PETER D CARAVANSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agentPeter Caravan
EPIX Pharmaceuticals, Cambridge, MA 02142, USA
Inorg Chem 46:6632-9. 2007..01-50 MHz at 5, 15, 25, and 35 degrees C in a 4.5% HSA in PBS solution for each isomer (0.1 mM). Differences in the relaxivity in HSA between the two isomers could be attributed to the differing water exchange rates...
Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of actionPeter Caravan
A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Acc Chem Res 42:851-62. 2009..Through judicious molecular design, we show that high-relaxivity complexes with high target affinity can be realized...- Collagen-targeted MRI contrast agent for molecular imaging of fibrosisPeter Caravan
EPIX Pharmaceuticals, Inc. 4 Maguire Road, Lexington, MA 02421, USA
Angew Chem Int Ed Engl 46:8171-3. 2007 - Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agentsPeter Caravan
A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
Contrast Media Mol Imaging 4:89-100. 2009..Per ion relaxivities of 80, 45, and 18 mM(-1) s(-1) at 1.5, 3 and 9.4 T, respectively, are feasible for Gd(3+) and Mn(2+) complexes... - Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agentZoltan Tyeklar
EPIX Pharmaceuticals Inc, Cambridge, MA 02142, USA
Inorg Chem 46:6621-31. 2007..The rate of isomerization was highly pH dependent: k1 = (1.45 +/- 0.08) x 102[H+] + (4.16 +/- 0.30) x 105[H+]2; k-1 = (2.57 +/- 0.17) x 102[H+] + (7.54 +/- 0.60) x 105[H+]2... - The interaction of MS-325 with human serum albumin and its effect on proton relaxation ratesPeter Caravan
EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
J Am Chem Soc 124:3152-62. 2002..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)... - EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombusKirsten Overoye-Chan
EPIX Pharmaceuticals, 4 Maguire Road, Lexington, Massachusetts 02421, USA
J Am Chem Soc 130:6025-39. 2008..4 per Gd), about 25 times higher than that of GdDOTA measured under the same conditions. Strong fibrin binding, fibrin selectivity, and high molecular relaxivity enable EP-2104R to detect blood clots in vivo... - Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325Harriet B Eldredge
EPIX Pharmaceuticals, Cambridge, Massachusetts. 02142-1118, USA
Invest Radiol 41:229-43. 2006..Binding ranged from 64% to 91% and was species dependent: human > pig approximately rabbit > dog approximately rat approximately mouse... - Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agentJeffrey S Troughton
EPIX Medical Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 43:6313-23. 2004..5 T. In a rabbit model of carotid artery injury, MnL1 clearly delineated both arteries and veins while also distinguishing between healthy tissue and regions of vessel damage... - Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanideStephan G Zech
EPIX Pharmaceuticals, 67 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 46:3576-84. 2007..The approach of using surrogate lanthanides to identify specific molecular parameters influencing relaxivity is applicable to other protein-targeted GdIII contrast agents... - The gadolinium(III)-water hydrogen distance in MRI contrast agentsPeter Caravan
EPIX Medical, Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 42:3972-4. 2003..1 +/- 0.1 A. These distance estimates should aid in the design of new contrast agents, and in the interpretation of other molecular factors influencing relaxivity... - Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopyStephan G Zech
EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142, USA
Chemphyschem 6:2570-7. 2005..These essential parameters directly correlate with the efficacy of MRI contrast agents and should therefore aid the development of novel, highly efficient compounds targeted to various proteins... 
Molecular MRI of intracranial thrombus in a rat ischemic stroke modelRitika Uppal
Department of Radiology, Massachusetts General Hospital East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA
Stroke 41:1271-7. 2010..In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi...- Strategies for increasing the sensitivity of gadolinium based MRI contrast agentsPeter Caravan
EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
Chem Soc Rev 35:512-23. 2006..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging... - When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivityPeter Caravan
EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142 1118, USA
Chemistry 11:5866-74. 2005..5 mM(-1) s(-1)) measured under the same conditions. Despite having two exchangeable water molecules, slow water exchange limits the potential efficacy of Gd-L1 as an MRI contrast agent... - Multilocus binding increases the relaxivity of protein-bound MRI contrast agentsZhaoda Zhang
EPIX Pharmaceuticals, Inc. 67 Rogers Street, Cambridge, MA 02142, USA
Angew Chem Int Ed Engl 44:6766-9. 2005 - On the philosophy of optimizing contrast agents. An analysis of 1H NMRD profiles and ESR lineshapes of the Gd(III)complex MS-325+HSAXiangzhi Zhou
Department of Bio-physical Chemistry, , SE-901 87 Umea, Sweden
J Magn Reson 167:147-60. 2004..A computer program based on this theory is developed which calculates solvent water proton T1 NMRD profiles and the corresponding X-, Q-, U-, and W-bands ESR lineshapes... - Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pHFerenc K Kalman
Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
Inorg Chem 46:5260-70. 2007.... - Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agentPatrick A Helm
Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
Radiology 247:788-96. 2008..To prospectively evaluate a gadolinium-based collagen-targeting contrast agent, EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse model of healed myocardial infarction (MI)... - Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopyArnold M Raitsimring
Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
Chemphyschem 7:1590-7. 2006..Under the experimental conditions used for the hydration number determination (30 mol % methanol), fewer than 15 % of the coordination sites were found to be occupied by methanol... - Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agentM Meser Ali
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA
Chemistry 14:7250-8. 2008..8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer... - Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombusShrikumar A Nair
Affinergy, Inc. 617 Davis Drive, Suite 100, RTP, NC 27713, USA
Angew Chem Int Ed Engl 47:4918-21. 2008
Research Grants
- Stable, High Relaxivity MRI Contrast AgentsPETER D CARAVAN; Fiscal Year: 2010..The technology that we are developing can be readily used by others to prepare new imaging probes for imaging specific organs or diseases. ..
- Stable High Relaxivity MRI Contrast AgentsPeter Caravan; Fiscal Year: 2009..These probes may be useful in detecting coronary artery disease and identifying cancerous lesions. ..
- Stable, High Relaxivity MRI Contrast AgentsPeter Caravan; Fiscal Year: 2009..The technology that we are developing can be readily used by others to prepare new imaging probes for imaging specific organs or diseases. ..