Hsiu Ching Chang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer
    Hsiu Ching Chang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 23:661-71. 2005
  2. ncbi CD8alphabeta has two distinct binding modes of interaction with peptide-major histocompatibility complex class I
    Hsiu Ching Chang
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:28090-6. 2006
  3. ncbi An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation
    Yoon Joong Kang
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
    Eur J Immunol 40:836-48. 2010
  4. ncbi Stalk region of beta-chain enhances the coreceptor function of CD8
    Jenny S Wong
    Dana Farber Cancer Institute, Department of Cancer Immunology and AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:867-74. 2003
  5. ncbi Involvement of the TCR Cbeta FG loop in thymic selection and T cell function
    Tetsuro Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115
    J Exp Med 195:1419-31. 2002

Research Grants

  1. MOLECULAR BASIS OF CD8 CO-RECEPTOR FUNCTION
    Hsiu Ching Chang; Fiscal Year: 2004

Collaborators

Detail Information

Publications5

  1. ncbi Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer
    Hsiu Ching Chang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 23:661-71. 2005
    ..The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed...
  2. ncbi CD8alphabeta has two distinct binding modes of interaction with peptide-major histocompatibility complex class I
    Hsiu Ching Chang
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:28090-6. 2006
    ..We propose that CD8alphabeta binds to pMHCI in at least two distinguishable orientations...
  3. ncbi An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation
    Yoon Joong Kang
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
    Eur J Immunol 40:836-48. 2010
    ....
  4. ncbi Stalk region of beta-chain enhances the coreceptor function of CD8
    Jenny S Wong
    Dana Farber Cancer Institute, Department of Cancer Immunology and AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:867-74. 2003
    ....
  5. ncbi Involvement of the TCR Cbeta FG loop in thymic selection and T cell function
    Tetsuro Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115
    J Exp Med 195:1419-31. 2002
    ..Compared with N15alphabeta, N15alphabeta.betaDeltaFG T cells respond poorly to cognate antigens and weak agonists. Thus, the Cbeta FG loop facilitates negative selection of thymocytes and activation of T cells...

Research Grants5

  1. MOLECULAR BASIS OF CD8 CO-RECEPTOR FUNCTION
    Hsiu Ching Chang; Fiscal Year: 2004
    ..In parallel, the potential molecules involved in signal transduction of CD8beta will be cloned in the yeast two hybrid system. ..