Rami Burstein


Affiliation: Harvard University
Country: USA


  1. request reprint
    Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005;115:21-8 pubmed
  2. Burstein R, Strassman A, Moskowitz M. Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia. 2012;32:509-11 pubmed publisher
  3. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015;35:6619-29 pubmed publisher
  4. Zhang X, Strassman A, Novack V, Brin M, Burstein R. Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?. Cephalalgia. 2016;36:875-86 pubmed publisher
    ..In the context of chronic migraine, reduced sensitivity to molecules that activate meningeal nociceptors through the TRPV1 and TRPA1 channels can be important for BoNT-A's ability to act as a prophylactic. ..
  5. Noseda R, Bernstein C, Nir R, Lee A, Fulton A, Bertisch S, et al. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016;139:1971-86 pubmed publisher
    ..Additionally, the findings provide substrate for the soothing effects of green light. ..
  6. Schain A, Melo Carrillo A, Strassman A, Burstein R. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci. 2017;37:2904-2915 pubmed publisher
    ..This closure holds the potential to define a novel mechanism for regulation of glymphatic flow. It also implicates the glymphatic system in the altered cortical and endothelial functioning of the migraine brain. ..
  7. Melo Carrillo A, Noseda R, Nir R, Schain A, Stratton J, Strassman A, et al. Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017;37:7149-7163 pubmed publisher
  8. Noseda R, Lee A, Nir R, Bernstein C, Kainz V, Bertisch S, et al. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017;114:E5683-E5692 pubmed publisher
  9. Burstein R, Jakubowski M, Garcia Nicas E, Kainz V, Bajwa Z, Hargreaves R, et al. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010;68:81-91 pubmed publisher

More Information


  1. Burstein R, Jakubowski M, Rauch S. The science of migraine. J Vestib Res. 2011;21:305-14 pubmed publisher
    ..Both our clinical and pre-clinical findings of the last five years point to possible short- and long-term advantages in using an early-treatment approach in the treatment of acute migraine attacks. ..
  2. Melo Carrillo A, Strassman A, Nir R, Schain A, Noseda R, Stratton J, et al. Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017;37:10587-10596 pubmed publisher