Affiliation: Harvard University
- The role of the hippocampus in prediction and imaginationRandy L Buckner
Howard Hughes Medical Institute at Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Psychol 61:27-48, C1-8. 2010....
- The organization of the human striatum estimated by intrinsic functional connectivityEun Young Choi
Program in Neuroscience, Division of Medical Sciences, Harvard University, Cambridge, MA, USA
J Neurophysiol 108:2242-63. 2012..The resulting estimates of striatal organization provide a reference for exploring how the striatum contributes to processing motor, limbic, and heteromodal information through multiple large-scale corticostriatal circuits...
- Opportunities and limitations of intrinsic functional connectivity MRIRandy L Buckner
Department of Psychology, Center for Brain Science, Harvard University, Cambridge Massachusetts, USA
Nat Neurosci 16:832-7. 2013..Critically to study of between-group differences, fcMRI is sensitive to head motion and to differences in the mental states of participants during the scans. We discuss the potential of fcMRI in the context of its limitations. ..
- The serendipitous discovery of the brain's default networkRandy L Buckner
Department of Psychology, Harvard University, Center for Brain Science, Cambridge, MA 02138, USA
Neuroimage 62:1137-45. 2012..Later, its presence was shunned as evidence of an experimental confound. Finally, it emerged as a mainstream target of focused study. Here, I describe a personal perspective of the default network's serendipitous discovery...
- The organization of the human cerebellum estimated by intrinsic functional connectivityRandy L Buckner
Howard Hughes Medical Institute, Cambridge, Massachusetts, USA
J Neurophysiol 106:2322-45. 2011..The orderly topography of the representations suggests that the cerebellum possesses at least two large, homotopic maps of the full cerebrum and possibly a smaller third map...
- Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's diseaseRandy L Buckner
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 29:1860-73. 2009....
- Functional-anatomic fractionation of the brain's default networkJessica R Andrews-Hanna
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 65:550-62. 2010..During certain experimentally directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged, presumably to facilitate construction of mental models of personally significant events...
- Disruption of large-scale brain systems in advanced agingJessica R Andrews-Hanna
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 56:924-35. 2007..These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition...
- The organization of local and distant functional connectivity in the human brainJorge Sepulcre
Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America
PLoS Comput Biol 6:e1000808. 2010..We discuss the implications of these observations and applications of the present method for exploring normal and atypical brain function...
- Clan mentality: evidence that the medial prefrontal cortex responds to close othersFenna M Krienen
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 30:13906-15. 2010..These results encourage further exploration of the idea that frontal systems linked with limbic circuits facilitate assessment of the relevance or personal significance in social contexts...
- Functional connectivity of the macaque posterior parahippocampal cortexJustin L Vincent
1Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurophysiol 103:793-800. 2010..By specifying the location of the putative macaque homologue in parietal cortex, we provide a target for future physiological exploration of this area's role in mnemonic or alternative processes...
- Disruption of functional connectivity in clinically normal older adults harboring amyloid burdenTrey Hedden
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Neurosci 29:12686-94. 2009....
- Amyloid deposition is associated with impaired default network function in older persons without dementiaReisa A Sperling
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 63:178-88. 2009....
- Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivityFenna M Krienen
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Cereb Cortex 19:2485-97. 2009..We conclude by providing a provisional map of the topography of the cerebellum based on functional correlations with the frontal cortex...
- Predicting the location of entorhinal cortex from MRIBruce Fischl
Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 47:8-17. 2009....
- Self-projection and the brainRandy L Buckner
Department of Psychology and Center for Brain Science, Harvard University, William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Trends Cogn Sci 11:49-57. 2007....
- Unrest at rest: default activity and spontaneous network correlationsRandy L Buckner
Department of Psychology, Center for Brain Science, Harvard University, and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge 02138, USA
Neuroimage 37:1091-6; discussion 1097-9. 2007..Maps of spontaneous network correlations also provide tools for functional localization and study of comparative anatomy between primate species. For all of these reasons, we advocate the systematic exploration of rest activity...
- Remembering the past to imagine the future: the prospective brainDaniel L Schacter
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
Nat Rev Neurosci 8:657-61. 2007..We suggest that processes such as memory can be productively re-conceptualized in light of this idea...
- Distinct cortical anatomy linked to subregions of the medial temporal lobe revealed by intrinsic functional connectivityItamar Kahn
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
J Neurophysiol 100:129-39. 2008..The cortical pathways include regions that have undergone considerable areal expansion in humans, providing insight into how the MTL memory system has evolved to support a diverse array of cognitive domains...
- The brain's default network: anatomy, function, and relevance to diseaseRandy L Buckner
Department of Psychology, Harvard University, William James Hall, 33 Kirkland Drive, Cambridge, MA 02148, USA
Ann N Y Acad Sci 1124:1-38. 2008..We conclude by discussing the relevance of the default network for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease...
- Episodic simulation of future events: concepts, data, and applicationsDaniel L Schacter
Department of Psychology, Harvard University, 33 Kirkland St, Cambridge, MA 02138, USA
Ann N Y Acad Sci 1124:39-60. 2008..These processes together comprise what we have termed "the prospective brain," whose primary function is to use past experiences to anticipate future events...
- The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009....
- Evidence for a frontoparietal control system revealed by intrinsic functional connectivityJustin L Vincent
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Neurophysiol 100:3328-42. 2008..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems...
- Regional white matter volume differences in nondemented aging and Alzheimer's diseaseDavid H Salat
Department of Radiology, Massachusetts General Hospital, Boston MA, USA
Neuroimage 44:1247-58. 2009..Overall, these results demonstrate the utility of automated regional WM measures in revealing the distinct patterns of age and AD associated volume loss that may contribute to cognitive decline...
- Repetition priming influences distinct brain systems: evidence from task-evoked data and resting-state correlationsGagan S Wig
Harvard University, Department of Psychology, 33 Kirkland Street, Cambridge, MA 02138, USA
J Neurophysiol 101:2632-48. 2009..These results thus explain the long-known dissociation between perceptual and conceptual components of priming by revealing how a single experience can separately influence distinct, concurrently active brain systems...
- Thinning of the cerebral cortex in agingDavid H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Cereb Cortex 14:721-30. 2004..These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex...
- Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimizationKoene R A van Dijk
Harvard University Center for Brain Science, 52 Oxford Street, Cambridge, MA 02138, USA
J Neurophysiol 103:297-321. 2010..We conclude by discussing the strengths and limitations of fcMRI and how it can be combined with HARDI techniques to support the emerging field of human connectomics...
- The organization of the human cerebral cortex estimated by intrinsic functional connectivityB T Thomas Yeo
Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
J Neurophysiol 106:1125-65. 2011..We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition...
- Neural Processes Underlying Cognitive AgingRandy L Buckner; Fiscal Year: 2010..Here we seek to understand the brain factors in normal aging that impair cognition as well as compensate to mitigate cognitive decline. By understanding these factors we hope to promote healthy, graceful aging. ..
- Functional-anatomic exploration of cognitive controlRandy Buckner; Fiscal Year: 2009..abstract_text> ..
- Functional-anatomic exploration of cognitive controlRandy Buckner; Fiscal Year: 2007....
- FUNCTIONAL ANATOMIC EXPLORATION OF TASK REPETITIONRandy Buckner; Fiscal Year: 2002..It thus seems likely that the principles by which normal brains are able to facilitate task performance and acquire new skills will extend to how the damaged brain acquires skills that were lost. ..