R Burstein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Unitary hypothesis for multiple triggers of the pain and strain of migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:9-14. 2005
  2. ncbi request reprint Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine
    R Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Rev Neurol (Paris) 161:658-60. 2005
  3. ncbi request reprint Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:27-36. 2004
  4. ncbi request reprint Defeating migraine pain with triptans: a race against the development of cutaneous allodynia
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:19-26. 2004
  5. pmc Migraine prophylaxis with botulinum toxin A is associated with perception of headache
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Toxicon 54:624-7. 2009
  6. ncbi request reprint The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine
    R Burstein
    Department of Anesthesia and Critical Care, Harvard Medical School, Boston, MA 02115, USA
    Brain 123:1703-9. 2000
  7. ncbi request reprint Implications of multimechanism therapy: when to treat?
    Rami Burstein
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Neurology 64:S16-20. 2005
  8. ncbi request reprint Sensitization of meningeal sensory neurons and the origin of headaches
    A M Strassman
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 384:560-4. 1996
  9. pmc Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion
    M Jakubowski
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuroscience 148:573-83. 2007
  10. ncbi request reprint Distinct lateral and medial projections of the spinohypothalamic tract of the rat
    R Burstein
    Department of Anesthesia and Critical Care, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 373:549-74. 1996

Research Grants

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Unitary hypothesis for multiple triggers of the pain and strain of migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:9-14. 2005
    ....
  2. ncbi request reprint Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine
    R Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Rev Neurol (Paris) 161:658-60. 2005
    ..We also present evidence that the development of cutaneous allodynia during migraine is detrimental to termination of acute migraine attacks using triptans (5HT1B/1D receptor agonist)...
  3. ncbi request reprint Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:27-36. 2004
    ..Thus, triptan action appears to be exerted directly on peripheral rather than central trigeminovascular neurons...
  4. ncbi request reprint Defeating migraine pain with triptans: a race against the development of cutaneous allodynia
    Rami Burstein
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 55:19-26. 2004
    ..We conclude that the probability of consistent pain-free outcome increases drastically if triptan therapy is vigilantly timed to precede any signs of cutaneous allodynia...
  5. pmc Migraine prophylaxis with botulinum toxin A is associated with perception of headache
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Toxicon 54:624-7. 2009
    ..Imploding/ocular migraine headache is more likely than exploding headache to be prevented by prophylactic BTX-A treatment. Further validation of this principle should await large-scale prospective, placebo-controlled studies...
  6. ncbi request reprint The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine
    R Burstein
    Department of Anesthesia and Critical Care, Harvard Medical School, Boston, MA 02115, USA
    Brain 123:1703-9. 2000
    ..Because currently available drugs that aim to suppress central sensitization are ineffective, this study stresses the need to develop them for the treatment of migraine...
  7. ncbi request reprint Implications of multimechanism therapy: when to treat?
    Rami Burstein
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Neurology 64:S16-20. 2005
  8. ncbi request reprint Sensitization of meningeal sensory neurons and the origin of headaches
    A M Strassman
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 384:560-4. 1996
    ....
  9. pmc Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion
    M Jakubowski
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuroscience 148:573-83. 2007
    ..Though impractical as a routine migraine therapy, parenteral NSAID administration should be useful as a non-narcotic rescue therapy for migraine in the setting of the emergency department...
  10. ncbi request reprint Distinct lateral and medial projections of the spinohypothalamic tract of the rat
    R Burstein
    Department of Anesthesia and Critical Care, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 373:549-74. 1996
    ..They also suggest a site that can be lesioned without affecting other ascending sensory spinal pathways...
  11. pmc A neurohistochemical blueprint for pain-induced loss of appetite
    A Malick
    Department of Neurobiology and the Program in Neuroscience, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9930-5. 2001
    ..Based on these findings, we suggest that at least one of several groups of hypothalamic neurons that normally inhibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake by pain signals...
  12. pmc Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States
    E A Moulton
    Pain Analgesia Imaging Neuroscience Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Cereb Cortex 21:435-48. 2011
    ..Observed temporal lobe abnormalities may provide a basis for many of the perceptual changes in migraineurs and may serve as a potential interictal biomarker for drug efficacy...
  13. ncbi request reprint Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 115:21-8. 2005
    ....
  14. doi request reprint Neural substrate of depression during migraine
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 330 Brookline Avenue, Boston, MA 02215, USA
    Neurol Sci 30:S27-31. 2009
    ....
  15. pmc Sensitization of meningeal nociceptors: inhibition by naproxen
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 27:917-22. 2008
    ..The findings suggest that local COX activity in the dura could mediate the peripheral sensitization that underlies migraine headache...
  16. pmc Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators
    Xi Chun Zhang
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Pharmacol Exp Ther 322:806-12. 2007
