James M Carothers

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Chemical synthesis using synthetic biology
    James M Carothers
    California Institute for Quantitative Biosciences and Berkeley Center for Synthetic Biology, University of California, Berkeley, CA 94720, USA
    Curr Opin Biotechnol 20:498-503. 2009
  2. doi request reprint Model-driven engineering of RNA devices to quantitatively program gene expression
    James M Carothers
    California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA
    Science 334:1716-9. 2011
  3. doi request reprint Dual-selection for evolution of in vivo functional aptazymes as riboswitch parts
    Jonathan A Goler
    University of California, Berkeley, CA, USA
    Methods Mol Biol 1111:221-35. 2014
  4. doi request reprint Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    Fuzhong Zhang
    Joint BioEnergy Institute, Emeryville, California, USA
    Nat Biotechnol 30:354-9. 2012
  5. pmc Selecting RNA aptamers for synthetic biology: investigating magnesium dependence and predicting binding affinity
    James M Carothers
    California Institute for Quantitative Biosciences and Berkeley Center for Synthetic Biology, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 38:2736-47. 2010

Collaborators

  • Jonathan A Goler
  • Jay D Keasling
  • Fuzhong Zhang

Detail Information

Publications5

  1. ncbi request reprint Chemical synthesis using synthetic biology
    James M Carothers
    California Institute for Quantitative Biosciences and Berkeley Center for Synthetic Biology, University of California, Berkeley, CA 94720, USA
    Curr Opin Biotechnol 20:498-503. 2009
    ..We highlight research that reduces reliance upon natural biological components and point to future work that may enable more rational design and assembly of synthetic biological systems for synthetic chemistry...
  2. doi request reprint Model-driven engineering of RNA devices to quantitatively program gene expression
    James M Carothers
    California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA
    Science 334:1716-9. 2011
    ..More broadly, we provide a framework for studying RNA functions and illustrate the potential for the use of biochemical and biophysical modeling to develop biological design methods...
  3. doi request reprint Dual-selection for evolution of in vivo functional aptazymes as riboswitch parts
    Jonathan A Goler
    University of California, Berkeley, CA, USA
    Methods Mol Biol 1111:221-35. 2014
    ..Because this method uses selection, it does not rely on sequence-specific design and thus should be generalizable for the generation of in vivo operational aptazymes that respond to any targeted molecules. ..
  4. doi request reprint Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    Fuzhong Zhang
    Joint BioEnergy Institute, Emeryville, California, USA
    Nat Biotechnol 30:354-9. 2012
    ..Given the large number of natural sensors available, this DSRS strategy can be extended to many other biosynthetic pathways to balance metabolism, thereby increasing product titers and conversion yields and stabilizing production hosts...
  5. pmc Selecting RNA aptamers for synthetic biology: investigating magnesium dependence and predicting binding affinity
    James M Carothers
    California Institute for Quantitative Biosciences and Berkeley Center for Synthetic Biology, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 38:2736-47. 2010
    ..We suggest that it may be possible to estimate aptamer-ligand affinities and predict whether a particular aptamer-based design goal is achievable before performing the selection...