Research Topics
| Deborah BursteinSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the kneeStanley B Cohen
Rheumatology, Metroplex Clinical Research Center, 8144 Walnut Hill Lane, Dallas, TX 75231, USA
Arthritis Res Ther 13:R125. 2011..The purpose of this two-part study was to evaluate the safety and pharmacokinetics (PK; Part A) and clinical effect (Part B) of AMG 108 in a double-blind, placebo-controlled, multiple-dose study in patients with OA of the knee...
Tracking longitudinal changes in knee degeneration and repairDeborah Burstein
Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Mailstop 148, Boston, MA 02115, USA
J Bone Joint Surg Am 91:51-3. 2009..The ability of magnetic resonance imaging to visualize osteoarthritis as a regional and responsive (reversible) disease may lead to new paradigms for developing and applying lifestyle, medical, and surgical therapeutic interventions...
Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: the influence of timing after contrast injectionCarl J Tiderius
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Magn Reson Med 57:803-5. 2007..At all time points, T(1)(Gd) was 20-30% lower in patients than in asymptomatic volunteers (P < 0.003), which demonstrates the sensitivity of dGEMRIC to early hip OA...- MRI for development of disease-modifying osteoarthritis drugsDeborah Burstein
Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA 02115, USA
NMR Biomed 19:669-80. 2006..In the second part, applications of the MRI parameters in preclinical and clinical drug development are presented... - Measures of molecular composition and structure in osteoarthritisDeborah Burstein
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
Radiol Clin North Am 47:675-86. 2009..Specific examples illustrate new opportunities and insights emerging from these methods... - Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0TCharles A McKenzie
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Magn Reson Imaging 24:928-33. 2006..5T and 3.0T... - Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus: an index of meniscal tissue degeneration?Nitya Krishnan
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:1507-11. 2007..The goal of this study was to explore T1(Gd) in the meniscus and its relationship with articular cartilage T1(Gd) in knee dGEMRIC image data sets... - Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applicationsAshley Williams
Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir, Rm. 147, Boston, MA 02115, USA
AJR Am J Roentgenol 182:167-72. 2004..Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions... - Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilageYoung Jo Kim
Children s Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 85:1987-92. 2003..We performed this comparison by assessing the correlation between the findings of each technique and clinically important factors such as pain, severity of dysplasia, and age... - Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignmentAshley Williams
Beth Israel Deaconess Medical Center and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
Arthritis Rheum 52:3528-35. 2005..43, P = 0.02). CONCLUSION: The biochemical information provided by dGEMRIC scans may augment radiography by improving the differentiation of disease status within a given radiographic grade, especially in early OA... - Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0TAshley Williams
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Magn Reson Med 58:830-4. 2007..5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T... - Osteoarthritis: current role of imagingAli Guermazi
Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Third Floor, Boston, MA 02118, USA
Med Clin North Am 93:101-26, xi. 2009..This article focuses on radiography and MRI, with insight into other modalities, such as ultrasound, scintigraphy, and CT. Their role in OA diagnosis, follow-up, and research is discussed... - Diffusion tensor imaging of native and degenerated human articular cartilageXiang Deng
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 25:168-71. 2007..DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here... - Imaging in osteoarthritisAli Guermazi
Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Third Floor, Boston, MA 02118, USA
Rheum Dis Clin North Am 34:645-87. 2008..The other modalities discussed in this article are valuable additional techniques indicated on a case-by-case basis... - Delayed contrast-enhanced MRI of cartilage: comparison of nonionic and ionic contrast agentsWei Li
Department of Radiology, NorthShore University Healthsystem, Evanston, Illinois 60201, USA
Magn Reson Med 64:1267-73. 2010..Future studies could be designed to use contrast-enhanced dynamics to understand the transport properties of tissues in the joint and to evaluate the concentration of tissue constituents... - Radiographic and patient factors associated with pre-radiographic osteoarthritis in hip dysplasiaRebecca H Jessel
Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
J Bone Joint Surg Am 91:1120-9. 2009.... - T2 of articular cartilage in the presence of Gd-DTPA2-Miika T Nieminen
