Catherine M Cahill

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript
    Jack T Rogers
    Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 277:45518-28. 2002
  2. pmc Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
  3. doi The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen
    Jack T Rogers
    Neurochemistry Laboratory, Psychiatry Neuroscience, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neural Transm 118:493-507. 2011
  4. pmc Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1
    Hyun Hee Cho
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 285:31217-32. 2010
  5. pmc Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital East, Harvard Medical School, CNY2, Building 149, Charlestown, MA 02129, USA
    Biochim Biophys Acta 1790:615-28. 2009
  6. pmc Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
    Jack T Rogers
    Department of Psychiatry, Neurochemistry Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Soc Trans 36:1282-7. 2008
  7. ncbi Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol
    Sandra Payton
    Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Mol Neurosci 20:267-75. 2003
  8. ncbi Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
    Sanghamitra Bandyopadhyay
    Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci Res 84:106-18. 2006
  9. pmc The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression
    Sohan Mikkilineni
    Neurochemistry Laboratory, Massachusetts General Hospital East, CNY2, 149, 13th Street, Charlestown, MA 02129, USA
    Parkinsons Dis 2012:142372. 2012
  10. ncbi Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region
    Jack T Rogers
    Genetics and Aging Unit, Massachusetts General Hospital Harvard Medical School, Charlestown 02129 4404, USA
    J Mol Neurosci 19:77-82. 2002

Collaborators

Detail Information

Publications12

  1. ncbi An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript
    Jack T Rogers
    Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 277:45518-28. 2002
    ....
  2. pmc Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
    ..This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1...
  3. doi The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen
    Jack T Rogers
    Neurochemistry Laboratory, Psychiatry Neuroscience, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neural Transm 118:493-507. 2011
    ..These are candidate drugs with the potential to limit toxic SNCA expression in the brains of PD patients and animal models in vivo...
  4. pmc Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1
    Hyun Hee Cho
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 285:31217-32. 2010
    ..Functionally, shRNA knockdown of IRP1 caused increased expression of neural APP consistent with IRP1-APP IRE-driven translation...
  5. pmc Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital East, Harvard Medical School, CNY2, Building 149, Charlestown, MA 02129, USA
    Biochim Biophys Acta 1790:615-28. 2009
    ..In the case of AD, metal based therapeutics may ultimately prove more cost effective than the use of an amyloid vaccine as the preferred anti-amyloid therapeutic strategy to ameliorate the cognitive decline of AD patients...
  6. pmc Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
    Jack T Rogers
    Department of Psychiatry, Neurochemistry Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Soc Trans 36:1282-7. 2008
    ..The same constellation of RNA-binding proteins [IRP1/IRP2/poly(C) binding protein] control ferritin and APP translation with implications for the biology of metals in AD...
  7. ncbi Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol
    Sandra Payton
    Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Mol Neurosci 20:267-75. 2003
    ..In the future, we will identify further novel compounds that influence Abeta levels, either via translation inhibition or by changing the activity of proteins coupled between APP translation and APP processing...
  8. ncbi Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
    Sanghamitra Bandyopadhyay
    Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci Res 84:106-18. 2006
    ..Our data show a complex mechanism of sAPPalpha regulation by IL-1alpha that involves ADAM-10, ADAM-17 and p38 MAPK upstream of MEK and PI3K...
  9. pmc The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression
    Sohan Mikkilineni
    Neurochemistry Laboratory, Massachusetts General Hospital East, CNY2, 149, 13th Street, Charlestown, MA 02129, USA
    Parkinsons Dis 2012:142372. 2012
    ..Primary metabolic analogs of posiphen were, likewise, characterized using primary fetal neurons grown ex vivo from the brains of Parkinson's transgenic mice expressing the human SNCA gene...
  10. ncbi Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region
    Jack T Rogers
    Genetics and Aging Unit, Massachusetts General Hospital Harvard Medical School, Charlestown 02129 4404, USA
    J Mol Neurosci 19:77-82. 2002
    ..These APP 5'UTR directed drugs exemplify a new strategy to identify RNA-directed agents to lower APP translation and A beta peptide output for Alzheimer's disease therapeutics...
  11. ncbi The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins
    Andrew M Thomson
    Laboratory for Cancer Medicine, School of Medicine and Pharmacology, UWA Centre for Medical Research, Western Australian Institute for Medical Research and University of Western Australia, Royal Perth Hospital
    J Biol Chem 280:30032-45. 2005
    ..The regulated association of H-ferritin mRNA with the poly(C)-binding proteins suggests a novel role for these proteins in ferritin translation and iron homeostasis in human liver...
  12. ncbi Internalization and trafficking of opioid receptor ligands in rat cortical neurons
    Mao Cheng Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec, Canada
    Synapse 43:102-11. 2002
    ..It is proposed that their retrograde transport into target cells might be involved in mediating some of the long-term, transcriptional effects of opioids...