Research Topics
Species | Martin CareySummaryAffiliation: Harvard University Country: USA Publications
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Publications
Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesisMeimin Xie
Department of Medicine, Harvard Medical School, Boston, MA, USA
J Physiol 590:1811-24. 2012..Intestinal hypomotility promotes cholelithogenesis by augmenting formation of deoxycholate, a pro-lithogenic secondary bile salt, and increasing the fraction of intestinal cholesterol absorbed...
Epidemiology of the American Indians' burden and its likely genetic originsMartin C Carey
Department of Medicine, Harvard Medical School and Digestive Diseases Center, Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Hepatology 36:781-91. 2002....- Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasisFrank Lammert
Department of Medicine III, University Hospital Aachen and Aachen University, Aachen, Germany
Hepatology 39:117-28. 2004..The mouse model supports the concept that this gene is a monogenic risk factor for cholesterol gallstones and a target for novel therapeutic strategies... - Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred miceMalcolm A Lyons
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 17:114-21. 2004..Overall, we detected eight QTLs for lipoprotein cholesterol concentrations on Chrs 1, 9, 12, and 17 (each two per chromosome), including a new QTL for non-HDL cholesterol, Nhdlq3, on Chr 17... - Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasisDavid Q H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Clin Invest 114:521-8. 2004.... - Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formationKirk J Maurer
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Gastroenterology 128:1023-33. 2005..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model... - Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective studyKirk J Maurer
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006..Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively... - Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ miceHenning Wittenburg
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Mamm Genome 16:495-504. 2005..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/Abcg8 was responsible for lithogenicity underlying Lith9... - Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) miceHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Digestive Diseases Center, Boston, MA, USA
Hepatology 45:998-1006. 2007..Moreover, the mutation has no influence on acute uptake of cholesterol and sitostanol by the enterocyte nor small intestinal transit time... - T-cell function is critical for murine cholesterol gallstone formationKirk J Maurer
Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
Gastroenterology 133:1304-15. 2007..Although gallbladder inflammation is believed to be common during cholelithogenesis, the role of immunologic factors is unknown... 
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosisSudha B Biddinger
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Cell Metab 7:125-34. 2008..Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome...- Hepatic insulin resistance directly promotes formation of cholesterol gallstonesSudha B Biddinger
Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02215, USA
Nat Med 14:778-82. 2008..As a result, after twelve weeks on a lithogenic diet, all of the LIRKO mice develop gallstones. Thus, hepatic insulin resistance provides a crucial link between the metabolic syndrome and increased cholesterol gallstone susceptibility... - Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred miceMalcolm A Lyons
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 17:60-8. 2004..Our analysis furthers the knowledge of the genetic control of lipoprotein levels and points to the importance of Hdlq10, which was detected repeatedly in multiple studies... - FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in miceHenning Wittenburg
The Jackson Laboratory, Bar Harbor, Maine, USA
Gastroenterology 125:868-81. 2003..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice... - New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred miceMalcolm A Lyons
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 14:225-39. 2003..Our work continues to demonstrate the genetic complexity and to elucidate the pathophysiology of cholesterol gallstone formation. It should facilitate the development of new approaches for treating this common human disorder... - Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis riskGuylaine Bouchard
Department of Medicine, Harvard Medical School, Division of Gastroenterology, Brigham and Women s Hospital and Harvard Digestive Diseases Center, Boston, MA, USA
J Lipid Res 43:1105-13. 2002..Rather, specific genes and distinct pathophysiological pathways are responsible for the shared susceptibility to both of these common diseases... - Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BIDavid Q H Wang
Department of Medicine, Gastroenterology Division, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02115, USA
