L R Caplan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Diagnosis of intracranial atherosclerosis
    Gayle Rebovich
    Beth Israel Deaconess Medical Center, Stroke Division, Boston, MA, USA 617 632 8911
    Expert Opin Med Diagn 4:267-79. 2010
  2. doi request reprint The intracranial vertebral artery: a neglected species. The Johann Jacob Wepfer Award 2012
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cerebrovasc Dis 34:20-30. 2012
  3. pmc Effect of pre-stroke use of ACE inhibitors on ischemic stroke severity
    Magdy Selim
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, USA
    BMC Neurol 5:10. 2005
  4. ncbi request reprint Transient ischemic attack: definition and natural history
    Louis R Caplan
    Cerebrovascular Disease Service, Palmer 127, West Campus, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Atheroscler Rep 8:276-80. 2006
  5. ncbi request reprint Cardiac encephalopathy and congestive heart failure: a hypothesis about the relationship
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 66:99-101. 2006
  6. ncbi request reprint Dissection of the posterior cerebral arteries
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    Arch Neurol 62:1138-43. 2005
  7. ncbi request reprint Antiplatelet therapy in stroke prevention: present and future
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cerebrovasc Dis 21:1-6. 2006
  8. ncbi request reprint Thoughts evoked by MATCH and other trials
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Department of Neurology, DNA 779, 330 Brookline Ave, Boston, MA 02215 5400, USA
    Stroke 35:2604-5. 2004
  9. ncbi request reprint New England Medical Center Posterior Circulation registry
    Louis R Caplan
    Cerebrovascular Disease Sections of the New England Medical Center, Boston, MA, USA
    Ann Neurol 56:389-98. 2004
  10. ncbi request reprint Charles Franklin Hoover (1865-1927)
    L R Caplan
    Division of Cerebrovascular Diseases, Dept of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Neurol 251:118-9. 2004

Detail Information

Publications91

  1. doi request reprint Diagnosis of intracranial atherosclerosis
    Gayle Rebovich
    Beth Israel Deaconess Medical Center, Stroke Division, Boston, MA, USA 617 632 8911
    Expert Opin Med Diagn 4:267-79. 2010
    ..Take home message: Non-invasive imaging modalities have a high negative predictive value in detecting intracranial atherosclerosis. The gold standard for confirmation of the diagnosis remains catheter angiography...
  2. doi request reprint The intracranial vertebral artery: a neglected species. The Johann Jacob Wepfer Award 2012
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cerebrovasc Dis 34:20-30. 2012
    ..The therapeutics of patients with ICVA disease is uncharted territory and begs for attention and clarification...
  3. pmc Effect of pre-stroke use of ACE inhibitors on ischemic stroke severity
    Magdy Selim
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, USA
    BMC Neurol 5:10. 2005
    ..We aimed to compare stroke severity between stroke patients who were taking ACEI before their stroke onset and those who were not, to examine the effects of pretreatment with ACEI on ischemic stroke severity...
  4. ncbi request reprint Transient ischemic attack: definition and natural history
    Louis R Caplan
    Cerebrovascular Disease Service, Palmer 127, West Campus, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Atheroscler Rep 8:276-80. 2006
    ..Treatment will depend on the nature of the causative cervico-cranial vascular, cardiac, and hematologic abnormalities found on investigation...
  5. ncbi request reprint Cardiac encephalopathy and congestive heart failure: a hypothesis about the relationship
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 66:99-101. 2006
    ..I have not seen this syndrome discussed in any cardiology or neurology texts or reports, and it seems to be completely unknown to cardiologists and neurologists. I have recognized about one patient per year with this syndrome...
  6. ncbi request reprint Dissection of the posterior cerebral arteries
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    Arch Neurol 62:1138-43. 2005
  7. ncbi request reprint Antiplatelet therapy in stroke prevention: present and future
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cerebrovasc Dis 21:1-6. 2006
    ..Aspirin, ticlopidine, clopidogrel, dipyridamole, cilostazol, and glycoprotein llb/llla inhibitors are all used now and have various different modes of action and functions...
  8. ncbi request reprint Thoughts evoked by MATCH and other trials
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Department of Neurology, DNA 779, 330 Brookline Ave, Boston, MA 02215 5400, USA
    Stroke 35:2604-5. 2004
  9. ncbi request reprint New England Medical Center Posterior Circulation registry
    Louis R Caplan
    Cerebrovascular Disease Sections of the New England Medical Center, Boston, MA, USA
    Ann Neurol 56:389-98. 2004
    ..The best outcome was in patients who had multiple arterial occlusive sites; they had position-sensitive TIAs during months to years...
