pmc Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chim Acta 412:199-202. 2011
    ..Candidate genes associated with telomere length maintenance, an important molecular marker for biological aging, represent potential risk predictors for cardiovascular disease (CVD). To date, no prospective data are available...
  51. ncbi request reprint Pharmacogenetic study of statin therapy and cholesterol reduction
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 291:2821-7. 2004
    ..Polymorphisms in genes involved in cholesterol synthesis, absorption, and transport may affect statin efficacy...
  52. pmc Genome-wide association study of relative telomere length
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19635. 2011
    ..10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed...
  53. pmc Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine Leiomyomata
    Stacey L Eggert
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 91:621-8. 2012
    ..FASN represents the initial UL risk allele identified in white women by a genome-wide, unbiased approach and opens a path to management and potential therapeutic intervention...
  54. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  55. pmc Functional classification of proteins and protein variants
    Albert Y Lau
    Variagenics, Incorporated, 60 Hampshire Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:6576-81. 2004
    ....
  56. pmc Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hum Mol Genet 21:5329-43. 2012
    ..The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general...
  57. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
    ....
  58. pmc Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Hypertens 29:62-9. 2011
    ....
  59. ncbi request reprint Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA P R, D I C, L R Divisions of Preventive Medicine and Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA P R, D I C, J L
    J Am Heart Assoc 3:e000897. 2014
    ....
  60. pmc Genome-wide meta-analysis identifies new susceptibility loci for migraine
    Verneri Anttila
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Genet 45:912-7. 2013
    ..Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B...
  61. pmc Genome-wide association study reveals three susceptibility loci for common migraine in the general population
    Daniel I Chasman
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 43:695-8. 2011
    ..TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology...
  62. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  63. pmc Common variants associated with plasma triglycerides and risk for coronary artery disease
    Ron Do
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 4 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 45:1345-52. 2013
    ..These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. ..
  64. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  65. pmc Tracing sub-structure in the European American population with PCA-informative markers
    Peristera Paschou
    Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
    PLoS Genet 4:e1000114. 2008
    ..Furthermore, our redundancy removal algorithm can be applied on sets of ancestry informative markers selected with any method in order to select the most uncorrelated SNPs, and significantly decreases genotyping costs...
  66. doi request reprint A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
  67. ncbi request reprint Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations
    R Scott Williams
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 278:53007-16. 2003
    ....