Research Topics
Genomes and Genes
| Alan B CantorSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesisAaron N Chang
Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:9237-42. 2002..On the basis of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG protein function...- Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineageAlan B Cantor
Division of Pediatric Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
J Exp Med 205:611-24. 2008..They also provide evidence for lineage instability during early stages of hematopoietic lineage commitment... 
GATA transcription factors in hematologic diseaseAlan B Cantor
Division of Pediatric Hematology Oncology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Int J Hematol 81:378-84. 2005..This review summarizes the role of GATA-1 during normal hematopoiesis and discusses how disease-associated mutations may affect its function...- A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiationHui Huang
Department of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 26:1587-601. 2012..These findings link SFK and Shp2 signaling pathways to the regulation of RUNX1 activity in hematopoiesis via control of RUNX1 multiprotein complex assembly... - Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factorsMing Yu
Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 45:330-43. 2012..Genetic depletion of Runx1 results in reduced Ring1b binding at these sites in vivo. These findings provide evidence for site-specific PRC1 chromatin recruitment by core binding transcription factors in mammalian cells... - Role of ZBP-89 in human globin gene regulation and erythroid differentiationAndrew J Woo
Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Blood 118:3684-93. 2011..Addition of the histone deacetylase inhibitor valproic acid partially reverses the reduced globin gene expression. These findings reveal an activating role for ZBP-89 in human globin gene regulation and erythroid differentiation... - Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesisJulio D Amigo
Department of Medicine, Division of Hematology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 31:1344-56. 2011.... - GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineagesHiromi Iwasaki
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Immunity 19:451-62. 2003..Thus, GATA-1 specifically instructs MegE commitment while excluding other fate outcomes in stem and progenitor cells, suggesting that regulation of GATA-1 is critical in maintaining multilineage homeostasis... - Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivoChanning Yu
Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Exp Med 195:1387-95. 2002..Mice lacking the ability to produce eosinophils should prove useful in ascertaining the role of eosinophils in a variety of inflammatory or allergic disorders... - Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysisMing Yu
Department of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, MA 02115, USA
Mol Cell 36:682-95. 2009..These data provide insights into GATA-1-mediated gene regulation in vivo... - TIF1gamma controls erythroid cell fate by regulating transcription elongationXiaoying Bai
Howard Hughes Medical Institute, Boston, MA 02115, USA
Cell 142:133-43. 2010..Our study establishes a mechanism for regulating tissue cell fate and differentiation through transcription elongation... - The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafishJulio D Amigo
Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
Blood 114:4654-63. 2009..One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1... 
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11AVijay G Sankaran
Division of Hematology Oncology, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
Science 322:1839-42. 2008..BCL11A emerges as a therapeutic target for reactivation of HbF in beta-hemoglobin disorders...- Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid developmentAndrew J Woo
Department of Pediatric Oncology, Children s Hospital Boston Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 28:2675-89. 2008.... - Transcriptional regulation of erythropoiesis: an affair involving multiple partnersAlan B Cantor
Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital Boston and the Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Oncogene 21:3368-76. 2002..This provides a possible mechanism by which dysregulated expression of hematopoietic transcription factors leads to lineage maturation arrest in leukemias... - Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturationAlan B Cantor
Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 22:4268-79. 2002..Importantly, we find that distinct regions of FOG-1 differentially influence erythroid versus megakaryocyte maturation. As such, we propose that FOG-1 may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell... - A Myc network accounts for similarities between embryonic stem and cancer cell transcription programsJonghwan Kim
Department of Pediatric Oncology, Children s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
Cell 143:313-24. 2010..The apparent similarity of cancer and ES cell signatures reflects, in large part, the pervasive nature of Myc regulatory networks... - Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteinsAlan B Cantor
Division of Pediatric Hematology/Oncology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Semin Cell Dev Biol 16:117-28. 2005..In this review, we will discuss the identification and characterization of FOG proteins, their role in human disease, and recent studies that shed new light on their function and regulation... - Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte developmentHui Huang
Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Mol Cell Biol 29:4103-15. 2009..We propose that dephosphorylation of FLI-1 is a key event in the transcriptional regulation of megakaryocyte maturation. These findings have implications for other cell types where interactions between runx and ets family proteins occur... - Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivoSamuel G Katz
Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, U SA
Mol Cell Biol 22:3121-8. 2002..Thus, despite conservation of the FOG-CtBP interaction site, the in vivo function of FOG-1 in erythroid development is not affected by its inability to interact with the corepressor CtBP... - Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cellsJonghwan Kim
Division of Hematology Oncology, Department of Pediatric Oncology, Children s Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
Nat Protoc 4:506-17. 2009..The system setup takes approximately 50 d to complete, and it takes another approximately 15 d and approximately 3 d to perform affinity purification of protein complexes and bioChIP, respectively... - Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylationJianlong Wang
Children s Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts, USA
Curr Protoc Stem Cell Biol . 2009..In addition, we present a protocol employing SDS-PAGE fractionation to reduce sample complexity prior to submission for mass spectrometry (MS) protein identification... - Common features of megakaryocytes and hematopoietic stem cells: what's the connection?Hui Huang
Division of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biochem 107:857-64. 2009..Overall, these findings may be of relevance in the development of techniques for HSC ex vivo culture and/or possible generation of HSCs via somatic cell reprogramming... - Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 functionKirby D Johnson
Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI, USA
Blood 109:5230-3. 2007..The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1-mediated transcriptional regulation... - Coregulator-dependent facilitation of chromatin occupancy by GATA-1Saumen Pal
Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, 383 Medical Sciences Center, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 101:980-5. 2004..We propose that FOG-1 is a prototype of a new class of coregulators termed chromatin occupancy facilitators, which confer coregulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo... - Prediction of radiation sensitivity using a gene expression classifierJavier F Torres-Roca
Department of Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Res 65:7169-76. 2005..We establish that radiation sensitivity can be predicted based on gene expression profiles and we introduce a genomic approach to the identification of novel molecular markers of radiation sensitivity... - Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myelomaMelissa Alsina
Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute and Department of Oncology, University of South Florida, Tampa, FL 33612, USA
Blood 103:3271-7. 2004..We conclude that tipifarnib is tolerable, can induce disease stabilization, and can inhibit farnesylation and oncogenic/tumor survival pathways... - p21Cip1 nullizygosity increases tumor metastasis in irradiated miceRosalind J Jackson
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Cancer Res 63:3021-5. 2003..Importantly, we also show that p21(Cip1) nullizygosity increases the incidence of metastatic tumors in irradiated mice. We suggest that p21(Cip1) is haploinsufficient for tumor suppression and functions as an antimetastatic agent...
Research Grants
- FOG1 AND HEMATOPOIESISAlan Cantor; Fiscal Year: 2003..abstract_text> ..
- Proteomic Study of Megakaryocyte Transcriptional ControlAlan Cantor; Fiscal Year: 2007..The results of this study should provide new insights into the transcriptional regulation of megakaryopoiesis, and possibly new therapeutic targets for disorders of megakaryocyte proliferation and development. ..
- Proteomic Approach to Further Understanding the Role of*Alan Cantor; Fiscal Year: 2007..These studies should provide important insights that will facilitate the design of novel therapies for MDS. ..