S K Calderwood

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Double-stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70, and stabilization of ARE-containing HSP70 mRNA during stress
    Meijuan Zhao
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:44539-47. 2002
  2. ncbi request reprint Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1
    B Chu
    Dana Farber Cancer Institute and Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:30847-57. 1996
  3. ncbi request reprint Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta
    B Chu
    Department of Adult Oncology, Dana Farber Cancer Institute and Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:18640-6. 1998
  4. ncbi request reprint Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo
    A Asea
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Int J Hyperthermia 17:347-56. 2001
  5. ncbi request reprint Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms
    D Tang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 280:280-5. 2001
  6. ncbi request reprint Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation
    A Asea
    Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Hyperthermia 17:401-14. 2001
  7. ncbi request reprint Regulation of heat shock gene transcription in neuronal cells
    J Tonkiss
    Center for Behavioral Development, Boston University School of Medicine, Boston, MA, USA
    Int J Hyperthermia 21:433-44. 2005
  8. ncbi request reprint Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
    M A Khaleque
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 2215, USA
    Oncogene 27:1886-93. 2008
  9. ncbi request reprint Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells
    S T Palayoor
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 4:763-71. 1998
  10. ncbi request reprint Targeting HSP70-induced thermotolerance for design of thermal sensitizers
    S K Calderwood
    Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Int J Hyperthermia 18:597-608. 2002

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Double-stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70, and stabilization of ARE-containing HSP70 mRNA during stress
    Meijuan Zhao
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:44539-47. 2002
    ....
  2. ncbi request reprint Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1
    B Chu
    Dana Farber Cancer Institute and Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:30847-57. 1996
    ....
  3. ncbi request reprint Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta
    B Chu
    Department of Adult Oncology, Dana Farber Cancer Institute and Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:18640-6. 1998
    ..Regulation at 37 degrees C, therefore, involves the action of three protein kinase cascades that repress HSF1 through phosphorylation of serine residues 303, 307, and 363 and may promote growth by suppressing the heat shock response...
  4. ncbi request reprint Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo
    A Asea
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Int J Hyperthermia 17:347-56. 2001
    ..These experiments, thus, suggest the use of Quercetin as a hyperthermia sensitizer in the treatment of prostate carcinoma...
  5. ncbi request reprint Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms
    D Tang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 280:280-5. 2001
    ..These data indicate that the repression of the HSP70B promoter by NF-IL6, Ku70, and MAPK occurs independently of each other and involves three complementary mechanisms...
  6. ncbi request reprint Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation
    A Asea
    Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Hyperthermia 17:401-14. 2001
    ..01) inhibition of hyperthemia-induced serum prostaglandin E2. These findings indicate that NSAID may have both sensitizing effects on prostate tumour growth and may function by inhibiting prostaglandin synthesis...
  7. ncbi request reprint Regulation of heat shock gene transcription in neuronal cells
    J Tonkiss
    Center for Behavioral Development, Boston University School of Medicine, Boston, MA, USA
    Int J Hyperthermia 21:433-44. 2005
    ..HSF1 transcriptional activity has been discussed in neuronal cells, concentrating on the regulation and activity of HSF1 and HSF2 and their role in HSP expression, during neurodegenerative diseases and as mediators of cell survival...
  8. ncbi request reprint Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
    M A Khaleque
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 2215, USA
    Oncogene 27:1886-93. 2008
    ..Repression of estrogen-dependent transcription may contribute to the role of HSF1 in cancer...
  9. ncbi request reprint Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells
    S T Palayoor
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 4:763-71. 1998
    ....
  10. ncbi request reprint Targeting HSP70-induced thermotolerance for design of thermal sensitizers
    S K Calderwood
    Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Int J Hyperthermia 18:597-608. 2002
    ..This paper will concentrate on the molecular pathways of thermotolerance induction for designing inhibitors of heat resistance/thermal sensitizers, which may allow the full potential of thermal therapy to be utilized...
