Research Topics
Genomes and Genes
Species | Daniel I ChasmanSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trialDaniel I Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circ Cardiovasc Genet 5:257-64. 2012..However, interindividual variation in low-density lipoprotein cholesterol (LDL-C) response to statins is wide and may partially be determined on a genetic basis...
Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinaseBrian Td Tobe
Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
Cell Div 4:12. 2009..When facing nutrient-limited conditions, Ras2-mediated PKA and MAPK signaling cascades induce a switch from round to filamentous morphology resulting in delayed mitotic progression...- On the utility of gene set methods in genomewide association studies of quantitative traitsDaniel I Chasman
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Genet Epidemiol 32:658-68. 2008..While extremely strong associations remain best identified by conventional methods, the gene set approach may provide a complementary mode of analysis for revealing the full spectrum of genes that influence a quantitative trait... - Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysisDaniel I Chasman
Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000730. 2009.... - Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicationDaniel I Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circ Cardiovasc Genet 1:21-30. 2008.... - Population-based genomewide genetic analysis of common clinical chemistry analytesDaniel I Chasman
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Clin Chem 55:39-51. 2009..These early studies have also led to development of a set of principles for conducting a successful genomewide association study (GWAS)... - Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapyDaniel I Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, United States
Atherosclerosis 203:371-6. 2009..We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers... 
Pharmacogenetics: the outlook for genetic testing in statin therapyDaniel I Chasman
Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA
Nat Clin Pract Cardiovasc Med 2:2-3. 2005- Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE proteinD I Chasman
Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
Genes Immun 7:211-9. 2006..Quantitative analysis suggested that the effect on CRP is more likely a consequence of intrinsic functional differences among the E2, E3, and E4 apoE proteins than different levels of apoE protein or LDL-C in the plasma... - Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health StudyPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 82:1185-92. 2008.... - Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health StudyJacqueline S Danik
Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, and Translational Medicine Division, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
Circ Cardiovasc Genet 2:134-41. 2009..Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available... - Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 lociGuillaume Pare
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 7:e1001374. 2011..These associations provide insights into the genetic regulation of sICAM-1 levels and implicate these loci in the regulation of endothelial function... - Association between a literature-based genetic risk score and cardiovascular events in womenNina P Paynter
Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
JAMA 303:631-7. 2010..While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women... - Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health StudyPaul M Ridker
Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circ Cardiovasc Genet 2:26-33. 2009..One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction... - Common variants in cardiac ion channel genes are associated with sudden cardiac deathChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
Circ Arrhythm Electrophysiol 3:222-9. 2010.... - Pharmacogenetic determinants of statin-induced reductions in C-reactive proteinAudrey Y Chu
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circ Cardiovasc Genet 5:58-65. 2012..However, whether different mechanisms underlie statin-induced CRP and LDL-C reduction is unknown... - Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysisMarkus Schürks
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, 3rd f, Boston, MA 02215 1204, USA
Cephalalgia 31:1381-404. 2011..Data on the association between TNFα and TNFβ gene polymorphisms and migraine are conflicting... - Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health StudyRobert Y L Zee
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Clin Chim Acta 412:785-7. 2011..Islet amyloid polypeptide (IAPP) gene variation has recently been implicated in type 2 diabetes mellitus (T2D). However, to date, no prospective epidemiological data are available... - Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestryTariq Ahmad
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circ Cardiovasc Genet 4:74-80. 2011..Whether these associations are modified by physical activity, which increases HDL-C levels and reduces the risk of cardiovascular disease, is uncertain... - Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american womenPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
Clin Chem 54:249-55. 2008..Thus, with continued follow-up of the WHS, the WGHS provides a unique scientific resource-a full-cohort, prospective, genome-wide association study among initially healthy American women... - Genetic variants of 11 telomere-pathway gene loci and the risk of incident type 2 diabetes mellitus: the Women's Genome Health StudyRobert Y L Zee
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Atherosclerosis 218:144-6. 2011..Whether this observation was modulated by genetic variation within the telomere-pathway genes remains elusive. To date, no prospective epidemiological data on the relationship of telomere-pathway gene variation with T2D are available... - Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levelsMeian He
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 30:885-90. 2010..We sought to identify the common genetic variants associated with IL-18 levels... - Genome-wide association studies identify loci associated with age at menarche and age at natural menopauseChunyan He
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Genet 41:724-8. 2009..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits... - Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3Nina P Paynter
Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Ann Intern Med 150:65-72. 2009..Although genetic variation at chromosome 9p21.3 is associated with incident cardiovascular disease, it is unclear whether screening for this polymorphism improves risk prediction... - Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health StudyRobert Y L Zee
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Atherosclerosis 214:107-9. 2011..Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available... - Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolismRobert Y L Zee
Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medial School, 900 CommonwealthAvenue East, Boston, MA 02215, USA
Atherosclerosis 197:694-9. 2008..The present investigation provides evidence for an association of the P2RY12 haplotype H2 with lower risk of DVT/PE; however these findings require replication in other well-designed studies... - Sugar-sweetened beverages and genetic risk of obesityQibin Qi
