Deborah Burstein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
    Stanley B Cohen
    Rheumatology, Metroplex Clinical Research Center, 8144 Walnut Hill Lane, Dallas, TX 75231, USA
    Arthritis Res Ther 13:R125. 2011
  2. doi request reprint Tracking longitudinal changes in knee degeneration and repair
    Deborah Burstein
    Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Mailstop 148, Boston, MA 02115, USA
    J Bone Joint Surg Am 91:51-3. 2009
  3. ncbi request reprint Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: the influence of timing after contrast injection
    Carl J Tiderius
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Magn Reson Med 57:803-5. 2007
  4. ncbi request reprint MRI for development of disease-modifying osteoarthritis drugs
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA 02115, USA
    NMR Biomed 19:669-80. 2006
  5. doi request reprint Measures of molecular composition and structure in osteoarthritis
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    Radiol Clin North Am 47:675-86. 2009
  6. ncbi request reprint Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T
    Charles A McKenzie
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson Imaging 24:928-33. 2006
  7. ncbi request reprint Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus: an index of meniscal tissue degeneration?
    Nitya Krishnan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1507-11. 2007
  8. ncbi request reprint Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications
    Ashley Williams
    Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir, Rm 147, Boston, MA 02115, USA
    AJR Am J Roentgenol 182:167-72. 2004
  9. ncbi request reprint Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment
    Ashley Williams
    Beth Israel Deaconess Medical Center and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Arthritis Rheum 52:3528-35. 2005
  10. ncbi request reprint Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T
    Ashley Williams
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Magn Reson Med 58:830-4. 2007

Research Grants

  1. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2002
  2. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2009

