M C Carroll

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Linkages of innate and adaptive immunity
    M C Carroll
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Immunol 10:36-40. 1998
  2. ncbi request reprint The role of complement and complement receptors in induction and regulation of immunity
    M C Carroll
    Department of Pathology, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 16:545-68. 1998
  3. ncbi request reprint Complement and the immune response
    M C Carroll
    Department of Pathology, Harvard Medical School, Building D 2, Room 533, 200 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 9:64-9. 1997
  4. ncbi request reprint The role of complement in inflammation and adaptive immunity
    R Barrington
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunol Rev 180:5-15. 2001
  5. ncbi request reprint A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation
    J L Gommerman
    Department of Pathology, Center for Blood Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:6915-21. 2000
  6. ncbi request reprint Regulation of the B cell response to T-dependent antigens by classical pathway complement
    M B Fischer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:549-56. 1996
  7. ncbi request reprint Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18)
    J Yan
    Division of Experimental Immunology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 163:3045-52. 1999
  8. ncbi request reprint Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement
    M B Fischer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:976-82. 1997
  9. ncbi request reprint A critical role for complement in maintenance of self-tolerance
    A P Prodeus
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 9:721-31. 1998
  10. ncbi request reprint Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria
    M J Hebert
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Nephrol Dial Transplant 13:2799-803. 1998

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Linkages of innate and adaptive immunity
    M C Carroll
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Immunol 10:36-40. 1998
    ....
  2. ncbi request reprint The role of complement and complement receptors in induction and regulation of immunity
    M C Carroll
    Department of Pathology, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 16:545-68. 1998
    ....
  3. ncbi request reprint Complement and the immune response
    M C Carroll
    Department of Pathology, Harvard Medical School, Building D 2, Room 533, 200 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 9:64-9. 1997
    ..At least one important requirement for the enhancing effect was determined to be expression of the CD21 (C3d receptor) on B cells...
  4. ncbi request reprint The role of complement in inflammation and adaptive immunity
    R Barrington
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunol Rev 180:5-15. 2001
    ..Significantly, the lymphocytes that produce natural antibody, the B-1 lymphocytes, are regulated in part by the complement system...
  5. ncbi request reprint A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation
    J L Gommerman
    Department of Pathology, Center for Blood Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:6915-21. 2000
    ..Taken together, these findings suggest that the engagement of complement receptors CD21/CD35 along with CD19 on the mast cell surface by C3 fragments may be necessary for the full expression of mast cell activation in the CLP model...
  6. ncbi request reprint Regulation of the B cell response to T-dependent antigens by classical pathway complement
    M B Fischer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:549-56. 1996
    ..e., C3b and C3d to the Ag-Ab complex, increases its immunogenicity...
  7. ncbi request reprint Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18)
    J Yan
    Division of Experimental Immunology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 163:3045-52. 1999
    ..Therapy fails when tumors lack iC3b, but can be restored by tumor-specific Abs that deposit iC3b onto the tumors...
  8. ncbi request reprint Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement
    M B Fischer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:976-82. 1997
    ..Replacement of C1 INH rescued the endotoxin-challenged complement-deficient mice from shock and death. These findings suggest a novel therapy for treatment of endotoxemia with C1 INH protein...
  9. ncbi request reprint A critical role for complement in maintenance of self-tolerance
    A P Prodeus
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 9:721-31. 1998
    ..These findings suggest a novel role for the complement system in B cell tolerance and provide insight into the genetic association of complement deficiency with susceptibility to systemic lupus erythematosus...
  10. ncbi request reprint Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria
    M J Hebert
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Nephrol Dial Transplant 13:2799-803. 1998
    ..To further address the role of this mediator system, we evaluated the influence of absolute deficiency of C3 and C4 on acute nephrotoxic serum nephritis (NSN)...
  11. ncbi request reprint The role of complement and natural antibody in intestinal ischemia-reperfusion injury
    W G Austen
    Department of Surgery and Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Int J Immunopathol Pharmacol 16:1-8. 2003
    ..It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury...
  12. ncbi request reprint Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice
    M B Fischer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 160:2619-25. 1998
    ..Furthermore, local C3 synthesis by donor macrophages reversed the impaired Ag trapping by splenic follicular dendritic cells in C3-deficient mice...
  13. ncbi request reprint Impaired mast cell-dependent natural immunity in complement C3-deficient mice
    A P Prodeus
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 390:172-5. 1997
    ..These results provide formal evidence that complement activation is essential for the full expression of innate immunity in this mast cell-dependent model of bacterial infection...
  14. pmc The route of antigen entry determines the requirement for L-selectin during immune responses
    M D Catalina
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    J Exp Med 184:2341-51. 1996
    ....
  15. ncbi request reprint Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection
    A Verschoor
    Department of Pathology, Harvard Medical School The Center for Blood Research, Boston, MA 02115, USA
    J Immunol 167:2446-51. 2001
    ..Using these chimeric mice, extrahepatic C3 was determined sufficient to initiate specific Ab and memory responses to a peripheral HSV-1 infection...
  16. pmc A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis
    T Tang
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 186:1853-63. 1997
    ..Since Mac-1 on PMNs is the principal ligand for ic3b, an absence of Mac-1 interaction with C3 probably contributed to the abrogation of proteinuria in Mac-1-null mice...
  17. ncbi request reprint Intestinal reperfusion injury is mediated by IgM and complement
    J P Williams
    Department of Surgery, Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Appl Physiol 86:938-42. 1999
    ..We conclude that intestinal ischemia-reperfusion injury is dependent on the classic complement pathway and IgM...
  18. ncbi request reprint Endotoxin shock in antibody-deficient mice: unraveling the role of natural antibody and complement in the clearance of lipopolysaccharide
    R R Reid
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:970-5. 1997
    ..Taken together, these studies demonstrate the important role of natural Ab and complement in the clearance of pathogenic substances from the circulation...
  19. ncbi request reprint Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
    J M Ahearn
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 4:251-62. 1996
    ..These results indicate an obligatory role of B cell complement receptors in responses of the B cells to protein antigens...