Elena H Chartoff

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report
    Elena H Chartoff
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Stem Cells Int 2011:586586. 2011
  2. pmc Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue
    Elena H Chartoff
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Mol Pharmacol 75:704-12. 2009
  3. pmc Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:2676-87. 2008
  4. ncbi request reprint Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy
    Elena H Chartoff
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res 1022:71-80. 2004
  5. pmc Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 204:227-39. 2009
  6. pmc Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
    Elena Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 62:167-76. 2012
  7. ncbi request reprint Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6450-7. 2006
  8. ncbi request reprint Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 87:107-18. 2003
  9. ncbi request reprint Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Neuropsychopharmacology 30:1324-33. 2005
  10. pmc Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
    David N Potter
    Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 70:744-53. 2011

Collaborators

Detail Information

Publications18

  1. pmc Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report
    Elena H Chartoff
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Stem Cells Int 2011:586586. 2011
    ..Furthermore, our observations highlight the necessity of including appropriate controls when working with GFP as a cellular marker...
  2. pmc Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue
    Elena H Chartoff
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Mol Pharmacol 75:704-12. 2009
    ....
  3. pmc Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:2676-87. 2008
    ..These findings suggest that SalvA regulates the stimulant effects of cocaine through interactions with D1 receptor-mediated signaling in the dorsal striatum...
  4. ncbi request reprint Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy
    Elena H Chartoff
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res 1022:71-80. 2004
    ....
  5. pmc Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 204:227-39. 2009
    ..These data suggest that D1 receptors acquire the ability to regulate reward and withdrawal in morphine-dependent rats. The brain regions involved in these effects are not known...
  6. pmc Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
    Elena Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 62:167-76. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  7. ncbi request reprint Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6450-7. 2006
    ..Regardless, these findings suggest for the first time that D1 agonists might be useful for the treatment of withdrawal symptoms that contribute to the maintenance of opiate addiction in humans...
  8. ncbi request reprint Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 87:107-18. 2003
    ..Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal...
  9. ncbi request reprint Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Neuropsychopharmacology 30:1324-33. 2005
    ..These results suggest that glutamate, rather than dopamine, is required for the locomotor and molecular effects of NMDA receptor antagonists, but that glutamate and dopamine can act cooperatively...
  10. pmc Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
    David N Potter
    Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 70:744-53. 2011
    ..Acute KOR activation produces dysphoria that might contribute to addictive behavior. How repeated KOR activation modulates reward circuitry is not understood...
  11. ncbi request reprint Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1003:368-71. 2003
  12. pmc The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward
    Hilarie C Tomasiewicz
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 64:982-8. 2008
    ....
  13. ncbi request reprint LTP in the lateral amygdala during cocaine withdrawal
    Ivan Goussakov
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Eur J Neurosci 23:239-50. 2006
    ..As such, they raise the possibility that the development and maintenance of addictive behaviours may involve, at least in part, mechanisms of synaptic plasticity within specific amygdala circuits...
  14. pmc Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity
    Ashlee Van't Veer
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 38:1585-97. 2013
    ..These mouse lines may be useful in future studies of KOR function...
  15. ncbi request reprint Extreme chipping: addiction to a high-fat diet?
    William A Carlezon
    Behavioral Genetics Laboratory, McLean Hospital, 115 Mill Street, Belmont MA 02478, USA
    Biol Psychiatry 61:1019-20. 2007
  16. ncbi request reprint Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 59:1236-9. 2006
    ..Here we examined if Ca2+ influx via L-type Ca2+ channels within the NASh would influence cocaine reward...
  17. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
    ..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...
  18. ncbi request reprint Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Nat Protoc 2:2987-95. 2007
    ....

Research Grants4

  1. Role of dopamine D1 receptors in morphine withdrawal
    Elena Chartoff; Fiscal Year: 2006
    ..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
  2. Consequences of repeated kappa receptor activation on brain stimulation reward
    Elena Chartoff; Fiscal Year: 2006
    ..abstract_text> ..
  3. Role of dopamine signaling in the mood-related effects of salvinorin A
    Elena H Chartoff; Fiscal Year: 2010
    ..The goal of the proposed studies is to determine if salvinorin A modulates brain reward systems by altering dopamine-mediated signaling in the nucleus accumbens, a brain region involved in the regulation of reward. ..