Collaborators

Detail Information

Publications32

  1. pmc A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
    Stanley B Cohen
    Rheumatology, Metroplex Clinical Research Center, 8144 Walnut Hill Lane, Dallas, TX 75231, USA
    Arthritis Res Ther 13:R125. 2011
    ..The purpose of this two-part study was to evaluate the safety and pharmacokinetics (PK; Part A) and clinical effect (Part B) of AMG 108 in a double-blind, placebo-controlled, multiple-dose study in patients with OA of the knee...
  2. doi request reprint Tracking longitudinal changes in knee degeneration and repair
    Deborah Burstein
    Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Mailstop 148, Boston, MA 02115, USA
    J Bone Joint Surg Am 91:51-3. 2009
    ..The ability of magnetic resonance imaging to visualize osteoarthritis as a regional and responsive (reversible) disease may lead to new paradigms for developing and applying lifestyle, medical, and surgical therapeutic interventions...
  3. ncbi request reprint Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: the influence of timing after contrast injection
    Carl J Tiderius
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Magn Reson Med 57:803-5. 2007
    ..At all time points, T(1)(Gd) was 20-30% lower in patients than in asymptomatic volunteers (P < 0.003), which demonstrates the sensitivity of dGEMRIC to early hip OA...
  4. ncbi request reprint MRI for development of disease-modifying osteoarthritis drugs
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA 02115, USA
    NMR Biomed 19:669-80. 2006
    ..In the second part, applications of the MRI parameters in preclinical and clinical drug development are presented...
  5. doi request reprint Measures of molecular composition and structure in osteoarthritis
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    Radiol Clin North Am 47:675-86. 2009
    ..Specific examples illustrate new opportunities and insights emerging from these methods...
  6. ncbi request reprint Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T
    Charles A McKenzie
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson Imaging 24:928-33. 2006
    ..5T and 3.0T...
  7. ncbi request reprint Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus: an index of meniscal tissue degeneration?
    Nitya Krishnan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1507-11. 2007
    ..The goal of this study was to explore T1(Gd) in the meniscus and its relationship with articular cartilage T1(Gd) in knee dGEMRIC image data sets...
  8. ncbi request reprint Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications
    Ashley Williams
    Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir, Rm 147, Boston, MA 02115, USA
    AJR Am J Roentgenol 182:167-72. 2004
    ..We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique...
  9. ncbi request reprint Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment
    Ashley Williams
    Beth Israel Deaconess Medical Center and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Arthritis Rheum 52:3528-35. 2005
    ....
  10. ncbi request reprint Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T
    Ashley Williams
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Magn Reson Med 58:830-4. 2007
    ..5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T...
  11. doi request reprint Osteoarthritis: current role of imaging
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Third Floor, Boston, MA 02118, USA
    Med Clin North Am 93:101-26, xi. 2009
    ..This article focuses on radiography and MRI, with insight into other modalities, such as ultrasound, scintigraphy, and CT. Their role in OA diagnosis, follow-up, and research is discussed...
  12. ncbi request reprint Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage
    Young Jo Kim
    Children s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 85:1987-92. 2003
    ..We performed this comparison by assessing the correlation between the findings of each technique and clinically important factors such as pain, severity of dysplasia, and age...
  13. ncbi request reprint Diffusion tensor imaging of native and degenerated human articular cartilage
    Xiang Deng
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Magn Reson Imaging 25:168-71. 2007
    ..DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here...
  14. doi request reprint Imaging in osteoarthritis
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Third Floor, Boston, MA 02118, USA
    Rheum Dis Clin North Am 34:645-87. 2008
    ..The other modalities discussed in this article are valuable additional techniques indicated on a case-by-case basis...
  15. doi request reprint Delayed contrast-enhanced MRI of cartilage: comparison of nonionic and ionic contrast agents
    Wei Li
    Department of Radiology, NorthShore University Healthsystem, Evanston, Illinois 60201, USA
    Magn Reson Med 64:1267-73. 2010
    ..Future studies could be designed to use contrast-enhanced dynamics to understand the transport properties of tissues in the joint and to evaluate the concentration of tissue constituents...
  16. doi request reprint Radiographic and patient factors associated with pre-radiographic osteoarthritis in hip dysplasia
    Rebecca H Jessel
    Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    J Bone Joint Surg Am 91:1120-9. 2009
    ....
  17. ncbi request reprint T2 of articular cartilage in the presence of Gd-DTPA2-
    Miika T Nieminen
    Beth Israel Deaconess Medical Center, Department of Radiology, Boston, Massachusetts, USA
    Magn Reson Med 51:1147-52. 2004
    ..Therefore, it may be possible to perform a comprehensive clinical examination of dGEMRIC, T(2), and cartilage volume in one scanning session without T(2) data correction...
  18. doi request reprint Articular cartilage in the knee: current MR imaging techniques and applications in clinical practice and research
    Michel D Crema
    Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine and Boston Imaging Core Laboratory, 820 Harrison Ave, FGH Building, 3rd Floor, Boston, MA 02118, USA
    Radiographics 31:37-61. 2011
    ..These techniques may be used in various combinations and at various magnetic field strengths in clinical and research settings to improve the characterization of changes in cartilage...
  19. ncbi request reprint New MRI techniques for imaging cartilage
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Bone Joint Surg Am 85:70-7. 2003
  20. pmc Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation
    Ashley Williams
    New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    Arthritis Res Ther 5:R97-105. 2003
    ..This finding could suggest that the most severely degraded regions do not recover fully, possibly because of more severe collagen damage; this possibility requires further examination...
  21. pmc Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis
    Ali Guermazi
    Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
    Arthritis Res Ther 13:247. 2011
    ..Detection of joint space narrowing on radiography seems outdated now that it is possible to directly visualize morphologic and pre-morphologic changes of cartilage by using conventional as well as complex MRI techniques...
  22. ncbi request reprint Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction
    Marta Baldassarri
    New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    J Orthop Res 25:904-12. 2007
    ..A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error...
  23. ncbi request reprint Relaxivity and diffusion of gadolinium agents in cartilage
    Amy Gillis
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Magn Reson Med 48:1068-71. 2002
    ..From the perspective of transport, if Gd(HPDO3A) has fully penetrated the cartilage, Gd(DTPA)(2-) would have in the same time frame. Therefore, the data confirm the efficacy of using Gd(HPDO3A) as a "control agent" for dGEMRIC...
  24. ncbi request reprint Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors
    Aaron L Nelson
    Division of Neurology, Department of Neurosciences, Children s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Neurooncol 62:259-67. 2003
    ..Results also show that experimental mice, even symptomatic mice, tolerate repeated serial imaging studies over weeks to months to follow tumor progression and to visualize placement of an intracerebral drug delivery system...
  25. ncbi request reprint In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction
    Nathan Himes
    Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Magn Reson Med 52:1214-9. 2004
    ..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction...
  26. ncbi request reprint Perfusion MRI of U87 brain tumors in a mouse model
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:893-9. 2004
    ..The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy...
  27. ncbi request reprint 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications
    Martha L Gray
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    J Orthop Res 26:281-91. 2008
    ..This new technical capability offers the promises of speeding development of effective therapies and focusing their use in areas where they can be most successful...
  28. ncbi request reprint T2 and T1rho MRI in articular cartilage systems
    Nina M Menezes
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    Magn Reson Med 51:503-9. 2004
    ..Overall, these studies illustrate that T2 and T1rho are sensitive to biologically meaningful changes in cartilage. However, contrary to some previous reports, they are not specific to any one inherent tissue parameter...
  29. ncbi request reprint Potential for misinterpretation of combined T1- and T2-weighted contrast-enhanced MR imaging of cartilage
    Deborah Burstein
    Radiology 233:619-20; author reply 621-2. 2004
  30. ncbi request reprint Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the Look Locker method
    Tali Kimelman
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA
    Invest Radiol 41:198-203. 2006
    ..The objective of this study was to implement a three-dimensional (3-D) T1 mapping sequence (3DLL) at 3.0 T for dGEMRIC based on the Look Locker scheme...
  31. ncbi request reprint MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers
    Garry E Gold
    Stanford University, USA
    Osteoarthritis Cartilage 14:A76-86. 2006
    ..The following report summarizes the results of these discussions with respect to novel MRI pulse sequences for evaluating articular cartilage of the knee in OA and notes any additional advances that have been made since...
  32. ncbi request reprint Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
    NMR Biomed 19:822-54. 2006
    ....

Research Grants12

  1. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2002
    ..abstract_text> ..
  2. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2009
    ....