Manuela Cernadas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc CD1a expression defines an interleukin-12 producing population of human dendritic cells
    M Cernadas
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Exp Immunol 155:523-33. 2009
  2. doi request reprint Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens
    Manuela Cernadas
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:1235-41. 2010
  3. pmc NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation
    Oliver Haworth
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Immunol 186:6129-35. 2011
  4. ncbi request reprint Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development
    Manuela Cernadas
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:4149-55. 2003
  5. pmc Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice
    Clinton S Robbins
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 180:6623-8. 2008
  6. pmc Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected]
    Karen Muindi
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:3052-7. 2010
  7. pmc Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    Cindy Barnig
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 5:174ra26. 2013
  8. pmc Adam8 limits the development of allergic airway inflammation in mice
    Martin D Knolle
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 190:6434-49. 2013
  9. pmc Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin
    Peggy S Lai
    Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e62910. 2013
  10. pmc Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion
    Peggy S Lai
    Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 47:209-17. 2012

Research Grants

  1. INTEGRIN CD103-ROLE IN TH2 PULMONARY IMMUNE RESPONSES
    Manuela Cernadas; Fiscal Year: 2004
  2. Cathepsins in Antigen Presentation and Lung Immunity
    Manuela Cernadas; Fiscal Year: 2006
  3. Cathepsins in Antigen Presentation and Lung Immunity
    Manuela Cernadas; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. pmc CD1a expression defines an interleukin-12 producing population of human dendritic cells
    M Cernadas
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Exp Immunol 155:523-33. 2009
    ....
  2. doi request reprint Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens
    Manuela Cernadas
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:1235-41. 2010
    ..Thus, the intracellular trafficking route of CD1a is essential for efficient presentation of lipid Ags that traffic through the early endocytic and recycling pathways...
  3. pmc NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation
    Oliver Haworth
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Immunol 186:6129-35. 2011
    ..Together, these findings indicate new functions in catabasis for NK cells that can also serve as targets for proresolving mediators in the resolution of adaptive immunity...
  4. ncbi request reprint Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development
    Manuela Cernadas
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:4149-55. 2003
    ..Here we show the dominant mechanism for this trafficking is mediated by AP-3...
  5. pmc Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice
    Clinton S Robbins
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 180:6623-8. 2008
    ..Smoke-induced defects in DC function leading to impaired CD4(+) T cell function could inhibit tumor surveillance and predispose patients with chronic obstructive pulmonary disease to infections and exacerbations...
  6. pmc Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected]
    Karen Muindi
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:3052-7. 2010
    ..Together, these studies identify the range of GSL presented by CD1d and how presentation varies based on CD1d intracellular trafficking and microbial activation...
  7. pmc Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    Cindy Barnig
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 5:174ra26. 2013
    ..Because lipoxin A4 generation is decreased in severe asthma, these findings also implicate unrestrained ILC activation in asthma pathobiology...
  8. pmc Adam8 limits the development of allergic airway inflammation in mice
    Martin D Knolle
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 190:6434-49. 2013
    ..Thus, ADAM8 has anti-inflammatory activities during AAI in mice by activating the intrinsic apoptosis pathway in myeloid leukocytes. Strategies that increase ADAM8 levels in myeloid leukocytes may have therapeutic efficacy in asthma...
  9. pmc Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin
    Peggy S Lai
    Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e62910. 2013
    ..Identification of differentially expressed genes shared across all published murine models of chronic inhaled endotoxin will provide insight into the biology underlying endotoxin-associated lung disease...
  10. pmc Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion
    Peggy S Lai
    Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 47:209-17. 2012
    ..These findings point to a novel underlying mechanism of airflow obstruction as a result of occupational LPS exposure, and suggest molecular and cellular targets for therapeutic development...
  11. ncbi request reprint IL-6 production by pulmonary dendritic cells impedes Th1 immune responses
    Ingrid L Dodge
    Division of Rheumatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 170:4457-64. 2003
    ....
  12. pmc PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis
    Hui Hsin Chang
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33067. 2012
    ..Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis...
  13. pmc Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis
    Laura E Fredenburgh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 187:5255-67. 2011
    ..Taken together, our results suggest that epithelial expression of COX-2 in the ileum is a critical modulator of tight junction protein expression and intestinal barrier function during sepsis...
  14. pmc Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation
    Oliver Haworth
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:873-9. 2008
    ....
  15. ncbi request reprint PU.1 regulates cathepsin S expression in professional APCs
    Ying Wang
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:275-83. 2006
    ..1 alone. These data indicate that PU.1 participates in the regulation of CTSS transcription in APCs. Thus, manipulation of PU.1 expression may directly alter the endosomal proteolytic environment in these cells...
  16. pmc Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    Kiichi Nakahira
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:222-30. 2011
    ..Our study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondrial integrity...

Research Grants4

  1. INTEGRIN CD103-ROLE IN TH2 PULMONARY IMMUNE RESPONSES
    Manuela Cernadas; Fiscal Year: 2004
    ..These studies may provide significant insights into the role of integrin alphaEbeta7 in T helper cell differentiation and dendritic cell biology. ..
  2. Cathepsins in Antigen Presentation and Lung Immunity
    Manuela Cernadas; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cathepsins in Antigen Presentation and Lung Immunity
    Manuela Cernadas; Fiscal Year: 2007
    ..abstract_text> ..