    ..We propose that dural mast cells could promote headache by releasing 5-HT, PGI(2), and histamine...
  17. pmc Mast cell degranulation activates a pain pathway underlying migraine headache
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 130:166-76. 2007
    ..Our findings provide evidence linking dural mast cell degranulation to prolonged activation of the trigeminal pain pathway believed to underlie intracranial headaches such as that of migraine...
  18. pmc Thalamic sensitization transforms localized pain into widespread allodynia
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 68:81-91. 2010
    ....
  19. ncbi request reprint Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
    J Neurobiol 61:107-25. 2004
    ..These advances are likely to contribute greatly to the diagnosis and treatment of clinical pain conditions affecting the trigeminal system (e.g., neuropathic pain, migraine)...
  20. ncbi request reprint Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 58:698-705. 2005
    ..The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors...
  21. ncbi request reprint Can allodynic migraine patients be identified interictally using a questionnaire?
    Moshe Jakubowski
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 65:1419-22. 2005
    ..In this study, the authors developed a questionnaire that tested the recollection of the patients on their skin sensitivity during past migraine attacks...
  22. pmc Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 30:8807-14. 2010
    ..We suggest that migraine with aura is initiated by waves of CSD that lead up to delayed activation of the trigeminovascular pathway...
  23. pmc A neural mechanism for exacerbation of headache by light
    Rodrigo Noseda
    Department of Anesthesia, Boston, Massachusetts, USA
    Nat Neurosci 13:239-45. 2010
    ..We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons...
  24. ncbi request reprint Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors
    Moshe Jakubowski
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Headache 45:850-61. 2005
    ..To determine whether delayed infusion of COX1/COX2 inhibitors (ketorolac, indomethacin) will stop migraine in allodynic patients, and suppress ongoing sensitization in central trigeminovascular neurons in the rat...
  25. pmc Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists
    Dan Levy
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:4274-9. 2004
    ..We therefore suggest that the analgesic action of triptan can be attained specifically in the absence, but not in the presence, of central sensitization...
  26. doi request reprint A critical view on the role of migraine triggers in the genesis of migraine pain
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Headache 49:953-7. 2009
    ....
  27. pmc Interictal dysfunction of a brainstem descending modulatory center in migraine patients
    Eric A Moulton
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 3:e3799. 2008
    ..To determine whether a brainstem dysfunction could play a role in facilitating migraine attacks, we measured brainstem function in migraineurs when they were not having an attack (i.e. the interictal phase)...
  28. pmc Sensory innervation of the calvarial bones of the mouse
    Bela Kosaras
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 515:331-48. 2009
    ..In view of the concentration of sensory fibers in the sutures, it may be useful to avoid drilling the sutures in patients undergoing craniotomies for a variety of neurosurgical procedures...
  29. pmc Localization of COX-1 and COX-2 in the intracranial dura mater of the rat
    Xi Chun Zhang
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
    Neurosci Lett 452:33-6. 2009
    ..The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater...
  30. pmc The enigma of the dorsolateral pons as a migraine generator
    D Borsook
    Harvard Medical School, USA
    Cephalalgia 32:803-12. 2012
    ....
  31. ncbi request reprint 2003 Wolff Award: Possible parasympathetic contributions to peripheral and central sensitization during migraine
    David Yarnitsky
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Headache 43:704-14. 2003
    ....
  32. doi request reprint Predicting migraine responsiveness to botulinum toxin type A injections
    Christine C Kim
    SkinCare Physicians, Chestnut Hill, Massachusetts, USA
    Arch Dermatol 146:159-63. 2010
    ....
  33. ncbi request reprint Mast cell involvement in the pathophysiology of migraine headache: A hypothesis
    Dan Levy
    Department of Anesthesia and Critical Care, Headache Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Headache 46:S13-8. 2006
    ..Further studies are needed to test directly the nature of mast cell involvement in the pathogenesis of migraine headache...
  34. doi request reprint Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine
    Thomas Simopoulos
    Beth Israel Deaconess Medical Center Anesthesia, Boston, MA, USA
    Headache 50:1064-9. 2010
    ..To report a case of improved pain control and function in a patient with chronic migraine after treatment with auriculotemporal nerve stimulation...
  35. pmc Exploding vs. imploding headache in migraine prophylaxis with Botulinum Toxin A
    Moshe Jakubowski
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Pain 125:286-95. 2006
    ..The amenability of imploding and ocular headaches to BTX-A treatment suggests that these types of migraine pain involve extracranial innervation as well...
  36. pmc Cutaneous allodynia in the migraine population
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 63:148-58. 2008
    ..To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population...
  37. ncbi request reprint Functional imaging of the trigeminal system: applications to migraine pathophysiology
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Headache 46:S32-8. 2006
    ....

Research Grants11

  1. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2009
    ....
  2. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2007
    ....
  3. NEUROBIOLOGY OF ANOREXIA INDUCED BY MIGRAINE PAIN
    Rami Burstein; Fiscal Year: 2004
    ..abstract_text> ..
  4. Migraine pathophysiology: neural basis of photophobia
    Rami Burstein; Fiscal Year: 2010
    ..This application could potentially open a unique window into the biology of an adverse phenomenon described by millions of headache sufferers. ..