Hyang Min Byun

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Environmental exposure and mitochondrial epigenetics: study design and analytical challenges
    Hyang Min Byun
    Exposure Epidemiology and Risk Program, Laboratory of Environmental Epigenetics, Harvard School of Public Health, Boston, MA, 02115, USA
    Hum Genet 133:247-57. 2014
  2. pmc Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA
    Part Fibre Toxicol 10:28. 2013
  3. pmc Effects of airborne pollutants on mitochondrial DNA methylation
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Part Fibre Toxicol 10:18. 2013
  4. pmc Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39220. 2012
  5. pmc Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Biomed Sci 19:13. 2012
  6. pmc Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease
    Carrie V Breton
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 120:1320-6. 2012
  7. pmc Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children
    Muhammad T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90089, USA
    J Allergy Clin Immunol 129:232-9.e1-7. 2012
  8. ncbi request reprint Rapid and quantitative method of allele-specific DNA methylation analysis
    Hui Lee Wong
    University of Southern California, Los Angeles, CA 90089, USA
    Biotechniques 41:734-9. 2006
  9. pmc Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu
    Heather H Burris
    Department of Neonatology, Beth Israel Deaconess Medical Center and Division of Newborn Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Epigenomics 5:271-81. 2013
  10. pmc Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
    Erika M Wolff
    Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 6:e1000917. 2010

