J C Celedon

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
  2. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
  3. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
  4. pmc Lack of reproducibility of linkage results in serially measured blood pressure data
    Sanjay R Patel
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    BMC Genet 4:S37. 2003
  5. ncbi request reprint Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1239-43. 2003
  6. ncbi request reprint Bottle feeding in the bed or crib before sleep time and wheezing in early childhood
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:e77. 2002
  7. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
  8. ncbi request reprint Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 125:85-92. 2004
  9. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
  10. pmc Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:144-9. 2007

Detail Information

Publications87

  1. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  2. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  3. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  4. pmc Lack of reproducibility of linkage results in serially measured blood pressure data
    Sanjay R Patel
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    BMC Genet 4:S37. 2003
    ....
  5. ncbi request reprint Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1239-43. 2003
    ..Our findings suggest that maternal history of asthma influences the relation between day care-related exposures and childhood asthma...
  6. ncbi request reprint Bottle feeding in the bed or crib before sleep time and wheezing in early childhood
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:e77. 2002
    ..We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life...
  7. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
    ..A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results...
  8. ncbi request reprint Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 125:85-92. 2004
    ..To examine the relationship between ethnicity and sensitization to allergens among children with asthma living in urban and suburban areas of Connecticut...
  9. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
    ..IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases...
  10. pmc Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:144-9. 2007
    ..There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age...
  11. ncbi request reprint Antibiotic use in the first year of life and asthma in early childhood
    J C Celedon
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Clin Exp Allergy 34:1011-6. 2004
    ..An association between antibiotic use in early life and asthma in childhood has been reported in five retrospective studies and one longitudinal study...
  12. ncbi request reprint Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica
    Juan C Celedon
    Channing Laboratory, Department of Medicine and Respiratory Disorders Program, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 120:691-9. 2007
    ..Our results suggest that chromosome 12q24.31 contains a locus (or loci) that influence a critical intermediate phenotype of asthma (airway responsiveness) in Costa Ricans...
  13. ncbi request reprint Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 360:781-2. 2002
    ..There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure...
  14. ncbi request reprint Use of antibacterials in infancy: clinical implications for childhood asthma and allergies
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Treat Respir Med 3:291-4. 2004
    ..Although antibacterials should not be used excessively in young children, their use in early childhood is not likely to explain the increased prevalence of asthma and allergies in children in industrialized countries...
  15. ncbi request reprint Application of an algorithm for the diagnosis of asthma in Chinese families: limitations and alternatives for the phenotypic assessment of asthma in family-based genetic studies
    J C Celedon
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 162:1679-84. 2000
    ..Genetic studies of intermediate phenotypes related to asthma, which are objectively defined and may be influenced by a smaller number of genes, continue to be of great importance...
  16. ncbi request reprint Asthma, rhinitis, and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 163:1108-12. 2001
    ..Our findings also suggest that allergic rhinitis is far less common among asthmatic subjects in rural China than in asthmatic subjects in industrialized countries with a Western lifestyle...
  17. ncbi request reprint Sensitization to silk and childhood asthma in rural China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 107:E80. 2001
    ..Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma...
  18. ncbi request reprint Risk factors for childhood asthma in Costa Rica
    J C Celedon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 120:785-90. 2001
    ..Little is known about factors determining the pathogenesis and severity of asthma in Latin American countries. Costa Rica, one of the most prosperous Latin American nations, has a very high asthma prevalence...
  19. ncbi request reprint Body mass index and asthma in adults in families of subjects with asthma in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:1835-40. 2001
    ..21) (kg/m)(2) = 1.3 to 3.1; 95% CI(30) (vs.) (21) (kg/m)(2) = 1.2 to 4.5). Among adults in families of subjects with asthma living in rural China, both underweight and overweight are associated with an increased risk of asthma...
  20. ncbi request reprint Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood
    Juan C Celedon
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 156:241-5. 2002
    ..It has been hypothesized that day care--related infections may explain the inverse relation between day care attendance in early life and asthma in childhood...
  21. ncbi request reprint Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica
    J C Celedon
    Channing Laboratory Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Exp Allergy 32:387-90. 2002
    ..Single nucleotide polymorphisms (SNPs) in the IL-13 gene have been associated with asthma and total serum IgE level in Caucasian populations...
