WILLIAM CARLEZON

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
    Thomas A Munro
    McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    BMC Pharmacol 12:5. 2012
  2. ncbi request reprint Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1
    W A Carlezon
    Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 20:RC62. 2000
  3. ncbi request reprint Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 47:47-60. 2004
  4. ncbi request reprint Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 57:343-50. 2005
  5. ncbi request reprint The many faces of CREB
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
    Trends Neurosci 28:436-45. 2005
  6. ncbi request reprint Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
    William A Carlezon
    Dept of Psychiatry, Harvard Medical School, and McLean Hospital, MRC 217, 115 Mill Street, Belmont MA 02478, USA
    Trends Neurosci 25:610-5. 2002
  7. ncbi request reprint Behavioral interactions caused by combined administration of morphine and MK-801 in rats
    W A Carlezon
    Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 151:261-72. 2000
  8. ncbi request reprint Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 57:571-6. 2005
  9. ncbi request reprint Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 62:687-93. 2007
  10. ncbi request reprint Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 87:107-18. 2003

Research Grants

Detail Information

Publications79

  1. pmc Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
    Thomas A Munro
    McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    BMC Pharmacol 12:5. 2012
    ..Recent evidence suggests, instead, that they induce prolonged desensitization of the κ opioid receptor...
  2. ncbi request reprint Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1
    W A Carlezon
    Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 20:RC62. 2000
    ..These results suggest that distinct substrates within the VTA itself differentially contribute to the rewarding and aversive properties of opiates...
  3. ncbi request reprint Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 47:47-60. 2004
    ..It may also identify periods of development during which administration of these agents is particularly safe or risky...
  4. ncbi request reprint Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 57:343-50. 2005
    ..We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine...
  5. ncbi request reprint The many faces of CREB
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
    Trends Neurosci 28:436-45. 2005
    ....
  6. ncbi request reprint Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
    William A Carlezon
    Dept of Psychiatry, Harvard Medical School, and McLean Hospital, MRC 217, 115 Mill Street, Belmont MA 02478, USA
    Trends Neurosci 25:610-5. 2002
    ..However, there is ongoing debate over whether elevated levels of GluR1 in the VTA are a primary cause, or secondary effect, of the neurobiological underpinnings of sensitization...
  7. ncbi request reprint Behavioral interactions caused by combined administration of morphine and MK-801 in rats
    W A Carlezon
    Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 151:261-72. 2000
    ..However, evidence in the existing literature suggests that some of MK-801's effects are additive (or synergistic) with those of morphine...
  8. ncbi request reprint Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 57:571-6. 2005
    ..We examined whether a low-energy component of EP-MRSI (low-field magnetic stimulation [LFMS]) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats...
  9. ncbi request reprint Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 62:687-93. 2007
    ..The five-choice serial reaction time task (5CSRTT) is one such model. Here, we characterized the effects of four standard psychotropic agents on performance in the 5CSRTT...
  10. ncbi request reprint Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 87:107-18. 2003
    ..Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal...
  11. ncbi request reprint Altered responsiveness to cocaine in rats exposed to methylphenidate during development
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Nat Neurosci 5:13-4. 2002
    ..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine...
  12. ncbi request reprint LTP in the lateral amygdala during cocaine withdrawal
    Ivan Goussakov
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Eur J Neurosci 23:239-50. 2006
    ..As such, they raise the possibility that the development and maintenance of addictive behaviours may involve, at least in part, mechanisms of synaptic plasticity within specific amygdala circuits...
  13. ncbi request reprint Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats
    Mark S Todtenkopf
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, MRC 217, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 172:463-70. 2004
    ..Furthermore, each effect appears due to increases in CREB-mediated expression of dynorphin, since each is attenuated by intracranial injections of the kappa-opioid receptor antagonist norBNI...
  14. ncbi request reprint Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences
    Rachael M Youngs
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6031-9. 2006
    ..Our results indicate that Li administration to the normal brain has the potential for lasting adverse effects...
  15. pmc Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory
    Anita J Bechtholt-Gompf
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2049-59. 2010
    ..These finding may have implications for the etiology of depression and other disorders that share the features of anhedonia and cognitive impairment...
  16. ncbi request reprint Enduring behavioral effects of early exposure to methylphenidate in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:1330-7. 2003
    ..Stimulant drugs can cause enduring behavioral adaptations, including altered drug sensitivity, in laboratory animals. We examined how early developmental exposure to stimulants affects behavior in several rodent models...
