SIMON B CAINE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Cocaine self-administration in dopamine D₃ receptor knockout mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, MA 02478, USA
    Exp Clin Psychopharmacol 20:352-63. 2012
  2. ncbi request reprint Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts, USA
    J Pharmacol Exp Ther 291:353-60. 1999
  3. ncbi request reprint Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 148:41-51. 2000
  4. ncbi request reprint Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 22:2977-88. 2002
  5. ncbi request reprint Behavioral pharmacologists: don't just say "no" to knockout mice. Commentary on Stephens et al. 'Studying the neurobiology of stimulant and alcohol abuse and dependence in genetically manipulated mice'
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Behav Pharmacol 13:349-52. 2002
  6. ncbi request reprint Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male rats
    S Barak Caine
    McLean Hospital, Alcohol and Drug Abuse Research Center, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 29:929-42. 2004
  7. pmc Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 27:13140-50. 2007

Research Grants

Detail Information

Publications7

  1. pmc Cocaine self-administration in dopamine D₃ receptor knockout mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, MA 02478, USA
    Exp Clin Psychopharmacol 20:352-63. 2012
    ..In addition, the D₃ antagonist PG01037 failed to affect cocaine self-administration under an FR 1 schedule in WT mice. The present data do not support a necessary role for the D₃ receptor in the direct reinforcing effects of cocaine...
  2. ncbi request reprint Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts, USA
    J Pharmacol Exp Ther 291:353-60. 1999
    ..Consequently, D(2) receptor-related neuronal mechanisms may be especially important in mediating the abuse-related effects of cocaine...
  3. ncbi request reprint Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 148:41-51. 2000
    ..Although it is generally believed that both D(1-like )and D(2-like )receptor mechanisms may be involved, recent studies suggest that D(1-like )and D(2-like )agonists have differing profiles of cocaine-related actions...
  4. ncbi request reprint Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 22:2977-88. 2002
    ..Our results also suggest that D3 and D4 receptors do not play major roles in the modulation of cocaine self-administration by D2-like drugs...
  5. ncbi request reprint Behavioral pharmacologists: don't just say "no" to knockout mice. Commentary on Stephens et al. 'Studying the neurobiology of stimulant and alcohol abuse and dependence in genetically manipulated mice'
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Behav Pharmacol 13:349-52. 2002
  6. ncbi request reprint Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male rats
    S Barak Caine
    McLean Hospital, Alcohol and Drug Abuse Research Center, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 29:929-42. 2004
    ..These findings suggest that the behavioral training history, the unit dose of cocaine, and the schedule of reinforcement are important variables in studies of sex and gonadal hormone effects on cocaine self-administration...
  7. pmc Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 27:13140-50. 2007
    ..We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice...

Research Grants1

  1. COCAINE SELF ADMINISTRATION IN DOPAMINE KNOCKOUT MICE
    SIMON CAINE; Fiscal Year: 2003
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