  10. ncbi request reprint Charles Franklin Hoover (1865-1927)
    L R Caplan
    Division of Cerebrovascular Diseases, Dept of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Neurol 251:118-9. 2004
  11. ncbi request reprint Anticoagulants to prevent stroke occurrence and worsening
    Louis R Caplan
    Department of Neurology, Israel Deaconess Medical Center Boston, MA 02215, USA
    Isr Med Assoc J 8:773-8. 2006
  12. doi request reprint Dissections of brain-supplying arteries
    Louis R Caplan
    Division of Cerebrovascular Disease, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Clin Pract Neurol 4:34-42. 2008
    ..Treatment for arterial dissections has not been studied with randomized trial methodology, but most clinicians prescribe antithrombotic medications as prophylaxis. The recurrence rate of infarction or arterial dissections is very low...
  13. doi request reprint Ataxia in patients with brain infarcts and hemorrhages
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215 5400, USA
    Handb Clin Neurol 103:147-60. 2012
    ..Lesions that affect the posterior limb of the internal capsule and its afferent and efferent projections may also cause an ataxic hemiparesis syndrome, often with accompanying hemisensory abnormalities...
  14. pmc Stroke-related translational research
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Neurol 68:1110-23. 2011
    ....
  15. doi request reprint Binswanger disease--an update
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Neurol Sci 299:9-10. 2010
    ..Binswanger disease is a common cause of vascular dementia in the elderly. This report up-dates the pathological and clinical findings, imaging identification emphasizing recent advances, and diagnosis of this condition...
  16. doi request reprint Cerebrovascular disease
    Louis R Caplan
    Department of Neurology, Cerebrovascular Division, Beth Israel Deaconess Medical Center, Boston, MA 02215 5400, USA
    Med Clin North Am 93:353-69, viii. 2009
    ..This article shares a process by which clinicians can combine a patient's history, neurologic examination, and brain and vascular imaging to localize a lesion and diagnose cerebrovascular disease...
  17. doi request reprint The last 50 years of cerebrovascular disease: Part 1
    L R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Int J Stroke 1:104-8. 2006
  18. doi request reprint Caplan's short rendition of Stroke during the 20th century: part II
    L R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Int J Stroke 1:228-34. 2006
  19. doi request reprint Funny turns: they do mean something
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Palmer 127 West Campus, Boston, MA 02215, USA
    Arch Neurol 65:601-2. 2008
  20. doi request reprint A 70-year-old man with a transient ischemic attack: review of internal carotid artery stenosis
    Louis R Caplan
    Beth Israel Deaconess Medical Center, Division of Cerebrovascular Stroke, One Deaconess Rd, Boston, MA 02215, USA
    JAMA 300:81-90. 2008
    ..These decisions, in this and other complex patients, often cannot be directly informed by results from randomized trials...
  21. ncbi request reprint Cerebrovascular disease: historical background, with an eye to the future
    Louis R Caplan
    Department of Neurology, Harvard Medical School, and the Cerebrovascular Disorders Stroke Clinic, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Cleve Clin J Med 71:S22-4. 2004
  22. ncbi request reprint Acute [corrected] stroke thrombolysis: an update [corrected]
    Manu Mehdiratta
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Prog Cardiovasc Dis 49:430-8. 2007
    ....
  23. ncbi request reprint Patterns of cerebral perfusion in patients with asymptomatic internal carotid artery disease
    Claudia Chaves
    Department of Neurology, Lahey Clinic, Burlington, MA, USA
    Cerebrovasc Dis 22:396-401. 2006
    ....
  24. ncbi request reprint Neurology case studies: cerebrovascular disease
    Michael Chen
    Beth Israel Deaconess Medical Center, Department of Neurology, Division of Cerebrovascular Disease, 330 Brookline Avenue, Palmer 132, Boston, MA 02215, USA
    Neurol Clin 24:181-98. 2006
    ....
  25. ncbi request reprint Thrombolysis 2004: the good, the bad, and the ugly
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Cambridge, MA, USA
    Rev Neurol Dis 1:16-26. 2004
    ..Finally, the author shares his advice to doctors about present thrombolytic management of patients with acute ischemic stroke...