  17. ncbi request reprint Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1003:368-71. 2003
  18. pmc Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 34:2143-55. 2009
    ..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders...
  19. pmc Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior
    Gail Pereira Do Carmo
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Pain 144:170-7. 2009
    ..Both lactic acid and morphine were equipotent in the stretching and ICSS procedures. These results suggest that ICSS may be useful as a behavioral baseline for studies of pain-depressed behavior...
  20. pmc Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult mice
    C J Malanga
    Laboratory of Molecular and Developmental Neuroscience, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 63:214-21. 2008
    ..Animal models of prenatal cocaine exposure have yielded differing results depending on the behavioral method used to assess drug potency...
  21. ncbi request reprint Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell
    Mark S Todtenkopf
    Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:11665-9. 2006
    ..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior...
  22. pmc Dynorphin, stress, and depression
    Allison T Knoll
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res 1314:56-73. 2010
    ....
  23. pmc Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats
    Perry F Renshaw
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 92:88-92. 2009
    ..Altered cholesterol levels can affect serotonergic neurotransmission, which might be involved in the clinical efficacy of standard antidepressants...
  24. pmc Activation of raphe efferents to the medial prefrontal cortex by corticotropin-releasing factor: correlation with anxiety-like behavior
    Edward G Meloni
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 63:832-9. 2008
    ....
  25. ncbi request reprint Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Nat Protoc 2:2987-95. 2007
    ....
  26. pmc Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers
    Thomas A Munro
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 16:1279-86. 2008
    ..These protecting groups may prove useful in related work not only by enabling the use of harsher synthetic conditions, but potentially by optimizing the potency of the products...
  27. ncbi request reprint N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy
    Cecile Beguin
    Department of Psychiatry, McLean Hospital, MRC 322A, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 324:188-95. 2008
    ....
  28. ncbi request reprint Antidepressant effect of stem cell-derived monoaminergic grafts
    Miles G Cunningham
    Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Neuroreport 18:1663-7. 2007
    ..These results suggest that transplantation of customized stem cells might perhaps be useful in the study treatment of psychiatric disorders...
  29. pmc Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 001, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 56:788-97. 2009
    ....
  30. ncbi request reprint Extreme chipping: addiction to a high-fat diet?
    William A Carlezon
    Behavioral Genetics Laboratory, McLean Hospital, 115 Mill Street, Belmont MA 02478, USA
    Biol Psychiatry 61:1019-20. 2007
  31. pmc Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice
    Kiersten S Smith
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 213:697-706. 2011
    ..Recent surges in the diagnosis of posttraumatic stress disorder (PTSD) from combat-exposed veterans have prompted an urgent need to understand the pathophysiology underlying this debilitating condition...
  32. pmc Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction
    Karyn M Myers
    Behavioral Genetics Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 35:285-302. 2010
    ..Using the fear extinction literature as a template, it is possible to organize the observations on drug cue extinction into a cohesive framework...
  33. pmc The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward
    Hilarie C Tomasiewicz
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 64:982-8. 2008
    ....
  34. ncbi request reprint Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Methods Mol Med 79:331-50. 2003
  35. pmc Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in rats
    Miles Gregory Cunningham
    Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Behav Brain Res 205:146-53. 2009
    ..Our results raise the possibility that distinct components of emotion can be modulated by strategic neural engraftment...
  36. doi request reprint Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice
    Carolin J Straub
    Laboratory of Genetic Neuropharmacology, McLean Hospital, and Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Behav Brain Res 206:17-20. 2010
    ..Interestingly, the maximum decrease in ICSS thresholds was comparable for both drugs, suggesting a similar ability to affect reward and motivation despite different effects on brain reward systems...
  37. pmc Kappa-opioid ligands in the study and treatment of mood disorders
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Ther 123:334-43. 2009
    ..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications...
  38. pmc Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 204:227-39. 2009
    ..These data suggest that D1 receptors acquire the ability to regulate reward and withdrawal in morphine-dependent rats. The brain regions involved in these effects are not known...
  39. pmc Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor
    Cecile Beguin
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 17:1370-80. 2009
    ..Finally, substitution of oxadiazoles for the furan ring abolished affinity for the KOPR. None of the compounds displayed any KOPR antagonism or any affinity for mu or delta opioid receptors...
  40. pmc Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue
    Elena H Chartoff
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Mol Pharmacol 75:704-12. 2009
