Rami Burstein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The science of migraine
    Rami Burstein
    Departments of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Vestib Res 21:305-14. 2011
  2. pmc Excitatory neurotransmitters in brain regions in interictal migraine patients
    Andrew Prescot
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Mol Pain 5:34. 2009
  3. ncbi request reprint Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 115:21-8. 2005
  4. doi request reprint Neural substrate of depression during migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 330 Brookline Avenue, Boston, MA 02215, USA
    Neurol Sci 30:S27-31. 2009
  5. pmc Thalamic sensitization transforms localized pain into widespread allodynia
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 68:81-91. 2010
  6. pmc Activation of central trigeminovascular neurons by cortical spreading depression
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 69:855-65. 2011
  7. ncbi request reprint Unitary hypothesis for multiple triggers of the pain and strain of migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:9-14. 2005
  8. ncbi request reprint Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors
    Moshe Jakubowski
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Headache 45:850-61. 2005
  9. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
  10. pmc Mast cell degranulation activates a pain pathway underlying migraine headache
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 130:166-76. 2007

Collaborators

Detail Information

Publications42

  1. pmc The science of migraine
    Rami Burstein
    Departments of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Vestib Res 21:305-14. 2011
    ..Both our clinical and pre-clinical findings of the last five years point to possible short- and long-term advantages in using an early-treatment approach in the treatment of acute migraine attacks...
  2. pmc Excitatory neurotransmitters in brain regions in interictal migraine patients
    Andrew Prescot
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Mol Pain 5:34. 2009
    ..We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain...
  3. ncbi request reprint Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 115:21-8. 2005
    ....
  4. doi request reprint Neural substrate of depression during migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 330 Brookline Avenue, Boston, MA 02215, USA
    Neurol Sci 30:S27-31. 2009
    ....
  5. pmc Thalamic sensitization transforms localized pain into widespread allodynia
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 68:81-91. 2010
    ....
  6. pmc Activation of central trigeminovascular neurons by cortical spreading depression
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 69:855-65. 2011
    ....
  7. ncbi request reprint Unitary hypothesis for multiple triggers of the pain and strain of migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:9-14. 2005
    ....
  8. ncbi request reprint Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors
    Moshe Jakubowski
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Headache 45:850-61. 2005
    ..To determine whether delayed infusion of COX1/COX2 inhibitors (ketorolac, indomethacin) will stop migraine in allodynic patients, and suppress ongoing sensitization in central trigeminovascular neurons in the rat...
  9. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
    ....
  10. pmc Mast cell degranulation activates a pain pathway underlying migraine headache
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 130:166-76. 2007
    ..Our findings provide evidence linking dural mast cell degranulation to prolonged activation of the trigeminal pain pathway believed to underlie intracranial headaches such as that of migraine...
  11. ncbi request reprint Can allodynic migraine patients be identified interictally using a questionnaire?
    Moshe Jakubowski
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 65:1419-22. 2005
    ..In this study, the authors developed a questionnaire that tested the recollection of the patients on their skin sensitivity during past migraine attacks...
  12. pmc Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms
    Rodrigo Noseda
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 31:14204-17. 2011
    ....
  13. pmc Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 30:8807-14. 2010
    ..We suggest that migraine with aura is initiated by waves of CSD that lead up to delayed activation of the trigeminovascular pathway...
  14. pmc Sensitization of meningeal nociceptors: inhibition by naproxen
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 27:917-22. 2008
    ..The findings suggest that local COX activity in the dura could mediate the peripheral sensitization that underlies migraine headache...
  15. pmc Her versus his migraine: multiple sex differences in brain function and structure
    Nasim Maleki
    Department of Anaesthesia, Centre for Pain and the Brain, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain 135:2546-59. 2012
    ....
  16. pmc Concurrent functional and structural cortical alterations in migraine
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, USA
    Cephalalgia 32:607-20. 2012
    ..Defining concurrent cortical alterations may provide specific insights into the unfolding adaptive or maladaptive changes taking place in cortex in migraine...
  17. pmc Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess, Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Behav Immun 26:311-7. 2012
    ..Our data further suggest that MC activation may lead to widespread tactile pain hypersensitivity...
  18. pmc Localization of COX-1 and COX-2 in the intracranial dura mater of the rat
    Xi Chun Zhang
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
    Neurosci Lett 452:33-6. 2009
    ..The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater...
  19. pmc Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators
    Xi Chun Zhang
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Pharmacol Exp Ther 322:806-12. 2007
