A J Burger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Circadian patterns of heart rate variability in normals, chronic stable angina and diabetes mellitus
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cardiol 71:41-8. 1999
  2. ncbi Effect of nesiritide (B-type natriuretic peptide) and dobutamine on ventricular arrhythmias in the treatment of patients with acutely decompensated congestive heart failure: the PRECEDENT study
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Am Heart J 144:1102-8. 2002
  3. ncbi Age and sex as determinants of ventricular arrhythmic events in patients with decompensated congestive heart failure
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA
    Ann Noninvasive Electrocardiol 7:234-41. 2002
  4. ncbi Nesiritide: past, present, and future
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Harvard Medical School, Boston, MA 02215, USA
    Minerva Cardioangiol 53:509-22. 2005
  5. ncbi Marked abnormalities in heart rate variability are associated with progressive deterioration of renal function in type I diabetic patients with overt nephropathy
    Andrew J Burger
    Beth Israel Deaconess Medical Center and Harvard Medical School, Noninvasive Cardiology Laboratory, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 86:281-7. 2002
  6. ncbi Blunted sympathetic response in diabetic patients with decompensated congestive heart failure
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, West Campus Noninvasive Cardiology Laboratory, Baker 3 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 81:243-9. 2001
  7. ncbi Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 79:159-65. 2001
  8. ncbi Comparison of the occurrence of ventricular arrhythmias in patients with acutely decompensated congestive heart failure receiving dobutamine versus nesiritide therapy
    A J Burger
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 88:35-9. 2001
  9. ncbi Effect of beta-blockade on autonomic modulation of heart rate and neurohormonal profile in decompensated heart failure
    D Aronson
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Noninvasive Electrocardiol 6:98-106. 2001
  10. ncbi New therapies for the treatment of congestive heart failure
    Andrew J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
    Drugs Today (Barc) 38:31-48. 2002

Collaborators

Detail Information

Publications44

  1. ncbi Circadian patterns of heart rate variability in normals, chronic stable angina and diabetes mellitus
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cardiol 71:41-8. 1999
    ....
  2. ncbi Effect of nesiritide (B-type natriuretic peptide) and dobutamine on ventricular arrhythmias in the treatment of patients with acutely decompensated congestive heart failure: the PRECEDENT study
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Am Heart J 144:1102-8. 2002
    ..In this randomized, multicenter trial, we compared the safety and clinical effectiveness of the cardiac hormone nesiritide (human B-type natriuretic peptide) with dobutamine in hospitalized patients with decompensated CHF...
  3. ncbi Age and sex as determinants of ventricular arrhythmic events in patients with decompensated congestive heart failure
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA
    Ann Noninvasive Electrocardiol 7:234-41. 2002
    ..Patients with congestive heart failure (CHF) have a high prevalence of ventricular ectopy. However, in the setting of CHF, it is not known whether sex-related or age-dependent differences exist in the susceptibility to arrhythmias...
  4. ncbi Nesiritide: past, present, and future
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Harvard Medical School, Boston, MA 02215, USA
    Minerva Cardioangiol 53:509-22. 2005
    ..The possibility of subcutaneous injections of nesiritide has been studied in both animals and humans...
  5. ncbi Marked abnormalities in heart rate variability are associated with progressive deterioration of renal function in type I diabetic patients with overt nephropathy
    Andrew J Burger
    Beth Israel Deaconess Medical Center and Harvard Medical School, Noninvasive Cardiology Laboratory, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 86:281-7. 2002
    ..We sought to examine the relationship between cardiac autonomic neuropathy as assessed by heart rate variability and overt nephropathy, with emphasis on the progression of renal dysfunction over 1 year...
  6. ncbi Blunted sympathetic response in diabetic patients with decompensated congestive heart failure
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, West Campus Noninvasive Cardiology Laboratory, Baker 3 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 81:243-9. 2001
    ..Altered neurohumoral physiology may underlie the poor prognosis of diabetic patients with heart failure...
  7. ncbi Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 79:159-65. 2001
    ..This association was initially based on small numbers of patients, limited data on dose and duration of drug therapy, and no correlation with matched controls...
  8. ncbi Comparison of the occurrence of ventricular arrhythmias in patients with acutely decompensated congestive heart failure receiving dobutamine versus nesiritide therapy
    A J Burger
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 88:35-9. 2001
    ....
  9. ncbi Effect of beta-blockade on autonomic modulation of heart rate and neurohormonal profile in decompensated heart failure
    D Aronson
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Noninvasive Electrocardiol 6:98-106. 2001
    ..The purpose of the current study was to evaluate the effect of beta-blockers on heart rate variability (HRV) in decompensated CHF...