Collaborators

Detail Information

Publications22

  1. doi request reprint Environmental exposure and mitochondrial epigenetics: study design and analytical challenges
    Hyang Min Byun
    Exposure Epidemiology and Risk Program, Laboratory of Environmental Epigenetics, Harvard School of Public Health, Boston, MA, 02115, USA
    Hum Genet 133:247-57. 2014
    ..Furthermore, we suggest future directions and perspectives in the field of mitochondrial epigenetic epidemiological studies. ..
  2. pmc Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA
    Part Fibre Toxicol 10:28. 2013
    ..The purpose of the study is to evaluate sensitivity of DNA methylation in differentially‒evolved LINE, Alu, and HERV subfamilies to different types of airborne pollutants...
  3. pmc Effects of airborne pollutants on mitochondrial DNA methylation
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Part Fibre Toxicol 10:18. 2013
    ..However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures...
  4. pmc Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39220. 2012
    ..Characterizing the degree and determinants of DNA methylation stability can provide critical information for the design and conduction of human epigenetic studies...
  5. pmc Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Biomed Sci 19:13. 2012
    ..Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability...
  6. pmc Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease
    Carrie V Breton
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 120:1320-6. 2012
    ..Epigenetic regulation of nitric oxide synthase--the gene responsible for nitric oxide production--may be affected by air pollutants and contribute to the pathogenesis of asthma and wheeze...
  7. pmc Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children
    Muhammad T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90089, USA
    J Allergy Clin Immunol 129:232-9.e1-7. 2012
    ..Short-term exposure to air pollution, haplotypes, and DNA methylation in the NOS2 promoter has been associated independently with iNOS expression, Feno levels, or both...
  8. ncbi request reprint Rapid and quantitative method of allele-specific DNA methylation analysis
    Hui Lee Wong
    University of Southern California, Los Angeles, CA 90089, USA
    Biotechniques 41:734-9. 2006
    ..Although we could reliably determine allele-specific methylation with our technique, additional studies will be required to confirm the ability of our assay to measure loss of imprinting...
  9. pmc Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu
    Heather H Burris
    Department of Neonatology, Beth Israel Deaconess Medical Center and Division of Newborn Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Epigenomics 5:271-81. 2013
    ..We examined the association between birth weight and methylation in the imprinted IGF/H19 loci, the nonimprinted gene NR3C1 and repetitive element DNA (LINE-1 and Alu)...
  10. pmc Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
    Erika M Wolff
    Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 6:e1000917. 2010
    ..These data show that, in addition to contributing to chromosomal instability, hypomethylation of LINE-1s can alter the functional transcriptome and plays a role not only in human disease but also in disease predisposition...
  11. doi request reprint Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 18:4808-17. 2009
    ..05). Finally, we found that the Illumina GoldenGate assay features a large number of probes (265/1505 probes, 17.6%) that contain single-nucleotide polymorphisms, which may interfere with DNA methylation analyses in genome-wide studies...
  12. ncbi request reprint Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition
    Si Ho Choi
    Division of Hematology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Br J Haematol 138:616-23. 2007
    ..This data suggest that concurrent combination of HC blocks the ability of azacitidine and decitabine to inhibit DNA methylation and therefore these drugs should be used sequentially...
  13. doi request reprint Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer
    Si Ho Choi
    Jane Anne Nohl Division of Hematology, Center for Blood Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 125:723-9. 2009
    ....
  14. ncbi request reprint Examination of IGF2 and H19 loss of imprinting in bladder cancer
    Hyang Min Byun
    Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Cancer Res 67:10753-8. 2007
    ..LOI and allele-specific DNA methylation changes are present in bladder cancer; however, a better understanding of the biology of LOI and its relationship to DNA methylation changes is needed before its use as an epigenetic biomarker...
  15. pmc Genome-scale analysis of aberrant DNA methylation in colorectal cancer
    Toshinori Hinoue
    Department of Surgery and Department of Biochemistry and Molecular Biology, University of Southern California, USC Epigenome Center, Los Angeles, California 90089 9601, USA
    Genome Res 22:271-82. 2012
    ..Together, we identified four distinct DNA methylation subgroups of CRC and provided novel insight regarding the role of CIMP-specific DNA hypermethylation in gene silencing...
  16. doi request reprint A phase I biological study of azacitidine (Vidaza™) to determine the optimal dose to inhibit DNA methylation
    Ilan Bernstein
    Jane Anne Nohl Division of Hematology, University of Southern California, Los Angeles, CA, USA
    Epigenetics 5:750-7. 2010
    ..7% with 75 mg/m² IV and 3.4% by subcutaneous administration. The data indicates that 75 mg/m² azacitidine given IV or SC effectively leads to global DNA methylation reduction by LINE-1 analysis...
  17. pmc Identification of preferential target sites for human DNA methyltransferases
    Si Ho Choi
    Jane Anne Nohl Division of Hematology, Norris Cancer Center, University of Southern California, Los Angeles, CA, 90033, USA
    Nucleic Acids Res 39:104-18. 2011
    ..Our data suggest that different DNMT domains are responsible for targeting DNA methylation to specific regions of the genome, and this targeting might be associated with histone modifications...
  18. pmc 2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1
    Hyang Min Byun
    Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Room 6428, Los Angeles, CA, USA
    Cancer Lett 266:238-48. 2008
    ..Theses differences between decitabine and NPEOC-DAC are dependent on the cleavage of the carboxylester bond, and could be potentially exploited pharmacologically...
  19. doi request reprint Predicting DNA methylation level across human tissues
    Baoshan Ma
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK, Department of Clinical Sciences and Community, University of Milan, Milan 20122, Italy, Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA and Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Nucleic Acids Res 42:3515-28. 2014
    ..g. blood) could be recalibrated to improve understanding of epigenetics in hard-to-access tissues (e.g. atrium) and might enable non-invasive disease screening using epigenetic profiles. ..
  20. pmc DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma
    Carrie V Breton
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 184:191-7. 2011
    ..Genetic variation in arginase (ARG) and nitric oxide synthase (NOS) has been associated with exhaled nitric oxide (FeNO) levels in children. Little is known about whether epigenetic variation in these genes modulates FeNO...
  21. doi request reprint Effects of short-term exposure to inhalable particulate matter on DNA methylation of tandem repeats
    Liqiong Guo
    Laboratory of Environmental Epigenetics, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts Key Laboratory of Pollution Processes and Environmental Criteria Ministry of Education, College of Environmental Sciences and Engineering, Nankai University, Tianjin, China
    Environ Mol Mutagen 55:322-35. 2014
    ..Environ. Mol. Mutagen. 55:322-335, 2014. © 2014 Wiley Periodicals, Inc. ..
  22. doi request reprint Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice
    Christine B Yoo
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9181, USA
    Cancer Prev Res (Phila) 1:233-40. 2008
    ..Importantly, prolonged treatment of mice with epigenetic drugs resulted in only minor developmental and histologic changes...