Verne Caviness

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The G1 restriction point as critical regulator of neocortical neuronogenesis
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neurochem Res 24:497-506. 1999
  2. pmc Our unborn children at risk?
    V S Caviness
    Department of Neurology, Division of Pediatric Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:12661-2. 2006
  3. pmc Histogenetic processes leading to the laminated neocortex: migration is only a part of the story
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neurosci 30:82-95. 2008
  4. pmc Neocortical neurogenesis: morphogenetic gradients and beyond
    Verne S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Neurosci 32:443-50. 2009
  5. ncbi request reprint MRI-based brain volumetrics: emergence of a developmental brain science
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Brain Dev 21:289-95. 1999
  6. ncbi request reprint Neocortical malformation as consequence of nonadaptive regulation of neuronogenetic sequence
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ment Retard Dev Disabil Res Rev 6:22-33. 2000
  7. ncbi request reprint Advanced applications of MRI in human brain science
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Keio J Med 49:66-73. 2000
  8. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
  9. ncbi request reprint Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections
    Nikos Makris
    Harvard Medical School Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 18:1210-20. 2008
  10. ncbi request reprint Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005

Research Grants

  1. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 2007
  2. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 2003
  3. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 1993

Detail Information

Publications49

  1. ncbi request reprint The G1 restriction point as critical regulator of neocortical neuronogenesis
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neurochem Res 24:497-506. 1999
    ..e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan...
  2. pmc Our unborn children at risk?
    V S Caviness
    Department of Neurology, Division of Pediatric Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:12661-2. 2006
  3. pmc Histogenetic processes leading to the laminated neocortex: migration is only a part of the story
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neurosci 30:82-95. 2008
    ..Work yet ahead will emphasize mechanisms that coordinate the molecular events that integrate proliferation and cell class specification in relation to the final neocortical neural system map...
  4. pmc Neocortical neurogenesis: morphogenetic gradients and beyond
    Verne S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Neurosci 32:443-50. 2009
    ..We review evidence that suggests that the two mechanisms might be linked via operations of Notch1 and p27(Kip1), molecules known to regulate precursor cell proliferation and neuron production...
  5. ncbi request reprint MRI-based brain volumetrics: emergence of a developmental brain science
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Brain Dev 21:289-95. 1999
    ..These hypotheses, if supported by extensive observation, may guide the design of applications of MRI based volumetric analysis of the human brain...
  6. ncbi request reprint Neocortical malformation as consequence of nonadaptive regulation of neuronogenetic sequence
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ment Retard Dev Disabil Res Rev 6:22-33. 2000
    ..MRDD Research Reviews 6:22-33, 2000...
  7. ncbi request reprint Advanced applications of MRI in human brain science
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Keio J Med 49:66-73. 2000
    ..We will also consider potential offerings of the extended applications of brain MRI to the characterization and insights into biological origins of certain obscure developmental disorders...
  8. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
    ....
  9. ncbi request reprint Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections
    Nikos Makris
    Harvard Medical School Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 18:1210-20. 2008
    ..The demonstration of FA abnormalities in the CB and SLF II in adults with childhood ADHD provides further support for persistent structural abnormalities into adulthood...
  10. ncbi request reprint Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005
    ..Since DT-MRI allows the precise definition of only the stem portion of each fiber pathway, the origin and termination of the subdivisions of SLF are extrapolated from the available data in experimental material from non-human primates...
  11. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  12. pmc The occipitofrontal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Neuroimage 37:1100-11. 2007
    ..The OFF may have a role in visual spatial processing along with SLF II...
  13. ncbi request reprint An introduction to MR imaging-based stroke morphometry
    Nikos Makris
    Department of Neurology, Harvard Medical School, Charlestown, MA, USA
    Neuroimaging Clin N Am 15:325-39, x. 2005
    ..These samples highlight anatomic-based considerations regarding the nature of stroke and its repercussions within the brain parenchyma...
  14. ncbi request reprint Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:935-45. 2007
    ..We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia...
  15. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006
    ....
  16. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  17. ncbi request reprint Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging
    Larry J Seidman
    Harvard Medical School, Department of Psychiatry, Center for Morphometric Analysis, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Biol Psychiatry 60:1071-80. 2006
    ..This structural MRI study used an a priori region of interest approach...
  18. ncbi request reprint Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder
    Nikos Makris
    Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Health Sciences and Technology Athinoula A Martinos Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 17:1364-75. 2007
    ..This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF...
  19. pmc Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
    Isabelle M Rosso
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 123:15-21. 2010
    ..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients...
  20. pmc White matter volume abnormalities and associations with symptomatology in schizophrenia
    Nikolaos Makris
    Athinoula A Martinos Imaging Center, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA, United States
    Psychiatry Res 183:21-9. 2010
    ..These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia...
  21. ncbi request reprint A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
    Psychiatry Res 122:13-9. 2003
    ..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
  22. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  23. pmc Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study
    Nikos Makris
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Atten Disord 13:407-13. 2010
    ..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD...
  24. pmc Cerebellum, language, and cognition in autism and specific language impairment
    Steven M Hodge
    Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA
    J Autism Dev Disord 40:300-16. 2010