  22. ncbi request reprint The relationship among markers of allergy, asthma, allergic rhinitis, and eczema in Costa Rica
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatr Allergy Immunol 13:91-7. 2002
    ....
  23. ncbi request reprint Day care attendance in the first year of life and illnesses of the upper and lower respiratory tract in children with a familial history of atopy
    J C Celedon
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatrics 104:495-500. 1999
    ..To examine the relationship between day care attendance and illnesses of the upper and lower respiratory tract in the first year of life...
  24. ncbi request reprint Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:72-5. 2002
    ..4; OR for two or more versus no courses of antibiotics, 0.9; 95% CI, 0.5 to 1.4). Our findings do not support the hypothesis that antibiotic use in early life is associated with the subsequent development of asthma and atopy in childhood...
  25. pmc Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness
    S Sharma
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA
    Eur Respir J 33:1287-94. 2009
    ..VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness...
  26. pmc Multiple microbial exposures in the home may protect against asthma or allergy in childhood
    J E Sordillo
    Channing Laboratory, Boston, MA, USA
    Clin Exp Allergy 40:902-10. 2010
    ....
  27. pmc Risk factors for allergic rhinitis in Costa Rican children with asthma
    S Bunyavanich
    Channing Laboratory, Boston, MA 02115, USA
    Allergy 65:256-63. 2010
    ..Risk factors for allergic rhinitis (AR) in asthmatics are likely distinct from those for AR or asthma alone. We sought to identify clinical and environmental risk factors for AR in children with asthma...
  28. pmc Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:765-71. 2009
    ..Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood...
  29. ncbi request reprint Gender-related differences in severe, early-onset chronic obstructive pulmonary disease
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 162:2152-8. 2000
    ..56, 95% CI 1.08-11.71), and bronchodilator response greater than 10% of baseline FEV(1) (OR 4.74, 95% CI 1.91-11.75). These results suggest that women may be more susceptible to the development of severe COPD...
  30. pmc Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study
    A A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thorax 57:581-5. 2002
    ..The relationship between body mass index (BMI) and the development of an objective marker for asthma, methacholine airway hyperresponsiveness (AHR), was investigated in adult men...
  31. pmc Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Thorax 62:224-30. 2007
    ..A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans...
  32. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  33. ncbi request reprint A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 110:736-42. 2002
    ..It has been postulated that exposure to bacterial endotoxins and animals early in life might confer protection against the development of asthma and allergies...
  34. pmc Maternal intestinal flora and wheeze in early childhood
    N E Lange
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Exp Allergy 42:901-8. 2012
    ..Increasing evidence links altered intestinal flora in infancy to eczema and asthma. No studies have investigated the influence of maternal intestinal flora on wheezing and eczema in early childhood...
  35. pmc Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
    Sunita Sharma
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 179:356-62. 2009
    ..Polymorphisms in the gene for transforming growth factor-beta1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma...
  36. ncbi request reprint Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica
    Gary M Hunninghake
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Allergy Clin Immunol 119:654-61. 2007
    ..Little is known about sensitization (defined as a positive IgE) to helminths and disease severity in patients with asthma...
  37. ncbi request reprint On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice
    David Fardo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 31:376-82. 2007
    ..The guidelines are illustrated by an application to an asthma study...
  38. pmc Mouse allergen exposure, wheeze and atopy in the first seven years of life
    W Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Allergy 63:1512-8. 2008
    ..Little is known about mouse allergen exposure in home environments and the development of wheezing, asthma and atopy in childhood...
  39. pmc TSLP polymorphisms are associated with asthma in a sex-specific fashion
    G M Hunninghake
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Allergy 65:1566-75. 2010
    ..Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion...
  40. ncbi request reprint Predictors of cord blood IgE levels in children at risk for asthma and atopy
    Christina V Scirica
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:81-8. 2007
    ..Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels...
  41. ncbi request reprint Respiratory illnesses in early life and asthma and atopy in childhood
    Clare D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:150-6. 2007
    ..The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood...
  42. ncbi request reprint Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica
    Ngoc P Ly
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 133:107-14. 2008
    ..Little is known about the determinants of airway hyperresponsiveness (AHR) among children with asthma in Hispanic America...
  43. pmc Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans
    Gary M Hunninghake
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:830-6. 2008
    ....
