HORACIO CANTIELLO

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Electrodiffusional ATP movement through CFTR and other ABC transporters
    H F Cantiello
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Charlestown, MA 02129 USA
    Pflugers Arch 443:S22-7. 2001
  2. ncbi Role of actin filament organization in CFTR activation
    H F Cantiello
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Pflugers Arch 443:S75-80. 2001
  3. ncbi Cation channel activity of mucolipin-1: the effect of calcium
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA
    Pflugers Arch 451:304-12. 2005
  4. ncbi Regulation of calcium signaling by polycystin-2
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Renal Physiol 286:F1012-29. 2004
  5. ncbi A tale of two tails: ciliary mechanotransduction in ADPKD
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA
    Trends Mol Med 9:234-6. 2003
  6. ncbi Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel
    Malay K Raychowdhury
    Renal Unit, Massachusetts General Hospital East, Charlestown 02129, USA
    Hum Mol Genet 13:617-27. 2004
  7. ncbi Characterization of single channel currents from primary cilia of renal epithelial cells
    Malay K Raychowdhury
    Renal Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:34718-22. 2005
  8. pmc The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1
    Peng Zhang
    Nephrology Division and Electrophysiology Core, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Hum Mol Genet 18:1238-51. 2009
  9. ncbi Polycystin-1 activates and stabilizes the polycystin-2 channel
    G Mark Xu
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    J Biol Chem 278:1457-62. 2003
  10. doi Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells
    Malay K Raychowdhury
    Nephrology Div and Electrophysiology Core, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Renal Physiol 296:F87-97. 2009

Research Grants

  1. Molecular Physiology of Polycystin-2
    Horacio F Cantiello; Fiscal Year: 2010
  2. Molecular Physiology of Polycystin-2
    HORACIO CANTIELLO; Fiscal Year: 2009

Collaborators

  • Xing Zhen Chen
  • Peng Zhang
  • Wolfgang H Goldmann
  • Jing Zhou
  • Ehud Goldin
  • Richard Bouley
  • G Mark Xu
  • M A Arnaout
  • Guanqing Wu
  • Alan S Lader
  • Nicolás Montalbetti
  • Malay K Raychowdhury
  • Qiang Li
  • Xiao Qing Dai
  • Silvia Gonzalez-Perrett
  • Yuliang Wu
  • Dennis A Ausiello
  • Bernard Chasan
  • Arnolt J Ramos
  • Gustavo A Timpanaro
  • Edward Karpinski
  • Margaret McLaughlin
  • Patrick Y Shen
  • Paul C Zamecnik
  • Cristina Ibarra
  • Basilio A Kotsias
  • María Del Rocío Cantero
  • Margaret McLaughin
  • Wentong Long
  • Richard Glynne
  • Weiyi Mai
  • Arnolt Ramos
  • Zahir Hussain
  • Guochun Li
  • Carl X Chen
  • Shaohua Wang
  • Jimena Semprine
  • Christopher I Cheeseman
  • George R Jackson
  • Adriana G Prat
  • Stefanie Stahl
  • Peter R Smith
  • Adele Cooney
  • David R Tabatadze
  • Alicia Damiano
  • Marisa Batelli
  • David G Wooster
  • Keetae Kim
  • Nicholas A Geisse
  • Nicolas Moltabetti
  • Martin Teintze
  • Marcelo D Carattino
  • Yanina Assef
  • Alicia E Damiano
  • Gustavo Timpanaro
  • Kate Pedatella
  • Sebastian Godoy
  • Ignacio L Reisin
  • Makram Essafi