    ..These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention...
  25. doi request reprint Frontal white matter and cingulum diffusion tensor imaging deficits in alcoholism
    Gordon J Harris
    Department of Neurology, Athinoula A Martinos Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 32:1001-13. 2008
    ..In the present study, we examined the integrity of white matter tracts that are critical to frontal and limbic connectivity...
  26. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....
  27. ncbi request reprint Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging
    Nikos Makris
    Massachusetts General Hospital, USA
    J Cogn Neurosci 15:584-99. 2003
    ..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment...
  28. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  29. ncbi request reprint Human cerebral cortex: a system for the integration of volume- and surface-based representations
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 33:139-53. 2006
    ..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain...
  30. pmc Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients
    Bernhard Suter
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 27:10777-84. 2007
    ..This mapping system consisting of a combination of signals from two different sources is a novel perspective on the source of positional information for neuronal specification in the developing CNS...
  31. ncbi request reprint Abnormal asymmetry in language association cortex in autism
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, CNY 149, Room 6012, Boston, MA 02114, USA
    Ann Neurol 52:588-96. 2002
    ..In boys with autism, language and social/face processing-related regions displayed abnormal asymmetry. These structural abnormalities may relate to language and social disturbances observed in autism...
  32. ncbi request reprint MRI volumetric analysis in rasmussen encephalitis: a longitudinal study
    Masanori Takeoka
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, U S A
    Epilepsia 44:247-51. 2003
    ..We report a case of early-stage Rasmussen encephalitis with a relatively stable clinical course in whom we performed magnetic resonance imaging (MRI)-based volumetric analysis over an interval of 1 year, to assess for volumetric changes...
  33. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  34. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  35. pmc Decreased volume of the brain reward system in alcoholism
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Boston, Massachusetts, USA
    Biol Psychiatry 64:192-202. 2008
    ..We examined whether reward-network brain volumes are reduced in alcoholics and how volumes of subcomponents within this system are correlated with memory and drinking history...
  36. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
    ..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex...
  37. ncbi request reprint Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results
    Mitsuhiro Nishida
    Center for Morphometric Analysis, Department of Neurology, Massachusetts General Hospital, 34 Fruit Street, Boston, MA 02114, USA
    Neuroimage 32:1041-9. 2006
    ..These preliminary results are consistent with the heterochronous nature of cerebral development and provide initial estimates of regional brain growth and therefore regional vulnerability in the perinatal time period...
  38. ncbi request reprint White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
    ..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder...
  39. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  40. ncbi request reprint Decreased absolute amygdala volume in cocaine addicts
    Nikos Makris
    Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
    Neuron 44:729-40. 2004
    ..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use...
  41. ncbi request reprint Selective rotation of egocentric spatial representation following right putaminal hemorrhage
    Danica Mijovic-Prelec
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychologia 42:1827-37. 2004
    ..By contrast, performance could be rectified by presentation of correctly-oriented stimuli. These findings suggest that the putamen is part of a circuit underlying egocentric, as opposed to allocentric, representation of space in humans...
  42. ncbi request reprint Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
    ..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
  43. ncbi request reprint Analysis of cell generation in the telencephalic neuroepithelium
    Takao Takahashi
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Methods Mol Biol 198:101-13. 2002
  44. ncbi request reprint Size distribution of retrovirally marked lineages matches prediction from population measurements of cell cycle behavior
    Li Cai
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 69:731-44. 2002
    ....
  45. ncbi request reprint Population dynamics during cell proliferation and neuronogenesis in the developing murine neocortex
    Richard S Nowakowski
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Results Probl Cell Differ 39:1-25. 2002
    ..The presence of the gradient across the hemisphere is a possible source of positional information that could be exploited during development to establish the areal borders that characterize the adult neocortex...
  46. ncbi request reprint Forty-one year follow-up of childhood-onset opsoclonus-myoclonus-ataxia: cerebellar atrophy, multiphasic relapses, and response to IVIG
    Michael R Pranzatelli
    The National Pediatric Myoclonus Center, Departments of Neurology and Pediatrics, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    Mov Disord 17:1387-90. 2002
    ..We report on an adult with opsoclonus-myoclonus-ataxia syndrome experiencing widely spaced neurological relapses, who was followed for 41 years. His responses to treatment are described...
  47. ncbi request reprint Language-association cortex asymmetry in autism and specific language impairment
    Lies De Fossé
    Center for Morphometric Analysis, Massachusetts General Hospital
    Ann Neurol 56:757-66. 2004
    ..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis...
  48. ncbi request reprint Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
    Mary S Ahn
    Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
    J Affect Disord 104:147-54. 2007
    ..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and therefore may be implicated in BPD...
  49. doi request reprint Amygdala volume associated with alcohol abuse relapse and craving
    Jana Wrase
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Am J Psychiatry 165:1179-84. 2008
    ..This study sought an association in alcohol-dependent subjects between volumes of reward-related brain regions, alcohol craving, and the risk of relapse...

Research Grants18

  1. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 2007
    ..Specific Aim 3 will define a larger set of signal transduction, cell cycle and differentiation related transcripts that regulate with Q and not TG1 in response to p27Kip1 overexpression in the transgenic mice...
  2. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 2003
    ..Associated variations in the parameters of cdk2-cyclin complex kinase activity or the phosphorylation state of Rb should reinforce those observed with TG1 prolongation between E12 -E15 in vivo. ..
  3. CORTICAL DEVELOPMENT
    Verne Caviness; Fiscal Year: 1993
    ..The patterns of clonal output and of clonal dispersion will be corroborated by labeling with retroviral transfer of xgal at E12...