Emanuela Castigli

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Molecular basis of common variable immunodeficiency
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Allergy Clin Immunol 117:740-6; quiz 747. 2006
  2. ncbi TACI, isotype switching, CVID and IgAD
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Department of Pediatrics, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Immunol Res 38:102-11. 2007
  3. ncbi TACI and BAFF-R mediate isotype switching in B cells
    Emanuela Castigli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:35-9. 2005
  4. ncbi Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:885-91. 2007
  5. ncbi TACI is mutant in common variable immunodeficiency and IgA deficiency
    Emanuela Castigli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:829-34. 2005
  6. ncbi Impaired IgA class switching in APRIL-deficient mice
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3903-8. 2004
  7. ncbi TACI mutation in common variable immunodeficiency and IgA deficiency
    Rima Rachid
    Division of Immunology, Children s Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 6:357-62. 2006
  8. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
  9. ncbi Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
    Emanuela Castigli
    Nat Genet 39:430-1. 2007
  10. ncbi Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    Micah J Benson
    Department of Microbiology and Immunology, Dartmouth Medical School, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 180:3655-9. 2008

Research Grants

  1. APRIL-TACI: Role in mucosal IgA and human IgA deficiency
    Emanuela Castigli; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. ncbi Molecular basis of common variable immunodeficiency
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Allergy Clin Immunol 117:740-6; quiz 747. 2006
    ..These results suggest that TACI mutations can lead to CVID and IgAD...
  2. ncbi TACI, isotype switching, CVID and IgAD
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Department of Pediatrics, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Immunol Res 38:102-11. 2007
    ..These results suggest that TACI mutations can lead to CVID...
  3. ncbi TACI and BAFF-R mediate isotype switching in B cells
    Emanuela Castigli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:35-9. 2005
    ..The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching...
  4. ncbi Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:885-91. 2007
    ....
  5. ncbi TACI is mutant in common variable immunodeficiency and IgA deficiency
    Emanuela Castigli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:829-34. 2005
    ..These results suggest that TACI mutations can result in CVID and IgAD...
  6. ncbi Impaired IgA class switching in APRIL-deficient mice
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3903-8. 2004
    ..APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching...
  7. ncbi TACI mutation in common variable immunodeficiency and IgA deficiency
    Rima Rachid
    Division of Immunology, Children s Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 6:357-62. 2006
    ....
  8. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
    ..These results suggest that binding to TRAF2 and/or TRAF3 but not TRAF6 is essential for CD40 isotype switching and activation in B cells...
  9. ncbi Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
    Emanuela Castigli
    Nat Genet 39:430-1. 2007
  10. ncbi Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    Micah J Benson
    Department of Microbiology and Immunology, Dartmouth Medical School, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 180:3655-9. 2008
    ..These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity...

Research Grants1

  1. APRIL-TACI: Role in mucosal IgA and human IgA deficiency
    Emanuela Castigli; Fiscal Year: 2006
    ..Identification of genes mutated in IgA deficient patients is critical for devising therapies that boost their IgA antibody response. ..