    ..We propose that dural mast cells could promote headache by releasing 5-HT, PGI(2), and histamine...
  20. ncbi request reprint Defeating migraine pain with triptans: a race against the development of cutaneous allodynia
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:19-26. 2004
    ..We conclude that the probability of consistent pain-free outcome increases drastically if triptan therapy is vigilantly timed to precede any signs of cutaneous allodynia...
  21. ncbi request reprint Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:27-36. 2004
    ..Thus, triptan action appears to be exerted directly on peripheral rather than central trigeminovascular neurons...
  22. ncbi request reprint Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 58:698-705. 2005
    ..The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors...
  23. pmc A neural mechanism for exacerbation of headache by light
    Rodrigo Noseda
    Department of Anesthesia, Boston, Massachusetts, USA
    Nat Neurosci 13:239-45. 2010
    ..We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons...
  24. doi request reprint A critical view on the role of migraine triggers in the genesis of migraine pain
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Headache 49:953-7. 2009
    ....
  25. pmc Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia
    Nasim Maleki
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Hum Brain Mapp 33:75-88. 2012
    ..Consistent with physiological and anatomical studies in rats, the data provide an anatomical substrate for exacerbation of migraine headache by light in the human...
  26. pmc Sensory innervation of the calvarial bones of the mouse
    Bela Kosaras
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 515:331-48. 2009
    ..In view of the concentration of sensory fibers in the sutures, it may be useful to avoid drilling the sutures in patients undergoing craniotomies for a variety of neurosurgical procedures...
  27. pmc Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists
    Dan Levy
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:4274-9. 2004
    ..We therefore suggest that the analgesic action of triptan can be attained specifically in the absence, but not in the presence, of central sensitization...
  28. pmc Common hippocampal structural and functional changes in migraine
    Nasim Maleki
    Department of Anesthesia and Radiology, Center for Pain and the Brain, MCL, MGH and CHB, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Brain Struct Funct 218:903-12. 2013
    ..The results implicate involvement of hippocampus in the pathophysiology of the migraine...
  29. ncbi request reprint Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
    J Neurobiol 61:107-25. 2004
    ..These advances are likely to contribute greatly to the diagnosis and treatment of clinical pain conditions affecting the trigeminal system (e.g., neuropathic pain, migraine)...
  30. pmc Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Epilepsy Behav 28:243-8. 2013
    ....
  31. pmc Exploding vs. imploding headache in migraine prophylaxis with Botulinum Toxin A
    Moshe Jakubowski
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Pain 125:286-95. 2006
    ..The amenability of imploding and ocular headaches to BTX-A treatment suggests that these types of migraine pain involve extracranial innervation as well...
  32. ncbi request reprint Implications of multimechanism therapy: when to treat?
    Rami Burstein
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Neurology 64:S16-20. 2005
  33. doi request reprint Advances in understanding the mechanisms of migraine-type photophobia
    Rodrigo Noseda
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 24:197-202. 2011
    ....
  34. pmc Migraine prophylaxis with botulinum toxin A is associated with perception of headache
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Toxicon 54:624-7. 2009
    ..Imploding/ocular migraine headache is more likely than exploding headache to be prevented by prophylactic BTX-A treatment. Further validation of this principle should await large-scale prospective, placebo-controlled studies...
  35. pmc Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
    ....
  36. doi request reprint Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine
    Thomas Simopoulos
    Beth Israel Deaconess Medical Center Anesthesia, Boston, MA, USA
    Headache 50:1064-9. 2010
    ..To report a case of improved pain control and function in a patient with chronic migraine after treatment with auriculotemporal nerve stimulation...
  37. ncbi request reprint Mast cell involvement in the pathophysiology of migraine headache: A hypothesis
    Dan Levy
    Department of Anesthesia and Critical Care, Headache Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Headache 46:S13-8. 2006
    ..Further studies are needed to test directly the nature of mast cell involvement in the pathogenesis of migraine headache...
  38. doi request reprint Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
    Rodrigo Noseda
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Pain 154:S44-53. 2013
    ....
  39. doi request reprint Altered placebo and drug labeling changes the outcome of episodic migraine attacks
    Slavenka Kam-Hansen
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 6:218ra5. 2014
    ..The benefits of placebo persisted even if placebo was honestly described. Whether treatment involves medication or placebo, the information provided to patients and the ritual of pill taking are important components of care. ..
  40. ncbi request reprint 2003 Wolff Award: Possible parasympathetic contributions to peripheral and central sensitization during migraine
    David Yarnitsky
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Headache 43:704-14. 2003
    ....
  41. pmc Cutaneous allodynia in the migraine population
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 63:148-58. 2008
    ..To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population...
  42. ncbi request reprint Functional imaging of the trigeminal system: applications to migraine pathophysiology
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Headache 46:S32-8. 2006
    ....