    ....
  41. doi request reprint D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats
    Karyn M Myers
    Behavioral Genetics Laboratory, McLean Hospital, and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 67:85-7. 2010
    ..We examined conditioned withdrawal extinction using naloxone-induced conditioned place aversion (CPA) in morphine-dependent rats...
  42. pmc Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 56:122-32. 2009
    ..g., mood disorders) associated with dysregulation of brain motivation systems...
  43. pmc Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats
    Elena H Chartoff
    Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:2676-87. 2008
    ..These findings suggest that SalvA regulates the stimulant effects of cocaine through interactions with D1 receptor-mediated signaling in the dorsal striatum...
  44. ncbi request reprint Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence
    Yolanda D Black
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:9656-65. 2006
    ..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased...
  45. ncbi request reprint Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats
    William A Carlezon
    Department of Psychiatry, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478
    J Pharmacol Exp Ther 316:440-7. 2006
    ....
  46. ncbi request reprint Corticotropin-releasing factor from the rat brain measured by protein immunoblot
    Edward G Meloni
    Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill St Belmont, MA 02478, USA
    Peptides 26:2252-6. 2005
    ..These data provide a positive validation for the use of the immunoblot assay to detect treatment-induced changes in brain CRF levels...
  47. ncbi request reprint Use of herpes virus amplicon vectors to study brain disorders
    Rachael L Neve
    Harvard Medical School, MA, USA
    Biotechniques 39:381-91. 2005
    ..The HSV amplicon virus is a user-friendly vector for the delivery of genes into neurons that has come of age for the study of brain function...
  48. ncbi request reprint Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice
    Brian Gilliss
    Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 163:238-48. 2002
    ..It is not known if SKF-82958 reduces drug-seeking behaviors in animals exposed previously to cocaine by causing reward-like effects or withdrawal-like aversive effects...
  49. ncbi request reprint Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders
    David Borsook
    PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States
    Eur J Pain 11:7-20. 2007
    ..These underlying features have implications for understanding the neurobiology of functional illnesses such as depression and anxiety and for the development and evaluation of novel therapeutic interventions...
  50. ncbi request reprint Contribution of drug doses and conditioning periods to psychomotor stimulant sensitization
    Mark S Todtenkopf
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 185:451-8. 2006
    ..Sensitization to the stimulant effects of these drugs might contribute to the development and maintenance of addictive behaviors (e.g. compulsive drug use)...
  51. ncbi request reprint Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat
    Edward G Meloni
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:3855-63. 2006
    ..These data also suggest that compounds with D1 receptor antagonist properties might have anxiolytic-like effects that could be useful for treating conditions associated with hyperactive CRF systems...
  52. ncbi request reprint Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6450-7. 2006
    ..Regardless, these findings suggest for the first time that D1 agonists might be useful for the treatment of withdrawal symptoms that contribute to the maintenance of opiate addiction in humans...
  53. ncbi request reprint Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18)
    Cecile Beguin
    Molecular Pharmacology Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem Lett 16:4679-85. 2006
    ..Our preliminary SAR study at C(18) suggested that this part of the molecule interacts with a tight lipophilic pocket of the kappa-receptor...
  54. ncbi request reprint Place conditioning to study drug reward and aversion
    William A Carlezon
    Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Methods Mol Med 84:243-9. 2003
  55. ncbi request reprint Role of the bed nucleus of the stria terminalis (BST) in the expression of conditioned fear
    Edward G Meloni
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1071:538-41. 2006
    ..The data suggest that the BST plays a role in the expression of conditioned fear and that GABA-mediated inhibition at this level may influence the level of this expression...
  56. pmc Glutamate receptors in extinction and extinction-based therapies for psychiatric illness
    Karyn M Myers
    Behavioral Genetics Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:274-93. 2011
    ..We then discuss how these findings have been applied in clinical research...
  57. ncbi request reprint Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats
    Allison T Knoll
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 323:838-45. 2007
    ....
  58. ncbi request reprint Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats
    Stephen D Mague
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 305:323-30. 2003
    ..Furthermore, they raise the possibility that kappa-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects...
  59. ncbi request reprint Antidepressant-like effects of cytidine in the forced swim test in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 51:882-9. 2002
    ..Because antidepressants can reduce cocaine craving, we explored in rats the possibility that citicoline has antidepressant effects. We also tested the primary metabolites of citicoline, cytidine and choline...
  60. ncbi request reprint Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences
    Elena H Chartoff
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 59:1236-9. 2006