Biochim Biophys Acta 1583:141-50. 2002.... - Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8Henning Wittenburg
Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women's Hospital, and Harvard Digestive Diseases Center, Boston, Massachusetts 02115, USA
J Clin Invest 110:605-9. 2002 - Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred miceFrank Lammert
Department of Medicine III, University Hospital Aachen, Aachen University, Germany
Hepatology 36:1145-54. 2002..Characterization of the pathophysiologic roles of Lith3 and the new biliary mucin gene Glycam1 might provide insights into primary defects of human cholelithiasis and lead to new therapeutic strategies for prestone intervention... - Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologiesDavid Q-H Wang
Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Lipid Res 44:1042-59. 2003.... - Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of miceHenning Wittenburg
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 8:67-77. 2002..According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5... - Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strainsMalcolm A Lyons
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Lipid Res 44:1763-71. 2003.... - Hydrophilic but not hydrophobic bile acids prevent gallbladder muscle dysfunction in acute cholecystitisZuo-Liang Xiao
Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI, USA
Hepatology 37:1442-50. 2003..In conclusion, oral treatment with UDCA prevents gallbladder muscle damage caused by BDL, whereas oral treatment with CDCA worsens the defective muscle contractility and the oxidative stress... - Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouseDavid Q H Wang
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Physiol Gastrointest Liver Physiol 285:G494-502. 2003..Natural alpha- and beta-muricholic acids are the most powerful inhibitors of cholesterol absorption in mice and might act as potent cholesterol-lowering agents for prevention of cholesterol deposition diseases in humans... - QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strainsHenning Wittenburg
The Jackson Laboratory, Bar Harbor, ME, USA
J Lipid Res 47:1780-90. 2006.... - Interfacial properties of most monofluorinated bile acids deviate markedly from the natural congeners: studies with the Langmuir-Pockels surface balanceJohn M Kauffman
Department of Medicine, Harvard Medical School, Harvard Digestive Diseases Center, Brigham and Women's Hospital, Boston, MA, USA
J Lipid Res 46:571-81. 2005..These results provide a framework for designing F-modified bile acids to mimic or diverge from the natural compounds in vivo... - Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred miceMalcolm A Lyons
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Lipid Res 44:953-67. 2003.... - Pathophysiological basis of liver disease in cystic fibrosis employing a DeltaF508 mouse modelFolke Freudenberg
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Gastrointest Liver Physiol 294:G1411-20. 2008..This study of the earliest stages of CF liver disease provides a framework for investigating the molecular pathophysiology of more advanced disease in murine models and in humans with CF... - Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomersErik R M Eckhardt
Gastroenterology Division of Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Gastroenterology 122:948-56. 2002..Natural phospholipids with high affinity for cholesterol, as evidenced particularly by sphingomyelin, decrease A(t) and curtail intestinal cholesterol absorption... - Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SMMalcolm A Lyons
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Mamm Genome 16:152-63. 2005..The QTLs identified herein largely contributed to gallstone formation rather than gallstone severity. Cloning the genes underlying these murine QTLs should facilitate prediction and cloning of the orthologous human genes...
Research Grants
- ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASEMartin Carey; Fiscal Year: 2003..The systematic project should lead to new targets and strategies for prevention of pigment and cholesterol gallstone diseases as well as lipid transport abnormalities sin cholestasis. ..
- Phenotypic Determinants of Murine CholelithiasisMartin Carey; Fiscal Year: 2004..abstract_text> ..
- Molecular Pathogenesis of Cystic Fibrosis Liver DiseaseMartin Carey; Fiscal Year: 2007....
- ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASEMartin Carey; Fiscal Year: 2007..The results of these hypothesis-driven basic research aims will provide insights that correlate native and model systems and should be readily translatable to prevent and treat these common hepatobiliarv diseases in humans. ..
- PHENOTYPIC DETERMINANTS OF MURINE CHOLESTEROL GALLSTONESMartin Carey; Fiscal Year: 2000..This work should pave the way for identifying the major Lith genes in humans, which, in turn, should lead to strategies for early diagnosis of the trait and rational approaches to prevention. ..