  11. ncbi request reprint HSF1, a versatile factor in tumorogenesis
    S K Calderwood
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Mol Med 12:1102-7. 2012
    ..Inhibitors of HSF1 are undergoing selection and future studies may see the testing of HSF1 as a target in cancer therapy...
  12. ncbi request reprint Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells
    S L Nunes
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 213:1-6. 1995
    ..These experiments show a profound effect of heat shock on the structure and stability of HSF-1 complexes during nuclear localization and support the hypothesis that HSC70 binding may control HSF-1 function...
  13. ncbi request reprint Evolving connections between molecular chaperones and neuronal function
    S K Calderwood
    Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Hyperthermia 21:375-8. 2005
  14. ncbi request reprint Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme
    S Lechpammer
    Department of Radiation Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Hyperthermia 18:203-15. 2002
    ....
  15. doi request reprint Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene
    M Jaskelioff
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Oncogene 28:4225-36. 2009
    ..Together, these results indicate that, in the setting of viral oncoprotein mammary tumorigenesis, telomerase-dependent telomere maintenance facilitates the formation and metastatic progression of mammary tumors...
  16. pmc Heat shock proteins in physiology and pathology: the Berlin meeting
    Alexzander A A Asea
    Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center, Temple, TX 76508, USA
    Cell Stress Chaperones 12:205-8. 2007
  17. pmc The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages
    Daolin Tang
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Changsha, People s Republic of China
    J Immunol 179:1236-44. 2007
    ..Our experimental data provide important insights into the anti-inflammatory mechanisms of heat shock protein protection...
  18. ncbi request reprint Extracellular heat shock proteins in cell signaling
    Stuart K Calderwood
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 581:3689-94. 2007
    ..The possession of a wide range of receptors for the Hsp and Grp family permits binding to a diverse range of cells and the performance of complex multicellular functions particularly in immune cells and neurones...
  19. ncbi request reprint Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells
    Yutaka Enomoto
    Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Immunol 177:5946-55. 2006
    ..These experiments indicate that HSP70-peptide complexes (PC) derived from DC-tumor fusion cells have increased their immunogenicity and therefore constitute an improved formulation of chaperone protein-based tumor vaccine...
  20. ncbi request reprint The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways
    Yongzhong Shi
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410008, People s Republic of China
    Shock 26:277-84. 2006
    ....
  21. ncbi request reprint Heat shock proteins in cancer: chaperones of tumorigenesis
    Stuart K Calderwood
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Biochem Sci 31:164-72. 2006
    ....
  22. ncbi request reprint Extracellular heat shock proteins in cell signaling and immunity
    Stuart K Calderwood
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann N Y Acad Sci 1113:28-39. 2007
    ..The possession of a wide range of receptors for the Hsp and Grp family permits binding to a diverse range of cells and the performance of complex multicellular functions particularly in immune cells and neurons...
  23. ncbi request reprint Cell surface receptors for molecular chaperones
    Stuart K Calderwood
    Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Room 553, 21 27 Burlington Avenue, Boston, MA 02215, USA
    Methods 43:199-206. 2007
    ..Understanding how heat shock protein-receptor binding orchestrates individual components of tumor immunity will permit enhanced design of molecular chaperone based immunotherapy...
  24. doi request reprint Cell fusion: from hybridoma to dendritic cell-based vaccine
    Jianlin Gong
    Department of Medicine, Boston University Medical School, Boston, MA 02118, USA
    Expert Rev Vaccines 7:1055-68. 2008
    ..In addition, we discuss the challenges facing effective fusion cell vaccine production, including factors in preparation, selection and quality control of fusion cell vaccines, as well as approaches for enhancing anti-tumor immunity...
  25. doi request reprint Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation
    Ayesha Murshid
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Expert Rev Vaccines 7:1019-30. 2008
    ....
