Paul Chang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Poly(ADP-ribose) is required for spindle assembly and structure
    Paul Chang
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 432:645-9. 2004
  2. ncbi Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function
    Paul Chang
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:1133-9. 2005
  3. ncbi Epsilon-tubulin is required for centriole duplication and microtubule organization
    Paul Chang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Nat Cell Biol 5:71-6. 2003
  4. ncbi Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes
    Ryan K Louie
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 117:1117-28. 2004

Research Grants

  1. Mechanism of Poly-ADP-ribose function in the spindle
    Paul Chang; Fiscal Year: 2005

Collaborators

Detail Information

Publications4

  1. ncbi Poly(ADP-ribose) is required for spindle assembly and structure
    Paul Chang
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 432:645-9. 2004
    ..Thus, PAR is a non-proteinaceous, non-chromosomal component of the spindle required for bipolar spindle assembly and function...
  2. ncbi Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function
    Paul Chang
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:1133-9. 2005
    ..We also demonstrate a requirement for tankyrase-1 in the assembly of bipolar spindles, and identify the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1...
  3. ncbi Epsilon-tubulin is required for centriole duplication and microtubule organization
    Paul Chang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Nat Cell Biol 5:71-6. 2003
    ....
  4. ncbi Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes
    Ryan K Louie
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 117:1117-28. 2004
    ..In summary, our data indicate that APC and EB1 are functional components of mammalian centrosomes and that EB1 is important for anchoring cytoplasmic MT minus ends to the subdistal appendages of the mother centriole...

Research Grants1

  1. Mechanism of Poly-ADP-ribose function in the spindle
    Paul Chang; Fiscal Year: 2005
    ..Preliminary experiments demonstrate a requirement for PAR in spindle function. Here, I propose to examine the mechanism by which PAR acts in the mitotic spindle. ..