Martin Carey

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesis
    Meimin Xie
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Physiol 590:1811-24. 2012
  2. ncbi request reprint Epidemiology of the American Indians' burden and its likely genetic origins
    Martin C Carey
    Department of Medicine, Harvard Medical School and Digestive Diseases Center, Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hepatology 36:781-91. 2002
  3. ncbi request reprint Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis
    Frank Lammert
    Department of Medicine III, University Hospital Aachen and Aachen University, Aachen, Germany
    Hepatology 39:117-28. 2004
  4. ncbi request reprint Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:114-21. 2004
  5. pmc Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
    David Q H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 114:521-8. 2004
  6. ncbi request reprint Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
  7. ncbi request reprint Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006
  8. ncbi request reprint Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
    Henning Wittenburg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:495-504. 2005
  9. pmc Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Digestive Diseases Center, Boston, MA, USA
    Hepatology 45:998-1006. 2007
  10. pmc T-cell function is critical for murine cholesterol gallstone formation
    Kirk J Maurer
    Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
    Gastroenterology 133:1304-15. 2007

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesis
    Meimin Xie
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Physiol 590:1811-24. 2012
    ..Intestinal hypomotility promotes cholelithogenesis by augmenting formation of deoxycholate, a pro-lithogenic secondary bile salt, and increasing the fraction of intestinal cholesterol absorbed...
  2. ncbi request reprint Epidemiology of the American Indians' burden and its likely genetic origins
    Martin C Carey
    Department of Medicine, Harvard Medical School and Digestive Diseases Center, Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hepatology 36:781-91. 2002
    ....
  3. ncbi request reprint Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis
    Frank Lammert
    Department of Medicine III, University Hospital Aachen and Aachen University, Aachen, Germany
    Hepatology 39:117-28. 2004
    ..The mouse model supports the concept that this gene is a monogenic risk factor for cholesterol gallstones and a target for novel therapeutic strategies...
  4. ncbi request reprint Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:114-21. 2004
    ..Overall, we detected eight QTLs for lipoprotein cholesterol concentrations on Chrs 1, 9, 12, and 17 (each two per chromosome), including a new QTL for non-HDL cholesterol, Nhdlq3, on Chr 17...
  5. pmc Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
    David Q H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 114:521-8. 2004
    ....
  6. ncbi request reprint Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
    ..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
  7. ncbi request reprint Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006
    ..Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively...
  8. ncbi request reprint Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
    Henning Wittenburg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:495-504. 2005
    ..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/Abcg8 was responsible for lithogenicity underlying Lith9...
  9. pmc Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Digestive Diseases Center, Boston, MA, USA
    Hepatology 45:998-1006. 2007
    ..Moreover, the mutation has no influence on acute uptake of cholesterol and sitostanol by the enterocyte nor small intestinal transit time...
  10. pmc T-cell function is critical for murine cholesterol gallstone formation
    Kirk J Maurer
    Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
    Gastroenterology 133:1304-15. 2007
    ..Although gallbladder inflammation is believed to be common during cholelithogenesis, the role of immunologic factors is unknown...
  11. doi request reprint Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 7:125-34. 2008
    ..Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome...
  12. pmc Hepatic insulin resistance directly promotes formation of cholesterol gallstones
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nat Med 14:778-82. 2008
    ..As a result, after twelve weeks on a lithogenic diet, all of the LIRKO mice develop gallstones. Thus, hepatic insulin resistance provides a crucial link between the metabolic syndrome and increased cholesterol gallstone susceptibility...
  13. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:60-8. 2004
    ..Our analysis furthers the knowledge of the genetic control of lipoprotein levels and points to the importance of Hdlq10, which was detected repeatedly in multiple studies...
  14. ncbi request reprint FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Gastroenterology 125:868-81. 2003
    ..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice...
  15. ncbi request reprint New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice
    Malcolm A Lyons
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 14:225-39. 2003
    ..Our work continues to demonstrate the genetic complexity and to elucidate the pathophysiology of cholesterol gallstone formation. It should facilitate the development of new approaches for treating this common human disorder...