  26. ncbi request reprint The stroke patient who woke up: clinical and radiological features, including diffusion and perfusion MRI
    John N Fink
    Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Stroke 33:988-93. 2002
    ..Functional imaging techniques may allow estimation of benefit and risk of acute stroke therapy. We compared the clinical and multimodal MRI findings of patients with uncertain stroke onset with those with known onset time...
  27. ncbi request reprint Outcome at 30 days in the New England Medical Center Posterior Circulation Registry
    Thomas A Glass
    Division of Cerebrovascular Disease, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215
    Arch Neurol 59:369-76. 2002
    ..Vertebrobasilar disease is generally considered a condition with a poor prognosis because of high rates of mortality and severe disability...
  28. ncbi request reprint Basilar artery occlusive disease in the New England Medical Center Posterior Circulation Registry
    Barbara Voetsch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA, USA
    Arch Neurol 61:496-504. 2004
    ..Most reports on basilar artery (BA) occlusive disease have retrospectively described single cases or small patient series...
  29. ncbi request reprint Heparin and oral anticoagulants in the treatment of brain ischemia
    C J Chaves
    Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    J Neurol Sci 173:3-9. 2000
    ..None of these drugs have proven effective for all forms of cerebral ischemia. Further studies examining the efficacy of anticoagulants in different stroke subgroups will be necessary in order to clarify optimal clinical practice...
  30. ncbi request reprint Efficacy of MR angiography in the detection and characterization of occlusive disease in the vertebrobasilar system
    R A Bhadelia
    Department of Radiology, New England Medical Center Hospitals, Boston, MA 02111, USA
    J Comput Assist Tomogr 25:458-65. 2001
    ..The purpose of this work was to determine the efficacy of MR angiography (MRA) in the detection and characterization of occlusive disease in the vertebrobasilar system...
  31. ncbi request reprint MRI features of intracerebral hemorrhage within 2 hours from symptom onset
    I Linfante
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Stroke 30:2263-7. 1999
    ..It is unknown whether MRI can detect ICH earlier than 2.5 hours. We describe 5 patients with ICH who had MRI between 23 and 120 minutes from symptom onset and propose diagnostic patterns of evolution of hyperacute ICH on MRI...
  32. ncbi request reprint Evidence-based treatment of patients with ischemic cerebrovascular disease
    R Llinas
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Neurol Clin 19:79-105. 2001
    ..Until then, clinicians must understand the context of the trial data to determine if the results are applicable to Mr. or Ms. Jones, and the patients sitting before them in the office or in the hospital bed...
  33. ncbi request reprint Diffusion-weighted imaging and National Institutes of Health Stroke Scale in the acute phase of posterior-circulation stroke
    I Linfante
    Division of Cerebrovascular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, East Campus DA 779, 330 Brookline Ave, Boston, MA 02115, USA
    Arch Neurol 58:621-8. 2001
    ..Correlation between NIHSS score and lesion volume in posterior-circulation infarcts is unknown...
  34. ncbi request reprint Paradoxical clustering of brain metastases in an underperfused cerebral hemisphere
    Marcus Yountz
    Department of Neurology, Beth Israel Deaconess Medical Center, K 4, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Neurol 64:1659-60. 2007
    ..To describe a patient with a predominantly unilateral intracranial arterial stenosis who then developed metastatic lung cancer to the brain, with the tumors preferentially depositing in the underperfused cerebral hemisphere...
  35. ncbi request reprint Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator: prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume
    Magdy Selim
    Department of Neurology, Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass 02215, USA
    Stroke 33:2047-52. 2002
    ..We sought to examine which pretreatment DWI parameters and clinical data are predictive of ICH after intravenous thrombolysis...
  36. ncbi request reprint The endothelium, platelets, and brain ischemia
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 4:113-21. 2007
    ..In patients with penetrating artery disease, agents with substantial endothelial effects have a theoretical advantage...
  37. ncbi request reprint Radiological diagnosis of cerebral venous thrombosis
    Magdy Selim
    Division of Cerebrovascular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Front Neurol Neurosci 23:96-111. 2008
    ..However, they also have pitfalls that can lead to false-positive and -negative results. Conventional cerebral angiography should be reserved for doubtful cases or when endovascular intervention is advocated...
  38. ncbi request reprint How great is the risk of future bleeding for children with brain arteriovenous malformations?
