Cristian I Castillo-Davis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint GeneMerge--post-genomic analysis, data mining, and hypothesis testing
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Biological Laboratories, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Bioinformatics 19:891-2. 2003
  2. ncbi request reprint Sex-dependent gene expression and evolution of the Drosophila transcriptome
    Jose M Ranz
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Science 300:1742-5. 2003
  3. pmc The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 14:802-11. 2004
  4. pmc Systems-level analysis and evolution of the phototransduction network in Drosophila
    Christian R Landry
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:3283-8. 2007
  5. pmc cis-Regulatory and protein evolution in orthologous and duplicate genes
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, 02138 USA
    Genome Res 14:1530-6. 2004
  6. pmc A data-driven clustering method for time course gene expression data
    Ping Ma
    Department of Statistics, Harvard University, Cambridge, MA 02138, USA
    Nucleic Acids Res 34:1261-9. 2006
  7. ncbi request reprint The evolution of noncoding DNA: how much junk, how much func?
    Cristian I Castillo-Davis
    Department of Statistics, Harvard University, Cambridge, MA 02138, USA
    Trends Genet 21:533-6. 2005
  8. ncbi request reprint Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Masschusetts, USA
    Mol Biol Evol 21:1422-7. 2004
  9. ncbi request reprint Conservation, relocation and duplication in genome evolution
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Trends Genet 19:593-7. 2003
  10. ncbi request reprint Selection for short introns in highly expressed genes
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Genet 31:415-8. 2002

Detail Information

Publications11

  1. ncbi request reprint GeneMerge--post-genomic analysis, data mining, and hypothesis testing
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Biological Laboratories, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Bioinformatics 19:891-2. 2003
    ..GeneMerge can perform analyses on a wide variety of genomic data quickly and easily and facilitates both data mining and hypothesis testing...
  2. ncbi request reprint Sex-dependent gene expression and evolution of the Drosophila transcriptome
    Jose M Ranz
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Science 300:1742-5. 2003
    ..Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome...
  3. pmc The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 14:802-11. 2004
    ..Thus, strong purifying selection appears to act on the same core cellular processes in both mammalian and nematode lineages, whereas positive and/or relaxed selection acts on different biological processes in each lineage...
  4. pmc Systems-level analysis and evolution of the phototransduction network in Drosophila
    Christian R Landry
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:3283-8. 2007
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change...
  5. pmc cis-Regulatory and protein evolution in orthologous and duplicate genes
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, 02138 USA
    Genome Res 14:1530-6. 2004
    ....
  6. pmc A data-driven clustering method for time course gene expression data
    Ping Ma
    Department of Statistics, Harvard University, Cambridge, MA 02138, USA
    Nucleic Acids Res 34:1261-9. 2006
    ..Software and source code implementing the algorithm, SSClust, is freely available (http://genemerge.bioteam.net/SSClust.html)...
  7. ncbi request reprint The evolution of noncoding DNA: how much junk, how much func?
    Cristian I Castillo-Davis
    Department of Statistics, Harvard University, Cambridge, MA 02138, USA
    Trends Genet 21:533-6. 2005
    ....
  8. ncbi request reprint Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Masschusetts, USA
    Mol Biol Evol 21:1422-7. 2004
    ....
  9. ncbi request reprint Conservation, relocation and duplication in genome evolution
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Trends Genet 19:593-7. 2003
  10. ncbi request reprint Selection for short introns in highly expressed genes
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Genet 31:415-8. 2002
    ..Thus, natural selection appears to favor short introns in highly expressed genes to minimize the cost of transcription and other molecular processes, such as splicing...
  11. ncbi request reprint Genome evolution and developmental constraint in Caenorhabditis elegans
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Mol Biol Evol 19:728-35. 2002
    ..Developmental constraint at the level of gene duplication may have important implications for macroevolutionary change...