Detail Information

Publications24

  1. ncbi Electrodiffusional ATP movement through CFTR and other ABC transporters
    H F Cantiello
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Charlestown, MA 02129 USA
    Pflugers Arch 443:S22-7. 2001
    ..The relevance of the ABC domains in ATP transport is also explored, and the hypothesis is forwarded that improper ATP transport by a dysfunctional CFTR is a relevant factor in cystic fibrosis...
  2. ncbi Role of actin filament organization in CFTR activation
    H F Cantiello
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Pflugers Arch 443:S75-80. 2001
    ..The possibility is also explored that actin must be directly associated with CFTR to elicit its activation, further suggesting that this channel protein may bind actin as well...
  3. ncbi Cation channel activity of mucolipin-1: the effect of calcium
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA
    Pflugers Arch 451:304-12. 2005
    ..The new evidence provides support for a novel role of ML1 cation channels in vesicular acidification and normal endosomal function...
  4. ncbi Regulation of calcium signaling by polycystin-2
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Renal Physiol 286:F1012-29. 2004
    ..Nonrenal-targeted expression of PC2 and related proteins, including the cardiovascular system, also suggests previously unforeseeable roles in signal transduction...
  5. ncbi A tale of two tails: ciliary mechanotransduction in ADPKD
    Horacio F Cantiello
    Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA
    Trends Mol Med 9:234-6. 2003
    ..When working properly, this functional complex elicits a transient Ca(2+) influx, which is coupled to the release of Ca(2+) from intracellular stores...
  6. ncbi Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel
    Malay K Raychowdhury
    Renal Unit, Massachusetts General Hospital East, Charlestown 02129, USA
    Hum Mol Genet 13:617-27. 2004
    ..The evidence also supports a novel role for cation channels in the acidification and normal endosomal function...
  7. ncbi Characterization of single channel currents from primary cilia of renal epithelial cells
    Malay K Raychowdhury
    Renal Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:34718-22. 2005
    ..Ion channel activity in the primary cilium of renal cells may be an important component of its role as a sensory transducer...
  8. pmc The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1
    Peng Zhang
    Nephrology Division and Electrophysiology Core, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Hum Mol Genet 18:1238-51. 2009
    ..The data support tetrameric models of both the PC2 and TRPC1 channels, where the overall conductance of a particular channel will depend on the contribution of the various functional monomers in the complex...
  9. ncbi Polycystin-1 activates and stabilizes the polycystin-2 channel
    G Mark Xu
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    J Biol Chem 278:1457-62. 2003
    ..The modulation of polycystin-2 channel activity by polycystin-1 may be important for the various biological processes mediated by this molecular complex...
  10. doi Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells
    Malay K Raychowdhury
    Nephrology Div and Electrophysiology Core, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Renal Physiol 296:F87-97. 2009
    ....
  11. ncbi Alpha-actinin associates with polycystin-2 and regulates its channel activity
    Qiang Li
    Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta, T6G 2H7 Canada
    Hum Mol Genet 14:1587-603. 2005
    ..Thus, physical and functional interactions between PC2 and alpha-actinin may play an important role in abnormal cell adhesion, proliferation and migration observed in ADPKD...
  12. ncbi Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells
    Qiang Li
    Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 281:37566-75. 2006
    ..The data indicate that microtubular organization regulates PC2 function, which may explain, among others, the regulatory role of PC2 in the sensory function of primary cilia...
  13. ncbi Evidence for direct interaction between actin and the cystic fibrosis transmembrane conductance regulator
    Bernard Chasan
    Physics Department, Boston University, MA, USA
    Eur Biophys J 30:617-24. 2002
    ..The present study indicates that CFTR may directly bind actin and that this interaction helps affect the functional properties of this channel protein...
  14. ncbi Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast
    Nicolás Montalbetti
    Laboratorio de Canales Iónicos, Departamento de Fisicoquimica y Quimica Analitica, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    Pflugers Arch 451:294-303. 2005
