Jon A Buras

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Inhibition of C5 or absence of C6 protects from sepsis mortality
    Jon A Buras
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Immunobiology 209:629-35. 2004
  2. ncbi request reprint Animal models of sepsis: setting the stage
    Jon A Buras
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 4:854-65. 2005
  3. ncbi request reprint Hyperbaric oxygen protects from sepsis mortality via an interleukin-10-dependent mechanism
    Jon A Buras
    New England Inflammation and Tissue Protection Institute Consortium at Northeastern University, Boston, MA, USA
    Crit Care Med 34:2624-9. 2006
  4. ncbi request reprint Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression
    Steven D Salhanick
    Program in Toxicology, Division of Emergency Medicine, Children s Hospital, Boston, MA, USA
    Acad Emerg Med 13:707-14. 2006
  5. ncbi request reprint CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17
    Lauren Rice
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 191:1368-76. 2005
  6. ncbi request reprint Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice
    Steven D Salhanick
    Department of Emergency Medicine, Beth Israel Deaconess Hospital, Boston, MA, USA
    Acad Emerg Med 13:479-85. 2006
  7. ncbi request reprint Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:6373-80. 2005
  8. pmc Role for the alternative complement pathway in ischemia/reperfusion injury
    Gregory L Stahl
    Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 162:449-55. 2003
  9. pmc A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice
    Bryan G Belikoff
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 186:2444-53. 2011

Collaborators

  • Michail Sitkovsky
  • GREGORY STAHL
  • Kazue Takahashi
  • Akio Ohta
  • WILLIAM AIRD
  • Steven D Salhanick
  • Daniel Orlow
  • Bryan G Belikoff
  • Wende Reenstra
  • Melanie L Hart
  • Lauren Rice
  • Stephen Hatfield
  • Daniel G Remick
  • Dmitriy Lukashev
  • Peter Georgiev
  • Bryan Belikoff
  • Doug E Holt
  • Stavros Pavlides
  • Douglas Holt
  • Kathleen A Ceonzo
  • Wende R Reenstra
  • Lisa A Shaffer
  • Hiromi Wada
  • Katherine Ceonzo
  • Aurthur O Tzianabos
  • Russell P Rother

Detail Information

Publications9

  1. ncbi request reprint Inhibition of C5 or absence of C6 protects from sepsis mortality
    Jon A Buras
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Immunobiology 209:629-35. 2004
    ..Inhibition of the complement MAC does not increase bacterial load or mortality, therefore, the use of anti-C5 therapy may be beneficial rather than detrimental in sepsis...
  2. ncbi request reprint Animal models of sepsis: setting the stage
    Jon A Buras
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 4:854-65. 2005
    ..This review summarizes the common animal sepsis models and highlights how results of recent human clinical trials might affect their use...
  3. ncbi request reprint Hyperbaric oxygen protects from sepsis mortality via an interleukin-10-dependent mechanism
    Jon A Buras
    New England Inflammation and Tissue Protection Institute Consortium at Northeastern University, Boston, MA, USA
    Crit Care Med 34:2624-9. 2006
    ..Finally, we wished to determine whether the mechanism of HBO2 protection in sepsis was dependent on IL-10 production...
  4. ncbi request reprint Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression
    Steven D Salhanick
    Program in Toxicology, Division of Emergency Medicine, Children s Hospital, Boston, MA, USA
    Acad Emerg Med 13:707-14. 2006
    ..In vitro assays were performed to better understand the effects of HBO2 on HIF-1alpha function...
  5. ncbi request reprint CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17
    Lauren Rice
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 191:1368-76. 2005
    ..Anti-IL-17 antibody inhibited the CpG-mediated prevention of mortality. These data suggest that IL-17 may mediate CpG-inducible host defenses during intraabdominal sepsis...
  6. ncbi request reprint Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice
    Steven D Salhanick
    Department of Emergency Medicine, Beth Israel Deaconess Hospital, Boston, MA, USA
    Acad Emerg Med 13:479-85. 2006
    ..The authors sought to evaluate the effect of eNOS-derived NO during APAP toxicity...
  7. ncbi request reprint Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:6373-80. 2005
    ..These data demonstrate that C2 and MBL, but not C1q, are necessary for gut injury after GI/R. Lung injury in mice after GI/R is MBL and C1q independent, but C2 dependent, suggesting a potential role for ficolins in this model...
  8. pmc Role for the alternative complement pathway in ischemia/reperfusion injury
    Gregory L Stahl
    Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 162:449-55. 2003
    ..These data suggest that the alternative complement pathway plays an important role in local and remote tissue injury after GI/R. Inhibition of factor D may represent an effective therapeutic approach for GI/R injury...
  9. pmc A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice
    Bryan G Belikoff
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 186:2444-53. 2011
    ..Our findings of enhanced bacterial clearance and host survival suggest that antagonism of A2BRs offers a therapeutic target to improve macrophage function in a late treatment protocol that improves sepsis survival...