    Louis R Caplan
    Harvard Medical School and Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Clin Pract Neurol 2:308-9. 2006
  39. ncbi request reprint Basilar artery branch disease imaged by magnetic resonance imaging
    Manu Mehdiratta
    Stroke Division, Harvard Medical School, Beth Israel Deaconess Medical Center, Palmer 127, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Neurol 64:1666. 2007
  40. pmc Cell therapy for stroke
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    NeuroRx 1:406-14. 2004
    ..We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials...
  41. ncbi request reprint Pitfalls in the diagnosis of cerebellar infarction
    Sean I Savitz
    Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:63-8. 2007
    ..Cerebellar infarctions are an important cause of neurologic disease. Failure to recognize and rapidly diagnose cerebellar infarction may lead to serious morbidity and mortality due to hydrocephalus and brain stem infarction...
  42. ncbi request reprint Why identification of stroke syndromes is still important
    Sandeep Kumar
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Curr Opin Neurol 20:78-82. 2007
    ..This article highlights some of the pitfalls of this approach. It discusses the continuing importance of identifying stroke syndromes in implementing individualized patient care...
  43. ncbi request reprint Angioplasty and stenting to treat occlusive vascular disease
    Louis R Caplan
    Department of Neurology, Harvard Medical Center, Boston, MA, USA
    Rev Neurol Dis 3:8-18. 2006
    ....
  44. ncbi request reprint Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator
    Italo Linfante
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass 02115, USA
    Stroke 33:2066-71. 2002
    ....
  45. ncbi request reprint Vertebral artery compression of the medulla
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Arch Neurol 63:234-41. 2006
    ..Much less is known about vertebral artery compression of the medulla...
  46. ncbi request reprint Transient monocular visual loss
    Amy Amick
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Compr Ophthalmol Update 8:91-8; discussion 99-100. 2007
    ..Transient monocular visual loss may also be related to conditions that cause papilledema and some conditions intrinsic to the eye, such as optic disk drusen and colobomas...
  47. ncbi request reprint Cervicocranial arterial dissections
    Louis R Caplan
    Department of Neurology LRC, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neuroophthalmol 24:299-305. 2004
    ..Alterations in the endothelium activate the coagulation cascade, leading to the formation of intramural clot that may embolize distally to cause brain infarction. Pain and neuro-ophthalmic symptoms and signs are common manifestations...
  48. doi request reprint Medical complications after stroke
    Sandeep Kumar
    Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Lancet Neurol 9:105-18. 2010
    ..Systematic investigations are therefore needed to further study the effects of medical complications on stroke recovery and to improve interventions for the prevention and treatment of these events...
  49. ncbi request reprint Resolved: Heparin may be useful in selected patients with brain ischemia
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass 02215 5400, USA
    Stroke 34:230-1. 2003
  50. ncbi request reprint Vertebrobasilar disease
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 352:2618-26. 2005
  51. doi request reprint Vertebral artery origin thrombus in a patient with cerebellar infarct
    D Eric Searls
    Cerebrovascular Division, Department of Neurology, Palmer 127, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Brookline, MA 02215, USA
    Arch Neurol 65:1386-7. 2008
  52. doi request reprint Reducing the delay in thrombolysis: is it necessary to await the results of renal function tests before computed tomography perfusion and angiography in patients with code stroke?
    Manu Mehdiratta
    Stroke Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Stroke Cerebrovasc Dis 17:273-5. 2008
    ....
  53. pmc Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly
    Refeeque A Bhadelia
    Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Stroke 40:3816-20. 2009
    ..Our purpose was to investigate the relationship between the integrity of white matter in the corpus callosum as determined by DTI and quantitative measures of gait in the elderly...
  54. ncbi request reprint Clinical diagnosis of patients with cerebrovascular disease
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215 5400, USA
    Prim Care 31:95-109. 2004
  55. ncbi request reprint Intracranial large artery occlusive disease
    Louis R Caplan
    Division of Cerebrovascular Disease Stroke, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Curr Neurol Neurosci Rep 8:177-81. 2008
  56. ncbi request reprint Is the promise of randomized control trials ("evidence-based medicine") overstated?