  16. ncbi request reprint Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk
    Guylaine Bouchard
    Department of Medicine, Harvard Medical School, Division of Gastroenterology, Brigham and Women s Hospital and Harvard Digestive Diseases Center, Boston, MA, USA
    J Lipid Res 43:1105-13. 2002
    ..Rather, specific genes and distinct pathophysiological pathways are responsible for the shared susceptibility to both of these common diseases...
  17. ncbi request reprint Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BI
    David Q H Wang
    Department of Medicine, Gastroenterology Division, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02115, USA
    Biochim Biophys Acta 1583:141-50. 2002
    ....
  18. pmc Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8
    Henning Wittenburg
    Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women s Hospital, and Harvard Digestive Diseases Center, Boston, Massachusetts 02115, USA
    J Clin Invest 110:605-9. 2002
  19. ncbi request reprint Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice
    Frank Lammert
    Department of Medicine III, University Hospital Aachen, Aachen University, Germany
    Hepatology 36:1145-54. 2002
    ..Characterization of the pathophysiologic roles of Lith3 and the new biliary mucin gene Glycam1 might provide insights into primary defects of human cholelithiasis and lead to new therapeutic strategies for prestone intervention...
  20. ncbi request reprint Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies
    David Q H Wang
    Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Lipid Res 44:1042-59. 2003
    ....
  21. ncbi request reprint Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice
    Henning Wittenburg
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 8:67-77. 2002
    ..According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5...
  22. ncbi request reprint Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:1763-71. 2003
    ....
  23. ncbi request reprint Hydrophilic but not hydrophobic bile acids prevent gallbladder muscle dysfunction in acute cholecystitis
    Zuo Liang Xiao
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI, USA
    Hepatology 37:1442-50. 2003
    ..In conclusion, oral treatment with UDCA prevents gallbladder muscle damage caused by BDL, whereas oral treatment with CDCA worsens the defective muscle contractility and the oxidative stress...
  24. ncbi request reprint Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse
    David Q H Wang
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 285:G494-502. 2003
    ..Natural alpha- and beta-muricholic acids are the most powerful inhibitors of cholesterol absorption in mice and might act as potent cholesterol-lowering agents for prevention of cholesterol deposition diseases in humans...
  25. ncbi request reprint QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Lipid Res 47:1780-90. 2006
    ....
  26. ncbi request reprint Interfacial properties of most monofluorinated bile acids deviate markedly from the natural congeners: studies with the Langmuir-Pockels surface balance
    John M Kauffman
    Department of Medicine, Harvard Medical School, Harvard Digestive Diseases Center, Brigham and Women s Hospital, Boston, MA, USA
    J Lipid Res 46:571-81. 2005
    ..These results provide a framework for designing F-modified bile acids to mimic or diverge from the natural compounds in vivo...
  27. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:953-67. 2003
    ....
  28. pmc Pathophysiological basis of liver disease in cystic fibrosis employing a DeltaF508 mouse model
    Folke Freudenberg
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1411-20. 2008
    ..This study of the earliest stages of CF liver disease provides a framework for investigating the molecular pathophysiology of more advanced disease in murine models and in humans with CF...
  29. ncbi request reprint Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers
    Erik R M Eckhardt
    Gastroenterology Division of Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 122:948-56. 2002
    ....
  30. ncbi request reprint Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:152-63. 2005
    ..The QTLs identified herein largely contributed to gallstone formation rather than gallstone severity. Cloning the genes underlying these murine QTLs should facilitate prediction and cloning of the orthologous human genes...

Research Grants20

  1. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    Martin Carey; Fiscal Year: 2003
    ..The systematic project should lead to new targets and strategies for prevention of pigment and cholesterol gallstone diseases as well as lipid transport abnormalities sin cholestasis. ..
  2. Phenotypic Determinants of Murine Cholelithiasis
    Martin Carey; Fiscal Year: 2004
    ..abstract_text> ..
  3. Molecular Pathogenesis of Cystic Fibrosis Liver Disease
    Martin Carey; Fiscal Year: 2007
    ....
  4. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    Martin Carey; Fiscal Year: 2007
    ..The results of these hypothesis-driven basic research aims will provide insights that correlate native and model systems and should be readily translatable to prevent and treat these common hepatobiliarv diseases in humans. ..
  5. PHENOTYPIC DETERMINANTS OF MURINE CHOLESTEROL GALLSTONES
    Martin Carey; Fiscal Year: 2000
    ..This work should pave the way for identifying the major Lith genes in humans, which, in turn, should lead to strategies for early diagnosis of the trait and rational approaches to prevention. ..