  44. doi request reprint Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
    ..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...
  45. pmc IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  46. ncbi request reprint Sensitization to aeroallergens and airway hyperresponsiveness at 7 years of age
    Elizabeth C TePas
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 129:1500-8. 2006
    ..To investigate the relationship between current and early life factors and airway responsiveness to inhaled methacholine in children with a median age of 7.0 years...
  47. ncbi request reprint Asthma and ethnic minorities: socioeconomic status and beyond
    Erick Forno
    Department of Pediatrics, Children s Hospital Boston, Massachusetts, USA
    Curr Opin Allergy Clin Immunol 9:154-60. 2009
    ..In addition, we review potential risk factors for ethnic disparities in asthma that are not mediated by socioeconomic status...
  48. doi request reprint HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults
    J Lasky-Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Clin Exp Allergy 42:1724-33. 2012
    ..An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies...
  49. pmc Chronic obstructive pulmonary disease in Hispanics
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:473-8. 2008
    ....
  50. pmc PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
    ..6 x 10(-)(5)). PRKCA is a pleiotropic locus that is associated with both BMI and asthma and that has been identified via linkage analysis of BMI in a population ascertained on asthma...
  51. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
    ..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma...
  52. pmc Violence, abuse, and asthma in Puerto Rican children
    Robyn T Cohen
    Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 178:453-9. 2008
    ..Puerto Ricans have the highest prevalence of and morbidity from asthma of all ethnic groups in the United States. One potential contributor to the high burden of asthma in Puerto Rican children is exposure to stress and violence...
  53. ncbi request reprint Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  54. doi request reprint Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy
    Michael Pistiner
    Division of Immunology, Children s Hospital Boston, Boston, Mass, USA
    J Allergy Clin Immunol 122:274-9. 2008
    ..Studies of the relation between cesarean delivery and allergic diseases in children not selected on the basis of a family history of atopy have yielded inconsistent findings...
  55. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  56. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  57. ncbi request reprint Area of residence, birthplace, and asthma in Puerto Rican children
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Chest 131:1331-8. 2007
    ..There have been no studies that directly compare the burden of asthma between Puerto Ricans living in Puerto Rico and those living in the mainland United States...
  58. pmc A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma
    Sunita Sharma
    Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:328-36. 2010
    ..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes...
  59. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
    ..Replication of gene-disease associations has become a requirement in complex trait genetics...
  60. ncbi request reprint Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica
    Benjamin A Raby
    Channing Laboratory and Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 16:243-53. 2007
    ..JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell development. This is the first demonstration of a possible genetic basis for differences in total IgE between sexes...
  61. ncbi request reprint Health-care use among Puerto Rican and African-American children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 130:463-71. 2006
    ..Medicaid and the supplementary State Children's Health Insurance Plan data about health-care utilization for asthma were obtained for each child for the 12 months preceding completion of the screening survey...
  62. ncbi request reprint Inflammatory markers of lung disease in adult patients with cystic fibrosis
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
    Pediatr Pulmonol 42:256-62. 2007
    ..We hypothesized that levels of serum biomarkers would correlate with clinical course of CF as defined by pulmonary function testing (FEV1)...
  63. pmc Mouse exposure and wheeze in the first year of life
    Wanda Phipatanakul
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 94:593-9. 2005
    ..Studies have found that exposure to mice is highly prevalent among children with asthma living in urban areas...
  64. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  65. pmc Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Med Genet 12:26. 2011
    ..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts...
  66. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  67. ncbi request reprint Variation in total and specific IgE: effects of ethnicity and socioeconomic status
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:751-7. 2005
    ..Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization...
  68. ncbi request reprint Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:1056-62. 2005
    ..Variants in the CD14 gene (CD14) are hypothesized to be associated with atopic disorders. However, most studies have only investigated one polymorphism in this gene...
  69. ncbi request reprint Eotaxin polymorphisms and serum total IgE levels in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:298-305. 2006
    ..Family-based association studies of CCL11 genetic variants have not been reported to date...
  70. ncbi request reprint Predictors of disease severity in children with asthma in Hartford, Connecticut
    Clare D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Pulmonol 39:268-75. 2005
    ..Our findings suggest that FEV1/FVC is a useful indicator of asthma severity in children...