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 367:1387-96. 2012..Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown... - Genetic variants at 2q24 are associated with susceptibility to type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
Hum Mol Genet 19:2706-15. 2010..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance... - Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levelsPiotr Kozlowski
Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
Ann Hum Genet 70:574-86. 2006.... - Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health StudyGuillaume Pare
Center for Cardiovascular Disease Prevention and the Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
Circ Cardiovasc Genet 2:142-50. 2009..Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown... - Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarctionRobert Y L Zee
Center for Cardiovascular Disease Prevention, The LeDucq Center for Cardiovascular Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Atherosclerosis 181:137-41. 2005..In conclusion, we found no evidence for an association between the common polymorphisms or haplotypes of the tryptophanyl-tRNA synthetase gene tested and risk of myocardial infarction... - Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 womenGuillaume Pare
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 4:e1000118. 2008..2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes... - Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health StudyGuillaume Pare
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
PLoS Genet 4:e1000312. 2008..This observed genetic association between glycated hemoglobin levels and HK1 polymorphisms paves the way for further studies of the role of HK1 in hemoglobin glycation, glucose metabolism, and diabetes... - Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapyAudrey Y Chu
Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
Circ Cardiovasc Genet 5:676-85. 2012..Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and no prior data are available addressing genetic determinants of statin-induced changes for this proinflammatory biomarker... - Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary preventionPaul M Ridker
Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Circ Cardiovasc Genet 4:312-7. 2011..Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed... - Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumptionMarilyn C Cornelis
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Genet 7:e1002033. 2011..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2... - Genetic determinants of cardiovascular events among women with migraine: a genome-wide association studyMarkus Schürks
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e22106. 2011..Migraine is associated with an increased risk for cardiovascular disease (CVD). Both migraine and CVD are highly heritable. However, the genetic liability for CVD among migraineurs is unclear... - Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health StudyRobert Y L Zee
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Chim Acta 412:199-202. 2011..Candidate genes associated with telomere length maintenance, an important molecular marker for biological aging, represent potential risk predictors for cardiovascular disease (CVD). To date, no prospective data are available... - Pharmacogenetic study of statin therapy and cholesterol reductionDaniel I Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
JAMA 291:2821-7. 2004..Polymorphisms in genes involved in cholesterol synthesis, absorption, and transport may affect statin efficacy... - Genome-wide association study of relative telomere lengthJennifer Prescott
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e19635. 2011..10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed... - Prospective evaluation of B-type natriuretic peptide concentrations and the risk of type 2 diabetes in womenBrendan M Everett
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Clin Chem 59:557-65. 2013.... - Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine LeiomyomataStacey L Eggert
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 91:621-8. 2012..FASN represents the initial UL risk allele identified in white women by a genome-wide, unbiased approach and opens a path to management and potential therapeutic intervention... - Meta-analysis identifies six new susceptibility loci for atrial fibrillationPatrick T Ellinor
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Nat Genet 44:670-5. 2012..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules... - Functional classification of proteins and protein variantsAlbert Y Lau
Variagenics, Incorporated, 60 Hampshire Street, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 101:6576-81. 2004.... - Physical activity, genes for physical fitness, and risk of coronary heart diseaseAndrea K Chomistek
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Med Sci Sports Exerc 45:691-7. 2013..Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD... - Genetic variation of fifteen folate metabolic pathway associated gene loci and the risk of incident head and neck carcinoma: the Women's Genome Health StudyRobert Y L Zee
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02215, USA
Clin Chim Acta 418:33-6. 2013..Whether the genetic variation within the FMP associated genes modulates HNC remains elusive. To date, prospective, epidemiological data on the relationship of FMP gene variation with the risk of HNC are sparse... - Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factorsQiong Yang
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Circ Cardiovasc Genet 3:523-30. 2010.... - Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health StudyJennifer E Ho
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
J Hypertens 29:62-9. 2011.... - Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexElizabeth K Speliotes
Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
Nat Genet 42:937-48. 2010..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation... - Genome-wide association study reveals three susceptibility loci for common migraine in the general populationDaniel I Chasman
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 43:695-8. 2011..TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology... - Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney functionDaniel I Chasman
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hum Mol Genet 21:5329-43. 2012..The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general... - A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health StudyDov Shiffman
Celera, Alameda, California 94502, USA
J Am Coll Cardiol 51:444-8. 2008..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women... - Tracing sub-structure in the European American population with PCA-informative markersPeristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
PLoS Genet 4:e1000114. 2008..Furthermore, our redundancy removal algorithm can be applied on sets of ancestry informative markers selected with any method in order to select the most uncorrelated SNPs, and significantly decreases genotyping costs... - Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive proteinAlexander P Reiner
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
Am J Hum Genet 82:1193-201. 2008.... - Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutationsR Scott Williams
Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 278:53007-16. 2003....