PETER D CARAVAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc [Gd(CyPic3A)(H2O)2](-): a stable, bis(aquated) and high-relaxivity Gd(iii) complex
    Eric M Gale
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Suite 2301, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Chem Commun (Camb) 49:8060-2. 2013
  2. doi request reprint Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Acc Chem Res 42:851-62. 2009
  3. doi request reprint Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
    Contrast Media Mol Imaging 4:89-100. 2009
  4. ncbi request reprint Collagen-targeted MRI contrast agent for molecular imaging of fibrosis
    Peter Caravan
    EPIX Pharmaceuticals, Inc 4 Maguire Road, Lexington, MA 02421, USA
    Angew Chem Int Ed Engl 46:8171-3. 2007
  5. ncbi request reprint Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent
    Peter Caravan
    EPIX Pharmaceuticals, Cambridge, MA 02142, USA
    Inorg Chem 46:6632-9. 2007
  6. ncbi request reprint Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent
    Zoltan Tyeklar
    EPIX Pharmaceuticals Inc, Cambridge, MA 02142, USA
    Inorg Chem 46:6621-31. 2007
  7. doi request reprint EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus
    Kirsten Overoye-Chan
    EPIX Pharmaceuticals, 4 Maguire Road, Lexington, Massachusetts 02421, USA
    J Am Chem Soc 130:6025-39. 2008
  8. ncbi request reprint The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
    J Am Chem Soc 124:3152-62. 2002
  9. ncbi request reprint Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent
    Jeffrey S Troughton
    EPIX Medical Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
    Inorg Chem 43:6313-23. 2004
  10. ncbi request reprint Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide
    Stephan G Zech
    EPIX Pharmaceuticals, 67 Rogers Street, Cambridge, Massachusetts 02142, USA
    Inorg Chem 46:3576-84. 2007

Research Grants

  1. Stable, High Relaxivity MRI Contrast Agents
    PETER D CARAVAN; Fiscal Year: 2010
  2. Stable High Relaxivity MRI Contrast Agents
    Peter Caravan; Fiscal Year: 2009
  3. Stable, High Relaxivity MRI Contrast Agents
    Peter Caravan; Fiscal Year: 2009

Collaborators

  • Stephan G Zech
  • Andrei V Astashkin
  • Christian T Farrar
  • Thomas J McMurry
  • Frederick H Epstein
  • ALMA GREGORY contact SORENSEN
  • JEFF BULTE
  • Christopher Kramer
  • Marga Spiller
  • Matthew T Greenfield
  • Eric M Gale
  • Ritika Uppal
  • Shrikumar A Nair
  • Andrew F Kolodziej
  • M Meser Ali
  • Patrick A Helm
  • Kirsten Overoye-Chan
  • Mark Woods
  • A Dean Sherry
  • Jaclyn M Chasse
  • Zoltan Tyeklar
  • Ferenc K Kalman
  • Randall B Lauffer
  • Harriet B Eldredge
  • Arnold M Raitsimring
  • Zhaoda Zhang
  • Xiangzhi Zhou
  • Jeffrey S Troughton
  • Nathaniel Kenton
  • Guangping Dai
  • Ilknur Ay
  • Young Ro Kim
  • Luhua Shen
  • Vincent Jacques
  • Brent A French
  • Qing Deng
  • Ana C L Opina
  • Richard J Looby
  • Gandhali Bhole
  • R Jack Roy
  • Steffi Koerner
  • Ronald J Beyers
  • James C Fettinger
  • Yaqin Xu
  • Ernö Brücher
  • Daniel M Scott
  • Karen Ong
  • Hirano Sajiki
  • Paul Jurek
  • Robert Kiraly
  • Gyula Tircsó
  • Stephen U Dunham
  • Katarina Midelfort
  • Debbie Baute
  • Matthew T Greenwood
  • Daniela Goldfarb
  • Mark P Lowe
  • Oleg G Poluektov
  • Jaclyn M Greenwood
  • R B Clarkson
  • Andrea J Wiethoff
  • Stephane Dumas
  • Jufeng Wang
  • Per Olof Westlund

