JACK BUKOWSKI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
    J F Bukowski
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:57-65. 1999
  2. ncbi L-theanine intervention enhances human gammadeltaT lymphocyte function
    Jack F Bukowski
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nutr Rev 66:96-102. 2008
  3. ncbi T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity
    J F Bukowski
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 30:3199-206. 2000
  4. ncbi Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 98:1616-8. 2001
  5. ncbi Human V gamma 2V delta 2 T cells produce IFN-gamma and TNF-alpha with an on/off/on cycling pattern in response to live bacterial products
    L Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:6195-201. 2001
  6. ncbi MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and, Harvard Medical School, Boston, MA 02115, USA
    Immunity 15:83-93. 2001
  7. ncbi Antibacterial effect of human V gamma 2V delta 2 T cells in vivo
    L Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 108:1349-57. 2001
  8. ncbi Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study
    Cheryl A Rowe
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Am Coll Nutr 26:445-52. 2007
  9. ncbi Human V gamma 2V delta 2 T cells augment migration-inhibitory factor secretion and counteract the inhibitory effect of glucocorticoids on IL-1 beta and TNF-alpha production
    Lisheng Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 168:4889-96. 2002
  10. ncbi Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells
    Hong Wang
    Division of Rheumatology, Department of Internal Medicine and Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City, IA 52442, USA
    J Immunol 170:3696-706. 2003

Research Grants

  1. Role of human gamma delta T cells in tumor immunity
    JACK BUKOWSKI; Fiscal Year: 2003

Collaborators

Detail Information

Publications11

  1. ncbi Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
    J F Bukowski
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:57-65. 1999
    ....
  2. ncbi L-theanine intervention enhances human gammadeltaT lymphocyte function
    Jack F Bukowski
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nutr Rev 66:96-102. 2008
    ..Supplementation of subjects with capsules containing L-theanine and catechins has recently been shown to decrease the incidence of cold and flu symptoms, while enhancing gammadeltaT cell function...
  3. ncbi T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity
    J F Bukowski
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 30:3199-206. 2000
    ..Given the possibility that endogenous ligands may bind to cell surface gangliosides, regulation of their levels and topology on the cell surface may constitute an immunoregulatory mechanism...
  4. ncbi Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 98:1616-8. 2001
    ....
  5. ncbi Human V gamma 2V delta 2 T cells produce IFN-gamma and TNF-alpha with an on/off/on cycling pattern in response to live bacterial products
    L Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:6195-201. 2001
    ..Thus, human gammadelta T cells may mediate innate resistance to extracellular bacteria via tightly regulated cytokine production without necessarily expanding in number...
  6. ncbi MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and, Harvard Medical School, Boston, MA 02115, USA
    Immunity 15:83-93. 2001
    ..Thus, a MICA-NKG2D interaction may be necessary for an effective innate immune response to microbe-associated antigens that also are constitutively present in vivo...
  7. ncbi Antibacterial effect of human V gamma 2V delta 2 T cells in vivo
    L Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 108:1349-57. 2001
    ....
  8. ncbi Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study
    Cheryl A Rowe
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Am Coll Nutr 26:445-52. 2007
    ..Determine if a specific formulation of Camellia sinensis (CSF) can prevent illness and symptoms due to cold and flu, and enhance gammadelta T cell function..
  9. ncbi Human V gamma 2V delta 2 T cells augment migration-inhibitory factor secretion and counteract the inhibitory effect of glucocorticoids on IL-1 beta and TNF-alpha production
    Lisheng Wang
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 168:4889-96. 2002
    ..Thus, human Vgamma2Vdelta2 T cells are likely to play broad-spectrum roles in immunoregulation and immunopathology by influencing MIF secretion and the immunomodulatory function of glucocorticoids...
  10. ncbi Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells
    Hong Wang
    Division of Rheumatology, Department of Internal Medicine and Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City, IA 52442, USA
    J Immunol 170:3696-706. 2003
    ..Thus, recognition of nonpeptide prenyl pyrophosphate, bisphosphonate, and alkylamine Ags is conserved in primates suggesting that primates can provide an animal model for human gammadelta T cell Ag responses...
  11. ncbi Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention
    Susan S Percival
    Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, USA
    J Nutr 138:1-4. 2008
    ..While clarifying the diet and gammadelta T interrelationship may not be simple, the societal implications are enormous...

Research Grants3

  1. Role of human gamma delta T cells in tumor immunity
    JACK BUKOWSKI; Fiscal Year: 2003
    ..These studies will thus help define the role of VgammaVdelta2 T cells in human tumor immunity. ..