  26. ncbi request reprint Cell stress proteins: novel immunotherapeutics
    Stuart K Calderwood
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Novartis Found Symp 291:115-31; discussion 131-40. 2008
    ..HSP-antigen complexes have proven effective in the treatment of rodent tumours in preclinical studies and are now undergoing clinical trials for treatment of human cancer...
  27. doi request reprint Heat shock proteins: stress proteins with Janus-like properties in cancer
    Stuart K Calderwood
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Hyperthermia 24:31-9. 2008
    ..Immunological approaches aim at increasing HSP levels in cells and tissues with the aim of increasing tumor antigen presentation to the immune system...
  28. pmc OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells
    Margaret A Park
    Department of Biochemistry, 401 College Street, Massey Cancer Center, Room 280a, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 73:1168-84. 2008
    ..OSU-03012 also increased expression of HSP70 in a PERK-dependent fashion, providing support for the contention that OSU-03012-induced PERK signaling promotes both cell survival and cell death processes...
  29. doi request reprint The dual immunoregulatory roles of stress proteins
    Alan Graham Pockley
    School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Trends Biochem Sci 33:71-9. 2008
    ....
  30. ncbi request reprint Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer
    Timothy Kottke
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer Res 67:11970-9. 2007
    ....
  31. ncbi request reprint How is the immune response affected by hyperthermia and heat shock proteins?
    Stuart K Calderwood
    Molecular and Cellular Radiation Oncology, BIDMC, Harvard Medical School, Boston, MA 02215, USA
    Int J Hyperthermia 21:713-6. 2005
    ..Understanding these process may permit the effective deployment of hyperthermia and hsp based vaccines in tumor treatment...
  32. ncbi request reprint Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding
    XiaoZhe Wang
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 281:782-91. 2006
    ..These experiments indicate a novel mechanism for the regulation of HSF1 by proinflammatory signaling and may permit HSF1 to respond rapidly to extracellular events, permitting optimal physiological regulation...
  33. ncbi request reprint Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress
    XiaoZhe Wang
    Dana Farber Cancer Institute and Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:49460-9. 2004
    ..Association of HSF1 with ERK and 14-3-3epsilon during heat shock may thus modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions...
  34. ncbi request reprint Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells
    Yiqun Wang
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:32651-9. 2004
    ..Our experiments therefore demonstrate that HSF1 plays a functional role in cancer cells under nonstress conditions and influences cell cycle behavior and progression through mitosis and promotes the development of the aneuploid state...
  35. pmc Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1
    XiaoZhe Wang
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:6013-26. 2003
    ..Our experiments indicate a novel pathway for HSF1 regulation and suggest a mechanism for suppression of its activity during cellular proliferation...
  36. ncbi request reprint Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress
    Haiying He
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:35465-75. 2003
    ..Our data suggest a mechanism involving the formation of heterocomplexes between HSF1 and HSF2 with enhanced activity to activate the hsp70 promoter when compared with HSF1 or HSF2 homotrimers...
  37. ncbi request reprint Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2
    Fabrice Soncin
    Centre National de la Recherche Scientifique EP 560, Institut Pasteur de Lille, 1 rue Calmette BP 245, 59021, Lille Cedex, France
    Biochem Biophys Res Commun 303:700-6. 2003
    ..Phosphorylation by CK2 on threonine 142 may therefore be an essential step in the thermal activation of latent HSF1 by stresses...
  38. ncbi request reprint Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes
    Yue Xie
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:4687-98. 2003
    ..Mapping the structural domains involved in this process should permit further characterization of molecular mechanisms that mediate repression...
  39. ncbi request reprint Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells
    Elfriede Noessner
    Clinical Cooperation Group Hyperthermie, Institute of Molecular Immunology, GSF National Research Center for Environment and Health, 81377 Munich, Germany
    J Immunol 169:5424-32. 2002
    ....
  40. ncbi request reprint NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 291:1071-80. 2002
    ..Our studies suggest a strong mutual antagonism between the heat shock response and APR, which may influence the sensitivity and duration of inflammatory responses...