Detail Information

Publications23

  1. pmc [Gd(CyPic3A)(H2O)2](-): a stable, bis(aquated) and high-relaxivity Gd(iii) complex
    Eric M Gale
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Suite 2301, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Chem Commun (Camb) 49:8060-2. 2013
    ..Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes. ..
  2. doi request reprint Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Acc Chem Res 42:851-62. 2009
    ..Through judicious molecular design, we show that high-relaxivity complexes with high target affinity can be realized...
  3. doi request reprint Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
    Contrast Media Mol Imaging 4:89-100. 2009
    ..Per ion relaxivities of 80, 45, and 18 mM(-1) s(-1) at 1.5, 3 and 9.4 T, respectively, are feasible for Gd(3+) and Mn(2+) complexes...
  4. ncbi request reprint Collagen-targeted MRI contrast agent for molecular imaging of fibrosis
    Peter Caravan
    EPIX Pharmaceuticals, Inc 4 Maguire Road, Lexington, MA 02421, USA
    Angew Chem Int Ed Engl 46:8171-3. 2007
  5. ncbi request reprint Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent
    Peter Caravan
    EPIX Pharmaceuticals, Cambridge, MA 02142, USA
    Inorg Chem 46:6632-9. 2007
    ..01-50 MHz at 5, 15, 25, and 35 degrees C in a 4.5% HSA in PBS solution for each isomer (0.1 mM). Differences in the relaxivity in HSA between the two isomers could be attributed to the differing water exchange rates...
  6. ncbi request reprint Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent
    Zoltan Tyeklar
    EPIX Pharmaceuticals Inc, Cambridge, MA 02142, USA
    Inorg Chem 46:6621-31. 2007
    ..The rate of isomerization was highly pH dependent: k1 = (1.45 +/- 0.08) x 102[H+] + (4.16 +/- 0.30) x 105[H+]2; k-1 = (2.57 +/- 0.17) x 102[H+] + (7.54 +/- 0.60) x 105[H+]2...
  7. doi request reprint EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus
    Kirsten Overoye-Chan
    EPIX Pharmaceuticals, 4 Maguire Road, Lexington, Massachusetts 02421, USA
    J Am Chem Soc 130:6025-39. 2008
    ..4 per Gd), about 25 times higher than that of GdDOTA measured under the same conditions. Strong fibrin binding, fibrin selectivity, and high molecular relaxivity enable EP-2104R to detect blood clots in vivo...
  8. ncbi request reprint The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
    J Am Chem Soc 124:3152-62. 2002
    ..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)...
  9. ncbi request reprint Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent
    Jeffrey S Troughton
    EPIX Medical Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
    Inorg Chem 43:6313-23. 2004
    ..5 T. In a rabbit model of carotid artery injury, MnL1 clearly delineated both arteries and veins while also distinguishing between healthy tissue and regions of vessel damage...
  10. ncbi request reprint Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide
    Stephan G Zech
    EPIX Pharmaceuticals, 67 Rogers Street, Cambridge, Massachusetts 02142, USA
    Inorg Chem 46:3576-84. 2007
    ..The approach of using surrogate lanthanides to identify specific molecular parameters influencing relaxivity is applicable to other protein-targeted GdIII contrast agents...
  11. ncbi request reprint Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325
    Harriet B Eldredge
    EPIX Pharmaceuticals, Cambridge, Massachusetts 02142 1118, USA
    Invest Radiol 41:229-43. 2006
    ..We sought to determine whether there is a species dependence on plasma protein and serum album binding and/or relaxivity of the MR contrast agent MS-325...
  12. ncbi request reprint Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy
    Stephan G Zech
    EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142, USA
    Chemphyschem 6:2570-7. 2005
    ..These essential parameters directly correlate with the efficacy of MRI contrast agents and should therefore aid the development of novel, highly efficient compounds targeted to various proteins...
  13. ncbi request reprint The gadolinium(III)-water hydrogen distance in MRI contrast agents
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
    Inorg Chem 42:3972-4. 2003
    ..1 +/- 0.1 A. These distance estimates should aid in the design of new contrast agents, and in the interpretation of other molecular factors influencing relaxivity...
  14. pmc Molecular MRI of intracranial thrombus in a rat ischemic stroke model
    Ritika Uppal
    Department of Radiology, Massachusetts General Hospital East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA
    Stroke 41:1271-7. 2010
    ..In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi...
  15. ncbi request reprint Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
    Peter Caravan
    EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
    Chem Soc Rev 35:512-23. 2006
    ..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging...
  16. ncbi request reprint When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity
    Peter Caravan
    EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142 1118, USA
    Chemistry 11:5866-74. 2005
    ..5 mM(-1) s(-1)) measured under the same conditions. Despite having two exchangeable water molecules, slow water exchange limits the potential efficacy of Gd-L1 as an MRI contrast agent...
  17. ncbi request reprint Multilocus binding increases the relaxivity of protein-bound MRI contrast agents
    Zhaoda Zhang
    EPIX Pharmaceuticals, Inc 67 Rogers Street, Cambridge, MA 02142, USA
    Angew Chem Int Ed Engl 44:6766-9. 2005
  18. doi request reprint Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent
    Patrick A Helm
    Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
    Radiology 247:788-96. 2008
    ..To prospectively evaluate a gadolinium-based collagen-targeting contrast agent, EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse model of healed myocardial infarction (MI)...
  19. ncbi request reprint On the philosophy of optimizing contrast agents. An analysis of 1H NMRD profiles and ESR lineshapes of the Gd(III)complex MS-325+HSA
    Xiangzhi Zhou
    Department of Bio physical Chemistry, Umea University, SE 901 87 Umea, Sweden
    J Magn Reson 167:147-60. 2004
    ..A computer program based on this theory is developed which calculates solvent water proton T1 NMRD profiles and the corresponding X-, Q-, U-, and W-bands ESR lineshapes...
  20. ncbi request reprint Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopy
    Arnold M Raitsimring
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Chemphyschem 7:1590-7. 2006
    ..Under the experimental conditions used for the hydration number determination (30 mol % methanol), fewer than 15 % of the coordination sites were found to be occupied by methanol...
  21. pmc Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH
    Ferenc K Kalman
    Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
    Inorg Chem 46:5260-70. 2007
    ....
  22. doi request reprint Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombus
    Shrikumar A Nair
    Affinergy, Inc 617 Davis Drive, Suite 100, RTP, NC 27713, USA
    Angew Chem Int Ed Engl 47:4918-21. 2008
  23. pmc Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent
    M Meser Ali
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA
    Chemistry 14:7250-8. 2008
    ..8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer...

Research Grants4

  1. Stable, High Relaxivity MRI Contrast Agents
    PETER D CARAVAN; Fiscal Year: 2010
    ..The technology that we are developing can be readily used by others to prepare new imaging probes for imaging specific organs or diseases. ..
  2. Stable High Relaxivity MRI Contrast Agents
    Peter Caravan; Fiscal Year: 2009
    ..These probes may be useful in detecting coronary artery disease and identifying cancerous lesions. ..
  3. Stable, High Relaxivity MRI Contrast Agents
    Peter Caravan; Fiscal Year: 2009
    ..The technology that we are developing can be readily used by others to prepare new imaging probes for imaging specific organs or diseases. ..