Anne M Cataldo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
    A Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Ann Neurol 50:661-5. 2001
  2. pmc Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Pathol 173:370-84. 2008
  3. ncbi App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6788-92. 2003
  4. ncbi Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurobiol Aging 25:1263-72. 2004
  5. ncbi Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, USA
    J Neuropathol Exp Neurol 63:821-30. 2004
  6. ncbi Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
  7. ncbi sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes
    Chun Wei David Chen
    Molecular Neuropathology Laboratory, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Alzheimer Res 3:63-70. 2006
  8. ncbi Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
    Paul M Mathews
    Nathan Kline Institute and New York University School of Medicine, Orangeburg, New York 10962, USA
    J Biol Chem 277:5299-307. 2002
  9. ncbi Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease
    Ralph A Nixon
    Center for Dementia Research, Nathan S Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Alzheimers Dis 9:277-89. 2006
  10. pmc Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    W Haung Yu
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Cell Biol 171:87-98. 2005

Research Grants

  1. Modulation of Alzheimer's Amyloidosis by Statins
    Anne M Cataldo; Fiscal Year: 2005

Detail Information

Publications12

  1. ncbi Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
    A Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Ann Neurol 50:661-5. 2001
    ....
  2. pmc Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Pathol 173:370-84. 2008
    ....
  3. ncbi App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6788-92. 2003
    ..These results identify an essential role for App gene triplication in causing AD-related endosomal abnormalities and further establish the pathogenic significance of endosomal dysfunction in AD...
  4. ncbi Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurobiol Aging 25:1263-72. 2004
    ....
  5. ncbi Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, USA
    J Neuropathol Exp Neurol 63:821-30. 2004
    ..Our findings suggest that presenilin mutations have amyloid-independent effects on the lysosomal system, which are synergistic with the lysosomal system pathology that is associated with beta-amyloid...
  6. ncbi Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
    ....
  7. ncbi sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes
    Chun Wei David Chen
    Molecular Neuropathology Laboratory, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Alzheimer Res 3:63-70. 2006
    ....
  8. ncbi Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
    Paul M Mathews
    Nathan Kline Institute and New York University School of Medicine, Orangeburg, New York 10962, USA
    J Biol Chem 277:5299-307. 2002
    ....
  9. ncbi Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease
    Ralph A Nixon
    Center for Dementia Research, Nathan S Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Alzheimers Dis 9:277-89. 2006
    ....
  10. pmc Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    W Haung Yu
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Cell Biol 171:87-98. 2005
    ..Our results, therefore, link beta-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD...
  11. ncbi Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production
    Olivera M Grbovic
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Biol Chem 278:31261-8. 2003
    ..Our findings in this model system suggest that the endosomal pathology seen at the earliest stage of sporadic AD may contribute to APP proteolysis along a beta-amyloidogenic pathway...
  12. pmc Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Rd, Bldg 39, Orangeburg, NY 10962, USA
    Am J Pathol 173:665-81. 2008
    ..Our findings establish apoptosis as a mode of neuronal cell death in aging PS/APP mice and identify the cross talk between autophagy and apoptosis, which influences neuronal survival in AD-related neurodegeneration...

Research Grants1

  1. Modulation of Alzheimer's Amyloidosis by Statins
    Anne M Cataldo; Fiscal Year: 2005
    ....