    ..Here we examined if Ca2+ influx via L-type Ca2+ channels within the NASh would influence cocaine reward...
  61. ncbi request reprint Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats
    Stephen D Mague
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 57:120-5. 2005
    ..Here we examined if early MPH exposure alters the ability of cocaine to potentiate the rewarding effects of electrical stimulation of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS)...
  62. ncbi request reprint Behavioral effects of short-term administration of lithium and valproic acid in rats
    Hilarie C Tomasiewicz
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217 115 Mill St, Belmont, MA 02478, USA
    Brain Res 1093:83-94. 2006
    ....
  63. pmc Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens
    Jennifer A DiNieri
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 29:1855-9. 2009
    ..Together with previous findings, these studies raise the possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria...
  64. pmc Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats
    Christina L Nemeth
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 210:263-74. 2010
    ..One way to study these states in rodents is with tests that require attention and visual perception for correct performance...
  65. ncbi request reprint Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala
    Evgeny Tsvetkov
    McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuron 34:289-300. 2002
    ....
  66. ncbi request reprint Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats
    Dost Ongur
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:505-12. 2007
    ..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation...
  67. ncbi request reprint Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues
    David Y W Lee
    Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Bioorg Med Chem Lett 15:4169-73. 2005
    ..These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human kappa-opioid receptor and several potent new agonists have been identified...
  68. ncbi request reprint Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine
    John F Neumaier
    Department of Psychiatry and Behavioral Sciences and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:10856-63. 2002
    ....
  69. ncbi request reprint The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
    ....
  70. ncbi request reprint Can't get enough of that dopamine
    Bruce M Cohen
    Am J Psychiatry 164:543-6. 2007
  71. ncbi request reprint Unmet expectations: the brain minds
    William A Carlezon
    Nat Med 9:15-6. 2003
  72. ncbi request reprint Prior experience with bromocriptine in the home cage attenuates locomotor sensitization in rats
    John E Kelsey
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Brain Res 134:1-8. 2002
    ..These data are consistent with other data indicating that repeated injections of drugs in the home cage often fail to produce the locomotor sensitization that is observed when these injections occur in novel cages...
  73. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
    ..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...
  74. ncbi request reprint Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)
    Cecile Beguin
    Molecular Pharmacology Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem Lett 15:2761-5. 2005
    ..Compound 10, containing an N-methyl carbamate at C(2), showed partial agonist activity with 81% efficacy when compared with the full agonist U50,488H. No antagonist ligands were observed...
  75. ncbi request reprint Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues
    David Y W Lee
    Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Bioorg Med Chem Lett 15:3744-7. 2005
    ..Compound 4, containing a methoxymethyl group at the 2-position, was a full kappa-agonist with an EC50 value at 0.6 nM, which is about 7 times more potent than salvinorin A...
  76. ncbi request reprint New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors
    David Y W Lee
    Bio Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Bioorg Med Chem 13:5635-9. 2005
    ..All these compounds were evaluated for their binding affinities to the human kappa opioid receptors. In comparison with divinatorin D (1), divinatorin E (2), and salvinorin G (3), salvinorin A (6) is still the most potent kappa agonist...
  77. ncbi request reprint Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders
    Antonello Bonci
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, CA 94110, USA
    Pharmacol Ther 108:65-75. 2005
    ....
  78. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    ..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...
  79. ncbi request reprint Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues
    David Y W Lee
    Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Bioorg Med Chem Lett 16:5498-502. 2006
    ..These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human kappa-opioid receptor and several new full agonists have been identified...

Research Grants21

  1. A Simple Behavioral Model of Cocaine Withdrawal in Rats
    WILLIAM CARLEZON; Fiscal Year: 2002
    ..Together, these studies may facilitate the identification and development of innovative treatments that more effectively treat the symptoms of withdrawal from cocaine and other drugs of abuse. ..
  2. Roles of Nucleus Accumbens CREB and Kappa Function in Depression
    WILLIAM CARLEZON; Fiscal Year: 2007
    ....
  3. BIOBEHAVIORAL MECHANISMS OF DRUG REWARD AND ADDICTION
    WILLIAM CARLEZON; Fiscal Year: 2009
    ..Understanding mechanistic links between cocaine-induced adaptations in gene expression and adaptations in behavior may facilitate the development of novel treatments for cocaine addiction and craving. ..
  4. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2005
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  5. Roles of Nucleus Accumbens CREB and Kappa Function in Depression
    William A Carlezon; Fiscal Year: 2010
    ....