  71. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  72. pmc Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
    ..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma...
  73. ncbi request reprint Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Hum Mol Genet 12:1199-210. 2003
    ..This study has also identified several genomic regions that could contain loci regulating BDR in early-onset COPD families...
  74. ncbi request reprint Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital
    Am J Respir Crit Care Med 165:1489-93. 2002
    ..These data suggest a complex relationship between ascariasis and susceptibility to childhood asthma among predisposed children that may involve an interaction with the immune response to inhaled aeroallergens...
  75. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  76. ncbi request reprint Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
    ..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear...
  77. ncbi request reprint Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1294-301. 2004
    ..LOD scores of greater than two were also observed for chromosomes 16, 20, and 22 with the smokers-only analysis, which may suggest gene-by-smoking interactions in these regions...
  78. pmc A genome-wide association study of bronchodilator response in asthmatics
    Q L Duan
    Channing Division of Network Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics J 14:41-7. 2014
    ..51 × 10(-6)). This study applied a robust approach for testing the genetic basis of BDR and identified novel loci associated with this drug response in asthmatics. ..
  79. ncbi request reprint Polymorphisms in the interleukin 17F gene (IL17F) and asthma
    C D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Genes Immun 6:236-41. 2005
    ..None of the SNPs or haplotypes tested in IL17F were associated with asthma. The polymorphisms identified in this study may be used in future studies of association between IL17F and phenotypes related to immune responses...
  80. ncbi request reprint Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
    Angela J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1332-7. 2007
    ..The role of these mutations in the development of asthma is less clear, particularly in patients who do not have coincident atopic dermatitis...
  81. ncbi request reprint Genetics of asthma: potential implications for reducing asthma disparities
    Christina V Scirica
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Chest 132:770S-781S. 2007
    ..These studies should also include an adequate assessment of potentially relevant environmental exposures and (for case-control association studies) population stratification...
  82. ncbi request reprint Recurrent wheeze in early childhood and asthma among children at risk for atopy
    Ngoc P Ly
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 117:e1132-8. 2006
    ..We examined the relation between early wheeze and asthma at 7 years of age among children with parental history of asthma or allergies followed from birth...
  83. pmc Asthma in Hispanics
    Gary M Hunninghake
    Channing Laboratory, Dept of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:143-63. 2006
    ..g., improving housing conditions) would likely have a major impact on reducing asthma morbidity in this population...
  84. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  85. ncbi request reprint Asthma in Hispanics in the United States
    Robyn T Cohen
    Channing Laboratory Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Chest Med 27:401-12, v. 2006
    ....
  86. ncbi request reprint The hygiene hypothesis and asthma
    Clare D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Curr Opin Pulm Med 11:14-20. 2005
    ..This review will examine recent epidemiologic studies of the hygiene hypothesis and asthma...
  87. ncbi request reprint Cytokines, allergy, and asthma
    P Ly Ngoc
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Allergy Clin Immunol 5:161-6. 2005
    ..This review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early life...

Research Grants9

  1. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  2. The Genetic Epidemiology of COPD in Costa Rica
    JUAN CELEDON; Fiscal Year: 2006
    ..This application will greatly contribute to our understanding of the pathogenesis of COPD in general, and among Hispanics in particular. ..
  3. Genes, Home Allergens and Asthma Puerto Rican Children
    JUAN CELEDON; Fiscal Year: 2006
    ..This application will contribute greatly to our understanding of asthma in general, and among Puerto Ricans in particular. ..
  4. The Genetic Epidemiology of COPD in Costa Rica
    JUAN CELEDON; Fiscal Year: 2007
    ..This application will greatly contribute to our understanding of the pathogenesis of COPD in general, and among Hispanics in particular. ..
  5. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CELEDON; Fiscal Year: 2007
    ..This application will contribute greatly to our understanding of asthma in general, and among Puerto Ricans in particular. ..
  6. The Genetic Epidemiology of COPD in Costa Rica
    JUAN CELEDON; Fiscal Year: 2009
    ..This application will greatly contribute to our understanding of the pathogenesis of COPD in general, and among Hispanics in particular. ..
  7. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CELEDON; Fiscal Year: 2009
    ..This application will contribute greatly to our understanding of asthma in general, and among Puerto Ricans in particular. ..