Research Topics
| William A CarlezonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawalElena H Chartoff
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:6450-7. 2006..Regardless, these findings suggest for the first time that D1 agonists might be useful for the treatment of withdrawal symptoms that contribute to the maintenance of opiate addiction in humans...
Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J miceKiersten S Smith
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 213:697-706. 2011..Recent surges in the diagnosis of posttraumatic stress disorder (PTSD) from combat-exposed veterans have prompted an urgent need to understand the pathophysiology underlying this debilitating condition...- Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in ratsWilliam A Carlezon
Department of Psychiatry, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478
J Pharmacol Exp Ther 316:440-7. 2006.... - Biological substrates of reward and aversion: a nucleus accumbens activity hypothesisWilliam A Carlezon
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 56:122-32. 2009..g., mood disorders) associated with dysregulation of brain motivation systems... - Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivationWilliam A Carlezon
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Nat Protoc 2:2987-95. 2007.... - Kappa-opioid ligands in the study and treatment of mood disordersWilliam A Carlezon
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Pharmacol Ther 123:334-43. 2009..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications... - Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedoniaCatherine S John
Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA, USA
Neuropsychopharmacology 37:2467-75. 2012..Overall, these results suggest that blockade of astrocytic glutamate uptake in the PFC is sufficient to produce anhedonia, a core symptom of depression... - Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in ratsAllison T Knoll
Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Biol Psychiatry 70:425-33. 2011..Here, we sought to identify neural circuits that mediate KOR system effects on fear and anxiety in rats... - N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacyCecile Beguin
Department of Psychiatry, McLean Hospital, MRC 322A, 115 Mill Street, Belmont, MA 02478, USA
J Pharmacol Exp Ther 324:188-95. 2008.... - Brain reward regulated by AMPA receptor subunits in nucleus accumbens shellMark S Todtenkopf
Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:11665-9. 2006..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior... - Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent ratsElena H Chartoff
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 204:227-39. 2009..These data suggest that D1 receptors acquire the ability to regulate reward and withdrawal in morphine-dependent rats. The brain regions involved in these effects are not known... - The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation rewardHilarie C Tomasiewicz
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Biol Psychiatry 64:982-8. 2008.... - Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in ratsElena Chartoff
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 218, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 62:167-76. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'... - LTP in the lateral amygdala during cocaine withdrawalIvan Goussakov
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
Eur J Neurosci 23:239-50. 2006..As such, they raise the possibility that the development and maintenance of addictive behaviours may involve, at least in part, mechanisms of synaptic plasticity within specific amygdala circuits... - Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analoguesDavid Y W Lee
Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Bioorg Med Chem Lett 15:4169-73. 2005..These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human kappa-opioid receptor and several potent new agonists have been identified... - Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18)Cecile Beguin
Molecular Pharmacology Laboratory, McLean Hospital, Belmont, MA 02478, USA
Bioorg Med Chem Lett 16:4679-85. 2006..Our preliminary SAR study at C(18) suggested that this part of the molecule interacts with a tight lipophilic pocket of the kappa-receptor... - Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Biol Psychiatry 57:343-50. 2005..We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine... - Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
Biol Psychiatry 57:571-6. 2005..We examined whether a low-energy component of EP-MRSI (low-field magnetic stimulation [LFMS]) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats... - Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley ratsTracie A Paine
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Biol Psychiatry 62:687-93. 2007..The five-choice serial reaction time task (5CSRTT) is one such model. Here, we characterized the effects of four standard psychotropic agents on performance in the 5CSRTT... - Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memoryAnita J Bechtholt-Gompf
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 35:2049-59. 2010..These finding may have implications for the etiology of depression and other disorders that share the features of anhedonia and cognitive impairment... - Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation rewardLauren M Reynolds
Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA
Neuropsychopharmacology 37:2531-40. 2012..This finding has important implications for the development of new medications that retain the therapeutic effects of benzodiazepines but lack abuse liability... - Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicityThomas A Munro
McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
BMC Pharmacol 12:5. 2012..Recent evidence suggests, instead, that they induce prolonged desensitization of the κ opioid receptor... - ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488John W Muschamp
Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Biol Psychiatry 71:44-50. 2012..This study examines how ΔFosB influences the responsiveness of the brain reward system to rewarding and aversive drugs... - Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivityDavid N Potter
Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 70:744-53. 2011..Acute KOR activation produces dysphoria that might contribute to addictive behavior. How repeated KOR activation modulates reward circuitry is not understood... - Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissueElena H Chartoff
Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Mol Pharmacol 75:704-12. 2009.... - Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethersThomas A Munro
Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
Bioorg Med Chem 16:1279-86. 2008..These protecting groups may prove useful in related work not only by enabling the use of harsher synthetic conditions, but potentially by optimizing the potency of the products... - Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analoguesDavid Y W Lee
Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Bioorg Med Chem Lett 16:5498-502. 2006..These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human kappa-opioid receptor and several new full agonists have been identified... - Enduring behavioral effects of early exposure to methylphenidate in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 54:1330-7. 2003..The effects of MPH on cocaine-related behaviors may be a general consequence of early stimulant exposure... - New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptorsDavid Y W Lee
Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Bioorg Med Chem 13:5635-9. 2005..All these compounds were evaluated for their binding affinities to the human kappa opioid receptors. In comparison with divinatorin D (1), divinatorin E (2), and salvinorin G (3), salvinorin A (6) is still the most potent kappa agonist... - Lovastatin potentiates the antidepressant efficacy of fluoxetine in ratsPerry F Renshaw
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Pharmacol Biochem Behav 92:88-92. 2009..Altered cholesterol levels can affect serotonergic neurotransmission, which might be involved in the clinical efficacy of standard antidepressants... - Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in ratsChristina L Nemeth
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Psychopharmacology (Berl) 210:263-74. 2010..One way to study these states in rodents is with tests that require attention and visual perception for correct performance... - Activation of raphe efferents to the medial prefrontal cortex by corticotropin-releasing factor: correlation with anxiety-like behaviorEdward G Meloni
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 63:832-9. 2008.... - Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in ratsMiles Gregory Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
Behav Brain Res 205:146-53. 2009..Our results raise the possibility that distinct components of emotion can be modulated by strategic neural engraftment... - Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of ratsTracie A Paine
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 34:2143-55. 2009..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders... - Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behaviorGail Pereira Do Carmo
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Pain 144:170-7. 2009..Both lactic acid and morphine were equipotent in the stretching and ICSS procedures. These results suggest that ICSS may be useful as a behavioral baseline for studies of pain-depressed behavior... - Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in ratsTracie A Paine
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 001, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 56:788-97. 2009.... - Altered responsiveness to cocaine in rats exposed to methylphenidate during developmentSusan L Andersen
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Nat Neurosci 5:13-4. 2002..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine... - Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in ratsJohn W Muschamp
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 31:3095-103. 2011..Although CREB activation is a common trigger, expression of these individual signs appears to involve divergent downstream mechanisms... - Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitroElena H Chartoff
Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 1003:368-71. 2003 - Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with moleculesWilliam A Carlezon
Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 47:47-60. 2004..It may also identify periods of development during which administration of these agents is particularly safe or risky... - Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbensJennifer A DiNieri
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 29:1855-9. 2009..Together with previous findings, these studies raise the possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria... 
Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J miceCarolin J Straub
Laboratory of Genetic Neuropharmacology, McLean Hospital, and Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Behav Brain Res 206:17-20. 2010..Interestingly, the maximum decrease in ICSS thresholds was comparable for both drugs, suggesting a similar ability to affect reward and motivation despite different effects on brain reward systems...- Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequencesRachael M Youngs
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:6031-9. 2006..Our results indicate that Li administration to the normal brain has the potential for lasting adverse effects... - Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the ratEdward G Meloni
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:3855-63. 2006..These data also suggest that compounds with D1 receptor antagonist properties might have anxiolytic-like effects that could be useful for treating conditions associated with hyperactive CRF systems... - Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptorCecile Beguin
Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
Bioorg Med Chem 17:1370-80. 2009..Finally, substitution of oxadiazoles for the furan ring abolished affinity for the KOPR. None of the compounds displayed any KOPR antagonism or any affinity for mu or delta opioid receptors... - Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdalaJun Hyeong Cho
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
Nat Neurosci 15:113-22. 2012..ITDP in the auditory projections to the LAn, determined by characteristics of presynaptic activity patterns, may contribute to the encoding of the complex CSa... - Effects of kappa-opioid receptor ligands on intracranial self-stimulation in ratsMark S Todtenkopf
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, MRC 217, Belmont, MA 02478, USA
Psychopharmacology (Berl) 172:463-70. 2004.... - Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in ratsStephen D Mague
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 57:120-5. 2005..Reduced sensitivity to these various types of reward may reflect general dysfunctions of brain reward systems... - Extreme chipping: addiction to a high-fat diet?William A Carlezon
Behavioral Genetics Laboratory, McLean Hospital, 115 Mill Street, Belmont MA 02478, USA
Biol Psychiatry 61:1019-20. 2007 - Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in ratsElena H Chartoff
Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 33:2676-87. 2008..These findings suggest that SalvA regulates the stimulant effects of cocaine through interactions with D1 receptor-mediated signaling in the dorsal striatum... - Behavioral effects of short-term administration of lithium and valproic acid in ratsHilarie C Tomasiewicz
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217 115 Mill St, Belmont, MA 02478, USA
Brain Res 1093:83-94. 2006.... - D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent ratsKaryn M Myers
Behavioral Genetics Laboratory, McLean Hospital, and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
Biol Psychiatry 67:85-7. 2010..We examined conditioned withdrawal extinction using naloxone-induced conditioned place aversion (CPA) in morphine-dependent rats... - Dynorphin, stress, and depressionAllison T Knoll
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
Brain Res 1314:56-73. 2010.... - Role of the bed nucleus of the stria terminalis (BST) in the expression of conditioned fearEdward G Meloni
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 1071:538-41. 2006..The data suggest that the BST plays a role in the expression of conditioned fear and that GABA-mediated inhibition at this level may influence the level of this expression... - Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuitJun Hyeong Cho
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Neurosci 32:14165-77. 2012..Thus, PACAP may upregulate excitatory neurotransmission in the BLA-CeL pathway postsynaptically, consistent with the known roles of PACAP in control of fear-related behaviors... - Extinction of conditioned opiate withdrawal in rats in a two-chambered place conditioning apparatusKaryn M Myers
Behavioral Genetics Laboratory, McLean Hospital, Belmont, Massachusetts, USA
Nat Protoc 7:517-26. 2012..The protocol takes a minimum of 7 d; the exact duration varies with the amount of extinction training, which is determined by the goals of the experiment... - Antidepressant effect of stem cell-derived monoaminergic graftsMiles G Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Neuroreport 18:1663-7. 2007..These results suggest that transplantation of customized stem cells might perhaps be useful in the study treatment of psychiatric disorders... - Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatumElena H Chartoff
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
J Neurochem 87:107-18. 2003..Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal... - CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacyAnita J Bechtholt-Gompf
Department of Psychiatry, Harvard Medical School McLean Hospital, 115 Mill Street, MRC 215, Belmont, MA 02478, USA
Psychopharmacology (Berl) 215:689-95. 2011..In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited... - Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analoguesDavid Y W Lee
Bioorganic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Bioorg Med Chem Lett 15:3744-7. 2005..Compound 4, containing a methoxymethyl group at the 2-position, was a full kappa-agonist with an EC50 value at 0.6 nM, which is about 7 times more potent than salvinorin A... - Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in ratsAllison T Knoll
Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
J Pharmacol Exp Ther 323:838-45. 2007.... - The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in ratsGail Pereira Do Carmo
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, United States
Eur J Pharmacol 604:58-65. 2009..These results suggest that non-peptidic delta opioid receptor agonists have negligible abuse-related effects in rats... - Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in ratsStephen D Mague
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Pharmacol Exp Ther 305:323-30. 2003..Furthermore, they raise the possibility that kappa-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects... - Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)Cecile Beguin
Molecular Pharmacology Laboratory, McLean Hospital, Belmont, MA 02478, USA