  10. ncbi New therapies for the treatment of congestive heart failure
    Andrew J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
    Drugs Today (Barc) 38:31-48. 2002
    ..All are being actively investigated and many show significant promise as beneficial therapies in the treatment of heart failure...
  11. ncbi Effect of vasoactive therapy on heart rate variability in patients with acutely decompensated congestive heart failure
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Cardiol 84:476-8, A10. 1999
    ..Improvement in heart rate variability is closely associated with improvement in heart failure, which may represent a decrease in sympathetic overactivity...
  12. ncbi Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 84:687-91. 1999
    ..Power spectral analysis of HRV allows early identification of potential reversibility as early as 1 year after the institution of strict glycemic control...
  13. ncbi Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 34:1153-8. 1999
    ..This investigation sought to determine the effect of phentermine-fenfluramine (phen-fen) on the prevalence of valvular heart disease in 226 obese subjects enrolled in a prospective, strict weight loss, research protocol...
  14. ncbi Safety and efficacy of an accelerated dobutamine stress echocardiography protocol in the evaluation of coronary artery disease
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 86:825-9. 2000
    ....
  15. ncbi Effect of diabetes mellitus on heart rate variability in patients with congestive heart failure
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Pacing Clin Electrophysiol 24:53-9. 2001
    ..Furthermore, during increased sympathetic stimulation in the setting of heart failure, diabetes does not worsen parasympathetic withdrawal but may mitigate sympathetic activation...
  16. ncbi Circadian patterns of heart rate variability, fibrinolytic activity, and hemostatic factors in type I diabetes mellitus with cardiac autonomic neuropathy
    D Aronson
    Division of Cardiology, Beth Israel Deaconess Medical Center, Joslin Diabetes Center, Boston, Massachusetts, USA
    Am J Cardiol 84:449-53. 1999
    ..These abnormalities may attenuate the relative protection from coronary events during the afternoon and nighttime...
  17. ncbi Effect of beta-blockade on heart rate variability in decompensated heart failure
    D Aronson
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cardiol 79:31-9. 2001
    ..6+/-1.5 vs. 19.0+/-5.3, P=0.04). CONCLUSIONS: beta-blockers improve the impaired cardiac autonomic regulation during high sympathetic stress of decompensated heart failure...
  18. ncbi Activity of the neurohormonal system and its relationship to autonomic abnormalities in decompensated heart failure
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Card Fail 7:122-8. 2001
    ..The ability of long-term HRV parameters to reflect in part the activation of diverse hormonal systems may explain their greater prognostic power for risk stratification in patients with CHF...
  19. ncbi Diabetes and the occurrence of ventricular arrhythmic events in patients with severe left ventricular dysfunction
    D Aronson
    Beth Israel Deaconess Medical Centre, Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
    Diabetologia 45:1440-5. 2002
    ..However, experimental and clinical studies are inconsistent with regard to the risk of arrhythmic events in patients with diabetes. We studied the frequency of ventricular arrhythmic events in patients with and without diabetes...
  20. ncbi Effect of beta-adrenergic blocker therapy on the circadian rhythm of heart rate variability in patients with chronic stable angina pectoris
    A J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 83:596-8, A8. 1999
    ....
  21. ncbi BNP in decompensated heart failure: diagnostic, prognostic and therapeutic potential
    M R Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, MA 02215, USA
    Curr Opin Investig Drugs 2:929-35. 2001
    ..Current research suggests an important role for use of nesiritide in the treatment of decompensated heart failure...
  22. ncbi Early cardioversion of atrial fibrillation facilitated by transesophageal echocardiography: short-term safety and impact on maintenance of sinus rhythm at 1 year
    M J Weigner
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Med 110:694-702. 2001
    ....
  23. ncbi Relation between pulse pressure and survival in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 93:785-8. 2004
    ..We found that the association of PP with outcome in this setting is reversed, with low PP being an independent predictor of mortality...
  24. ncbi Effect of elevated admission serum creatinine and its worsening on outcome in hospitalized patients with decompensated heart failure
    Mohammed W Akhter
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Cardiol 94:957-60. 2004
    ..Similarly, an increase in serum creatinine (>0.5 mg/dl) in the hospital results in a significantly longer length of stay and has an independent effect on long-term mortality...
  25. ncbi Prognosis assessment in patients with decompensated heart failure. Simple clinical parameters or neurohormonal factors
    Doron Aronson
    Ital Heart J 5:494-7. 2004
  26. ncbi Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 116:466-73. 2004
    ..In heart failure, renal function involves both cardiovascular and hemodynamic properties. We studied the relation between renal dysfunction and mortality in patients admitted for decompensated heart failure...