Beth Israel Deaconess Medical Center, Department of Radiology, Boston, Massachusetts, USA
Magn Reson Med 51:1147-52. 2004..Therefore, it may be possible to perform a comprehensive clinical examination of dGEMRIC, T(2), and cartilage volume in one scanning session without T(2) data correction... - Articular cartilage in the knee: current MR imaging techniques and applications in clinical practice and researchMichel D Crema
Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine and Boston Imaging Core Laboratory, 820 Harrison Ave, FGH Building, 3rd Floor, Boston, MA 02118, USA
Radiographics 31:37-61. 2011..These techniques may be used in various combinations and at various magnetic field strengths in clinical and research settings to improve the characterization of changes in cartilage... - New MRI techniques for imaging cartilageDeborah Burstein
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Bone Joint Surg Am 85:70-7. 2003 - Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradationAshley Williams
New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
Arthritis Res Ther 5:R97-105. 2003..This finding could suggest that the most severely degraded regions do not recover fully, possibly because of more severe collagen damage; this possibility requires further examination... - Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritisAli Guermazi
Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
Arthritis Res Ther 13:247. 2011..Detection of joint space narrowing on radiography seems outdated now that it is possible to directly visualize morphologic and pre-morphologic changes of cartilage by using conventional as well as complex MRI techniques... - Relationship between cartilage stiffness and dGEMRIC index: correlation and predictionMarta Baldassarri
New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Orthop Res 25:904-12. 2007..A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error... - Relaxivity and diffusion of gadolinium agents in cartilageAmy Gillis
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Magn Reson Med 48:1068-71. 2002..From the perspective of transport, if Gd(HPDO3A) has fully penetrated the cartilage, Gd(DTPA)(2-) would have in the same time frame. Therefore, the data confirm the efficacy of using Gd(HPDO3A) as a "control agent" for dGEMRIC... - Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumorsAaron L Nelson
Division of Neurology, Department of Neurosciences, Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
J Neurooncol 62:259-67. 2003..Results also show that experimental mice, even symptomatic mice, tolerate repeated serial imaging studies over weeks to months to follow tumor progression and to visualize placement of an intracerebral drug delivery system... - In vivo MRI of embryonic stem cells in a mouse model of myocardial infarctionNathan Himes
Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Magn Reson Med 52:1214-9. 2004..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction... - Perfusion MRI of U87 brain tumors in a mouse modelYanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 51:893-9. 2004..The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy... - 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applicationsMartha L Gray
Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
J Orthop Res 26:281-91. 2008..This new technical capability offers the promises of speeding development of effective therapies and focusing their use in areas where they can be most successful... - T2 and T1rho MRI in articular cartilage systemsNina M Menezes
Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
Magn Reson Med 51:503-9. 2004..Overall, these studies illustrate that T2 and T1rho are sensitive to biologically meaningful changes in cartilage. However, contrary to some previous reports, they are not specific to any one inherent tissue parameter... - Potential for misinterpretation of combined T1- and T2-weighted contrast-enhanced MR imaging of cartilageDeborah Burstein
Radiology 233:619-20; author reply 621-2. 2004 - Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the Look Locker methodTali Kimelman
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA
Invest Radiol 41:198-203. 2006..07 at 1.5 T and P = 0.07 at 3.0 T). CONCLUSIONS: The preliminary data presented here suggest that the 3DLL sequence provides accurate T1 values with sufficient in-plane resolution and allows full joint coverage in less than 10 minutes... - MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markersGarry E Gold
Stanford University, USA
Osteoarthritis Cartilage 14:A76-86. 2006..The following report summarizes the results of these discussions with respect to novel MRI pulse sequences for evaluating articular cartilage of the knee in OA and notes any additional advances that have been made since... - Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritisFelix Eckstein
Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
NMR Biomed 19:822-54. 2006....
Research Grants
- MULTIPARAMETRIC MRI OF CARTILAGEDeborah Burstein; Fiscal Year: 2002..abstract_text> ..
- MULTIPARAMETRIC MRI OF CARTILAGEDeborah Burstein; Fiscal Year: 2009....