Affiliation: Harvard University
- Poly(ADP-ribose) is required for spindle assembly and structurePaul Chang
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 432:645-9. 2004..Thus, PAR is a non-proteinaceous, non-chromosomal component of the spindle required for bipolar spindle assembly and function...
- Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and functionPaul Chang
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Nat Cell Biol 7:1133-9. 2005..We also demonstrate a requirement for tankyrase-1 in the assembly of bipolar spindles, and identify the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1...
- Epsilon-tubulin is required for centriole duplication and microtubule organizationPaul Chang
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Nat Cell Biol 5:71-6. 2003....
- Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomesRyan K Louie
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Cell Sci 117:1117-28. 2004..In summary, our data indicate that APC and EB1 are functional components of mammalian centrosomes and that EB1 is important for anchoring cytoplasmic MT minus ends to the subdistal appendages of the mother centriole...
- Mechanism of Poly-ADP-ribose function in the spindlePaul Chang; Fiscal Year: 2005..Preliminary experiments demonstrate a requirement for PAR in spindle function. Here, I propose to examine the mechanism by which PAR acts in the mitotic spindle. ..