  41. ncbi request reprint Regulatory interfaces between the stress protein response and other gene expression programs in the cell
    Stuart K Calderwood
    Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    Methods 35:139-48. 2005
    ..The expression of the stress protein response during periods of acute protein damage was shown to lead to efficient activation of HSF1 and HSP expression accompanied by repression of other gene expression programs...
  42. ncbi request reprint Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
    ..Interaction between HSF1 and NF-IL6 could thus be an important mechanism in HSF1 regulation of general gene transcription during endotoxin stress...
  43. ncbi request reprint Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells
    Jimmy R Theriault
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    FEBS Lett 579:1951-60. 2005
    ..In addition to APC, HSP70 can avidly bind to non-APC cell lines, especially those from epithelial or endothelial background...
  44. pmc Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo
    Dan Tang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell Stress Chaperones 10:46-58. 2005
    ....
  45. ncbi request reprint Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth
    Md Abdul Khaleque
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Oncogene 24:6564-73. 2005
    ..HSF1 activated by this pathway plays a key role in the protection of cells from apoptosis and the mediation of anchorage independent growth by HRGbeta1, indicating a role for HSF1 in this tumorigenic pathway...
  46. ncbi request reprint Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity
    Stuart K Calderwood
    Division of Molecular and Cellular Radiation Oncology, BIDMC, Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 35:2518-27. 2005
    ..HSP70-PC thus coordinately activate innate immune responses and deliver antigens for re-presentation by MHC class I and II molecules on the APC cell surface, leading to specific anti-tumor immunity...
  47. ncbi request reprint Chaperones and slow death--a recipe for tumor immunotherapy
    Stuart K Calderwood
    Molecular and Cellular Radiation Oncology, Department of Radiation Oncology, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA
    Trends Biotechnol 23:57-9. 2005
    ....
  48. pmc Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
    Daniel R Ciocca
    Oncology Laboratory, Institute of Experimental Medicine and Biology of Cuyo CRICYT CONICET, Mendoza, Argentina
    Cell Stress Chaperones 10:86-103. 2005
    ..In conclusion, the present times are of importance for the field of Hsps in cancer, with great contributions to both basic and clinical cancer research...
  49. ncbi request reprint Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4
    Alexzander Asea
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:15028-34. 2002
    ....
  50. ncbi request reprint Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells
    Salamatu S Mambula
    Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Hyperthermia 22:575-85. 2006
    ..Heat shock protein 70 (HSP70) is released from tumour cells and stimulates a potent anti-tumour immune response...
  51. ncbi request reprint Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes
    Salamatu S Mambula
    Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    J Immunol 177:7849-57. 2006
    ..Our experiments therefore suggest a mechanism for HSP70 secretion and binding to the surface of other cells that may be involved in recognition of the tumor cells by the immune system...
  52. ncbi request reprint Role of scavenger receptors in the binding and internalization of heat shock protein 70
    Jimmy R Theriault
    Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    J Immunol 177:8604-11. 2006
    ..The existence of a wide repertoire of cell surface Hsp70-binding structures may permit intracellular responses to extracellular Hsp70 that are cell specific and discriminate between Hsp70 family members...
  53. ncbi request reprint Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells
    Phillip J Gray
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 67:11942-50. 2007
    ..Thus, Cdc37 is essential for maintaining prostate tumor cell growth and may represent a novel target in the search for multitargeted therapies based on the HSP90 chaperone system...
  54. pmc Mechanisms for Hsp70 secretion: crossing membranes without a leader
    Salamatu S Mambula
    Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Room 553, Boston, MA 02215, USA
    Methods 43:168-75. 2007
    ..Thus an outline is beginning to of the mechanisms of Hsp70 secretion. Much further study will be required to fully elucidate mechanisms involved in targeting Hsp70 towards the non-canonical secretion pathways and its regulation...