Bioorg Med Chem Lett 15:2761-5. 2005..Compound 10, containing an N-methyl carbamate at C(2), showed partial agonist activity with 81% efficacy when compared with the full agonist U50,488H. No antagonist ligands were observed... - Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of ratsDost Ongur
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 62:505-12. 2007..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation... - Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescenceYolanda D Black
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:9656-65. 2006..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased... - Corticotropin-releasing factor from the rat brain measured by protein immunoblotEdward G Meloni
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill St Belmont, MA 02478, USA
Peptides 26:2252-6. 2005..These data provide a positive validation for the use of the immunoblot assay to detect treatment-induced changes in brain CRF levels... - Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferencesElena H Chartoff
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 59:1236-9. 2006..0-40 nmol/hemisphere). Microinjections into more dorsal regions had no effects. CONCLUSIONS: Blockade of Ca2+ influx through L-type channels Ca2+ within the ventral NASh increases cocaine reward... - Use of herpes virus amplicon vectors to study brain disordersRachael L Neve
Harvard Medical School, MA, USA
Biotechniques 39:381-91. 2005..The HSV amplicon virus is a user-friendly vector for the delivery of genes into neurons that has come of age for the study of brain function... - Antidepressant-like effects of cytidine in the forced swim test in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 51:882-9. 2002..At antidepressant doses, cytidine lacks stimulant and rewarding properties. This is the first report of potential antidepressant effects of cytidine... - The many faces of CREBWilliam A Carlezon
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
Trends Neurosci 28:436-45. 2005.... - Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA
Methods Mol Med 79:331-50. 2003 - Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?William A Carlezon
Dept of Psychiatry, Harvard Medical School, and McLean Hospital, MRC 217, 115 Mill Street, Belmont MA 02478, USA
Trends Neurosci 25:610-5. 2002..However, there is ongoing debate over whether elevated levels of GluR1 in the VTA are a primary cause, or secondary effect, of the neurobiological underpinnings of sensitization... - Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster miceBrian Gilliss
Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 163:238-48. 2002..The reward-facilitating effects of low doses of cocaine and SKF-82958 are additive (or synergistic). These data suggest that SKF-82958 may decrease cocaine-seeking behavior by mechanisms related to reward rather than aversion... - Reward-aversion circuitry in analgesia and pain: implications for psychiatric disordersDavid Borsook
PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States
Eur J Pain 11:7-20. 2007..These underlying features have implications for understanding the neurobiology of functional illnesses such as depression and anxiety and for the development and evaluation of novel therapeutic interventions... - Place conditioning to study drug reward and aversionWilliam A Carlezon
Behavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Methods Mol Med 84:243-9. 2003 - Glutamate receptors in extinction and extinction-based therapies for psychiatric illnessKaryn M Myers
Behavioral Genetics Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 36:274-93. 2011..We then discuss how these findings have been applied in clinical research... - Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addictionKaryn M Myers
Behavioral Genetics Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 35:285-302. 2010..Using the fear extinction literature as a template, it is possible to organize the observations on drug cue extinction into a cohesive framework... - Contribution of drug doses and conditioning periods to psychomotor stimulant sensitizationMark S Todtenkopf
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Psychopharmacology (Berl) 185:451-8. 2006..Sensitization to the stimulant effects of these drugs might contribute to the development and maintenance of addictive behaviors (e.g. compulsive drug use)... - Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdalaEvgeny Tsvetkov
McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuron 34:289-300. 2002.... - Unmet expectations: the brain mindsWilliam A Carlezon
Nat Med 9:15-6. 2003 - Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult miceC J Malanga
Laboratory of Molecular and Developmental Neuroscience, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 63:214-21. 2008..Animal models of prenatal cocaine exposure have yielded differing results depending on the behavioral method used to assess drug potency... - Can't get enough of that dopamineBruce M Cohen
Am J Psychiatry 164:543-6. 2007 - The mesolimbic dopamine reward circuit in depressionEric J Nestler
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Biol Psychiatry 59:1151-9. 2006.... - Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaineJohn F Neumaier
Department of Psychiatry and Behavioral Sciences and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA
J Neurosci 22:10856-63. 2002.... - Prior experience with bromocriptine in the home cage attenuates locomotor sensitization in ratsJohn E Kelsey
Department of Psychology, Concordia University, Montreal, Quebec, Canada
Behav Brain Res 134:1-8. 2002..These data are consistent with other data indicating that repeated injections of drugs in the home cage often fail to produce the locomotor sensitization that is observed when these injections occur in novel cages... - Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disordersAntonello Bonci
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, CA 94110, USA
Pharmacol Ther 108:65-75. 2005.... - CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addictionSubhash C Pandey
Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
Alcohol Clin Exp Res 29:176-84. 2005..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy... - Mania-like behavior induced by disruption of CLOCKKole Roybal
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 104:6406-11. 2007..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...