  27. ncbi Effect of nesiritide (human b-type natriuretic peptide) and dobutamine on heart rate variability in decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am Heart J 148:e16. 2004
    ..We sought to assess the effects of nesiritide compared with dobutamine on time-domain indices of heart rate variability (HRV) in patients with decompensated CHF...
  28. ncbi A review of the renal and neurohormonal effects of B-type natriuretic peptide
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Congest Heart Fail 11:30-8. 2005
    ..As a result, nesiritide quickly reduces clinical symptoms and improves mortality in patients with acute CHF...
  29. ncbi Prognostic impact of diabetes mellitus in patients with acute decompensated heart failure
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA
    Am J Cardiol 95:1117-9. 2005
    ..DM is common among patients admitted with decompensated HF, and diabetes-related biologic differences contribute to the progression of HF...
  30. ncbi Risk of death with nesiritide
    Andrew J Burger
    JAMA 294:897; author reply 898. 2005
  31. ncbi A pilot study to test the effect of pulsatile insulin infusion on cardiovascular mechanisms that might contribute to attenuation of renal compromise in type 1 diabetes mellitus patients with proteinuria
    Larry A Weinrauch
    Joslin Diabetes Center, Boston, MA, USA
    Metabolism 56:1453-7. 2007
    ....
  32. ncbi Improved glycemic control induces regression of left ventricular mass in patients with type 1 diabetes mellitus
    Franz C Aepfelbacher
    Noninvasive Cardiology Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Cardiol 94:47-51. 2004
    ..We sought to determine whether improved glycemic control in patients with type 1 diabetes mellitus will induce reversal of those abnormalities...
  33. ncbi Measures of heart period variability as predictors of mortality in hospitalized patients with decompensated congestive heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 93:59-63. 2004
    ..Together with previous studies, our findings suggest that indexes of overall HRV provide useful prognostic information in the full spectrum of CHF severity...
  34. ncbi The effect of sex on ventricular arrhythmic events in patients with congestive heart failure
    Doron Aronson
    Cardiology Division, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 25:1206-11. 2002
    ..Further understanding of the mechanisms involved in the protection conferred by the patient's sex would advance our understanding about arrhythmias in heart failure...
  35. ncbi Concomitant beta-blocker therapy is associated with a lower occurrence of ventricular arrhythmias in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    J Card Fail 8:79-85. 2002
    ..However, supporting data in patients with CHF are sparse, especially in the setting of excessive neurohumoral activation associated with symptomatic decompensated heart failure...
  36. ncbi False positive ST segment elevation during dobutamine stress echocardiography due to left ventricular hypertrophy
    Andrew J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Echocardiography 19:103-8. 2002
    ..This ST elevation may be related to transient electrocardiographic repolarization changes in the hypertrophied ventricle in the presence of altered loading conditions and/or altered catecholamine influences rather than true ischemia...
  37. ncbi Neurohumoral activation and ventricular arrhythmias in patients with decompensated congestive heart failure: role of endothelin
    Doron Aronson
    Cardiology Division, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 26:703-10. 2003
    ..Proarrhythmic effects may account, in part, for the poor outcome associated with increased endothelin-1 levels in patients with decompensated CHF...
  38. ncbi Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 26:1254-61. 2003
    ..These results suggest that cardiac K(ATP) channel activation may be involved in the genesis of ventricular arrhythmias in CHF...
  39. ncbi Comparison of the effects of dobutamine and nesiritide (B-type natriuretic peptide) on ventricular ectopy in acutely decompensated ischemic versus nonischemic cardiomyopathy
    Andrew J Burger
    Non Invasive Cardiology Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Baker 3, 1 Deaconess Road, Boston, MA 02215, USA harvard edu
    Am J Cardiol 91:1370-2. 2003
  40. ncbi Economic implications of nesiritide versus dobutamine in the treatment of patients with acutely decompensated congestive heart failure
    Gregory de Lissovoy
    MEDTAP International, Inc, Bethesda, Maryland 20814, USA
    Am J Cardiol 92:631-3. 2003
    ..Results indicate that the acquisition cost of nesiritide is fully offset by decreased hospital costs...
  41. ncbi Nesiritide in acute heart failure
    Andrew J Burger
    Lancet 362:998; author reply 998-9. 2003
  42. ncbi Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates
    Ajay J Kirtane
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    J Am Coll Cardiol 45:1781-6. 2005
    ..We hypothesized that elevated blood urea nitrogen (BUN) would be associated with adverse outcomes independent of serum creatinine (sCr)-based estimates of kidney function in patients with acute coronary syndromes (ACS)...
  43. ncbi Intravenous nesiritide (human B-type natriuretic peptide) reduces plasma endothelin-1 levels in patients with decompensated congestive heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 90:435-8. 2002
  44. ncbi Neurohormonal prediction of mortality following admission for decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 91:245-8. 2003