    Louis R Caplan
    Department of Neurology, Beth Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Neurol Neurosci Rep 2:1-8. 2002
  57. ncbi request reprint Technology insight: brain MRI and cardiac surgery--detection of postoperative brain ischemia
    Megan C Leary
    Harvard Clinical Research Institute, Boston, MA, USA
    Nat Clin Pract Cardiovasc Med 4:379-88. 2007
    ..Additionally, DWI could be a valuable tool for evaluating stroke preventive measures as well as therapeutic interventions in patients undergoing CABG surgery...
  58. pmc Atraumatic convexal subarachnoid hemorrhage: clinical presentation, imaging patterns, and etiologies
    S Kumar
    Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 74:893-9. 2010
    ..To identify patterns of clinical presentation, imaging findings, and etiologies in a cohort of hospitalized patients with localized nontraumatic convexal subarachnoid hemorrhage...
  59. ncbi request reprint The management of transient monocular visual loss
    Louis R Caplan
    Neurology, Harvard Medical School, Chief of Section in Cerebrovascular Disease, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Neuroophthalmol 25:304-12. 2005
  60. ncbi request reprint Latest developments in collateral circulation, pediatric stroke, and stroke recovery
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 4:153-6. 2007
  61. ncbi request reprint Seizure at stroke onset: should it be an absolute contraindication to thrombolysis?
    Magdy Selim
    Department of Neurology, Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cerebrovasc Dis 14:54-7. 2002
    ..Magnetic resonance imaging (MRI) with diffusion- (DWI) and perfusion-weighted images (PWI) and angiography (MRA) can be used to confirm the diagnosis of an acute ischemic process in the presence of concurrent seizures...
  62. ncbi request reprint Is hypoperfusion an important cause of strokes? If so, how?
    Louis R Caplan
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cerebrovasc Dis 21:145-53. 2006
    ..Thus hypoperfusion with embolism or embolism alone are the most common explanations for stroke, the former often associated with less severe clinical deficits than the latter...
  63. ncbi request reprint Is the association of National Institutes of Health Stroke Scale scores and acute magnetic resonance imaging stroke volume equal for patients with right- and left-hemisphere ischemic stroke?
    John N Fink
    Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Stroke 33:954-8. 2002
    ..The aim of this study was to investigate whether the relationship between acute NIHSS score and acute stroke volume as determined by acute diffusion- and perfusion-weighted MRI (DWI and PWI) differs between right- and left-sided stroke...
  64. ncbi request reprint Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Cerebrovasc Dis 20:101-7. 2005
    ..Cell transplantation is safe in animal models and enhances recovery from stroke in rats...
  65. ncbi request reprint Summation. The vessel wall and its endothelial lining, blood flow, and its coagulability
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 5:S28-30. 2008
  66. ncbi request reprint Patterns of perfusion-weighted imaging in patients with carotid artery occlusive disease
    Claudia J Chaves
    Department of Neurology, Lahey Clinic, Burlington, Mass 01805, USA
    Arch Neurol 60:237-42. 2003
    ..The importance of hemodynamic factors in the pathophysiology of stroke and transient ischemic attacks in patients with internal carotid artery (ICA) stenosis or occlusion remains controversial...
  67. doi request reprint Intraparenchymal hemorrhage in a patient with osteogenesis imperfecta and plasminogen activator inhibitor-1 deficiency
    Richard P Goddeau
    Department of Neurology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Arch Neurol 67:236-8. 2010
    ..Plasminogen activator inhibitor-1 deficiency is a rare fibrinolytic cause of systemic bleeding diathesis...
  68. ncbi request reprint Safety of latest-generation self-expanding stents in patients with NASCET-ineligible severe symptomatic extracranial internal carotid artery stenosis
    Italo Linfante
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Arch Neurol 61:39-43. 2004
    ..Previous-generation self-expanding stents were hampered by length foreshortening, which limited their application in multifactorial occlusive extracranial internal carotid artery stenosis...
  69. ncbi request reprint Diffusion- and perfusion-weighted MRI patterns in borderzone infarcts
    C J Chaves
    Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Stroke 31:1090-6. 2000
    ..We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts...
  70. ncbi request reprint Surgical treatment of systemic atheroembolism from the thoracic aorta
    R M Bojar
    Division of Cardiothoracic Surgery, New England Medical Center, Boston, MA 02111, USA
    Ann Thorac Surg 61:1389-93. 1996
    ..Surgical procedures performed exclusively for atheroembolic events arising from the thoracic aorta rarely have been reported. Presented here are 2 patients who underwent successful operation for these problems...