    ..This co-localization was disrupted by cytochalasin D. Taken together, our findings indicate that physical forces exerted on cells regulate PC2 channel activity by a sensory mechanism involving the actin cytoskeleton...
  15. pmc Cytoskeletal regulation of calcium-permeable cation channels in the human syncytiotrophoblast: role of gelsolin
    Nicolás Montalbetti
    Laboratorio de Canales Iónicos, Departmento de Fisicoquímica y Química Analítica, Facultad de Farmica y Bioquímica, Buenos Aires, Argentina
    J Physiol 566:309-25. 2005
    ..Cytoskeletal structures may thus be relevant to ion transport regulation in the human placenta...
  16. ncbi Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity
    Silvia Gonzalez-Perrett
    Laboratorio de Canales Iónicos, Departamento de Fisicoquimica y Quimica Analitica, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina 1113
    J Biol Chem 277:24959-66. 2002
    ..The data indicate the presence of an H(+) ion regulatory site in the channel protein, which is accessible from the cytoplasmic side of the protein. This protonation site controls polycystin-2 cation-selective channel activity...
  17. ncbi Actomyosin II interaction modulates cell cortex stability
    Wolfgang H Goldmann
    Zentralinstitut fur Biomedizinische Technik, Friedrich Alexander Universitat, Erlangen Nurnberg, D 91052 Erlangen, Germany
    Cell Biol Int 29:245-8. 2005
    ..This observation is supported by the demonstration of inactive myosin heads along actin filaments using atomic force microscopy...
  18. pmc Reversal of cystic fibrosis phenotype in a cultured Delta508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion
    Paul C Zamecnik
    Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:8150-5. 2004
    ..The mechanism of insertion of nucleotides has yet to be determined...
  19. doi Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton
    Xing Zhen Chen
    Department of Physiology, University of Alberta, Edmonton, Canada
    FEBS J 275:4675-83. 2008
    ....
  20. pmc Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures
    Nicolás Montalbetti
    Laboratorio de Canales Iónicos, Departamento de Fisicoquimica y Quimica Analitica, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    J Physiol 579:717-28. 2007
    ..We believe that the data are the first to provide a direct demonstration of a microtubular interaction with PC2 in the hST. This interaction thus plays an important regulatory role in the control of ion transport in the human placenta...
  21. ncbi Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin
    Yuliang Wu
    Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Hum Mol Genet 15:3280-92. 2006
    ..Taken together, we discovered that kinesin-2 is a linker between PC2 and FPC and mediates the regulation of PC2 channel function by FPC. Our study may be important for elucidating common molecular pathways for PKD of different genotypes...
  22. ncbi A modified mammalian tandem affinity purification procedure to prepare functional polycystin-2 channel
    Qiang Li
    Department of Physiology, University of Alberta, 7 29 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7
    FEBS Lett 576:231-6. 2004
    ..Thus, this modified TAP procedure provides a powerful alternative to functionally characterize membrane proteins, such as ion channels, transporters and receptors, using cell-free system derived from mammalian cells...
  23. ncbi Membrane currents in the oocyte of the toad Bufo arenarum
    Basilio A Kotsias
    Instituto de Investigaciones Medicas Alfredo Lanari, Facultad de Medicina, UBA, Buenos Aires, Argentina
    J Exp Zool 292:411-5. 2002
    ..This cell model may provide a viable alternative to the expression of ion channels, in particular those endogenously observed in Xenopus laevis oocytes...
  24. ncbi Characterization of Na+-permeable cation channels in LLC-PK1 renal epithelial cells
    Malay K Raychowdhury
    Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 279:20137-46. 2004
    ..The evidence provides new clues as to potentially relevant Na(+) transport mechanisms in the mammalian proximal nephron...

Research Grants2

  1. Molecular Physiology of Polycystin-2
    Horacio F Cantiello; Fiscal Year: 2010
    ..Our studies will provide a more complete understanding of polycystin-2 function, and will define the molecular basis of cystic diseases, including ADPKD. ..
  2. Molecular Physiology of Polycystin-2
    HORACIO CANTIELLO; Fiscal Year: 2009
    ..Our studies will provide a more complete understanding of polycystin-2 function, and will define the molecular basis of cystic diseases, including ADPKD. ..