  71. ncbi request reprint Vertebrobasilar disease
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Cerebrovascular Service, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Adv Neurol 92:131-40. 2003
  72. ncbi request reprint How well does "evidence-based" medicine help neurologists care for individual patients?
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 4:75-84. 2007
    ..More importantly, physicians should spend more time finding out what is wrong with each patient and getting to know his or her circumstances, family situations, psychosocial and economic stresses, thoughts, fears, biases, and wishes...
  73. ncbi request reprint Physicians now take for granted that infarction is explained by lack of blood supply and nutrition caused by obstruction of arteries that supply regions of ischemia. Introduction
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 5:S1-3. 2008
  74. ncbi request reprint Cell transplantation for stroke
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 52:266-75. 2002
    ..The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion...
  75. ncbi request reprint Diagnosis of cerebral venous thrombosis with echo-planar T2*-weighted magnetic resonance imaging
    Magdy Selim
    Department of Neurology, Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Arch Neurol 59:1021-6. 2002
    ..The value of T2*-weighted magnetic resonance imaging (MRI) in diagnosing CVT has not been well studied...
  76. doi request reprint Stroke in pregnant and postpartum women
    Evgeny V Sidorov
    Beth Israel Deaconess Medical Centre, Boston, MA, USA
    Expert Rev Cardiovasc Ther 9:1235-47. 2011
    ....
  77. ncbi request reprint Cerebrovascular diseases
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 5:100-3. 2008
  78. ncbi request reprint National Stroke Association guidelines for the management of transient ischemic attacks
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 60:301-13. 2006
    ..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks...
  79. ncbi request reprint Determination of etiologic mechanisms of strokes secondary to coronary artery bypass graft surgery
    Donald S Likosky
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Stroke 34:2830-4. 2003
    ..We developed and implemented a classification system to identify the distribution and timing of stroke subtypes...
  80. ncbi request reprint Angioplasty for intracranial atherosclerosis: is the treatment worse than the disease?
    Seemant Chaturvedi
    Neurology 61:1647-8. 2003
  81. ncbi request reprint Intra- and postoperative predictors of stroke after coronary artery bypass grafting
    Donald S Likosky
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Thorac Surg 76:428-34; discussion 435. 2003
    ..We developed a risk prediction model for stroke based on factors in intra- and postoperative care, after adjusting for a patient's preoperative risk...
  82. ncbi request reprint Dizziness: how do patients describe dizziness and how do emergency physicians use these descriptions for diagnosis?
    Louis R Caplan
    Mayo Clin Proc 82:1313-5. 2007
  83. ncbi request reprint Use of stents to treat intracranial cerebrovascular disease
    Philip M Meyers
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Annu Rev Med 58:107-22. 2007
    ..Determining which patients should undergo revascularization procedures will require carefully planned, randomized clinical trials...
  84. ncbi request reprint Treatment of acute stroke: still struggling
    Louis R Caplan
    JAMA 292:1883-5. 2004
  85. ncbi request reprint Intra-arterial thrombolysis in patients treated with warfarin
    Italo Linfante
    Department of Radiology, Neuroendovascular Surgery and Interventional Neuroradiology, University of Miami, Miami, FL 33136, USA
    Cerebrovasc Dis 19:133-5. 2005
  86. ncbi request reprint Use of stents to treat extracranial cerebrovascular disease
    Philip M Meyers
    Department of Radiology and Neurological Surgery, Columbia University, and Neuroendovascular Service, Neurological Institute of New York and New York Presbyterian Hospitals, New York, New York 10032, USA
    Annu Rev Med 57:437-54. 2006
    ..The review presents current developments in CAS...
  87. ncbi request reprint Recommendations for the endovascular treatment of intracranial aneurysms: a statement for healthcare professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radiology
    S Claiborne Johnston
    Stroke 33:2536-44. 2002
  88. doi request reprint Pontine warning syndrome
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Ste 931, Toronto ONM5C1R6, Canada
    Arch Neurol 65:1375-7. 2008
    ..Little is known about stroke mechanisms in patients with fluctuating symptoms and the role of branch atherosclerotic disease...
  89. ncbi request reprint Significance of early CT signs in acute stroke. A CT scan-diffusion MRI study
    Assia Jaillard
    Department of Clinical and Biological Neurosciences, Stroke Unit University Hospital, Grenoble, France
    Cerebrovasc Dis 13:47-56. 2002
    ..To study the pathophysiology of early CT signs...